Clinical trials: Calcium Oxalate Urolithiasis
Urolithiasis, Calcium Oxalate, Kidney Stone
A Single-Center Clinical Study on the Efficacy and Safety of VISOR
Goal of this trial: To test a new tool called VISOR in adults (aged 18-80) with 1-3 cm kidney or ureter stones. We want to see: 1. If it's safe and works well 2.
- Trial name
- NCT07071948
- Testing
- Multifunctional Integrated Flexible Ureteroscope
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Kidney Stone
Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers
The primary goals of this study are to determine the contribution of dietary oxalate absorption, renal oxalate handling, and endogenous oxalate synthesis to urinary oxalate excretion in normal Body Mass Index (BMI) and obese…
- Trial name
- NCT04333745
- Testing
- Controlled Diet, Carbon-13 Oxalate and Sucralose Ingestion
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Kidney Stone, Kidney Calculi
O. Formigenes Colonization in Calcium Oxalate Kidney Stone Disease
The goal of this trial is to test if colonization with the gut bacteria Oxalobacter formigenes leads to a reduction in urinary oxalate excretion in patients with calcium oxalate kidney stone disease.
- Conditions
- Kidney Stone, Kidney Calculi, Urolithiasis, Urolithiasis, Calcium Oxalate
- Trial name
- NCT06330246
- Testing
- Low oxalate fixed diets pre-colonization, Moderately high oxalate fixed diets pre-colonization, Colonization with Oxalobacter formigenes
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Nephrolithiasis, HIV
Kidney Stone Risk Factors in Patients Infected With HIV
The purpose of this study is to define the cause of renal stones and the risk pattern for recurrence of renal stones episodes (any kind of stones) in HIV1 patients.
- Trial name
- CALVIH (NCT02457494)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Corinne Isnard Bagnis
Nephrolithiasis
Nephrolithiasis Prevention by Lemon Juice
Calcium oxalate nephrolithiasis is a relatively common disease. The prevalence in the general population may range from 10 to 12 percent, and 0.4 to 1 percent of new cases are reported every year according to different series.
- Trial name
- LIMONE (NCT01217372)
- Testing
- Lemon supplementation
- Where
- Italy
- Volunteers
- 203 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Nephrolithiasis
Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria
Oxalate restricted diet is routinely prescribed in clinical practice of nephrolithiasis patients with hyperoxaluria. The effect of dietary oxalate on urinary oxalate is however controversial.
- Trial name
- NCT01650935
- Testing
- diet
- Where
- 2 sites in Iran
- Volunteers
- 48 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Secondary Hyperoxaluria, Nephrolithiasis
Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones
The purpose of this study is to evaluate the safety, tolerability, and efficacy of different doses of ALLN 177 for reducing urinary oxalate excretion in patients with secondary hyperoxaluria and recurrent kidney stones.
- Conditions
- Secondary Hyperoxaluria, Nephrolithiasis, Kidney Stones, Hyperoxaluria
- Trial name
- NCT02503345
- Testing
- ALLN-177 low dose, ALLN-177 mid dose, ALLN-177 high dose
- Where
- 16 sites in United States
- Volunteers
- 32 people
- Sponsor
- Allena Pharmaceuticals
Kidney Calculi
Efficacy of Potassium Sodium Hydrogen Citrate Therapy on Renal Stone Recurrence and/or Residual Fragments After Shockwave Lithotripsy and Percutaneous Nephrolithotomy in Calcium Oxalate Urolithiasis
Extracorporeal shock wave lithotripsy (ESWL) and Percutaneous nephrolithotomy (PCNL) become the therapy of choice for renal stone.
- Trial name
- NCT01329042
- Testing
- Potassium-sodium citrate
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ouiheng International Healthcare Co., Ltd
Kidney Stones, Urolithiasis
Evaluation of Stone Composition in Surgical Kidney Stone Patients in Vietnam
This is a prospective observational study conducted at Binh Dan Hospital, Ho Chi Minh City, Vietnam, from July to December 2023.
- Conditions
- Kidney Stones, Urolithiasis, Nephrolithiasis
- Trial name
- STONE-VN (NCT07038954)
- Testing
- Stone Composition Analysis
- Where
- Vietnam
- Volunteers
- 222 people
- Sponsor
- Binh Dan Hospital
Hyperuricosuria, Kidney Stones
Febuxostat Versus Allopurinol or Placebo in Patients With Hyperuricosuria and Calcium Oxalate Stones
The purpose of this study is to determine the efficacy of febuxostat, once daily (QD), compared to allopurinol or placebo in patients with excessive amounts of uric acid in their urine and who have recently had kidney stones.
