Clinical trials: CT Coronary Angiography
Acute Coronary Syndrome
Rapid Assessment of Potential Ischaemic Heart Disease With CTCA
This study aims to investigate the effect of early CTCA in patients with suspected or confirmed Acute Coronary Syndrome (ACS) presenting to the Emergency Department (ED) or Medical Assessment Unit (MAU), upon interventions, event…
- Trial name
- RAPID-CTCA (NCT02284191)
- Testing
- CT Coronary Angiogram
- Where
- 37 sites in Jersey, United Kingdom
- Volunteers
- 1,749 people
- Sponsor
- University of Edinburgh
Coronary Artery Disease
HeartFlowNXT - HeartFlow Analysis of Coronary Blood Flow Using Coronary CT Angiography
To determine the diagnostic performance of FFRCT by coronary computed tomographic angiography (cCTA), as compared to cCTA alone, for non-invasive determination of the presence of a hemodynamically significant coronary lesion…
- Trial name
- HFNXT (NCT01757678)
- Testing
- ICA (Invasive Coronary Angiography), FFR (Fractional Flow Reserve), cCTA (coronary computed tomography angiography)
- Where
- Denmark
- Volunteers
- 276 people
- Sponsor
- HeartFlow, Inc.
Chest Pain, Acute Coronary Syndrome
Computed Tomography Coronary Angiogram (CTCA) Versus Traditional Care in Emergency Department Assessment of Potential Acute Coronary Syndromes (ACS)
This multi-center, randomized, controlled trial conducted in Emergency Departments (ED) compares computed tomography (CT) coronary angiography with the traditional approach (usual care) for low- to intermediate-risk chest pain…
- Conditions
- Chest Pain, Acute Coronary Syndrome, Acute Myocardial Infarction, Coronary Artery Disease
- Trial name
- NCT00933400
- Testing
- CT Coronary Angiography (CTCA), Traditional Strategy
- Where
- 5 sites in United States
- Volunteers
- 1,392 people
- Sponsor
- American College of Radiology
Coronary Artery Disease
Role of On-site CT-derived FFR in the Management of Suspect CAD Patients
The primary of this registry is to evaluate whether the availability of CTA/CT-FFR procedure could effectively optimize the flow of clinical practice of stable chest pain versus conventional clinical pathway in decision making…
- Trial name
- TARGET (NCT03901326)
- Testing
- CT-FFR assessment
- Where
- China
- Volunteers
- 1,216 people
- Sponsor
- Chinese PLA General Hospital
Acute Coronary Syndromes, Coronary Artery Disease
Computed Tomographic Coronary Angiography for Acute Chest Pain Evaluation
The purpose of this study is to evaluate whether 64-slice Computed Tomographic coronary angiography is useful for rapid diagnosis or exclusion of significant coronary artery disease in patients who present to the Emergency…
- Trial name
- EDCCTA (NCT00615719)
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Virginia Commonwealth University
Coronary Artery Disease
Assessment of Coronary Artery Disease by Hybrid PET/CT
There have been many advances in the test used to look for heart disease. An example of this newer technology is the Multislice CT scan (MSCT) and Positron Emission Tomography (PET) scans.
- Trial name
- NCT00320931
- Testing
- Hybrid PET/CT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Maryland, Baltimore
Coronary Artery Disease
Clinical Evaluation of the CADence Device in Detection of Coronary Artery Diseases
This is a multi-center, prospective, non-randomized, double-blinded trial to evaluate the sensitivity and specificity of the CADence device in detecting the existence of clinically significant coronary artery disease as…
- Trial name
- TURBULENCE (NCT01743040)
- Testing
- CADence
- Where
- 24 sites in United States
- Volunteers
- 1,014 people
- Sponsor
- AUM Cardiovascular, Inc.
Coronary Artery Disease
Ultra-high-resolution CT vs. Conventional Angiography for Detecting Coronary Heart Disease
Cardiac catheterization with invasive coronary angiography is the gold standard for determining the presence or absence of significant coronary heart disease (CHD).
- Trial name
- NCT04272060
- Testing
- CT angiography, Invasive coronary angiography
- Where
- 3 sites in United States, Brazil and 1 more
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins University
Contrast Enhancement on Cardiac CT
Comparison of Contrast Agents During CT Angiography
The purpose of this study is to compare the effects of a certain contrast agent (iodixanol) to two other commonly used contrast agents called Iopamidol (Isovue) and iohexol (Omnipaque), on heart and kidney safety in patients…
- Trial name
- Visipaque (NCT01534975)
- Testing
- contrast agent
- Where
- United States
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Radiation Safety, Coronary Computed Tomography Angiography
Focused Field of View Calcium Scoring Prior to Coronary CT Angiography
Coronary computed tomography angiography (CCTA) is a frequently performed test for the diagnosis and/or exclusion of coronary artery disease (CAD) in appropriately selected patients.
