Clinical trials: Calcinosis
Coronary Calcification
Effects of Fhytomenadione on Coronary Artery Calcification of Hemodialysis Patients
Until 2013 the reported incidence of chronic kidney disease varied widely between countries, reporting the highest prevalence Taiwan, the region of Jalisco in Mexico and United States, with 458, 421 and 363 individuals per…
- Trial name
- NCT04247087
- Testing
- phytomenadione
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Mexicano del Seguro Social
Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk
Breast Artery Calcification (BAC) and Female Cardiovascular Disease
The investigators are recruiting women with and without Breast Artery Calcification (BAC) on their mammograms. Each participant in the study will undergo bloodwork at a Northwell Health lab, a cardiac CT scan, and fill out some…
- Conditions
- Cardiovascular Health Risk Communication, Cardiovascular (CV) Risk, Cardiovascular Disease Prevention
- Trial name
- NCT07809932
- Testing
- Cardiac CT Scan, Bloodwork
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Coronary Artery Calcification
Coronary Intravascular Lithotripsy System in Patients With Coronary Artery Calcification (VIGOUR)
This is a prospective and multicenter clinical investigation aiming to evaluate the safety and effectiveness of coronary intravascular lithotripsy system for the treatment of patients with coronary calcification.
- Trial name
- NCT05818098
- Testing
- Intravascular Lithotripsy System of Shanghai MicroPort Rhythm
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Mammography, Vascular Calcification
Mammography and Breast Arterial Calcification: An Information-Sharing Trial
The purpose of this research study was to determine the potential benefits of adding information on patients' breast arterial calcification (BAC) results to the standard results letter women receive after mammography.
- Trial name
- NCT04983875
- Testing
- BAC-Enhanced Letter, Waitlist Control
- Where
- United States
- Volunteers
- 5,492 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Kidney Disease, Anemia
SGLT2 Inhibitors in Non-Diabetic CKD: Effects on Vascular Calcification and Anemia
The goal of this clinical trial is to learn if the drug dapagliflozin (an SGLT2 inhibitor) can help protect the kidneys, improve anemia, and support heart health in adults with chronic kidney disease (CKD) who do not have…
- Conditions
- Chronic Kidney Disease, Anemia, Cardiovascular Calcification
- Trial name
- NCT07344922
- Testing
- Dapagliflozin (10Mg Tab) along with standard medical therapy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Mitral Regurgitation, Mitral Insufficiency
Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification
This study is a prospective, single-arm, multi-center feasibility clinical study of the Tendyne Mitral Valve System for the treatment of eligible subjects with symptomatic, severe mitral regurgitation and severe mitral annular…
- Conditions
- Mitral Regurgitation, Mitral Insufficiency, Mitral Annular Calcification, Mitral Annulus Calcification
- Trial name
- NCT03539458
- Testing
- Tendyne Mitral Valve System
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Abbott Medical Devices
Gene Mutations, Pseudoxanthoma Elasticum
ADAPT Study: Long-term Safety Study of INZ-701 in Patients With ENPP1 Deficiency and ABCC6 Deficiency
The purpose of this study (Study INZ701-304 [ADAPT]) is to assess the long-term safety of INZ-701 in patients with ENPP1 Deficiency or ABCC6 Deficiency who have received INZ-701 in an existing clinical study and choose to…
- Conditions
- Gene Mutations, Pseudoxanthoma Elasticum, Arterial Calcification, Ectonucleotide Pyrophosphatase/phosphodiesterase1 Deficiency
- Trial name
- NCT06462547
- Testing
- INZ-701
- Where
- 5 sites in United States, France and 2 more
- Volunteers
- 22 people
- Sponsor
- Inozyme Pharma
End Stage Renal Failure on Dialysis, Vascular Calcification
Pilot Study to Investigate the Effects of Increased Dialysate Magnesium and Dialysate Bicarbonate on the Calcification Propensity of Serum
The study aims to determine the effect size of magnesium and bicarbonate supplementation as a basis for future randomized controlled trials aiming at the T50-guided improvement of hard clinical endpoints in dialysis patients.
- Trial name
- BicMag (NCT02621762)
- Testing
- Magnesium, Bicarbonate
- Where
- Switzerland
- Volunteers
- 12 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Artery Calcification, Coronary Artery Disease
Intravascular Imaging-Guided Intravascular Lithotripsy for Severe Coronary Calcified Lesions.
This study aims to investigate the efficacy and safety of intravascular lithotripsy (IVL) balloon in treating coronary calcified lesions at our center.
- Trial name
- NCT07444346
- Testing
- percutaneous coronary intervention
- Where
- China
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Degenerative Heart Valve Disease, Heart Valve Calcification
Calcium-Phosphorus Regulation Therapy on Heart Valve Disease
The goal of this clinical trial is to learn if calcium-phosphorus regulation therapy can slow the progression of heart valve calcification in patients with degenerative heart valve disease and chronic kidney disease (CKD).
- Conditions
- Degenerative Heart Valve Disease, Heart Valve Calcification, Chronic Kidney Disease(CKD), Calcium-Phosphorus Metabolism Disorders
- Trial name
- NCT06660524
- Testing
- Sevelamer, Calcium carbonate
- Where
- China
- Volunteers
- 196 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hyperparathyroidism, Secondary
Optimal Anemia Treatment in End Stage Renal Disease (ERSD)
Clinical study aimed at improving anemia management in End Stage Renal Disease Patient (ESRD) on maintenance Hemodialysis with evidence of Chronic Kidney disease Mineral Bone Disorder (CKD-MBD)
- Trial name
- OPTIMAL (NCT02273570)
- Testing
- standard care, Optimal (I. iPTH control: Zemplar®,Mimpara®; phosphorous control: Renvela®, Phoslo®, Osvaren®, Foznol®,Maalox®; calcium control: calcium and vitamin D
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Azienda Ospedaliera Sant'Anna
Mitral Annulus Calcification
Bicycle Exercise Echocardiography to Assess Physiological Significance of Mitral Annular Calcification
Many people develop calcium deposits in the heart as they get older. One of the common places for this to occur is the mitral annulus, the band of tissue that supports the mitral valve (one of four heart valves).
- Trial name
- NCT04093973
- Testing
- bicycle stress echocardiography
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Albert Einstein Healthcare Network
Coronary Artery Calcification
Association Between Non-alcoholic Fatty Liver Disease (NAFLD) and Coronary Artery Calcification
Coronary artery disease are 8 times more prevalent in patients with NAFLD then the general population and are being considered the most common cause of death.
- Trial name
- NCT01158066
- Testing
- CT Cardiac
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Ziv Hospital
Calcinosis, Arteriosclerosis
CARE-2 (Calcium Acetate [PhosLo®]/Sevelamer[Renagel®] Evaluation Study 2) for Heart Calcification in Dialysis Patients
The purpose of the study is to evaluate the effects of two phosphate binders, PhosLo and sevelamer, on heart calcification in dialysis patients.
- Conditions
- Calcinosis, Arteriosclerosis, Hyperparathyroidism, Secondary
- Trial name
- NCT00211939
- Testing
- calcium acetate, sevelamer, atorvastatin
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Nabi Biopharmaceuticals
Coronary Calcification, Vascular Calcification
Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis
The present study will examine the treatment effect of sodium thiosulfate on coronary calcification in patients on hemodialysis.
- Trial name
- NCT00720772
- Testing
- 25% intravenous (IV) sodium thiosulfate
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Ramathibodi Hospital
Chronic Total Occlusion of Coronary Artery, Calcification
Calcification on CTCA of a CTO and PCI Outcomes
A chronic total occlusion (CTO) is present in 15-20% of patients who are referred for invasive coronary angiography. CTO Percutaneous Coronary Intervention (PCI) procedure success rates have increased over the years and can be as…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Calcification, Computed Tomography Angiography
- Trial name
- NCT06414551
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Coronary Artery Calcification
Toe-brachial Index and Coronary Calcification in Type 1 and 2 Diabetes
Diabetes is not a coronary risk equivalent, despite cardiovascular disease is the most common cause of death in diabetes. So, to identify diabetic patients at high cardiovascular risk is necessary.
- Trial name
- ACCoDiab (NCT03920683)
- Testing
- Data collection
- Where
- France
- Volunteers
- 707 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Coronary Artery Atherosclerosis
Intravascular Imaging Evaluated Calcified Nodule China Registry
What is this study about? This is a nationwide research study in China focused on understanding a specific type of challenging plaque in heart arteries called a Calcified Nodule (CN).
- Conditions
- Coronary Artery Disease, Coronary Artery Atherosclerosis, Coronary Calcified Nodules, Coronary Calcification
- Trial name
- NCT07262359
- Volunteers
- 500 people
- Sponsor
- Shanghai Zhongshan Hospital
Intravascular Lithotripsy
Clinical Trial on the Treatment of Stent Underexpansion Caused by Calcification Using Intravascular Lithotripsy
Our aim is to investigate the efficacy and safety of intravascular lithotripsy(IVL) in the treatment of stent underexpansion caused by calcification through a prospective, multicenter, randomized controlled trial.
- Trial name
- NCT06521905
- Testing
- intravascular lithotripsy, high-pressure ballon
- Volunteers
- 222 people
- Sponsor
- China National Center for Cardiovascular Diseases
Calciphylaxis
Calciphylaxis : Population, Risk Factors, Diagnostic Practice, Therapeutic and Outcome
Calciphylaxis, also called Calcific Uremic Arteriolopathy (CUA) is a lethal affection mostly affecting patient in end stage renal disease. The survival rate is described around 20 to 46% at one year.
- Trial name
- CalciWest (NCT02854046)
- Testing
- Calcific Uremic Arteriolopathy
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Nantes University Hospital