Clinical trials: CT Photon-Counting
Intracranial Stenosis, Venous Sinus Stenosis
This Prospective Observational Study Aims to Evaluate the Capability of Ultra-high-resolution Photon-counting CT Angiography (UHR PCD-CTA) for Noninvasive Evaluation of Intracranial Venous Sinus Stents. The Study Will Compare Image Quality, Stent Visualization, Metal-related Artifacts, and Diagnosti
This prospective observational study aims to evaluate the effectiveness of ultra-high-resolution photon-counting CT angiography (UHR PCD-CTA) for noninvasive assessment of intracranial venous sinus stents.
- Conditions
- Intracranial Stenosis, Venous Sinus Stenosis, Stent Implantation, Intracranial Venous Pressures
- Trial name
- NCT07762677
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
Coronary Artery Disease, Plaque
PCCT-Defined High-Risk Plaque and Future Coronary Events: The PREDICT Study
This prospective cohort study aims to determine whether high-risk coronary plaques identified by novel Photon-Counting Detector CT (PCCT) independently predict future major adverse cardiovascular events (MACE).
- Conditions
- Coronary Artery Disease, Plaque, Photon-Counting Computed Tomography
- Trial name
- PREDICT (NCT07822737)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Lung Neoplasm Malignant
Benefit of Spectral Information in Patients Suspected for Lung Cancer
Purpose The aim of the study is to investigate the utilization of photon counting CT (PCCT) and the spectral information provided to determine the impact of spectral information on follow-up examinations.
- Trial name
- NCT06440616
- Testing
- Spectral CT images generated by a photon counting CT scanner
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Copenhagen University Hospital at Herlev
Computed Tomography Angiography, Coronary Artery Disease
Randomized Prospective Trial on the Cost-Effectiveness of Photon-Counting CT Versus Energy-Integrating Detector CT in Suspected Chronic Coronary Syndrome
Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Coronary computed tomography angiography (CCTA) is recommended as a first-line imaging test in patients with suspected obstructive CAD.
- Trial name
- COST-PCCT-CCS (NCT07831304)
- Testing
- Radomization to undergo CCTA with EID-CT, Randomization to undergo CCTA with PCD-CT
- Where
- Italy
- Volunteers
- 630 people
- Sponsor
- IRCCS San Raffaele
Coronary Artery Disease, Atherosclerotic Plaque
Changes in Plaque Characteristics After Short-term Statin Therapy as Assessed With Coronary CT
INTENSE Trial is a prospective, double-blind, randomized, placebo-controlled, single-center study with two arms (40 mg intensified statin therapy vs matching placebo for rosuvastatin) among statin-naive patients referred to…
- Conditions
- Coronary Artery Disease, Atherosclerotic Plaque, Coronary Computed Tomography Angiography, Statin Therapy
- Trial name
- INTENSE (NCT06603363)
- Testing
- Rosuvastatin 40mg, Coronary Computed Tomography Angiography (Coronary CTA), Blood test
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- Prof. Maurovich-Horvat Pál
IPF, ILD
Photon-counting CT Scan vs Standard HRCT Scan in the Identification of Idiopathic Pulmonary Fibrosis
The CT-IPF ANTHEM study is designed to prospectively compare PCDCT to HRCT scan in the identification of specific ILD diagnosis discussed during the multidisciplinary discussion to increase diagnostic confidence and reduce…
- Conditions
- IPF, ILD, Interstitial Lung Disease (ILD), Interstitial Lung Diseases
- Trial name
- CT-IPF ANTHEM (NCT07790614)
- Testing
- Photon counting CT
- Where
- Italy
- Volunteers
- 156 people
- Sponsor
- Istituto Clinico Humanitas
Cardiovascular Diseases
Photon-Counting Cardiac CT in Post-PCI Patients
This study takes patients who have undergone percutaneous coronary intervention as the research subjects and employs a prospective observational cohort design, aiming to develop and validate a "one-stop" photon-counting computed…
- Trial name
- NCT07763340
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Chinese PLA General Hospital
Coronary Artery Bypass Grafting (CABG) Surgery, Coronary Artery Disease
Prospective Study Protocol for Multiparametric PCCT Assessment of Early Ventricular Outcomes After CABG
The goal of this observational study is to learn whether information about heart muscle tissue from preoperative photon-counting CT, a newer type of CT scan, can help predict heart recovery 3 months after coronary artery bypass…
- Trial name
- PCCT-CABG (NCT07883499)
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Xin Lou
Carotid Plaque
CT Evaluation of Carotid Plaque Components
The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the…
- Trial name
- NCT05764772
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Pennsylvania
Coronary Artery Disease, Aortic Valve Stenosis
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly…
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Tomography, X-Ray Computed
- Trial name
- Alpha Registry (NCT07016477)
- Testing
- Ultra-High Resolution Photon Counting Detector Coronary Computed Tomography Angiography
- Where
- 7 sites in United States, Germany and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Semmelweis University
Supra-Aortic Stenosis
Comparison of Spectral Photon Counting CT (SPCCT) With Dual Energy CT (DECT) and Magnetic Resonance Imaging (MRI) for Plaque and Lumen Carotid Arteries Evaluation
In this study, the investigator propose to determine the efficiency of a new and more sophisticated imaging prototype, the Spectral Photon Counting Computed Tomography (SPCCT), at characterizing vulnerable plaques and luminal…
- Trial name
- CAPL (NCT04466787)
- Testing
- Spectral Photon Counting Computed Tomography (SPCCT), Dual Energy CT (DECT)
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Hospices Civils de Lyon
CT Photon-Counting
Spectral CT With Advanced CT Technology
The purpose of the study is to collect data to evaluate feasibility of the using photon-counting CT in a clinical setting.
