Clinical trials: Caffeine-Related Disorders
Sleep, Mood
A Single-Arm, Virtual Clinical Trial to Evaluate the Effects of a Sleep Supporting Beverage and Two Coffee Substitute Products
This is a virtual, single-arm clinical trial that will last 12 weeks. Participants will trial three different products, each for 4 weeks.
- Conditions
- Sleep, Mood, Caffeine Withdrawal, Anxiety
- Trial name
- NCT06146517
- Testing
- Clevr Sleeptime, Clevr Matcha, Clevr Chai
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Clevr Blends
Sublingual, Caffeine
Sublingual Caffeine on Reducing Recovery Time and Postoperative Agitation in Elderly Patients Undergoing General Anesthesia
This study aims to evaluate the efficacy of sublingual caffeine in reducing recovery time and incidence of postoperative agitation in elderly patients undergoing general anesthesia.
- Conditions
- Sublingual, Caffeine, Recovery Time, Postoperative Agitation
- Trial name
- NCT07536568
- Testing
- Caffine citrate
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Sleep, Caffeine
Protocol PERCAF 2018
In this multicentric controlled study, we aims to evaluate effect of caffeine on mental performances during a sleep deprivation protocol. Genetic polymorphisms are considered as a covariable.
- Conditions
- Sleep, Caffeine, Polymorphism
- Trial name
- PERCAF (NCT03859882)
- Testing
- Sleep deprivation
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche Biomedicale des Armees
Dietary Supplement, Exercise
Coffee Increases Physical and Cognitive Performance Both in Men and Women
The impact of caffeine habituation on acute responses to different doses of caffeinated coffee has received minimal attention. This study aimed to investigate the effects of different doses of coffee on physical and cognitive…
- Trial name
- NCT07474753
- Testing
- Low Dose Caffeine (LCOF), Moderate Dose Caffeine (MCOF), High Dose Caffeine (HCOF)
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Cognitive Function, Mood
Cognitive and Cerebral Blood Flow Effects of 2-week Caffeine Abstinence or Maintenance
The purpose of this study is to determine the effects of 2 weeks caffeine abstinence as compared to 2 weeks caffeine maintenance (300mg per day)on cognition and mood.
- Conditions
- Cognitive Function, Mood, Cerebral Haemodynamics, Caffeine Withdrawal
- Trial name
- NCT01376882
- Testing
- Caffeine
- Where
- United Kingdom
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Recurrent Ovarian Cancer
A Drug-drug Interaction Study Of Fluzoparib (SHR3162) on Patients With Recurrent Ovarian Cancer
Primary objective: To evaluate the pharmacokinetic effects of fluzoparib on caffeine, S-warfarin, omeprazole, midazolam, repaglinide and bupropion in patients with recurrent ovarian cancer.
- Trial name
- NCT04718740
- Testing
- fluzoparib
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy Subjects
The Effects of Coffee
In this study, participants will be eligible to participate in a paid research study that will examine the effects of regular coffee drinking. The study takes approximately 2 hours total, 55 min. on 2 separate days.
- Trial name
- NCT00336271
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- American University
Healthy
Food Matrix Effect on Flavanol Absorption, Metabolism and Excretion: Methylxanthines
Dietary intervention study in healthy young adult males to evaluate concentration of flavanol metabolites in plasma and urine after single acute intakes of methylxanthines.
- Trial name
- NCT03526107
- Testing
- CF Control, CF-Theobromine, CF-Caffeine
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Alertness
Evaluating the Impact of Energy Drink Formulas on Alertness for an Extended Period
The primary purpose of the research is to evaluate in healthy adults the time course effects of energy drink formulas containing 120 mg caffeine with varying levels of taurine and b vitamins on subjective alertness in the…
- Trial name
- NCT07400614
- Testing
- All beverages are flavor and color matched, Flavored carbonated beverage, color-matched
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Healthy Volunteers
A Study to Assess the Effect of BMS-986419 on the Single Dose Drug Levels of Probe Substrates in Healthy Participants
The purpose of this study is to assess the effect of BMS-986419 on the pharmacokinetics (PK) of single doses of caffeine (CYP1A2 substrate), bupropion (CYP2B6 substrate), midazolam (CYP3A4 substrate), flurbiprofen (CYP2C9…
- Trial name
- NCT05932277
- Testing
- BMS-986419, Caffeine, Bupropion
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Maximum Force, Strength Endurance
The Effects of Caffeine and Vitamin C on Maximum Strength and Strength Endurance in Adolescents With Mild Mental Fatigue
Objective To investigate the independent and combined effects of caffeine and vitamin C on maximal strength and strength endurance in female adolescents with mild mental fatigue.
- Conditions
- Maximum Force, Strength Endurance, Mental Fatigue
- Trial name
- NCT07726745
- Testing
- 1RM squats and bench presses; repetitions at 65% of 1RM for squats and bench presses
- Volunteers
- 40 people
- Sponsor
- Yunliang Zhang
Caffeine, Caffeine Withdrawal
Influence of Caffeine Consumption on the Human Circadian System
Surveys indicate that 85% of the adult population consume caffeine on a daily basis. Caffeine acts on sleep homeostatic mechanisms by antagonizing the sleep factor adenosine.
- Conditions
- Caffeine, Caffeine Withdrawal, Sleep, Circadian Rhythm
- Trial name
- CICAFF (NCT05409339)
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Psychiatric Hospital of the University of Basel
Acute Pain Due to Trauma
Paracetamol Vs Caffeine Vs Codeine in the Management of Post Traumatic Pain in Emergencies
The purpose of this study is to: Compare the effect of paracetamol alone against Paracetamol+Codeine association against the association of paracetamol + Cafeine in the treatment of post-traumatic acute pain of the limbs.
- Trial name
- NCT05229965
- Testing
- Paracetamol, Paracetamol Codeine, Paracetamol caféine
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Caffeine
Effects of Caffeine in Hydration and Energy Metabolism
The main purposes of this randomized cross-over trial are to characterize and compare the effects of a moderate dose of caffeine intake in healthy physically active males on hydration and energy metabolism specifically: 1.
- Trial name
- NCT01477294
- Testing
- Caffeine
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technical University of Lisbon
Physiological Stress
Impact of Supplements on Stress Markers
The goal of this clinical trial is to examine the effects of caffeine, theanine and tyrosine ingestion on markers of stress in healthy college aged individuals that are exposed to a mental stress task.
- Trial name
- NCT05592561
- Testing
- mental stress task
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Texas State University
Sexual Behavior
Effects of Caffeine on Women's Sexual Arousal
The key research question in this study is whether or not caffeine facilitates genital sexual arousal in women in the presence of an external erotic stimulus.
- Trial name
- NCT01242046
- Testing
- Caffeine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Caffeine, Burning Mouth Syndrome
Caffeine vs. ALA in BMS Treatment. (BMS: Burning Mouth Syndrome. ALA: Alpha-Lipoic Acid.)
The aim of this study was to evaluate the efficacy of caffeine and alpha-lipoic acid in the treatment of burning mouth syndrome by symptom assessment with visual analogue scale.
- Trial name
- NCT06195137
- Testing
- Caffeine, Alpha Lipoic Acid
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Lu Jiang
Athletic Performance, Dietary Supplement
The Effects of Acute Nitrate and Caffeine Co-ingestion on Discipline-Specific Exercise Performance.
The purpose of this study is to investigate the acute, separate, and combined ergogenic effects of dietary nitrate (beetroot juice, BJ) and caffeine (CAF) supplementation on discipline-specific athletic performance.
- Conditions
- Athletic Performance, Dietary Supplement, Iron Status
- Trial name
- NCT07748416
- Testing
- Caffeine, Dietary Nitrate (Beetroot Juice)
- Where
- Poland
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Muscle Damage
Effect of Strength Versus Endurance Training on Muscle Damage in Gym Athletes on Caffeine Supplementation.
Dietary supplements to enhance exercise and athletic performance come in a variety of forms, including tablets, capsules, liquids, powders, and bars.
- Trial name
- NCT06086691
- Testing
- Strength Training with Caffeine, Endurance Training with Caffeine
- Where
- Pakistan
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Liver Disease
Inhibition of VAP-1 by Caffeine in Healthy Human Volunteers Study
Worldwide, liver related morbidity and mortality continue to rise. It is the 5th commonest cause of death in the UK. Liver damage consists of two main components - a) damage to the cells of the liver, called hepatocytes, meaning…
- Trial name
- NOCTUA (NCT02098785)
- Testing
- Caffeine citrate
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Birmingham