Clinical trials: CV Risk
Cardiovascular (CV) Risk, Metabolic Health
Advancing Health Equity and Preventive Cardiovascular Care in Indigenous and Remote Communities: a Mobile Healthcare Unit
Indigenous people living in Canada face significant healthcare inequities, particularly in basic, primary, and secondary prevention, leading to higher rates of cardiovascular disease and mortality.
- Conditions
- Cardiovascular (CV) Risk, Metabolic Health, Primary Prevention
- Trial name
- NCT07869069
- Testing
- Cardiovascular risk screening, Follow-up of cardiovascular risk factors
- Where
- Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Laval University
Cardiovascular Risk, Prostate Cancer
The Effect of Multidisciplinary Care Approach on CV Risk Modification in CaP Patients Receiving ADT
Prostate cancer is characterised by its slow progression nature, and even for metastatic disease, the 5-year survival is up to 30%.
- Trial name
- NCT06163924
- Where
- Hong Kong
- Volunteers
- 130 people
- Sponsor
- Chinese University of Hong Kong
Atherosclerosis
The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial
This study will test whether darapladib can safely lower the chances of having a cardiovascular event (such as a heart attack or stroke) in people with coronary heart disease.
- Trial name
- STABILITY (NCT00799903)
- Testing
- Darapladib
- Where
- 650 sites in United States, Argentina and 37 more
- Volunteers
- 15,828 people
- Sponsor
- GlaxoSmithKline
Perioperative Myocardial Injury, Autonomic Dysfunction
LANdiolol to Avoid TAchycardia in Patients at Risk for Cardiovascular Events Undergoing Major Non-cardiac Surgery
Limiting perioperative tachycardia (aiming for a heart rate <90 beats per minute throughout the perioperative period) using the ultra-short acting beta-blocker landiolol in patients with cardiovascular risk factors undergoing…
- Conditions
- Perioperative Myocardial Injury, Autonomic Dysfunction, Cardiovascular (CV) Risk, Major Surgery
- Trial name
- LANTA-P (NCT07168421)
- Testing
- Landiolol
- Where
- Switzerland
- Volunteers
- 114 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypercholesterolemia, Atherosclerotic Cardiovascular Diseases
Evaluation of Long-Term Safety and Tolerability of ETC-1002 in High-Risk Patients With Hyperlipidemia and High CV Risk (CLEAR Harmony)
The purpose of this study is to see if ETC-1002 (bempedoic acid) is safe and well-tolerated versus placebo in patients with high cardiovascular risk and elevated LDL cholesterol that is not adequately controlled by their current…
- Trial name
- NCT02666664
- Testing
- ETC-1002
- Where
- 104 sites in United States, Canada and 4 more
- Volunteers
- 2,230 people
- Sponsor
- Esperion Therapeutics, Inc.
MASLD, Cardiovascular (CV) Risk
Integrated Ultrasound-Derived Fat Fraction and 2D/4D HeartAI for Cardiovascular Risk Management in Patients With MASLD
This prospective observational cohort study aims to evaluate the association between liver fat fraction measured by ultrasound-derived fat fraction (UDFF) and cardiac functional parameters assessed by 2D and 4D HeartAI in adult…
- Conditions
- MASLD, Cardiovascular (CV) Risk, Subclinical Cardiovascular Impairments
- Trial name
- MUCHAI (NCT07545343)
- Where
- China
- Volunteers
- 700 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Patient-Perceived Versus
Perceive and Calculated CV Risk
Cardiovascular prevention guidelines use estimated 10-year atherosclerotic cardiovascular disease (ASCVD) risk to guide treatment decisions and engage patients in shared decision-making.
- Trial name
- NCT05693857
- Testing
- Cardiovascular prevention guidelines
- Where
- Hong Kong
- Volunteers
- 1,500 people
- Sponsor
- Chinese University of Hong Kong
Breast Cancer Survivorship, Weight Management
Weight Management After Cancer for Survivors in Rural Communities
This study is testing a new program called WeCan-Rural, designed to help breast cancer survivors manage symptoms and build healthy habits like eating well, staying active, and managing their weight.
- Conditions
- Breast Cancer Survivorship, Weight Management, Cardiovascular (CV) Risk, Breast Cancer
- Trial name
- WeCan-Rural (NCT07426952)
- Testing
- WeCan-Rural Program
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Cardiovascular Disease
A Phase III Study of AZD0780 on Major Adverse CV Events in Patients With a History of ASCVD Events or at High Risk for a First Event
The purpose of this phase 3, randomized, placebo controlled, event-driven study is to assess the effect of AZD0780, an oral PCSK9 inhibitor, compared with placebo in reducing the risk of MACE-PLUS in patients with established…
- Trial name
- AZURE-Outcomes (NCT07000357)
- Testing
- AZD0780
- Where
- 1,452 sites in United States, Argentina and 34 more
- Volunteers
- 15,100 people
- Sponsor
- AstraZeneca
Cardiovascular Disease
An Observational Study of Burden of Upper GI-Symptoms in CV Risk Patients
The purpose of this study is to investigate the burden of upper gastrointestinal symptoms in patients with cardiovascular disease taking low dose aspirin
- Trial name
- NCT00681759
- Where
- 3 sites in United States, Canada and 1 more
- Volunteers
- 1,836 people
- Sponsor
- AstraZeneca
Cystic Fibrosis (CF), Cardiovascular (CV) Risk
Heart and Blood Vessels Health in People With Cystic Fibrosis
Cystic fibrosis (CF) is a disease that affects over 11,000 people in the UK. It is a genetic condition that affects many organs including the lungs, pancreas, kidneys and liver.
