Clinical trials: Calcified Coronary Artery Disease
Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases
Immunomodulatory Effects of PCSK9 Inhibition
Cardiovascular disease (CVD) represents the leading cause of death worldwide. While medications, such as statins, significantly reduce atherosclerotic CVD (ASCVD) risk by lowering low density lipoprotein levels, they may also…
- Conditions
- Atherosclerotic Cardiovascular Disease, Cardiovascular Diseases, Atherosclerosis, Arterial Inflammation
- Trial name
- INSPIRAR (NCT05720156)
- Testing
- 99mTc-tilmanocept SPECT/CT scanning
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Atherosclerotic Cardiovascular Disease (ASCVD), Coronary Artery Calcification
Health Enhanced Artery Risk Tracking With Widespread Implementation and Screening Effort in ASCVD (HEARTWISE-ASCVD)
This multi-site study will test whether an opportunistic AI-based CAC screening and notification intervention can improve cholesterol treatment and lower cholesterol levels in adults.
- Trial name
- HEARTWISE (NCT07355894)
- Testing
- AI-Detected CAC Notification and Care Facilitation
- Where
- 6 sites in United States
- Volunteers
- 120,000 people
- Sponsor
- Stanford University
Coronary Calcification
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
Until 2013 the reported incidence of chronic kidney disease varied widely between countries, reporting the highest prevalence Taiwan, the region of Jalisco in Mexico and United States, with 458, 421 and 363 individuals per…
- Trial name
- NCT04247087
- Testing
- phytomenadione
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Mexicano del Seguro Social
Coronary Artery Disease
Equity in Modifying Plaque Of WomEn With UndeRtreated Calcified Coronary Artery Disease
Post-market, prospective, multi-center, single-arm observational study to generate real-world clinical evidence associated with coronary IVL in a population of female subjects with calcified coronary artery disease.
- Trial name
- EMPOWER CAD (NCT05755711)
- Testing
- Shockwave Medical Coronary IVL System
- Where
- 49 sites in United States, France and 3 more
- Volunteers
- 399 people
- Sponsor
- Shockwave Medical, Inc.
Coronary Artery Disease, Percutaneous Coronary Intervention (PCI)
A Randomized Study of Cutting Balloon Catheter for CAD
This study is designed as a prospective, multi-center, non-inferiority and randomized controlled clinical trial. A total of 158 eligible subjects from 18 sites across the country is planned to be enrolled, and they will be…
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention (PCI), Calcified Coronary Lesions
- Trial name
- NCT07140822
- Testing
- Coronary Cutting Balloon Catheter, VesscideTM Cutting Balloon System
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Shanghai Shenqi Medical Technology Co., Ltd
Type 2 Diabetes, Vascular Calcification
Coronary Artery Calcification in Type 2 Diabetes Mellitus (USCAC Study)
Coronary artery calcification (CAC) is a common complication of type 2 diabetes mellitus(T2DM), which can significantly increase all-cause mortality and the incidence of serious cardiovascular events, and increase the burden of…
- Conditions
- Type 2 Diabetes, Vascular Calcification, Coronary Artery Calcification, Strains
- Trial name
- NCT04889053
- Where
- China
- Volunteers
- 1,400 people
- Sponsor
- University of South China
Heart Failure
Calcium, Phosphate, Renal Impairment and Coronary Artery Disease in the Cardio-renal Syndrome, The CAPRICORN-CRS Study
Heart failure (HF) is a major public health problem, which affects about 5 million Americans.HF is when the heart muscle does not pump as much blood as the body needs.
- Trial name
- CAPRICORN (NCT00853541)
- Where
- United States
- Sponsor
- Massachusetts General Hospital
Coronary Heart Disease
A Cohort Study of PCI Strategies for Severely Calcified Lesions of Complex Coronary Arteries in the Elderly
The aim of this observational study is to compare the prognostic outcomes of various PCI strategies in elderly patients with complex coronary calcified lesions.
