Clinical trials: CRS, open to volunteers
Asthma, Chronic Rhinosinusitis With Nasal Polyps
Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps
Asthma and chronic rhinosinusitis (CRS) are inflammatory diseases of the respiratory tract, asthma from the lower part, and CRS, from the upper part.
- Conditions
- Asthma, Chronic Rhinosinusitis With Nasal Polyps, Chronic Rhinosinusitis (Diagnosis), Nasal Polyps
- Trial name
- PREMIUM (NCT05009758)
- Testing
- Blood sampling, Nasosorption, Oral sampling
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Chronic Rhinosinusitis (CRS)
Real-life Evaluation of the Efficacy of Biologicals in Chronic Rhinosinusitis With Nasal Polyposis (CRSwNP)
The goal of this observational study is to learn more about the real-world efficacy of biologics in patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).
- Trial name
- RELIBIO (NCT06683261)
- Testing
- Omalizumab, Dupilumab, Mepolizumab 100 mg
- Where
- 8 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Chronic Rhinosinusitis (CRS), Olfactory Dysfunction
Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction
This single-center randomized controlled trial evaluates whether budesonide nasal drops delivered in the Wu's position (Wu's 45° Head-Hanging Reclination Position) improve olfactory function more effectively than conventional…
- Trial name
- NCT07386873
- Testing
- Nasal Drops, Nasal Spray
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Peking University Third Hospital
Relapsed/Refractory Multiple Myeloma (RRMM)
Adult Outpatient Linvoseltamab With Tocilizumab Prophylaxis to Mitigate the Risk of Cytokine Release Syndrome (CRS)
This study is researching whether the use of tocilizumab before the first dose of linvoseltamab will decrease the risk of Cytokine Release Syndrome (CRS) in participants who have Relapsed or Refractory Multiple Myeloma (RRMM) who…
- Trial name
- POPLIN (NCT07609940)
- Testing
- Linvoseltamab, Tocilizumab
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- Regeneron Pharmaceuticals
Ovarian Cancer, Drug Related Neoplasm/Cancer
Secondary Cytoreductive Surgery (CRS) in Patients With Relapsed Ovarian Cancer Who Have Progressed on PARP Inhibitor Maintenance
This is a randomized phase II study of secondary cytoreductive surgery (CRS) in patients with relapsed ovarian cancer who have progressed on PARP inhibitor maintenance.
- Trial name
- SOCCER-P (NCT05704621)
- Testing
- secondary cytoreductive surgery, chemotherapy
- Where
- South Korea
- Volunteers
- 124 people
- Sponsor
- Korea University Guro Hospital
Relapsed Multiple Myeloma, Refractory Multiple Myeloma
INfections in Patients Treated With CAR-T
This study includes adults with multiple myeloma or B-cell lymphoma who were/will be treated with CAR-T cell therapy at the IRCCS Azienda Ospedaliero-Universitaria di Bologna.
- Conditions
- Relapsed Multiple Myeloma, Refractory Multiple Myeloma, B-Cell Non-Hodgkin Lymphoma, Bloodstream Infections
- Trial name
- IN-CART (NCT07713511)
- Where
- Italy
- Volunteers
- 290 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Graft Vs Host Disease, Graft-versus-host-disease
Ruxolitinib With and Without CTLA-4 Ig Abatacept for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation
Allogeneic hematopoietic cell transplantation (HCT) is one of the only curative intent therapies available for hematologic malignancies.
- Conditions
- Graft Vs Host Disease, Graft-versus-host-disease, Graft Versus Host Disease
- Trial name
- NCT06008808
- Testing
- Ruxolitinib, Abatacept
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Washington University School of Medicine
Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS)
Efficacy of Lavender Aromatherapy on Anxiety and Pain Reduction During Awake Otolaryngologic Procedures
The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting.
- Conditions
- Inferior Turbinate Hypertrophy, Chronic Rhinosinusitis (CRS), Rhinitis, Vasomotor, Thyroid Nodules
- Trial name
- NCT07299474
- Testing
- Lavender Aromatherapy
- Where
- United States
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Chronic Rhinosinusitis (CRS)
Propel Drug-Eluting Sinus Implant Family IBUKI Cohort
To confirm clinical safety and performance for the PROPEL family of products when used according to IFUs and standard of care in Japan.
- Trial name
- NCT07546682
- Testing
- None, observational standard of care study
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Medtronic
B Cell Malignancies, B-cell Leukemia
Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial)
This study is to provide locally produced, bispecific CD19 CD20 CAR T cells to patients with B-cell lymphoma/leukemia who have no access to commercial CAR T cells or who have relapsed thereafter.
