Clinical trials: Calcinosis
Aortic Stenosis, Aortic Valve Disease
Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis
The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.
- Conditions
- Aortic Stenosis, Aortic Valve Disease, Aortic Valve Calcification
- Trial name
- COMP-AS (NCT06136689)
- Where
- 2 sites in Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Breast Cancer, Cardiovascular (CV) Risk
Multicenter Cardiac Decision Impact Study in People With Breast Cancer
Background: Breast cancer is the most common cancer in women, and advances in early detection and treatment have led to steadily improved survival rates. Today, nearly 80% of breast cancer survivors are over 50 years of age.
- Conditions
- Breast Cancer, Cardiovascular (CV) Risk, Coronary Artery Calcifications
- Trial name
- CarDI (NCT07703033)
- Testing
- Measuring coronary artery calcifications (Agatston score) using routine radiotherapy planning CT scans and communicating the associated risk of cardiovascular disease to the patient.
- Where
- 5 sites in Denmark, Germany and 2 more
- Volunteers
- 1,000 people
- Sponsor
- UMC Utrecht
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry
Aortic Regurgitation Disease, Aortic Valve Calcification
Valvular Assessment of New Generation Aortic Replacement Devices
The VANGUARD study is an open-label, prospective, randomized trial comparing the long-term outcomes of two advanced bioprosthetic aortic valves, Dafodil® and INSPIRIS Resilia®, in patients undergoing aortic valve replacement…
- Conditions
- Aortic Regurgitation Disease, Aortic Valve Calcification, Bicuspid Aortic Valve Disease
- Trial name
- VANGUARD (NCT06688448)
- Testing
- Dafodil prosthesis, Aortic Valve Replacement - Inspires Resilia prosthesis
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Coronary Artery Calcification
Melatonin on Coronary Artery Calcification
We planned to evaluate the effects of melatonin on progression of coronary artery calcification (CAC) in patients with moderate calcified coronary atherosclerosis.
- Trial name
- MelonCAC (NCT03966235)
- Testing
- Melatonin 3 mg
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Chinese PLA General Hospital
Diabetes, Coronary Artery Calcification
A Study Comparing Skin Fluorescence to Coronary Artery Calcification
This study examines the relationship between the SCOUT DM device and coronary artery calcification as determined by rapid computed tomography in patients at risk for coronary heart disease.
- Trial name
- CACS (NCT00895427)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Bone Calcification, Osteoporosis
Evaluation of Bone Length Measurement
The purpose of this study is to determine if Lunar iXDA scanning with the use of a computer software program can make accurate measurements of the length of leg bones compared to conventional x-rays.
- Trial name
- NCT02165527
- Testing
- Lunar iXDA scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Vitamin D Deficiency, Malnutrition
Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition
Multi-center, prospective, randomized, controlled study to verify the clinical effectiveness of K / DOQI guidelines. The efficiency and safety of Vitamin D2 and low protein diet treatment for prevention and treatment of CKD-MBD…
- Trial name
- NCT02005302
- Testing
- 1,25(OH)2 Vitamin D3, Vitamin D2, low protein diet
- Where
- 5 sites in China
- Volunteers
- 600 people
- Sponsor
- Wenhu Liu
Chronic Kidney Disease Mineral and Bone Disorder, Hypertension
Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD
The overall objective of this pilot randomized clinical trial is to determine whether low-dose Colchicine (LoDoCo) improves vascular disease including vascular calcification, peripheral arterial disease (PAD), and chronic kidney…
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Hypertension, Diabetes, Dyslipidemia
- Trial name
- RESOLVE-CKD (NCT07654231)
- Testing
- Low-dose Colchicine at 0.5mg daily, Usual Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Breast Neoplasms
Diffusion Coefficient and Micro-calcifications to Kaiser Score in Evaluation of BI-RADS 4 Breast Lesions
Breast cancer is the most commonly diagnosed cancer worldwide and is the leading cause of cancer-related deaths in women. Mammography, breast ultrasonography (US), and breast magnetic resonance imaging (MRI) are essential for the…
- Trial name
- NCT07033507
- Testing
- MRI diffusion coefficient and micro-calcifications to Kaiser Score in evaluation of BI-RADS 4 breast lesions
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University Hospital
Aortic Valve Calcification
Vitamin K Supplement for Inhibition of the Progress in Aortic Valve Calcification
In this mono-center,open,three-armes, controlled, randomized phase I study the progress of aortic valve calcification with and without vitamin K supplementation will be investgated.
