Clinical trials: Caffeine-Related Disorders
Cognitive Change, Sleep Deprivation
Sleep Deprivation Study
The purpose of this study is to evaluate the measures of brain function, both neurophysiological (event-related potentials (ERPs) and functional (cognitive assessments), in response to sleep deprivation.
- Conditions
- Cognitive Change, Sleep Deprivation, Caffeine
- Trial name
- NCT05560620
- Testing
- Sleep Deprivation, Caffeine, No Caffeine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NeuroCatch Inc.
Transplant Rejection
Study to Evaluate Effect of Belatacept on Pharmacokinetics of Inje Cocktail in Healthy Volunteers
The purpose of this study is to determine the effects of belatacept on the pharmacokinetics of caffeine, losartan, omeprazole, dextromethorphan and midazolam
- Trial name
- NCT01766050
- Testing
- Caffeine, Losartan, Omeprazole
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
NASH
Drug-drug Interaction Study Between EDP-305, Midazolam, Caffeine and Rosuvastatin in Healthy Volunteers.
A non-randomized, multiple-dose, open-label, single sequence study to evaluate effect of concomitant administration of EDP-305 on the pharmacokinetics and safety of midazolam, caffeine, and rosuvastatin in healthy human…
- Trial name
- NCT03187496
- Testing
- Midazolam, Caffeine, Rosuvastatin
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Caffeine, Exercise
7-Day Caffeine and Upper-Body Power in Active Women
This study investigated the effects of a 7-day caffeine supplementation on heart rate variability, cognitive performance, and upper-body anaerobic power in active women.
- Conditions
- Caffeine, Exercise, Physical Fitness
- Trial name
- NCT07771556
- Testing
- Caffeine
- Where
- Iran
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Birjand University of Medical Sciences
Low Back Pain
Security and Efficacy of Dorilax® (Fixed Association of Paracetamol 350 mg, Carisoprodol 150 mg and Caffeine 50 mg) Plus Thermal Band Compared to Placebo Plus Thermal Band in the Treatment of Acute Low Back Pain.
National clinical trial, phase III, monocentric, randomized, double-blind, controlled, parallel, study of superiority, in which two hundred and thirty four (234) participants of both sexes, aged equal or more than 18 years and…
- Trial name
- Delfos (NCT03508167)
- Testing
- Thermal Band, Dorilax®
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Neonatal Apnea, Infants
Caffeine Optimization for Oxygen Saturation Index in ELBW Infants
The goal of this clinical trial is to determine whether a higher dose of caffeine citrate can improve breathing and reduce health complications in extremely premature infants, specifically those born before 28 weeks of pregnancy…
- Trial name
- COFIE trail (NCT07216365)
- Testing
- Caffeine Citrate
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Rochester
Pain and Discomfort, Orthodontic Appliance Complication
The Role of Paracetamol-caffeine and Laser Irradiation on Controlling Pain and Discomfort During Orthodontic Treatment
Patients with class I malocclusion who have mild to moderate crowding will be treated in this study. The efficacy of low level laser therapy and Panadol-extra® in relieving pain due to orthodontic treatment will be assessed.
- Trial name
- NCT03400111
- Testing
- low-level laser therapy, Panadol-extra
- Where
- Syria
- Volunteers
- 60 people
- Sponsor
- Damascus University
Overactive Bladder
Comparison of Caffeine Reduction and Anticholinergic Medications for Treatment of Overactive Bladder
The purpose of this study is to assess the effects of caffeine reduction/elimination on urinary symptoms in women with overactive bladders and compare this therapeutic approach to anticholinergic therapy.
- Trial name
- NCT00780832
- Testing
- Dietary Caffeine reduction, Anticholinergic medication
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- IWK Health Centre
Liver Cirrhosis
A Study to Compare How Different Substances (Caffeine, Warfarin, Omeprazole, Metoprolol, and Midazolam) Are Handled by the Body of Healthy People and People With Liver Cirrhosis
This study is open to healthy adults and adults with liver cirrhosis. The purpose of this study is to compare how different medicines are handled by the body in people with and without liver cirrhosis.
- Trial name
- NCT05741385
- Testing
- Caffeine, Warfarin sodium, Omeprazole
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- Boehringer Ingelheim
Caffeine, Apnea of Prematurity
Caffeine for Preterm Infants With Apnea of Prematurity(AOP)
Nowadays,caffein is commonly used for AOP, and it reduces the intubation rate in preterm infants. However, intubation is needed in about 20%-50% of partial neonates.