- Conditions
- Radiation Safety, Coronary Computed Tomography Angiography, Coronary Artery Disease
- Trial name
- FOCUS-CCTA (NCT02972242)
- Testing
- Field of View
- Volunteers
- 175 people
- Sponsor
- Walter Reed National Military Medical Center
Coronary Artery Diseases, Multivessel Coronary Artery Disease
SYNTAX III REVOLUTION Trial: A Randomized Study Investigating the Use of CT Scan and Angiography of the Heart to Help the Doctors Decide Which Method is the Best to Improve Blood Supply to the Heart in Patients With Complex Coronary Artery Disease
The SYNTAX III Revolution trial is a randomized diagnostic research study that investigates the use of CT scan and angiogram of the heart to help doctors decide which method is the best to improve blood supply to the heart in…
- Conditions
- Coronary Artery Diseases, Multivessel Coronary Artery Disease, Heart Diseases, Cardiovascular Diseases
- Trial name
- SYNTAX III (NCT02813473)
- Testing
- Coronary Angiography, Computed Tomography (CT) scan
- Where
- 6 sites in Belgium, France and 3 more
- Volunteers
- 223 people
- Sponsor
- ECRI bv
Bradycardia
Heart Rate Reducing Therapy in Cardiac CT Using Ivabradine and Bisoprolol
Out-patients scheduled for coronary computer tomographic angiography (CCTA) were screened regarding their baseline heart rate. If heart rate was > 75, patients were pretreated with 10mg bisoprolol (group 1) or 10mg bisoprolol…
- Trial name
- NCT02764970
- Testing
- Ivabradine 7.5mg orally
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cardiovascular Disease
CT COMPARE: CT Coronary Angiography to Measure Plaque Reduction
Background: Coronary artery disease causes plaque in arteries. This can cause stroke or heart disease. Drugs called statins might shrink plaque.
- Trial name
- NCT02740699
- Testing
- Rosuvastatin, Atorvastatin, Cardiac Computed Tomography (CT)
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Xenetix® 350: Comparative Assessment of Image Quality for Coronary CT Angiography
The purpose of this study is to demonstrate the (statistical) non-inferiority of iobitridol (Xenetix® 350) when compared to contrast agents with higher iodine concentrations, iopromide (Ultravist® 370) and iomeprol (Iomeron® 400)…
- Trial name
- X-ACT (NCT01255722)
- Testing
- iobitridol, iopromide, iomeprol
- Where
- 23 sites in France, Germany and 3 more
- Volunteers
- 468 people
- Sponsor
- Guerbet
Myocardial Infarction, Coronary Artery Disease
PET/CT Study in the Diagnosis of Coronary Plaque
This study is being done to determine if a picture taking test of the heart, positron emission tomography/computed tomography (or cardiac PET/CT), can identify the blockages in the heart arteries that lead to heart attacks when…
- Conditions
- Myocardial Infarction, Coronary Artery Disease, Cardiac Catheterization
- Trial name
- PET/CT (NCT00850473)
- Testing
- PET/CT
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Washington University School of Medicine
Atherosclerosis
Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary Calcium
Current oral anti-coagulation for atrial fibrillation is most commonly performed with warfarin. Warfarin is a vitamin K antagonist that has been shown in non-randomized trials to increase vascular calcification.
- Trial name
- NCT02376010
- Testing
- rivaroxaban, Warfarin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Coronary Artery Disease
Screening For Asymptomatic Obstructive Coronary Artery Disease Among High-Risk Diabetic Patients Using CT Angiography, Following Core 64
Patients with a known history of diabetes mellitus and no prior documented evidence of cardiovascular disease will be evaluated for inclusion in the study.
- Trial name
- faCTor-64 (NCT00488033)
- Testing
- CT Angiography
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- Intermountain Health Care, Inc.
Coronary Heart Disease, Coronary Artery Disease
Cardiogoniometry for Detecting Coronary Artery Disease by CT Angiography
Cardiogoniometry is a technique to process and evaluate vectorcardiography from regular ECG acquisitions. Vectorcardiography has a long tradition in cardiology for providing comprehensive information on myocardial function and…
- Conditions
- Coronary Heart Disease, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- NCT02725671
- Testing
- Explorer
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Johns Hopkins University
Coronary Artery Disease
Clinical Impact of Cardiac Photon-Counting Detector CT
The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) provide clinically important information about the severity of suspected coronary artery disease and…
- Trial name
- NCT05240807
- Testing
- Photon-counting detector computed tomography (PCD-CT)
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Effects of Sublingual and Transdermal Administration of Nitroglycerin for Coronary CT Angiography on Image Quality
To evaluate image quality of coronary CT angiography (cCTA) after sublingual and transdermal administration of Nitroglycerin. Aim of this prospective research study is to investigate equivalence on image quality after sublingual…
- Trial name
- NCT02961946
- Testing
- Nitroglycerin
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Massachusetts General Hospital