- Trial name
- 08-002 (NCT00785109)
- Testing
- Vitamin K supplementation
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- RWTH Aachen University
End Stage Renal Disease, Kidney Transplantation
Bone Mass and Strength After Kidney Transplantation
The purpose of this study is to test whether active vitamin D (calcitriol) protects bones from weakening and protects blood vessels from calcium deposits over the first year of kidney transplantation.
- Conditions
- End Stage Renal Disease, Kidney Transplantation, Bone Loss, Fractures
- Trial name
- NCT02224144
- Testing
- Vitamin D3, Calcitriol
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Columbia University
Calcinosis
Topical Sodium Thiosulfate and Fractional Carbon Dioxide Laser in Treating Dermatomyositis Associated Calcinosis
Dermatomyositis is an inflammatory muscle disorder that is often associated with many skin findings. One of the skin findings seen in up to 50% of individuals with juvenile dermatomyositis, an early onset form of this condition…
- Trial name
- NCT01572844
- Testing
- Fractionated Carbon Dioxide (FCO2) Laser, Sodium thiosulfate
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Alison Ehrlich
Coronary Artery Calcification, Vascular Calcification
Prevention of the Progression of Coronary Calcification With Use of Spironolactone in Peritoneal Dialysis Patients
Vascular calcification is a frequent complication in dialysis patients and is strongly associated with mortality. Its pathogenesis is complex and involves a series of markers that act on the vascular microenvironment.
- Trial name
- NCT03314493
- Testing
- Spironolactone 25Mg Tablet
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Professor Fernando Figueira Integral Medicine Institute
Aortic Valve Disease, Valve Heart Disease
Freestyle-Perimount Calcification Comparison
The aim of this study is to evaluate the rate and anatomy of the aortic wall and leaflet calcification of the FS prosthesis implanted as full root in patients younger than 60 years compared to a stented bioprostheses (Perimount…
- Trial name
- NCT04359030
- Testing
- Multislice CT scanning for aortic wall calcification, Transthoracic stress echocardiography
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Ziekenhuis Oost-Limburg
Dermatomyositis, Dermatomyositis With Calcinosis Cutis
Photoacoustic/Ultrasound Imaging in Patients of Dermatomyositis With Calcinosis Cutis: Characteristic Findings and Treatment Response Evaluation
Photoacoustic imaging (PAI) is an emerging biomedical modality that integrates the advantages of optical contrast and ultrasound imaging depth.
- Trial name
- NCT07037472
- Testing
- Multi-modal photoacoustic/ultrasonic (PA/US) imaging system, Drug treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Peking Union Medical College Hospital
Arterial Calcification, Aortic Stiffness
Short and Long-term Results of Arterial Stiffness and Central Aortic Pressure After Kidney Transplantation
Central blood pressure and pulse wave velocity were measured using a Complior Analyse device in Short and Long-term after kidney transplantation.
- Conditions
- Arterial Calcification, Aortic Stiffness, High Blood Pressure (& [Essential Hypertension])
- Trial name
- PWV/CP/KTx (NCT02443454)
- Testing
- Device: Complior Analyse System, Tanita BC 418- Bioelectrical impedance analysis
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Vascular Calcification, Chronic Kidney Failure
Sclerostin and Vascular Calcification in CKD and Renal Transplant
the aim of the research is to determine the degree of vascular calcification in chronic kidney disease and post-transplant and whether there is a correlation with the level of serum sclerostin.
- Trial name
- NCT04066855
- Volunteers
- 36 people
- Sponsor
- Ahmed Faisal Mohamed Mohamed Saleh
Chronic Kidney Disease
Tissue-nonspecific Alkaline Phosphatase in Phosphate and Pyrophosphate Homeostasis.
Vascular calcification is a common finding in chronic kidney disease and increases arterial stiffness leading to augmented cardiovascular morbidity.
- Trial name
- PIPAL (NCT03520738)
- Testing
- Blood samples, Urinary samples
- Where
- 4 sites in France
- Volunteers
- 35 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Systemic Sclerosis, Calcinosis
Safety and Efficacy of Topical Sodium Metabisulfite for the Treatment of Calcinosis in Patients With Systemic Sclerosis
This prospective placebo-controlled trial will enroll 20 patients with SSc and at least one calcinotic lesion of the hands that is palpable on physical examination and measurable on hand radiographs.
- Trial name
- Cal-23 (NCT06155578)
- Testing
- Topical 25% sodium metabisulfite (SM) in pediatric cold cream
- Where
- Chile
- Volunteers
- 20 people
- Sponsor
- Pontificia Universidad Catolica de Chile