Clinical trials: Calcitonin
Episodic Migraine
Study of Efficacy and Safety of AMG 334 in Adult Episodic Migraine Patients
This study is to evaluate the efficacy and safety of AMG334 in adult patients with episodic migraine
- Trial name
- EMPOwER (NCT03333109)
- Testing
- Erenumab
- Where
- 81 sites in Argentina, India and 9 more
- Volunteers
- 900 people
- Sponsor
- Novartis Pharmaceuticals
Migraine Headache
Repeat Dosing of Psilocybin in Migraine Headache
In seeking to understand the capacity for psilocybin to reduce migraine headache burden, this study will investigate single and repeated dosing of psilocybin up to two doses.
- Trial name
- NCT04218539
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Angina Pectoris, Coronary Heart Disease
A Study to Assess the Safety, Tolerability, and Effects of MK-0974 (Telcagepant) on Exercise Tolerance in Patients With Stable Angina (MK-0974-014)
This study will assess the safety of telcagepant in coronary artery disease (CAD) participants with stable angina during exercise treadmill testing and evaluate whether calcitonin gene-related peptide (CGRP) receptor antagonism…
- Conditions
- Angina Pectoris, Coronary Heart Disease, Calcitonin Gene-related Peptide Receptor
- Trial name
- NCT01294709
- Testing
- telcagepant
- Volunteers
- 64 people
- Sponsor
- Merck Sharp & Dohme LLC
Episodic Migraine, Chronic Migraine
CGRP Inhibition, Autonomic Function, and Migraine
The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e.
- Trial name
- CGRP-1 (NCT04628429)
- Testing
- Erenumab, Galcanezumab, Fremanezumab
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Migraine
Calcitonin Gene-related Peptide Levels in Chronic Migraine
Twenty patients will be enrolled in a 2-site, 7-month, double-blind study conducted to evaluate a reduction in headache days and attacks and calcitonin gene-related peptide (CGRP) levels in saliva following treatment with…
- Trial name
- NCT01071096
- Testing
- OnabotulinumtoxinA, Saline
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Cady, Roger, M.D.
Migraine Disorders
EptinezuMaB in ReAl-world evidenCE: Multicenter, Real Life, Cohort Study in Migraine.
The object of this study is to assess the effectiveness, safety, and tolerability of eptinezumab in a real life migraine population.
- Trial name
- EMBRACE (NCT05570149)
- Testing
- Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- IRCCS San Raffaele Roma
Dry Eye, Asthenopia
Evaluate the Safety and Efficacy of Calcitonin Gene-Related Peptide (CGRP) Antagonists in Patients With Dry Eye Disease and Asthenopia
Safety and Efficacy of Medications for Migraine in Patients with Dry Eye Disease or Asthenopia
- Trial name
- NCT05895500
- Testing
- Injection for SC administration (120mg/syringe), Tablet (50mg/tablet), oral
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Nvision Laser Eye Centers
Osteopenia
A Study of Oral Recombinant Salmon Calcitonin (rsCT) to Prevent Postmenopausal Osteoporosis
The primary purpose of this study was to evaluate the efficacy of oral calcitonin (rsCT)tablets in the prevention of bone loss in postmenopausal women with lower bone mineral density at increased risk of fracture.
- Trial name
- NCT01292187
- Testing
- Oral calcitonin at dinnertime, Oral calcitonin at bedtime
- Where
- 10 sites in United States
- Volunteers
- 129 people
- Sponsor
- Tarsa Therapeutics, Inc.
Migraine With Aura
Pharmacologically Triggered Migraine Without Aura and Neuroimaging
Migraine is a highly disabling disorder affecting 14% of the general population Worldwide and ranked as the 6th most debilitating disease worldwide by the WHO.
- Trial name
- NCT03143465
- Testing
- Calcitonin Gene-Related Peptide, Sildenafil
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Osteoarthritis
Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
The purpose of this phase III study is to Evaluate the Efficacy and Safety of Oral Salmon Calcitonin in the Treatment of Patients with Osteoarthritis of the Knee
- Trial name
- NCT00704847
- Testing
- Oral Salmon Calcitonin
- Where
- 18 sites in United States, Belgium and 8 more
- Volunteers
- 1,030 people
- Sponsor
- Nordic Bioscience A/S
Osteoarthritis
SMC021A - Absorption, Efficacy and Tolerance in Patients With Osteoarthritis. A Placebo-Controlled 14-Days Study
The purpose of this study is to expose patients with OA to calcitonin and to determine plasma calcitonin levels after administration of 0.6 mg and 0.8 mg oral calcitonin.
