Clinical trials: Caffeine-Related Disorders
Sleep, Sleep Inertia
Sensible Sleep: Measuring Alarm and Snooze Behavior in Teens Using Wearables and Smartphones
Pilot data suggests that working professionals and college students routinely use alarms and snooze. Alarm usage and snoozing is associated with several negative health biomarkers including lighter sleep, higher resting heart…
- Conditions
- Sleep, Sleep Inertia, Stress
- Trial name
- NCT04786678
- Testing
- Cell phone notification
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Notre Dame
Caffeine, Cognitive Change
Acute Effects of PLT Health Solutions zümXR Extended-Release Caffeine
This will be a (2 visit) double-blind, randomized, crossover design clinical study to assess the potential benefits of ER-CAFF versus IR-CAFF by assessing its impact on side effect profiles, mood states, alertness, and cognitive…
- Conditions
- Caffeine, Cognitive Change, Mood, Mood Change
- Trial name
- NCT06441695
- Testing
- xumXR extended release caffeine, immediate release caffeine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Skill Performance, Soccer Performance
Influence of Coffeeberry Ingestion on Soccer Skill Performance
The study of soccer skill performance has 3 objectives. Objective 1 is to compare effects of coffeeberry (300mg) and placebo ingestion on dribbling speed and precision and passing and shooting speed and accuracy compared to…
- Conditions
- Skill Performance, Soccer Performance, Coffeeberry Effects
- Trial name
- NCT04181619
- Testing
- Coffeeberry beverage, Comparator beverage
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Smoking Behaviors
Effect of Oral pH Changes on Smoking Desire
Nicotine is a psychoactive substance and its effect is demonstrated by neuronal nicotinic-acetylcholine receptors excreted in the brain and periphery.
- Trial name
- NCT04032236
- Testing
- caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Healthy Volunteers
Energy Drink Habituation Effects on Young Adults
The consumption of energy drinks has significantly increased in recent years but their adverse effects are not yet efficiently known.
- Trial name
- NCT04223167
- Testing
- Red Bull Energy Drink, Water
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Obstructive Sleep Apnea, Enlargement of Tonsil or Adenoid
Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
The aim of this study is to evaluate whether a smaller dose of caffeine sodium benzoate 10 mg/kg IV is as effective as 20 mg/kg IV in decreasing the number of children who develop post extubation adverse upper airway respiratory…
- Trial name
- NCT01349205
- Testing
- Caffeine and sodium Benzoate 10 mg/kg IV, Caffeine and Sodium Benzoate 20 mg/kg IV, 0.9 NS Saline
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Obesity
The Effect of Leptin A-200, Caffeine/Ephedrine and Their Combination Upon Weight Loss and Body Composition in Man
The purpose of this study is to compare three treatments to see which causes the most weight loss, fat loss, loss of stomach fat and improvement in blood tests like cholesterol.
- Trial name
- NCT01710722
- Testing
- caffeine and ephedrine, Leptin A, caffeine, ephedrine, and leptin A
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Drowsiness, Sleep Deprivation
TESTING AN MTM THEORY-BASED INTERVENTION ON REDUCING DROWSY DRIVING BEHAVIOR, "STAY AWAKE, STAY ALIVE ©," AMONG COLLEGE STUDENTS
The goal of this randomized controlled educational study is to learn whether a structured, theory-based program can help reduce drowsy driving among college students (18 years and older) in Nevada.
- Conditions
- Drowsiness, Sleep Deprivation, Fatigue
- Trial name
- NCT07434921
- Testing
- MTM Theory based intervention, Standard AAA Knowledge based
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Migraine, Caffeine Withdrawal
The Effects of Caffeine Withdrawal on Migraine
Sporadic and chronic dietary consumption of caffeine has substantial biological effects on the nervous system. The effects on migraine are at large not known.
- Trial name
- NCT03022838
- Testing
- Caffeine
- Where
- 3 sites in Norway
- Volunteers
- 10 people
- Sponsor
- Nordlandssykehuset HF
Sleep Inertia, Caffeine
Delayed-release Bedtime Caffeine and Sleep Inertia Symptoms Immediately Upon Awakening
Sleep inertia (sometimes also referred to as sleep drunkenness) is a disabling state of increased sleepiness, impaired mood and reduced vigilance immediately upon awakening.