- Trial name
- PSSCCE (NCT06168422)
- Testing
- DES, DCB
- Where
- China
- Volunteers
- 2,100 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Calcification, Left Main Coronary Artery Disease
Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention
The IVL Left Main study is a prospective non-randomised pilot study to investigate the mechanical and procedural outcomes and safety of distal left main stenting with coronary lithotripsy in addition to standard techniques in…
- Trial name
- NCT04319666
- Testing
- Left main stenting with intravascular lithotripsy
- Where
- 6 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- St George's, University of London
Coronary Artery Calcification, Coronary Artery Disease
MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Coronary artery disease (CAD) remains the leading cause of mortality in the UK with an estimated 80,000 fatalities in 2010. Coronary artery calcification (CAC) is associated with atherosclerotic plaque burden and cardiovascular…
- Conditions
- Coronary Artery Calcification, Coronary Artery Disease, Osteoporosis, Osteopenia
- Trial name
- NCT01992848
- Testing
- Venous blood sampling, 4-day food diary, 1 week UV dosimeter
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Surrey
Permanent Atrial Fibrillation, Venous Thrombosis
Vascular CalcIfiCation and sTiffness Induced by ORal antIcoAgulation
The VICTORIA Study (Vascular CalcIfiCation and sTiffness induced by ORal antIcoAgulation) is a comparative, parallel, prospective, controlled and randomized study of the structural and functional impact of rivaroxaban versus…
- Conditions
- Permanent Atrial Fibrillation, Venous Thrombosis, Pulmonary Embolism, Anticoagulation Treatment at Least > or = to 12-month
- Trial name
- VICTORIA (NCT02161965)
- Testing
- Rivaroxaban, Fluindione, Warfarin
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Angers
ASCVD, Coronary Artery Calcification
Notification of Incidental Coronary Artery Calcium in Patients With Atherosclerotic Cardiovascular Disease (NOTIFY-ASCVD)
Estimate the impact of notifying both patients and their clinicians of the presence of incidental coronary artery calcium (CAC) on initiation of lipid-lowering therapy in patients with ASCVD who are not receiving lipid-lowering…
- Trial name
- NOTIFY-ASCVD (NCT05858879)
- Testing
- Notification of patients and clinicians
- Where
- United States
- Volunteers
- 233 people
- Sponsor
- Stanford University
Myocardial Infarction (MI), Radiation Toxicity
A MAajor RAdiation-based PCI Study in STEMI and NSTEMI
In France and Italy, approximately 240,000 percutaneous coronary angioplasties (PCI) are performed annually, with an increasing number of complex procedures, including those involving the left coronary common trunk, a…
- Conditions
- Myocardial Infarction (MI), Radiation Toxicity, Coronary Stenosis, Coronary Thrombosis
- Trial name
- MARAA (NCT06565793)
- Testing
- Non Complex PCI, Complex PCI
- Where
- France
- Volunteers
- 15,630 people
- Sponsor
- Centre Cardiologique du Nord
Coronary Artery Disease, Calcification
Rotablation vs Intravascular Lithotripsy in Calcified Coronary Lesions
Prospective, 1:1 randomized, controlled, multicenter trial to assess effectiveness and safety of Intravascular Lithotripsy (IVL) compared to Rotational Atherectomy (RA) treatment in calcified coronary lesions
- Trial name
- DECALCIFY (NCT04960319)
- Testing
- Intravascular Lithotripsy
- Volunteers
- 100 people
- Sponsor
- Medical Care Center Prof. Mathey, Prof. Schofer, Ltd.
Coronary Artery Disease, Calcification
CRUSTAL Study in China
This is a prospective, multicenter, single-arm registry study, aimed to evaluate the clinical outcomes of using Shockwave IVL catheter in the treatment of coronary artery calcification in real-world clinical practice.
- Trial name
- NCT05828186
- Testing
- Shockwave Coronary Intravascular Lithotripsy (IVL) catheter
- Where
- 6 sites in China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Coronary Artery Disease
Study to Evaluate the Association of Testosterone Levels With Coronary Artery Calcification
Coronary artery calcification (CAC) is a pandemic condition in elderly patients with coronary artery disease (CAD) and associated with worse prognosis.
- Trial name
- NCT02310659
- Testing
- No intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Zhejiang University
Kidney Diseases, Coronary Artery Calcification
Vitamin K2 and Vessel Calcification in Chronic Kidney Disease Patients
Vessel calcification is a recognised cardiovascular morbidity risk factor in patients with chronic kidney disease (CKD). Recent reports indicate a significant role of Matrix Gla-protein (MGP) in decreasing calcification…
- Trial name
- CACSK2 (NCT01101698)
- Testing
- Vitamin K2+10μg cholecalciferol, Vitamin D
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Lodz
Coronary Artery Calcification
Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)
This is a prospective and multicenter clinical investigation aiming to evaluate the safety and effectiveness of coronary intravascular lithotripsy system for the treatment of patients with coronary calcification.
- Trial name
- NCT05818098
- Testing
- Intravascular Lithotripsy System of Shanghai MicroPort Rhythm
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
End Stage Renal Disease
Risk Factors for Coronary Artery Calcification and Left Ventricular Hypertrophy in Hemodialysis Patients
Individuals with kidney disease are at a higher risk for heart and vascular diseases, including heart attacks and strokes, than those with normal kidney function.
- Trial name
- NCT01427374
- Where
- 4 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- University of Alberta