- Conditions
- B Cell Malignancies, B-cell Leukemia, B Cell Lymphoma, Bispecific Chimeric Antigen Receptor (CAR) T Cells
- Trial name
- BaseCAR-01 (NCT07166549)
- Testing
- Experimental Intervention
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- University Hospital, Basel, Switzerland
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
CRS Questionnaire Validation Project
The 'CRS validation project' consists of a joint effort of 32 medical centers in Europe, the USA, and South Africa to carry out the validation of 2 novel questionnaires designated to measure self-perceived severity and control of…
- Trial name
- NCT06970977
- Where
- 32 sites in United States, Belgium and 9 more
- Volunteers
- 1,000 people
- Sponsor
- The European Forum for Research and Education in Allergy and Airway Diseases
Disorders of Consciousness, Vegetative State
Effectiveness of tTIs for Improving Consciousness in Patients With DoC
The goal of this clinical trial is to learn if a new type of brain stimulation called theta-burst patterned temporal interference stimulation (tTIs) works to improve awareness in people with disorders of consciousness (DoC).
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- NCT07539740
- Testing
- Theta-burst Patterned Temporal Interference Stimulation (tTIs)
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Zhujiang Hospital
Deformational Plagiocephaly, Deformational Posterior Plagiocephaly
Effectiveness of Repositioning and Cranial Remolding in Infants With Cranial Deformation
This study will examine how effective caregiver's repositioning strategies are in correcting an infant's deformational cranial shape, as well as the effectiveness of the use of a custom cranial remolding orthosis for treatment of…
- Conditions
- Deformational Plagiocephaly, Deformational Posterior Plagiocephaly, Brachycephaly, Torticollis
- Trial name
- NCT05917678
- Testing
- Repositioning Therapy, Cranial Remolding Orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
URTI, Bronchiolitis
Assessement of Effectiveness of Seawater Nasal Sprays on Sinonasal Symptoms
The purpose of this post-market clinical investigation is to assess in a real-life setting, the effectiveness, usage, tolerance, safety and satisfaction of 4 isotonic and hypertonic seawater-based CE-marked nasal sprays.
- Conditions
- URTI, Bronchiolitis, COVID - 19, Allergic Rhinitis
- Trial name
- SeaBridge (NCT07262450)
- Testing
- Respimer® Hygiene-Prevention -Baby, kids, adults, Respimer® Hygiene-Prevention Kids, adults, Respimer® Decongestion Baby, kids, adults
- Where
- 32 sites in France
- Volunteers
- 1,065 people
- Sponsor
- Laboratoire de la Mer
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Pseudomyxoma Peritonei
One vs Three HIPEC Cycles After CRS for Pseudomyxoma Peritonei
The goal of this clinical trial is to compare the efficacy and safety of one versus three sessions of hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) for patients with pseudomyxoma peritonei…
- Trial name
- NCT07328737
- Testing
- One HIPEC session, Three HIPEC sessions
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Cytokine Release Syndrome
Study of CTO1681 for the Prevention and Treatment of CRS in Patients Receiving CAR T-Cell Therapy
This is an interventional study to evaluate the use of CTO1681 in preventing or reducing CAR T-cell-induced toxicities like cytokine release syndrome (CRS).
- Trial name
- NCT05905328
- Testing
- CTO1681 10 µg, CTO1681 20 μg, CTO1681 30 μg
- Where
- 6 sites in United States
- Volunteers
- 54 people
- Sponsor
- CytoAgents, Inc.
Metopic Craniosynostosis, Craniosynostosis
Frontal Reconstruction Without Orbital Advancement for Moderate Metopic Craniosynostosis
Metopic craniosynostosis is a condition caused by the early fusion of the metopic suture, leading to restricted frontal bone growth and a triangular head deformity termed trigonocephaly.
- Conditions
- Metopic Craniosynostosis, Craniosynostosis, Metopic Synostosis
- Trial name
- NCT07837453
- Testing
- Frontal vault remodelling without orbital advancement
- Where
- Egypt
- Volunteers
- 15 people
- Sponsor
- Assiut University
Myeloma Multiple, Plasma Cell Leukemia
The Norwegian Immunotherapy in Multiple Myeloma Study
The goal of this observational study is to study the effectiveness and complications of novel immunotherapies used in the treatment of multiple myeloma in routine care in Norway.
- Conditions
- Myeloma Multiple, Plasma Cell Leukemia, AL Amyloidosis
- Trial name
- NIMMS (NCT06855121)
- Testing
- Teclistamab, Elranatamab, Ciltacabtagene Autoleucel
- Where
- 23 sites in Norway
- Volunteers
- 400 people
- Sponsor
- St. Olavs Hospital
Chronic Rhinosinusitis (CRS)
Impact of Structural and Microenvironmental Abnormalities in Olfactory Cleft on Olfaction in CRS
The purpose of this research is to investigate the impact of structural abnormalities and microenvironmental changes in the olfactory cleft on olfactory function in patients with chronic rhinosinusitis (CRS).
- Trial name
- NCT06834477
- Testing
- Computed Tomography
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital