Clinical trials: Caffeine-Related Disorders
Infant,Premature, Caffeine
Baby-CINO: CaffeINe Treatment Optimisation in Premature Infants
This study investigates how brain activity and breathing changes in premature babies when their dose of caffeine treatment is changed or stopped.
- Trial name
- Baby-CINO (NCT06416956)
- Testing
- Caffeine
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Oxford
Caffeine Dependence
A Long-term Safety and Efficacy of EnXtra (E-AG-01) in Healthy Adults
The present study has been proposed to investigate the long-term safety and efficacy of EnXtra in healthy adults habituated to caffeine.
- Trial name
- NCT03731286
- Testing
- Alpinia Galanga, Microcellulose crystalline
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Hypoxic-Ischemic Encephalopathy
Caffeine for Hypoxic-Ischemic Encephalopathy
Hypoxic-ischemic encephalopathy (HIE) due to perinatal asphyxia is common and often fatal. Therapeutic hypothermia reduces mortality and morbidity in infants with HIE.
- Trial name
- NCT03913221
- Testing
- Caffeine Citrate 5 mg/kg, Caffeine Citrate 10 mg/kg
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Healthy Male
A Study to Evaluate the Effects of D-1553 on PK of Midazolam, Caffeine, Rosuvastatin, Furosemide, Digoxin, and Itraconazole or Omeprazole on PK of D-1553
This is a phase I study to evaluate drug-drug interactions (DDIs) of D-1553 as a perpetrator combined with midazolam (CYP3A4 substrate), caffeine (CYP1A2 substrate), rosuvastatin (OATP1B1/OATP1B3 substrate), furosemide…
- Trial name
- NCT06105255
- Testing
- D-1553
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InventisBio Co., Ltd
Attention
Caffeine's Effect on Attention
The purpose of this study is to determine whether caffeine improves attention.
- Trial name
- NCT02264561
- Testing
- Food
- Where
- Netherlands
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Caffeine
Caffeinated Gum Softball Performance
The purpose of this study was to investigate the effects of caffeinated chewing gum on female softball pitching and hitting performance.
- Trial name
- NCT06079996
- Testing
- CAFFEINE GUM
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Chih-Hui Chiu
Chronic Obstructive Pulmonary Disease
Anti-inflammatory Effects of Caffeine in Chronic Obstructive Pulmonary Disease (COPD) Subjects
Nowadays it has become evident that a chronic systemic inflammation is present in patients suffering from chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT00826566
- Testing
- Caffeine
- Where
- Netherlands
- Sponsor
- Maastricht University Medical Center
Musculoskeletal Pain
Efficacy and Safety of the Combination of Ketoprofen and Cyclobenzaprine and Caffeine in Osteomuscular Treatment
The purpose of this study is to evaluate the safety and efficacy of an association with one anti-inflammatory and one muscle relaxant plus caffeine compared to one anti-inflammatory plus caffeine in the treatment of osteomuscular…
- Trial name
- NCT02862977
- Testing
- ketoprofen and cyclobenzaprine association with caffeine, Cyclobenzaprine with caffeine
- Where
- 6 sites in Brazil
- Volunteers
- 414 people
- Sponsor
- EMS
Spinal Hypotension, Caffeine
Oral Caffeine and Spinal-Induced Hypotension
Hypotension after spinal anesthesia is critical. Thus several interventions have been proposed to mitigate such effect.
- Trial name
- NCT07076654
- Testing
- Caffeine (200 mg)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Healthy Participants
A Study to Estimate the Effect of Multiple Dose Abrocitinib on Caffeine, Efavirenz, and Omeprazole in Healthy Participants
This is a Phase 1, open-label, multiple dose, single fixed-sequence, 2-period study to evaluate the effect of abrocitinib on the pharmacokinetics (PK) of caffeine, efavirenz and omeprazole in healthy adult participants.
