Clinical trials: Calcium
Autosomal Dominant Hypocalcemia
ADH1 and ADH2 Disease Monitoring Study (DMS)
A global, multi-center, Disease Monitoring Study (DMS) in participants with Autosomal Dominant Hypocalcemia Type 1 (ADH1) or Autosomal Dominant Hypocalcemia Type 2 (ADH2) designed to characterize ADH1 and ADH2 disease…
- Trial name
- CLARIFY (NCT05227287)
- Where
- 27 sites in United States, Australia and 11 more
- Volunteers
- 95 people
- Sponsor
- Calcilytix Therapeutics, Inc., a BridgeBio company
Orthopedic Disorder, Calcium Metabolism Disorders
High- Versus Low-calcium Water for Bone Health
The experimental study investigates which metabolic responses of calcium and parathyroid hormone are observable in blood and urine in a cohort of 41 healthy adults following a sequence of different exposures: low-calcium water…
- Conditions
- Orthopedic Disorder, Calcium Metabolism Disorders, Bone Resorption, Water-Electrolyte Imbalance
- Trial name
- NCT05772364
- Testing
- Loading of low-calcium water first, then high-calcium water
- Where
- Italy
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Caries, Dental, Calcium Hypophosphite
Comparative Study of Caries-Preventive Effects: 2% Calcium Hypophosphite Toothpaste vs. Sodium Fluoride Toothpaste (1450ppm F)
The aim of the study is to compare the caries-preventive effect of the test and control toothpaste in order to proof the non-inferiority of the test toothpaste compared to the control.
- Conditions
- Caries, Dental, Calcium Hypophosphite, Fluoridation
- Trial name
- NCT07068204
- Testing
- 2% Calcium Hypophosphite Toothpaste, Sodium Fluoride Toothpaste (1450 ppm F)
- Where
- 2 sites in Poland
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Dr. Joachim Enax
Osteoporosis, Post-Traumatic, Calcium Supplementation
Study of the Adequacy Between Calcium Supplementation and Dietary Intake in Treatment-naive Patients After a Fracture
Osteoporosis is a disease that causes many fractures. However, treatments exist such as anti-osteoporotic treatments, vitamin D supplementation and an adaptation of calcium intake.
- Conditions
- Osteoporosis, Post-Traumatic, Calcium Supplementation, Osteoporosis, Management Care, Fracture
- Trial name
- MONTE-CRIST'OS (NCT06847087)
- Testing
- Self-questionnaire
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier de Colmar
CPPD - Calcium Pyrophosphate Deposition Disease, Gout
The Orienting Study
This study at IRCCS Galeazzi - Sant'Ambrogio Hospital involves patients with gout, CPPD, and osteoarthritis as a control group. Patients will receive routine care with regular clinical, laboratory, and imaging assessments every…
- Trial name
- ORIENTING (NCT07504146)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Deep Caries, Indirect Pulp Capping
Comparison Between Egyptian MTA, Biodentine Versus Calcium Hydroxide as Indirect Pulp Capping Materials In Permanent Teeth
Compare the clinical performance and patient satisfaction of Egyptian MTA, Biodentine versus Calcium Hydroxide as indirect pulp capping materials in permanent teeth
- Conditions
- Deep Caries, Indirect Pulp Capping, Mineral Trioxide Aggregate (MTA), Calcium Hydroxide
- Trial name
- NCT06683833
- Testing
- Egyptian MTA, Biodentine, Calcium Hydroxide (Ca(OH)2)
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Cairo University
Calcium Phosphate Kidney Stones
Methionine for CaPhos Stone
Some kidney stones including calcium phosphate and struvite stones form in vary alkaline urine (high pH). Currently available medication for stone prevention, namely citrate supplementation, can lead to even higher pH levels and…
- Trial name
- NCT07465367
- Testing
- L-Methionine
- Volunteers
- 15 people
- Sponsor
- Ryan L Steinberg
Calcium Oxalate Urolithiasis
Oxalobacter Formigenes Colonization and Urinary Oxalate Excretion
The purpose of this research study is to assess the efficacy of ingesting a small amount of the harmless bacterium Oxalobacter formigenes in establishing residence in the guts of healthy participants and to determine whether this…
- Trial name
- NCT03752684
- Testing
- Moderately high oxalate/low calcium diet non-colonized, Oxalobacter formigenes, Moderately high oxalate/low calcium diet colonized
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
CAMK2, Calcium/Calmodulin-dependent Protein Kinase 2
CAMK2-related Synapthopathies Natural History Study
The key endpoint for this prospective cohort study is: Mapping of the disease course of all known patients (both children and adults, international) with a CAMK2 mutation, for which ENCORE has founded an expert clinic, and…
- Trial name
- NCT07372833
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Erasmus Medical Center
Kidney Stones, Urolithiasis
Pilot Study to Evaluate the Contribution of Gene Variants to Idiopathic Urolithiasis
Recent investigations from this group have identified that genetic variants of genes associated with monogenic forms of nephrolithiasis are expressed in idiopathic calcium oxalate kidney stone patients and could influence stone…
- Conditions
- Kidney Stones, Urolithiasis, Calcium Oxalate Urolithiasis
- Trial name
- NCT01127854
- Where
- United States
- Volunteers
- 2,900 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Calcium Pyrophosphate Deposition Disease
Tocilizumab in Chronic Inflammatory CPPD Disease
The aim of this clinical trial is to determine the efficacy of tocilizumab (an IL-6 inhibitor) in treatment-refractory chronic inflammatory forms of CPPD.
