Clinical trials: Caffeine-Related Disorders
Coronary Artery Disease
Effects of Espresso on Platelet Aggregability in Patients with Coronary Artery Disease
Discovered thousands of years ago, coffee is among the most consumed beverages in the world. The relationship between coffee and cardiovascular risk, more specifically coronary artery disease, is controversial.
- Trial name
- NCT04827251
- Testing
- Coffee
- Where
- Brazil
- Volunteers
- 29 people
- Sponsor
- University of Sao Paulo
HIV Infections
Evaluation of Pharmacokinetic Interaction Between GSK3640254 and Caffeine, Metoprolol, Montelukast, Flurbiprofen, Omeprazole, Midazolam, Digoxin, and Pravastatin in Healthy Adults
This is an open-label, single sequence study that is being conducted to investigate the potential drug-drug interaction (DDI) when GSK3640254 is co-administered with a cocktail of cytochrome P450 (CYP) enzymes and transporter…
- Trial name
- NCT04425902
- Testing
- GSK3640254 200 mg, Caffeine 200 mg, Metoprolol 100 mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Solid Tumor Malignancies
A Study to Evaluate the Effects of ASA404 Alone or in Combination With Taxane-based Chemotherapies on the Pharmacokinetics of Drugs in Patients With Advanced Solid Tumor Malignancies
The purpose of this study is to evaluate the potential inhibitory effects of ASA404 on CYP1A2, CYP2C9, CYP3A4 and CYP2C19 mediated metabolism on the respective probe drugs caffeine, diclofenac, simvastatin, and omeprazole…
- Trial name
- NCT01290380
- Testing
- ASA404, DMXAA, DXAA
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- Novartis Pharmaceuticals
Cytochrome, Pharmacokinetics
Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes
The purpose of this study is to assess whether a cocktail of seven approved drugs (so-called "Basel cocktail") can be used for simultaneous phenotyping of CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4.
- Trial name
- NCT01187862
- Testing
- caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
- Where
- Switzerland
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Sleep Apnea, Obstructive, Tonsillectomy
The Effect of Caffeine on Postextubation Adverse Respiratory Events in Children With Obstructive Sleep Apnea (OSA).
This is a research study using caffeine in children who have an obstructive sleep apnea (OSA). OSA means children who stop breathing during their sleep due to obstruction in their airway.
- Conditions
- Sleep Apnea, Obstructive, Tonsillectomy, Adenoidectomy, Postoperative Complications
- Trial name
- OSA (NCT00273754)
- Testing
- Caffeine
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The University of Texas Health Science Center, Houston
Sexual Behavior
Effects of Caffeine on Women's Sexual Arousal
The key research question in this study is whether or not caffeine facilitates genital sexual arousal in women in the presence of an external erotic stimulus.
- Trial name
- NCT01242046
- Testing
- Caffeine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Change of Gastric pH
Influence of a Bitter Compound and Bittermasking Compound on Gastric pH
The purpose of this study is to elucidate whether bitter taste induced by the bitter compound caffeine and the reduction of bitter taste by addition of the bitter masking compound Homoeriodictyol sodium salt (HED) influence…
- Trial name
- NCT02372188
- Testing
- water, caffeine, caffein + homoeriodictyol sodium salt
- Where
- Austria
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Cardiovascular Disease, Ischemia-Reperfusion Injury
Does Caffeine Reduce Dipyridamole-Induced Protection Against Ischemia-Reperfusion Injury?
The purpose of this project is to explore the interaction between caffeine and dipyridamole on ischemia-reperfusion injury in the forearm.
- Trial name
- NCT00430170
- Testing
- Dipyridamole, caffeine
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Prematurity, Apnea
Caffeine to Reduce Mechanical Ventilation in Preterm Infants
Most premature infants require mechanical ventilation for prolonged periods of time and a significant proportion of them develop Bronchopulmonary Dysplasia (BPD).