- Trial name
- NCT04781296
- Testing
- CT with a photon-counting detector
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- GE Healthcare
Coronary Artery Disease
Evaluation of PCD-CT Based Image Parameters in the Assessment and Quantification of Coronary Artery Disease
The goal of this observational study is to learn about a new type of computed tomography (Photon-Counting Detector CT) in patients with coronary artery disease.
- Trial name
- EPIPHANY (NCT05877768)
- Testing
- Photon Counting Detector Coronary Computed Tomography Angiography
- Where
- Germany
- Volunteers
- 3,000 people
- Sponsor
- University Medical Center Mainz
Radiation Protection, Image Enhancement
Next-Generation Photon-Counting CT Technology: Development and Clinical Evaluation
This project aims to develop and evaluate a next-generation photon-counting CT prototype, and assess whether next-generation photon-counting CT--which enables reduced radiation dose, high spatial resolution, and spectral…
- Trial name
- CT-DACE (NCT06691659)
- Testing
- CT-DACE
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Pennsylvania
Carotid Artery Stenosis, Carotid Atherosclerosis
Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis
This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of…
- Conditions
- Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque
- Trial name
- NCT07762664
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese PLA General Hospital
Computed Tomography
Next Generation CT System
The purpose of the study is to collect data to evaluate utility of a next generation CT system in a clinical setting.
- Trial name
- NCT06769594
- Testing
- Investigational CT Scan
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- GE Healthcare
Gastrointestinal Lesions
Photon-Counting CT for Detection of Small Gastrointestinal Lesions
This comparative matched-cohort study aims to evaluate the diagnostic performance of contrast-enhanced photon-counting computed tomography (PCCT) for detecting small gastrointestinal lesions compared with energy-integrating…
- Trial name
- PCCT-GI (NCT07748923)
- Testing
- Contrast-Enhanced Photon-Counting Computed Tomography, Contrast-Enhanced Energy-Integrating Detector Dual-Energy Computed Tomography
- Where
- China
- Volunteers
- 1,762 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis
Photon-counting CT for Intracranial Stent Assessment
Intracranial atherosclerotic disease is an important cause of ischemic stroke, and intracranial stent implantation is increasingly used for patients with severe stenotic lesions.
- Conditions
- Intracranial Atherosclerotic Disease (ICAD), Intracranial Arterial Stenosis, Stent Restenosis, Ischemic Stroke
- Trial name
- NCT07769814
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xin Lou
Cancer
Exploring Photon-Counting CT for Enhanced Target Delineation and Dose Accuracy in Personalized Radiotherapy - ANTHEM
Radiotherapy remains a cornerstone of oncology care, particularly for rare or orphan cancers and chronic oncologic and rare non oncologic conditions, where precision and individualized treatment planning are necessary.
- Trial name
- RAD4/RT_ANTHEM (NCT07098247)
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Istituto Clinico Humanitas
Coronary Artery Disease
Clinical Impact of Cardiac Photon-Counting Detector CT
The purpose of this research trial is to determine whether images taken using a Photon Counting Detector CT scanner (PCD-CT) provide clinically important information about the severity of suspected coronary artery disease and…
- Trial name
- NCT05240807
- Testing
- Photon-counting detector computed tomography (PCD-CT)
- Where
- United States
- Volunteers
- 276 people
- Sponsor
- Mayo Clinic