- Trial name
- NCT05067439
- Testing
- Abrocitinib, Omeprazole, Caffeine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Pfizer
Parkinson's Disease
Caffeine as a Therapy for Parkinson's Disease
Parkinson's disease is a common neurodegenerative disorder in which patients experience progressive motor disability and many disabling non-motor symptoms.
- Trial name
- NCT01738178
- Testing
- Caffeine
- Where
- 8 sites in Brazil, Canada
- Volunteers
- 119 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Apnea, Preterm Infants
High Versus Low Dose of Caffeine for Apnea of Prematurity
The optimum caffeine dose for apnea of prematurity has not been well investigated so the objective of the study is to compare high versus low dose of caffeine citrate to facilitate successful extubation in mechanically ventilated…
- Trial name
- NCT02103777
- Testing
- Caffeine citrate
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University Children Hospital
Behavioral Pharmacology of Cannabinoids
The Pharmacodynamics of Cannabinoid-Caffeine Combinations
Cannabis and caffeine are two of the most commonly consumed psychoactive substances in the world, with many consumers reporting positive impacts on energy, alertness, and focus.
- Trial name
- NCT05478863
- Testing
- Oral THC, Oral CBD, Oral Caffeine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 1 Diabetes
Effects of Acute Intake of Caffeinated Beverages in Type 1 Diabetes
The aim of this pilot study is to determine the impact of caffeine-enhanced energy drinks on blood glucose excursion on heart rate, blood pressure, cardiac output and cognitive performance in patients with type 1 diabetes.
- Trial name
- REDBULL (NCT01805700)
- Testing
- Caffeine enhanced energy drink, Glucose drink
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- The Royal Bournemouth Hospital
High Blood Pressure
Effects of High Caffeine Content Coffee on Blood Pressure in Young Adults
The purpose of this study is to help further the understanding of the effects of commercially available high-caffeine containing coffee on blood pressure in healthy adult subjects.
- Trial name
- NCT04060225
- Testing
- Coffee
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Placebo Effect, Placebo Mechanisms of Action
Measuring Placebo Effect by Elimination and Investigating Mechanism of Action
We propose to measure the effect of placebo by elimination as well as by a "balanced placebo" design, determine its interaction with active drug, and explore whether placebo exerts part of its effect at the pharmacokinetics level.
- Trial name
- NCT00426010
- Where
- Saudi Arabia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- King Faisal Specialist Hospital & Research Center
Exercise Recovery
Muscle Glycogen Synthesis When Caffeine and Protein is Co-Ingested With Carbohydrates
The aim of the present study is to investigate the effect of added protein+leucine or caffeine to 1.2 g/kg/h CHO on the rate of post-exercise muscle glycogen re-synthesis in healthy, recreational athletes.
- Trial name
- NCT00975390
- Testing
- Carbohydrate, Carbohydrate and protein ingestion, Carbohydrate and caffeine ingestion
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Caffeine, Placebo
Caffeinated Chewing Gum on 400-meter Performance
20 trained sprinter were divided into caffeine Gum trial (CAF) and Placebo trial (PL) with a randomized, double-blind study design.
- Trial name
- NCT06430996
- Testing
- caffeine
- Where
- Taiwan
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Chih-Hui Chiu
Caffeine, Sleep Deprivation
Real-Time Caffeine Optimization During Total Sleep Deprivation
Sleep deprivation (SD) has a powerful degrading effect on cognitive performance, particularly psychomotor vigilance (PV) and reaction time. Caffeine is well known to be an effective countermeasure to the effects of SD.
- Conditions
- Caffeine, Sleep Deprivation, Shift-Work Related Sleep Disturbance
- Trial name
- NCT04399083
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Caffeine and Resistance Exercise
Acute Caffeine Intake and Velocity Metrics
The purpose of this study was to determine whether the acute ergogenic effects of caffeine differ according to the velocity metric used to assess strength performance against different relative loads.
- Trial name
- CAF+Vel (NCT07701395)
- Testing
- Caffeine
- Where
- Spain
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Alcala