Clinical trials: CTEPH
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension
Non-Invasive Measurement of Cardiac Output and Stroke Volume in PAH/CTEPH
Pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) are severe clinical conditions that, despite advances in therapeutics over the past 20 years, lead to serious morbidity and…
- Trial name
- NCT05618093
- Testing
- Non-invasive hemodynamic measurements
- Where
- United States
- Sponsor
- University of California, Los Angeles
Chronic Thromboembolic Pulmonary Hypertension
Hemodynamic Effects of BPA at Rest and During Exercise in CTEPH
Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by obstruction of the pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular resistance (PVR), progressive pulmonary…
- Trial name
- EXPERT-BPA (NCT04052243)
- Testing
- Invasive exercise testing
- Where
- 3 sites in Denmark, Japan and 1 more
- Volunteers
- 80 people
- Sponsor
- Aarhus University Hospital
Chronic Thromboembolic Pulmonary Hypertension
Registry of Patients With Chronic Thromboembolic Pulmonary Hypertension in Novosibirsk Region
There will be assessment of patients after acute pulmonary embolism for the development of CTEPH
- Trial name
- NCTEPHR (NCT03349164)
- Testing
- acute PE survivors
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Novosibirsk Scientific Research Institute for Circulatory Pathology
Multidetector Computed Tomography, Pulmonary Embolism and Thrombosis
Lung Perfusion Measured With Dual-Energy CT in Patients With Chronic Thromboembolic Pulmonary Hypertension: Comparative Study With Right Heart Catheterization and V/Q
A comparative, observational, cross-sectional and prolective diagnostic test study, including patients that have had a right heart catheterization and were referred for a CT pulmonary angiography as part of their imaging workup…
- Conditions
- Multidetector Computed Tomography, Pulmonary Embolism and Thrombosis, Hypertension Pulmonary Secondary
- Trial name
- NCT03450304
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Chronic Thromboembolic Pulmonary Hypertension
The Prospective Risk Factor Evaluation & Discovery In CTEPH Study
This research study wants to find markers in the blood that may help to predict a patient's future risk of developing a disease called CTEPH.
- Trial name
- PREDICT PH (NCT03470207)
- Testing
- Post-pulmonary embolism follow up protocol
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Mark W. Dodson
Hypertension, Pulmonary
Electronic Activity Level Monitoring Pilot in Pulmonary Hypertension
Evaluate the correlation between activity level (monitored by Fitbit Flex remote activity tracker) and 6-minute walk distance (6MWD) (performed by investigator) in patients with Pulmonary Arterial Hypertension (PAH) or Chronic…
- Trial name
- e-MOTION PH (NCT02536534)
- Testing
- Correlation assessment
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Bayer
PAH, CTEPH
Effects of Pulmonary Rehabilitation on Quality of Life and Health in Pulmonary Arterial Hypertension Patients
Pulmonary hypertension (PH) is a major global health concern, affecting approximately 1% of the world's population. With global aging and increased life expectancy, its incidence continues to rise.
- Trial name
- EPRQoL-PAH (NCT06973382)
- Testing
- Comprehensive Pulmonary Rehabilitation Program, Standard Pulmonary Rehabilitation
- Volunteers
- 84 people
- Sponsor
- Beijing Chao Yang Hospital
Chronic Thromboembolic Pulmonary Hypertension
N-acetyl Cysteine in Post-reperfusion Pulmonary Injury in Chronic Thromboembolic Pulmonary Hypertension.
This study will evaluate the use of N-acetyl cysteine in post-reperfusion pulmonary injury in patients with chronic thromboembolic pulmonary hypertension undergoing pulmonary balloon angioplasty and pulmonary endarterectomy.
- Trial name
- NAC-PostRep (NCT04081012)
- Testing
- N-acetyl cysteine
- Where
- Mexico
- Volunteers
- 34 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Post Thrombotic Syndrome, Deep Vein Thrombosis
Long-term Outcome After Heparin and Edoxaban Versus Heparin Plus Vit K Antagonists for Acute DVT and PE
Centers that participated in the HOKUSAI VTE trial will be invited to collect follow of previously enrolled patients at least 2 years after the index VTE.
