Clinical trials: Caffeine-Related Disorders
Panic Disorder, Healthy
Neurobehavioral Correlates of Caffeine on Anxiety, Avoidance and Interoception in Healthy Individuals and Panic Disorder.
The current study is a placebo-controlled, double-blind, randomized controlled study using a cross-over design, including Healthy Controls (HC) and participants with Panic Disorder (PD).
- Trial name
- BINCAP (NCT06145490)
- Testing
- Caffeine
- Where
- 2 sites in Sweden
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Anesthesia
A Study to Determine if Caffeine Accelerates Emergence From Anesthesia
At present clinicians have no way to reverse anesthesia. Patients wake when their bodies clear the anesthetic. Most people wake quickly, but some do not.
- Trial name
- NCT02567968
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Autonomic Nervous System
The Influences of Caffeine on Heart Rate Variability of Preterm Infants
Caffeine has a stimulatory effect on the ANS. This has not yet been investigated in preterm infant who get caffeine before stopping ventilation.
- Trial name
- NCT01769118
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Rambam Health Care Campus
Postoperative Ileus
Does Caffeine Enhance Bowel Recovery After Colorectal Surgery?
Postoperative ileus is a frequently occurring surgical complication. It is defined as temporary inhibition of propulsive bowel activity and is manifested by abdominal distention, nausea, vomiting and diet intolerance.
- Trial name
- NCT03097900
- Testing
- Caffeine Citrate, Water
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Hadassah Medical Organization
Caffine, Placebo - Control
Effects of Caffeine Ingestion on Morning Cognitive and Muscle Strength Measures in Males
Tournament scheduling and environmental factors often require athletes to compete in the morning. Equally due to time constraints, athletes may choose to train in the morning.
- Conditions
- Caffine, Placebo - Control, No Pill
- Trial name
- NCT07466628
- Testing
- No Pill
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Apnea of Prematurity
Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial
The objective of this study is to evaluate the effect of continuing treatment with caffeine citrate in the hospital and at home in moderately preterm infants with resolved apnea of prematurity on days of hospitalization after…
- Trial name
- MoCHA (NCT03340727)
- Testing
- Caffeine Citrate
- Where
- 16 sites in United States
- Volunteers
- 827 people
- Sponsor
- NICHD Neonatal Research Network
Genetic Predisposition, Caffeine
Genetics in the Effect of Caffeine on Fat Oxidation
Genetic polymorphism on the effect of oral caffeine intake on fat oxidation during exercise has been studied in active and healthy population performing an incremental test on a cycle ergometer with 3-min stages at workloads from…
- Conditions
- Genetic Predisposition, Caffeine, Fat Burn
- Trial name
- NCT05975489
- Testing
- Acute caffeine supplementation
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Universidad Francisco de Vitoria
Bronchiolitis, Apnea
Caffeine Citrate for the Treatment of Apnea Associated With Bronchiolitis in Young Infants
Viral bronchiolitis is the most common lower respiratory tract infection of infancy. Apnea is a complication of bronchiolitis, reported in 16 - 21% of cases.
- Conditions
- Bronchiolitis, Apnea, Caffeine
- Trial name
- NCT01435486
- Testing
- Caffeine citrate, Normal saline
- Where
- Qatar
- Volunteers
- 90 people
- Sponsor
- Hamad Medical Corporation
Advanced Chronic Liver Disease, Healthy Participants
A Study to Investigate How Multiple Oral Doses of AZD2389 Affect the Pharmacokinetics of Midazolam, Caffeine, and Bupropion in Healthy Participants
The purpose of this study is to measure the effect of multiple doses of AZD2389 on the pharmacokinetics (PK) of midazolam, caffeine, and bupropion in healthy participants.
- Trial name
- CRIOLLO (NCT06973005)
- Testing
- AZD2389, Midazolam, Caffeine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Coffee Consumption, the Gut Microbiome, and the Microbiota-Gut-Brain Axis
The aim of this study is to investigate the potential of coffee to act as a prebiotic to alter gut microbiota and improve mood, memory and cognitive performance.
- Trial name
- NCT05927038
- Testing
- Caffeinated coffee, Decaffeinated coffee
- Where
- Ireland
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University College Cork
Energy Metabolism
Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells
This randomized, double-blind, placebo-controlled crossover study will evaluate the acute effects of caffeine consumption on substrate utilization, resting energy metabolism, and mitochondrial function in peripheral blood…
- Trial name
- MITOCAFFEINE (NCT07873047)
- Testing
- Caffeine (5 mg/kg)
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Pediatric Obesity
Body Composition Changes With Albuterol and Caffeine Versus Placebo in Adolescents
The purpose of this study is to determine whether taking a combination of caffeine and albuterol three times per day will increase muscle and decrease fat in your child's body and to determine how these medications make your…
- Trial name
- CAMP (NCT02740660)
- Testing
- Caffeine 100mg / Albuterol 4mg, Family weight management counseling
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Cytochrome, Pharmacokinetics
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
- Trial name
- NCT01187862
- Testing
- caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Metabolism, Alzheimer's Disease
Drug Interaction Study Between AZD3480 and Cytochrome P450
The purpose of the study is to evaluate if AZD3480 inhibits Cytochrome P450 1A2, 2C19, 3A4, 2C8, 2B6 and UGT1A1 activity.
- Trial name
- Cocktail (NCT00692510)
- Testing
- AZD3480, Cocktail mix (Caffeine, Bupropion, Rosiglitazone, Omeprazole, Midazolam, Bilirubin)
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Metabolic Syndrome, Caffeine
Changes in Metabolic Rate and Perceptual Indicators After Acute Ingestion of Paraxanthine
The purpose of this study is to evaluate the acute impact of ingesting individual and combined dosages of caffeine and paraxanthine in comparison to placebo on changes in resting metabolic rate, perceived levels of affect, and…
- Trial name
- PX (NCT05811923)
- Testing
- Venous Blood Collection, Resting Metabolic Rate Determination, Mood State
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Performance Enhancing Product Use
Effect of Creatine and Caffeine on Muscle Performance
To determine if creatine and caffeine can be co-supplemented without inhibiting the effects of creatine.
- Trial name
- NCT04290819
- Testing
- Creatine Monohydrate, Creatine Monohydrate and Caffeine, Caffeine
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Regina
Caffeine
The Effects of e+Shots Energy Beverage on Mental Energy
The aim of the research project is to determine the changes in motivation to perform mental and physical tasks, feelings of vigor and fatigue, mental task vigilance and fine motor function after consumption of a commercially…
- Trial name
- NCT03850275
- Testing
- Intervention/treatment
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clarkson University
Healthy
Effect of Multiple Doses of AZD6280 on the Pharmacokinetics of Midazolam (CYP3A4) and Caffeine (CYP1A2)
The aim of this study is to investigate the effects of taking repeated doses of AZD6280 on the blood levels of midazolam and caffeine in healthy volunteers
- Trial name
- CYP (NCT00824057)
- Testing
- AZD6280, Midazolam, Caffeine
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Caffeine, Thermoregulation
The Effects of Caffeine on Exercise Physiology and Time-trial Performance in a Hot Environment
Maintaining a stable core temperature is vital for physiological function; yet, exercise in heat can be problematic, and there is risk of exertional heat-related illness (Flouris \& Schlader, 2015; Leyk et al., 2019; Périard et…
- Trial name
- NCT07129200
- Testing
- Hot environment, Thermoneutral environment
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St. Mary's University, Twickenham