- Conditions
- Cystic Fibrosis (CF), Cardiovascular (CV) Risk, Flow-mediated Dilation Evaluation of the Brachial Artery, Pulse Wave Analysis
- Trial name
- CHi-CF (NCT07692594)
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Cardiovascular, Cardiovascular (CV) Risk
Improving the Heart Health of Home Health Aides
The goal of this early-stage study is to support the heart health of home health aides, a workforce that provides care for adults at home but whose own health has been historically poor.
- Conditions
- Cardiovascular, Cardiovascular (CV) Risk, Cardiovascular Disease (CVD) Risk Factors, Cardiovascular Health
- Trial name
- VITAL (NCT07067398)
- Testing
- Peer Coaching Delivered Life's Essential 8 Program
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cardiovascular Risk Factor, Blood Pressure
Exercise & Diet Effects on CV Risk in Firefighters
The study will explore the capacity for a lifestyle modification in firefighters to improve blood pressure, blood vessel stiffness, inflammation, and reduce oxidative stress.
- Conditions
- Cardiovascular Risk Factor, Blood Pressure, Exercise, Diet Modification
- Trial name
- NCT03344198
- Testing
- Circuit Training exercise & Modified Mediterranean diet
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of New Hampshire
Cardiovascular Disease, Chronic Kidney Disease Patients
A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients
The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.
- Conditions
- Cardiovascular Disease, Chronic Kidney Disease Patients, Hemodialytic Patients, High LDL Level
- Trial name
- L5 (NCT01236820)
- Where
- Taiwan
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Atherosclerosis
Cardiovascular Risk Reduction Study (Reduction in Recurrent Major CV Disease Events)
Main Study (CACZ885M2301): The purpose of the pivotal phase of this trial was to test the hypothesis that canakinumab treatment of patients with myocardial infarction (MI) at least one month prior to study entry and elevated…
- Trial name
- CANTOS (NCT01327846)
- Testing
- Canakinumab, Standard of care
- Where
- 1,131 sites in United States, Argentina and 38 more
- Volunteers
- 10,066 people
- Sponsor
- Novartis Pharmaceuticals
Nicotine, Mental Health
The SCAPIS-Snus Study
Historically, snus use in Sweden was very stable, primarily used by about 20% of men and only 4-5% of women. However, the recent introduction of "white snus" (nicotine pouches) has dramatically changed this landscape.
- Conditions
- Nicotine, Mental Health, Cardiovascular (CV) Risk, Metabolic Abnormalities
- Trial name
- SUCCESS (NCT07573319)
- Where
- 5 sites in Sweden
- Volunteers
- 30,154 people
- Sponsor
- Karolinska Institutet
Breast Cancer
Community Hospital Identification of High CV Risk Patients During Cancer Treatment
The overall of this proposal is to test in community hospitals the utility of a 10-min magnetic resonance imaging (MRI) scan protocol combined with proprietary image analysis algorithms for detecting early cardiovascular (CV)…
- Trial name
- CHI (NCT02566109)
- Testing
- Fast MRI
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wake Forest University Health Sciences
Cardiovascular (CV) Risk
Effect of Eliminating Red Meat Consumption on the Cardiovascular System
The objective of this clinical trial is to evaluate, in clinically healthy young omnivores, whether excluding red and processed meat from their diets for four weeks results in: measurable changes in arterial structure and…
- Trial name
- ERRM (NCT07205237)
- Testing
- Diet without Red and Processed Meat
- Where
- Portugal
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Maria Clara Rocha
ASCVD, Elevated Cholesterol
Trial to Assess the Effect of Long Term Dosing of Inclisiran in Subjects With High CV Risk and Elevated LDL-C
The purpose of this extension study was to evaluate the efficacy, safety, and tolerability of long-term dosing of Inclisiran. The study was a global multicenter study.
- Conditions
- ASCVD, Elevated Cholesterol, Heterozygous Familial Hypercholesterolemia, Homozygous Familial Hypercholesterolemia
- Trial name
- ORION-8 (NCT03814187)
- Testing
- Inclisiran Sodium
- Where
- 238 sites in United States, Canada and 11 more
- Volunteers
- 3,275 people
- Sponsor
- Novartis Pharmaceuticals
Cardiovascular (CV) Risk, Preeclampsia (PE)
Cardiovascular Risk Assessment in Young Women After Index Pregnancy With and Without Placental Complications
In this project, the investigators aim to study how all these factors determine the cardiovascular status of a total of 1,800 mothers, 3 to 6 years after delivery.
- Conditions
- Cardiovascular (CV) Risk, Preeclampsia (PE), Fetal Weight
- Trial name
- CARDIOMOM (NCT07356817)
- Where
- Spain
- Volunteers
- 1,260 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau