Clinical trials: Calcinosis
CKD 5D, Hemodialysis
Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications.
- Trial name
- NCT01407601
- Testing
- daily supplementation of MK-7 over 6 weeks
- Where
- 3 sites in Germany
- Volunteers
- 53 people
- Sponsor
- RWTH Aachen University
Common Femoral Artery Stenosis, Calcification; Heart
Shockwave™ vs Surgical Endarterectomy for Calcified Severe Common Femoral Artery Stenosis: Comparison of Efficacy, Safety and Long-Term Outcomes
The investigators hypothesize that Shockwave with DCB is non-inferior to surgical endarterectomy for common femoral artery (CFA) stenosis with regard to primary efficacy and safety endpoints.
- Trial name
- Shockify (NCT06829914)
- Testing
- Shockwave Catheter, CFA Endarterectomy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Baylor Research Institute
Coronary Artery Calcification, Coronary Artery Disease
TECTONIC CAD IVL IDE Study
A prospective, single-arm, open-label, multi-center IDE study with up to 55 US sites
- Conditions
- Coronary Artery Calcification, Coronary Artery Disease, Stenotic Coronary Lesion
- Trial name
- TECTONIC (NCT06885177)
- Testing
- Experimental
- Where
- 40 sites in United States
- Volunteers
- 335 people
- Sponsor
- Abbott Medical Devices
Carotid Artery Calcification, Carotid Artery Diseases
Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Femoral Stenting (SKYWARD Trans-Femoral IDE [Investigational Device Exemption] Study)
Prospective, Multi-center, Single-arm Study of the Shockwave Medical SkyRunner Carotid Intravascular Lithotripsy (IVL) System for the Treatment of Calcified Carotid Arteries Prior to Trans-Femoral stenting (SKYWARD Trans-Femoral…
- Trial name
- SKYWARD TF (NCT07512128)
- Testing
- Carotid Intravascular Lithotripsy
- Where
- 25 sites in United States
- Volunteers
- 185 people
- Sponsor
- Shockwave Medical, Inc.
Calciphylaxis, Calcific Uremic Arteriolopathy
Phase 3 Study of SNF472 for Calciphylaxis
The primary objectives are to assess the efficacy, safety, and tolerability of SNF472 compared to placebo when added to background care for the treatment of calciphylaxis (CUA).
- Trial name
- Calciphyx (NCT04195906)
- Testing
- Experimental: SNF472, Experimatenl SNF472 (Open-label)
- Where
- 58 sites in United States, Belgium and 4 more
- Volunteers
- 71 people
- Sponsor
- Sanifit Therapeutics S. A.
Aortic Valve Stenosis, AV Block
Prospective Arm of Conduct - Edwards SAPIEN3 PPI Registry
There are procedure related risk factors for permanent pacemaker implantation (PPI) that can be identified and assessed in a prospective cohort of 300 patients at high risk for PPI Prospective, multicenter, European registry in…
- Conditions
- Aortic Valve Stenosis, AV Block, Bundle-Branch Block
- Trial name
- Conduct-pro (NCT03715894)
- Testing
- transcatheter valve implantation
- Where
- 5 sites in Germany, Netherlands and 1 more
- Volunteers
- 300 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Coronary Artery Calcification
Picture of Incidental Calcium To Understand Risk Estimate (PICTURE) Trial
This is a prospective randomized controlled trial assessing the impact of notifying patients and their clinicians of an incidental finding of coronary artery calcification (CAC) indicating increased cardiovascular risk.
- Trial name
- PICTURE (NCT05588895)
- Testing
- Notification
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Stanford University
Arterial Calcification, Diabetes Mellitus Type 2
A Randomized, Placebo-controlled, Double Blind Trial to Investigate Whether Vitamin K2 Can Influence Arterial Calcification in Patients With Type 2 Diabetes
Arterial calcification is an independent predictor of coronary events associated with a 3-4 fold increased risk of cardiovascular events. Currently, no effective intervention exists to reduce arterial calcification.
- Trial name
- Vitacal (NCT02839044)
- Testing
- Menaquinone-7
- Where
- Netherlands
- Volunteers
- 68 people
- Sponsor
- UMC Utrecht
Coronary Calcification
IVL and RA in Treatment of Balloon-crossable Severely Calcified Coronary Lesions
This study to compare periprocedural safety, angiographic success as well as short and long term outcomes of intravascular lithotripsy and rotational atherectomy as a method of severely calcified coronary lesion preparation…
- Trial name
- NCT04556682
- Testing
- Rotational atherectomy, Intravascular lithotripsy
- Where
- Netherlands
- Volunteers
- 101 people
- Sponsor
- Assiut University
Heterozigous Familial Hypercholesterolemia
Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus Ezetimibe
Study Title: Evaluation of chylomicrons metabolism in sub-clinical atherosclerosis in patients whit Heterozigous Familial Hypercholesterolemia (FH) treated with statin plus ezetimibe.
- Trial name
- NCT00475826
- Testing
- Statins and Ezetimibe
- Where
- Brazil
- Sponsor
- University of Sao Paulo
Cardiovascular Disease, Atherosclerosis
Cardiovascular Molecular Calcification Assessed by 18F-NaF PET CT
The purpose of the CAMONA study is to demonstrate the feasibility of cardiovascular molecular calcification (CMC) assessment by means of 18F-sodium-fluoride (18F-NaF) positron emission tomography (PET) computed tomography (CT) in…
- Conditions
- Cardiovascular Disease, Atherosclerosis, Angina Pectoris
- Trial name
- CAMONA (NCT01724749)
- Where
- 2 sites in Denmark
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Chronic Kidney Disease, Vascular Calcification
Pentoxifylline for Vascular Calcification in Kidney Disease
This study is research to find out if the drug pentoxifylline can help prevent or lessen the problem of blood vessel hardening (vascular calcification) in people with chronic kidney disease (CKD).
- Conditions
- Chronic Kidney Disease, Vascular Calcification, Kidney Failure, Chronic
- Trial name
- PTX-CALC-CKD (NCT06903689)
- Testing
- Pentoxifylline 400 MG Oral Tablet, Conventional Medications for Chronic Kidney Disease
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Aortic Valve Stenosis, Aortic Valve Calcification
ACURATE Enhance Post Market Study
The objective of the ACURATE Enhance study is to assess valve frame expansion and hemodynamics in a routine clinical setting when optimized procedural steps for valve implantation are followed.
- Conditions
- Aortic Valve Stenosis, Aortic Valve Calcification, Aortic Diseases
- Trial name
- NCT06959862
- Testing
- Transcatheter Aortic Valve Implantation/Replacement
- Sponsor
- Boston Scientific Corporation
Cardiovascular Diseases, Heart Diseases
Epidemiology of Coronary Calcification in the Elderly
To investigate the prevalence and prognostic value of subclinical atherosclerosis in the Pittsburgh SHEP cohort and a cohort of normal controls.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Arteriosclerosis, Coronary Disease
- Trial name
- NCT00005756
- Sponsor
- University of Pittsburgh
Kidney Transplant; Complications, Bone Loss
Bone Density and Vascular Calcifications Evolution After Renal Transplant
The investigators project is based on: Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA); The non-invasive detection of vascular calcifications (by abdominal CT scanner)…
- Trial name
- NCT04713774
- Testing
- High-resolution peripheral quantitative CT scanner (HRpQCT)
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University of Liege
Healthy
Effects of Supradyn® Energy 3RDA on Fatigue/Stress, Substrate Metabolism During Exercise and Demanding Cognitive Tasks
Investigation of the acute and chronic effects of Supradyn® Energy 3RDA on subjective ratings of 'fatigue/stress', substrate metabolism and blood biomarkers of recovery, as a consequence of exercise and metabolically demanding…
- Trial name
- NCT03003442
- Testing
- Supradyn® Energy 3RDA
- Where
- United Kingdom
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Coronary Artery Calcification, Cardiac Disease
Personalization of CM Injection Protocols in Coronary Computed Tomographic Angiography
Cardiac computed tomography (CCT) is one of the standard non-invasive imaging techniques allowing imaging of the heart and coronary arteries with a high temporal and spatial resolution.
- Trial name
- PeopleCT (NCT03292354)
- Testing
- Contrast media administration
- Where
- Netherlands
- Volunteers
- 327 people
- Sponsor
- Maastricht University Medical Center
Vascular Calcification
Effect of Phosphorus on Valvular and Vascular Calcification in ESRD
Evaluation of the calcifying effect of phosphorus on vascular smooth muscle and detect the association between serum phosphorus and valvular and vascular calcification in end stage renal disease patients
- Trial name
- NCT03360331
- Volunteers
- 30 people
- Sponsor
- Assiut University
Sarcoidosis, Hypercalcemia Due to Sarcoidosis
ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot Study
ACTHAR Gel has activity in sarcoidosis associated hypercalciuria and calcium dysregulation.
- Trial name
- NCT02155803
- Testing
- ACTHAR Gel (adrenocorticotropic hormone)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Albany Medical College
Breast Carcinoma, Microcalcification
Ultrasound Imaging Technique in Detecting Breast Microcalcifications in Patients Undergoing Biopsy for a Breast Abnormality
This clinical trial studies a new type of ultrasound technique, MicroPure, in detecting breast microcalcifications in patients undergoing biopsy for a breast abnormality.
- Trial name
- NCT03031561
- Testing
- Ultrasound, MicoPure ultrasound, Biopsy of Breast
- Volunteers
- 85 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University