- Conditions
- Prematurity, Apnea, Respiratory Failure
- Trial name
- NCT01751724
- Testing
- Caffeine citrate, Normal saline
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- University of Miami
Migraine Disorders
Acetylsalicylic Acid (ASA) + Paracetamol + Caffeine Combination Compared With ASA + Paracetamol as Well as ASA, Paracetamol, and Caffeine in Headache Patients
To confirm the combination rationale for the combination of ASA + paracetamol + caffeine compared with the combination of ASA + paracetamol and the individual substances ASA, paracetamol, caffeine, and placebo administered orally…
- Trial name
- NCT02183688
- Testing
- Low dose ASA, High dose ASA, Low dose paracetamol
- Volunteers
- 1,889 people
- Sponsor
- Boehringer Ingelheim
Athletes
The Acute Effects of Combined Caffeine and Sodium Bicarbonate Consumption on Isometric Mid-thigh Pull
The aim of this study was to investigate the effects of isolated and combined caffeine and sodium bicarbonate consumption on acute isometric mid-thigh pull (IMTP) strength, and verify whether they are cumulative, neutral or…
- Trial name
- NCT05883046
- Testing
- Performance-Enhancing Substances, Baseline (Control)
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Bozok University
Drug Reactions
Effects of Repeated Doses of Lu AF35700 on Drug Metabolizing Enzymes
This study will help determine which types of drugs that may interact with Lu AF35700
- Trial name
- NCT03195946
- Testing
- Lu AF35700, Midazolam, Cocktail of CYP450 substrates
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- H. Lundbeck A/S
The Focus of the Study is Healthy Volunteers
Understanding the Effects of Daily Tea Consumption on Attention, Sleep, and Mood, in Healthy Adults
The goal of these series of N-of-1 trials is to compare the effects of three tea interventions on cognition, mood, and sleep, in healthy adult participants.
- Trial name
- Reactivi-Tea (NCT06224569)
- Testing
- Black tea flavoured, tea drink, Black tea flavoured, caffeine-only drink, Green tea flavoured, tea drink
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Hypoxia
Effects of Caffeine on Intermittent Hypoxia in Infants Born Preterm
The purpose of this pilot study is to document the extent to which intermittent hypoxia persists beyond the age of discontinuing clinical methylxanthine, and will assess the effect of caffeine treatment on the number of…
- Trial name
- NCT01875159
- Testing
- Caffeine citrate 6 mg/kg/day
- Where
- United States
- Volunteers
- 98 people
- Sponsor
- American SIDS Institute
Postoperative Dental Pain
A Study to Learn How Well a Single Dose of the Study Treatment Naproxen Sodium and Caffeine Combined in One Tablet (Fixed-dose Combination) Works to Relieve Pain After Dental Surgeries Compared to the Single Ingredients and to Placebo
Researchers are looking for a better way to relieve pain in people, such as after dental surgery. Participants in this study, have had 3 or 4 third molars (cheek teeth) removed and subsequently have moderate to severe tooth pain.
- Trial name
- NCT05485805
- Testing
- Naproxen sodium and caffeine (BAY2880376), Naproxen sodium (Aleve), Caffeine
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Bayer
Premature Infant Disease, Apnea of Prematurity
Caffeine Citrate in Preterm Infants at Risk of Apnea in Zambia
The goal of this clinical trial is to learn if caffeine citrate prevents apneic events that result in sick visits in moderately preterm infants after discharge from the hospital.
- Conditions
- Premature Infant Disease, Apnea of Prematurity, Development, Infant
- Trial name
- NCT06518603
- Testing
- Caffeine citrate 20mg/kg/day
- Where
- Zambia
- Volunteers
- 340 people
- Sponsor
- University of Alabama at Birmingham
Pain, Postoperative
Caffeine and Neurologic Recovery Following Surgery and General Anesthesia
The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may reduce pain after surgery.
- Trial name
- NCT03577730
- Testing
- Caffeine Citrate, Dextrose Water
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- University of Michigan
Healthy Subjects
The Effects of Coffee
In this study, participants will be eligible to participate in a paid research study that will examine the effects of regular coffee drinking. The study takes approximately 2 hours total, 55 min. on 2 separate days.
- Trial name
- NCT00336271
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- American University
Maximum Force, Strength Endurance
The Effects of Caffeine and Vitamin C on Maximum Strength and Strength Endurance in Adolescents With Mild Mental Fatigue
Objective To investigate the independent and combined effects of caffeine and vitamin C on maximal strength and strength endurance in female adolescents with mild mental fatigue.
- Conditions
- Maximum Force, Strength Endurance, Mental Fatigue
- Trial name
- NCT07726745
- Testing
- 1RM squats and bench presses; repetitions at 65% of 1RM for squats and bench presses
- Volunteers
- 40 people
- Sponsor
- Yunliang Zhang
Supplementation, Sports Nutrition
Caffeine Kinetics and CrossFit®-Specific Performance
The study aims at assessing the relation between caffeine (CAF) and paraxanthine (PAX) kinetics after acute ingestion of caffeine (3 mg/kg body mass) in the form or mono- or multi-ingredient preparations and CrossFit®-specific…
- Conditions
- Supplementation, Sports Nutrition, Ergogenic Support, Discipline-specific Performance
- Trial name
- NCT05516212
- Testing
- CAFMONO supplementation, CAFMIPS_1 supplementation, CAFMIPS_2 supplementation
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education