- Trial name
- TociCCAre (NCT07254637)
- Testing
- Tocilizumab
- Where
- 12 sites in France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vitamin D, Vitamin D and Calcium Homeostasis
Free Vitamin D and Steroid Metabolism in Endocrine Disorders
This clinical study aims to gain a better understanding of how different forms of vitamin D are processed in the body in healthy individuals, pregnant women, and patients with various hormonal (endocrine) and kidney (renal)…
- Trial name
- FREEDOM (NCT07268742)
- Testing
- Blood draw for the laboratory assessment
- Where
- Belgium
- Volunteers
- 930 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Urolithiasis, Calcium Oxalate, Kidney Stone
A Single-Center Clinical Study on the Efficacy and Safety of VISOR
Goal of this trial: To test a new tool called VISOR in adults (aged 18-80) with 1-3 cm kidney or ureter stones. We want to see: 1. If it's safe and works well 2.
- Trial name
- NCT07071948
- Testing
- Multifunctional Integrated Flexible Ureteroscope
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Urolithiasis, Calcium Oxalate, Ureteroscopy
Clinical Trial of VISOR vs fURS for Upper Urinary Tract Stone
This prospective randomized controlled clinical study aims to evaluate the safety and efficacy of a novel Vortex Intelligence Stone Optimized Removal (VISOR,The experimental group) system compared to a single-use ureterorenoscope…
- Conditions
- Urolithiasis, Calcium Oxalate, Ureteroscopy, Therapeutic Irrigation, Intraoperative Complications
- Trial name
- VISOR (NCT07181759)
- Testing
- VISOR, fURS
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
Hypoparathyroidism
Translation and Validation of the Hypoparathyroidism Patient Experience Scales (HPES) Questionnaire in Greek
This is a crossectional study that will be conducted at several tertiary centers in Greece. To participate in the study, patients should be ≥18 years of age, fluent in Greek language, diagnosed with chronic HP, on optimal…
- Trial name
- HPES (NCT07160348)
- Testing
- Questionnaire and Physical Exam
- Volunteers
- 200 people
- Sponsor
- Aristotle University Of Thessaloniki
Intracanal Dressing, Apical Periodontitis
Effect of Bio-C Temp Versus Calcium Ydroxide as Intracanal Dressings on Postoperative Pain Intensity and Periapical MMP-9 Level in Patients With Necrotic Pulp
To compare the effect of Bio-C Temp Bioceramic intracanal dressing versus calcium hydroxide as intracanal medicaments on: Intensity of postoperative pain levels of MMP -9 in Periapical Fluids.
- Conditions
- Intracanal Dressing, Apical Periodontitis, Calcium Hydroxide, Biomarkers
- Trial name
- NCT07101029
- Testing
- Bio-C Temp Intracanal Medication, Calcium Hydroxide Intracanal medication
- Volunteers
- 30 people
- Sponsor
- Cairo University
Kidney Calculi, Calcium Oxalate Kidney Stones
Evaluating the Vitamin K2 Status of Calcium-based Stone Formers
This is an observation, single site-study with one study visit during which all data and samples will be collected. Study participants will be asked to provide blood, urine, and fecal samples so that the investigators may study…
- Conditions
- Kidney Calculi, Calcium Oxalate Kidney Stones, Vitamin K 2, Human
- Trial name
- NCT05081960
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
BPPV, Benign Paroxysmal Positional Vertigo
Clinical Trial of Vit D and Calcium for Recurrent BPPV
Randomized double blind placebo controlled trial of vitamin D supplements, with or without calcium supplementation, versus placebo in reduction of recurrences in BPPV.
- Conditions
- BPPV, Benign Paroxysmal Positional Vertigo, Vertigo, Vertigo, Peripheral
- Trial name
- NCT05863949
- Testing
- vitamin D +/- calcium
- Volunteers
- 860 people
- Sponsor
- Ottawa Hospital Research Institute
Subcision, Calcium Hydroxylapatite
Subcision Followed by Diluted Calcium Hydroxylapatite Injection Versus Subcision Followed by Painting CROSS TCA Technique for the Treatment of Atrophic Acne Scars
This study aimed to compare the safety and efficacy of subcision followed by diluted calcium hydroxyapatite injection versus subcision followed by the painting original chemical reconstruction of skin scars (CROSS) technique…
- Conditions
- Subcision, Calcium Hydroxylapatite, Trichloroacetic Acid, Atrophic Acne Scar
- Trial name
- NCT07028567
- Testing
- Calcium hydroxylapatite filler, Painting chemical reconstruction of skin scars trichloroacetic acid technique
- Where
- Egypt
- Volunteers
- 13 people
- Sponsor
- Tanta University
Calcium Pyrophosphate Deposition Disease, Rheumatic Diseases
Calcium Pyrophosphate Deposition (CPPD) Disease
The goal of this clinical trial is to describe the transcriptomic and metabolomic profile of patients with chronic Calcium Pyrophosphate Deposition (CPPD) compared to those with acute CPPD.
- Trial name
- PYC-OMIC (NCT07005804)
- Testing
- transcriptomic and metabolomic analysis
- Where
- France
- Volunteers
- 137 people
- Sponsor
- Lille Catholic University