- Trial name
- NCT03298347
- Testing
- 80mg/kg of caffeine, 20mg/kg of caffeine
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Overweight
Effects of Caffeinated and Decaffeinated Coffee on Body Weight and Glucose Tolerance
Habitual consumption of coffee may have substantial beneficial effects on glucose metabolism according to recent findings of epidemiological studies in the U.S., Europe, and Japan.
- Trial name
- NCT00305097
- Testing
- Decaffeinated coffee, Caffeinated coffee, No coffee
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Energy Metabolism, Heart Rate
Effects of a Thermogenic Dietary Supplement on Metabolic, Hemodynamic, and Mood Responses
This a randomized, double blind, placebo controlled, crossover design study which measures the effect of an available thermogenic dietary supplement on resting energy expenditure (REE), blood pressure and heart rate, and mood…
- Conditions
- Energy Metabolism, Heart Rate, Blood Pressure, Mood
- Trial name
- NCT03678116
- Testing
- Caffeine (plus Teacrine and Cayenne), Caffeine (plus Teacrine)
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Mary Hardin-Baylor
Low; Birthweight, Extremely (999 Grams or Less)
Low Birth Weight Fetuses With Caffeine Use
Globally, it has been estimated that 15.5% of all infantsare born low birth weight, defined as birthweight less than 2,500 g .
- Trial name
- NCT03757780
- Testing
- Questionaire
- Where
- Egypt
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Healthy, Young Adults, Athletic Performance
Effects of an Acute Dose of Caffeine on the Performance of CrossFit Athletes
The goal of this clinical trial was to investigate the effect of an acute dose of caffeine on CrossFit performance in young, healthy male CrossFit athletes.
- Trial name
- NCT06891469
- Testing
- Caffeine administration according to body mass (moderate intake- 7 mg/kg)
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- Democritus University of Thrace
Change of Gastric pH
Influence of a Bitter Compound and Bittermasking Compound on Gastric pH
The purpose of this study is to elucidate whether bitter taste induced by the bitter compound caffeine and the reduction of bitter taste by addition of the bitter masking compound Homoeriodictyol sodium salt (HED) influence…
- Trial name
- NCT02372188
- Testing
- water, caffeine, caffein + homoeriodictyol sodium salt
- Where
- Austria
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Common Cold/Flu, Nasal Congestion
Fixed-dose Combination of 1000 mg Dipyrone Monohydrate + 60 mg Caffeine + 4 mg Chlorpheniramine Maleate in Improving Symptoms of the Common Cold and Flu in Adults
Phase III clinical trial to evaluate the efficacy and safety of a fixed-dose combination of 1000 mg dipyrone monohydrate + 60 mg caffeine + 4 mg chlorpheniramine maleate in improving symptoms of the common cold and flu in adults.
- Conditions
- Common Cold/Flu, Nasal Congestion, Nasal Obstruction
- Trial name
- PANAMA (NCT07626437)
- Testing
- dipyrone monohydrate 1000 mg + chlorpheniramine maleate 4 mg + caffeine 60 mg, dipyrone monohydrate 500 mg + chlorpheniramine maleate 2 mg + caffeine 30 mg
- Where
- 15 sites in Brazil
- Volunteers
- 620 people
- Sponsor
- Brainfarma Industria Química e Farmacêutica S/A
Asthma
Effects of Caffeine on Methacholine Challenge and Exhaled Nitric Oxide Levels.
To investigate whether or not the ingestion of caffeine with alter airway responsiveness to methacholine and/or change the level of exhaled nitric oxide.
- Trial name
- NCT01057875
- Testing
- caffeine, No caffeine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Saskatchewan
Apnea of Prematurity
Clinical Study of Caffeine for Apnea of Prematurity
The aim of the present Phase III study is to evaluate the safety, efficacy and pharmacokinetics of Caffeine Citrate for treatment of apnea of prematurity in Japan.
- Trial name
- NCT01408173
- Testing
- NPC-11 for intravenous or oral administration.
- Where
- 3 sites in Japan
- Volunteers
- 24 people
- Sponsor
- Nobelpharma
Physical Performance, Placebo Effect
Placebo Effect on Cycling Performance: Laboratory Crossover Study
This study aims to determine the impact of the placebo (PLA) effect on physical and cognitive performance in a controlled laboratory setting.
- Conditions
- Physical Performance, Placebo Effect, Cognitive Performance
- Trial name
- NCT07748429
- Testing
- Caffeine (6mg/kg)
- Where
- Poland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Chronic Pain
AZD2066 Cocktail Study
The aims of this study are to examine the effect of repeated doses of AZD2066 and of caffeine, bupropion, tolbutamide, omeprazole, metoprolol and midazolam on the blood concentrations of each other
- Trial name
- NCT00930306
- Testing
- AZD2066, Caffeine, Tolbutamide
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- AstraZeneca