- Conditions
- Post Thrombotic Syndrome, Deep Vein Thrombosis, Chronic Thromboembolic Pulmonary Hypertension
- Trial name
- NCT03757481
- Testing
- no intervention
- Where
- 11 sites in France
- Volunteers
- 156 people
- Sponsor
- University Hospital, Montpellier
Chronic Thromboembolic Pulmonary Hypertension
The Right Ventricle in Chronic Pressure Overload: Identifying Novel Molecular Targets for Functional Imaging
Chronically elevated pulmonary pressures do not immediately result in right ventricular failure. During the initial period of exposure, the RV adapts to the increased afterload by altering its metabolism and morphology so as to…
- Trial name
- MVD (NCT03199131)
- Testing
- Right ventricular biopsies
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
CTEPH
Biological Sex and CTEPH-related RV Dysfunction and Recovery (BIOSPHeRe)
1. To identify biological sex differences in baseline RV function in CTEPH 2. To identify biological sex differences in recovery of RV function after PTE surgery in CTEPH 3.
- Trial name
- NCT06105242
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Intermountain Health Care, Inc.
Chronic Thromboembolic Pulmonary Hypertension, Inspiratory Muscle Training
Inspiratory Muscle Training in Pulmonary Hypertension
Inspiratory muscle training for 8 weeks in patients with pulmonary hypertension.
- Conditions
- Chronic Thromboembolic Pulmonary Hypertension, Inspiratory Muscle Training, Inspiratory Muscle Weakness, Pulmonary Arterial Hypertension
- Trial name
- NCT03102294
- Testing
- inspiratory muscle training
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- Federal University of São Paulo
Pulmonary Hypertension
CTEPH DIAGNOSIS Europe - MRI
Phase III diagnostic trial to demonstrate that functional lung MRI can replace VQ-SPECT in a diagnostic strategy for patients with suspected CTEPH where positive findings are verified with catheter pulmonary angiography (CPA), or…
- Trial name
- NCT02791282
- Testing
- Index test: functional dynamic contrast enhanced (DCE)-MRI
- Where
- Germany
- Volunteers
- 1,080 people
- Sponsor
- Hannover Medical School
Chronic Thromboembolic Pulmonary Hypertension
Optimized Management After Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension
Balloon pulmonary angioplasty (BPA) is a new method of treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) or persistent CTEPH after surgery.
- Trial name
- POpPART (NCT04777448)
- Testing
- telerehabilitation
- Volunteers
- 54 people
- Sponsor
- University Hospital, Grenoble
Chronic Thromboembolic Pulmonary Hypertension
Riociguat Versus Balloon Pulmonary Angioplasty in Non-operable Chronic thromboEmbolic Pulmonary Hypertension
"Chronic thromboembolic pulmonary hypertension (CTEPH) is a severe form of pulmonary hypertension characterized by obstruction of the pulmonary vasculature by residual organized thrombi, leading to increased pulmonary vascular…
- Trial name
- RACE (NCT02634203)
- Testing
- Balloon Pulmonary Angioplasty (BPA), Riociguat
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Disease
Chronic Thromboembolic Disease Registry
The goal of this patient registry is to learn about the natural history in patients with chronic thromboembolic disease (CTD) and/or chronic thromboembolic pulmonary hypertension (CTEPH).
- Trial name
- NCT05843500
- Testing
- Survey
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Chronic Thromboembolic Pulmonary Hypertension (CTEPH), Pulmonary Embolism
Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH)
The prevalence of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism (PE) varies widely (0.4% to 8.8%) in the literature.
- Trial name
- Preva-CTEPH (NCT03719027)
- Testing
- Study population
- Where
- 4 sites in France
- Volunteers
- 2,003 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Thromboembolic Pulmonary Hypertension
Clinical Study to Assess the Efficacy, Safety and Tolerability of Macitentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension
Study to evaluate if macitentan is efficient, safe and tolerable enough to be used for treatment of inoperable chronic thromboembolic pulmonary hypertension (CTEPH).
- Trial name
- MERIT-1 (NCT02021292)
- Testing
- Macitentan
- Where
- 36 sites in Belgium, China and 14 more
- Volunteers
- 80 people
- Sponsor
- Actelion
Hypertension, Pulmonary
An Open Multiple Dose Titration Study In Patients With Pulmonary Hypertension
This is a study to demonstrate the feasibility of an individual dose titration scheme based on the systolic blood pressure with a dose range from 1.0 mg TID to 2.5 mg TID.
- Trial name
- NCT00454558
- Testing
- Riociguat (Adempas, BAY63-2521)
- Where
- 15 sites in Germany
- Volunteers
- 75 people
- Sponsor
- Bayer
CTEPH
Feasibility and Influence of Exercise Therapy on Oxygen Uptake and Right Heart Function in CTEPH Patients After PEA
Purpose of this study is to investigate whether and to what extent a cautious respiratory and movement therapy can complement medical treatment and the condition, oxygen uptake, quality of life, the pulmonary vascular pressures…
- Trial name
- NCT01393327
- Testing
- respiratory and exercise therapy
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- Heidelberg University