- Trial name
- NCT00486369
- Testing
- Oral salmon calcitonin
- Where
- Denmark
- Sponsor
- Nordic Bioscience A/S
Pelvic Pain, Varicose Veins Pelvic
Neuropeptides and Venous Pelvic Pain
Mechanisms of the development of pain in chronic venous diseases (CVD), including pelvic congestion syndrome (PCS), are studied incompletely.
- Conditions
- Pelvic Pain, Varicose Veins Pelvic, Pelvic Congestion Syndrome
- Trial name
- NVPP (NCT03921788)
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Pirogov Russian National Research Medical University
Coronary Disease
Pro-calcitonin Marker as Indicator of Ischemia in Patients With Complicated Coronary Intervention.
The aim of this study is to determine on preliminary basis weather an elevated pro-calcitonin level can be used to assess ischemia as a result of coronary artery complications during percutaneous coronary intervention (PCI).
- Trial name
- NCT01609569
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Saint Michael's Medical Center
Post Concussive Symptoms
Chasing Biomarkers in Post-concussion Syndrome
The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive…
- Trial name
- NCT05812742
- Testing
- Early intervention programme, Enhanced usual care
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Forearm Fracture
Efficacy and Safety of Salmon Calcitonin Nasal Spray in Improving Muscle Strength and Reducing Pain After Forearm Fracture in Postmenopausal Women
Calcitonin has been used for many years for treating osteoporosis in postmenopausal women, and it has been shown that calcitonin reduces pain after spine and hip fracture in women with osteoporosis.
- Trial name
- NCT00239889
- Testing
- Salmon calcitonin
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 300 people
- Sponsor
- Novartis
Calcinosis
Phase II Study of Calcitonin for Tumoral Calcinosis
OBJECTIVES: I. Determine whether intermittent, long-term, subcutaneous administration of calcitonin increases phosphaturia, reduces hyperphosphatemia, and increases intact parathyroid hormone levels in patients with tumoral…
- Trial name
- NCT00004358
- Testing
- calcitonin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- National Center for Research Resources (NCRR)
Ulcerative Colitis, Crohn's Disease
Nasal Calcitonin in the Treatment of Bone Mineral Loss in Children and Adolescents With Inflammatory Bowel Disease
The hypothesis underlying this study is that nasally administered calcitonin will stabilize or improve bone mineral density in young patients with ulcerative colitis or Crohn's disease.
- Trial name
- NCT00114803
- Testing
- Calcitonin nasal spray (salmon)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Boston Children's Hospital
Medullary Thyroid Carcinoma, Nodular Goiter
Calcitonin in Needle Wash Using Electrochemiluminescence Method For Diagnosis Of Medullary Thyroid Carcinoma.
Medullary thyroid carcinoma (MTC) is a tumor originating from parafollicular C cells of the thyroid. (1) Representing 1 to 7% of all thyroid carcinoma cases (2, 3, 4).
- Trial name
- NCT06067594
- Testing
- Fine Needle Aspiration Cytology (FNAC) procedure+calcitonin measurement
- Where
- Argentina
- Volunteers
- 155 people
- Sponsor
- Austral University, Argentina
Osteoarthritis
Effects of Oral Salmon Calcitonin in Human Osteoarthritis
To assess the safety, tolerability and clinical efficacy of oral salmon calcitonin in patients suffering from osteoarthritis
- Trial name
- NCT00376311
- Testing
- oral salmon calcitonin
- Where
- Belgium
- Volunteers
- 54 people
- Sponsor
- Université Catholique de Louvain
Thyroid Neoplasms
Phase II Two-step Radioimmunotherapy Clinical Study in Medullary Thyroid Carcinoma
Phase II clinical trial assessing efficacy and toxicity of pretargeted radioimmunotherapy using anti-CEAxanti-DTPA bispecific antibody and di-DTPA-131I peptide in patients with reccurrence of medullary thyroid carcinoma (abnormal…
- Trial name
- RIT in MTC (NCT00467506)
- Testing
- bispecific antibody and di-DTPA-131I
- Where
- 11 sites in France
- Sponsor
- Nantes University Hospital