- Trial name
- NCT01077284
- Testing
- Febuxostat, Allopurinol
- Where
- 28 sites in United States
- Volunteers
- 99 people
- Sponsor
- Takeda
Lithiasis, Nephrolithiasis
Study of the Administration of a Food Supplement in Patients With Lithiasis Treated With Extracorporeal Shock Wave Lithotripsy.
The extracorporeal shock wave lithotripsy (ESWL) is the treatment of choice for most stones in any of their locations. It is about breaking the stone without surgically intervening on the patient and getting him to expel the…
- Trial name
- FAGOTRICIA (NCT05525130)
- Testing
- Food supplement
- Where
- 3 sites in Spain
- Volunteers
- 81 people
- Sponsor
- Arafarma Group, S.A.
Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis
Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are…
- Trial name
- NCT07408076
- Testing
- Potassium Citrate, Sodium Bicarbonate
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Urolithiasis
Effect of Vinegar Consumption on 24-hour Urinary Risk Factors Associated With Stone Formation
Purpose: The aim of this present study is to investigate the effect of vinegar consumption on 24-hour urinary risk factors associated with calcium oxalate urinary stone formation and blood biochemical parameters.
- Trial name
- NCT02649140
- Testing
- Vinegar group
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Recurrent Calcium Oxalate Kidney Stone Disease, Elevated Urinary Oxalate Levels
A Study to Evaluate Lumasiran in Adults With Recurrent Calcium Oxalate Kidney Stone Disease and Elevated Urinary Oxalate Levels
The primary purpose of this study is to evaluate the effect of lumasiran on the percent change in urinary oxalate excretion in patients with recurrent calcium oxalate kidney stone disease.
- Trial name
- NCT05161936
- Testing
- Lumasiran
- Where
- 31 sites in United States, Belgium and 4 more
- Volunteers
- 2 people
- Sponsor
- Alnylam Pharmaceuticals
Urolithiasis, Calcium Oxalate
What Lies Beneath the Stone? Metabolic Insights From Composition-Based Analysis of Kidney Stones
This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition.
- Trial name
- Kidney stone (NCT06992206)
- Testing
- Metabolik taş analizi ile retrospektif gözlem
- Volunteers
- 506 people
- Sponsor
- Hisar Intercontinental Hospital
Nephrolithiasis
Mature Vinegar Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis
Kidney stones are one of the most common disorders of the urinary tract and cause a great deal of morbidity and economic loss. Because of the high recurrence rate, researchers are interested in finding medicinal therapies to…
- Trial name
- NCT03092908
- Testing
- mature vinegar
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Kidney Stones
CaOx Stone Prevention
This single-center randomized controlled trial at Mount Sinai West will enroll 80 patients undergoing percutaneous nephrolithotomy for calcium oxalate stones.
- Trial name
- NCT07225764
- Testing
- Chlorthalidone, Low oxalate diet
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hyperoxaluria, Nephrolithiasis
Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria
The purpose of this study is to evaluate the effect of ALLN-177 to reduce urinary oxalate excretion in patients with recurring kidney stones and enteric or idiopathic hyperoxaluria.
- Trial name
- NCT02289755
- Testing
- ALLN-177
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Allena Pharmaceuticals
Renal Calculi
Attached Stone Project: Do Calcium Oxalate Renal Calculi Originate From Randall's Plaque?
Urolithiasis is a common condition in the United States, and is associated with significant morbidity and even mortality. The most commonly occurring urinary calculi are comprised of calcium oxalate salts, and until recently, the…
- Trial name
- NCT00169754
- Testing
- mapping kidney anatomy
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Indiana Kidney Stone Institute
Primary Hyperoxaluria Type 1
A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)
A phase 1 study of DCR-PH1 in patients with primary hyperoxaluria type 1 (PH1) to determine the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics (PD) effects of DCR-PH1 administered via-intravenous infusion (IV)
- Trial name
- NCT02795325
- Testing
- DCR-PH1
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 41 people
- Sponsor
- Dicerna Pharmaceuticals, Inc., a Novo Nordisk company