- Conditions
- Sleep Inertia, Caffeine, Placebo
- Trial name
- NCT04975360
- Testing
- Caffeine
- Where
- Switzerland
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Healthy Volunteers
Phase 1 Study to Determine the Effects of PBT2 on the Pharmacokinetic Profile of Caffeine
This study is designed to determine the pharmacokinetic (PK) profile of a single oral dose of caffeine and the effects that PBT2 has on the metabolism of caffeine in healthy volunteers.
- Trial name
- NCT02109497
- Testing
- PBT2
- Where
- Australia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Prana Biotechnology Limited
Caffeine, Physical Endurance
Effect of Low-Dose Caffeine on Performance in Elite Sitting Volleyball Players
Background: Sitting volleyball is a sport that relies primarily on upper body strength and anaerobic capacity. In critical in-game skills such as serve and spike, factors such as speed-endurance time and impact power play a…
- Conditions
- Caffeine, Physical Endurance, Muscle Strength, Paralympic Athletes
- Trial name
- NCT07056231
- Testing
- Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 13 people
- Sponsor
- Ulaç Can YILDIRIM
Liver Functions, Bioequivalence
Coffee Bioequivalence Trial
The goal of this clinical trial is to test if coffee consumed as a tablet is biologically equivalent to that consumed traditionally as a drink.
- Conditions
- Liver Functions, Bioequivalence, Cardiovascular Risk, Cardiometabolic Risk Markers
- Trial name
- NCT06758531
- Testing
- Instant coffee given as a drink, Coffee given in a tablet form
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Reading
Second Stage of Labor
Caffeine in the Second Stage of Labor in Low-risk Nulliparous Mothers at Term
Single blind, randomized control trial to determine benefit of caffeine and sodium benzoate on the second stage of labor
- Trial name
- NCT05906303
- Testing
- Caffeine and Sodium Benzoate Injection, Normal Saline
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Reading Hospital and Medical Center
Alcohol or Other Drugs Effects
Combined Effects of Alcohol and Caffeine
The purpose of this study is to investigate the effects of caffeine on the self-administration of alcohol. The study will also examine the combined effects of alcohol and caffeine on behavioral performance, participant ratings of…
- Trial name
- NCT01289561
- Testing
- Alcohol + Caffeine Beverage
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Overweight, Obesity
A Study to Test Whether BI 456906 (Survodutide) Influences the Amount of Bupropion, Caffeine and Midazolam in the Blood in People With Overweight or Obesity
This study is open to adults with overweight or obesity who are otherwise healthy. People can join the study if they have a body mass index of 27 to 39.9 kg/m2 and a body weight over 70 kg.
- Trial name
- NCT06564441
- Testing
- Survodutide, Bupropion, Caffeine
- Where
- Belgium
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Exercise
Caffeine Supplementation on Movement Patterns and Reactive Agility in Rugby Sevens Matches
Caffeine is widely used by rugby players for its performance-enhancing effects. The main questions it aims to answer are: (1) the impact of caffeine supplementation on various performance metrics, including distance covered at…
- Trial name
- NCT06612463
- Testing
- Caffeine 6mg/kg
- Where
- Taiwan
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- National Taiwan Sport University
Drug Mechanism, Metabolism Medication Toxicity
Pharmacology Space Kit (PSK) - Dried Blood Spot for Caffeine Pharmacokinetics Under Microgravity Conditions
The PSK study is preliminary to the study of drug metabolism in space flight conditions. The investigators propose to use simplified blood sampling methods that can be applied in microgravity.
- Conditions
- Drug Mechanism, Metabolism Medication Toxicity, Space Motion Sickness
- Trial name
- PSK (NCT06431984)
- Testing
- prick test
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Breast Reconstruction, Deep Inferior Epigastric Perforator
The Effects of Caffeine on Deep Inferior Epigastric Perforator (DIEP) Flap Perfusion
Women that require breast reconstruction and meet eligibility will be enrolled in this study. The study is being completed to determine the effect of caffeine in deep inferior epigastric perforator (DIEP) flap perfusion using the…
- Conditions
- Breast Reconstruction, Deep Inferior Epigastric Perforator, Microvascular Free Flap Transfer
- Trial name
- NCT04249934
- Testing
- Caffeinated Coffee, DecaffeinatedCoffee
- Where
- United States
- Sponsor
- University of Michigan