Clinical trials: Caloric Restriction
Overweight and Obese Adults, Healthy
Sex Hormones as Regulators of the Age- and Sex-dependent Benefits of Caloric Restriction
Obesity increases the risk of type 2 diabetes, cardiovascular disease, and certain cancers, primarily due to elevated abdominal fat storage.
- Trial name
- GendAge (NCT07065643)
- Testing
- Phase 1 - Maintenance Diet, Phase 2 - Weight loss diet
- Where
- United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Obesity
Bariatric Surgery Versus Diet Alone in the Bile Acid Pathway and Weight Loss
It is unknown whether the bile acid pathway reacts differently to weight loss resulting from Roux-En-Y Gastric Bypass (RYGB) surgery than weight loss resulting from caloric restriction alone.
- Trial name
- NCT03238794
- Testing
- Roux-En-Y Gastric Bypass, Low-calorie Diet
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Mayo Clinic
Type2diabetes, Obesity
Depletion of Liver Fat in Type 2 Diabetes
The aim of this randomized trial is to determine whether liver fat depletion via a short-term (i.e., two weeks) very-low calorie diet will restore the normal exercise-induced secretion of a signaling protein (fibroblast growth…
- Trial name
- DepLiv (NCT06211556)
- Testing
- Very-low calorie diet
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Kidney, Autosomal Dominant
Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease
The proposed research will determine the feasibility of delivering two behavioral weight loss interventions for 1 year in adults with autosomal dominant polycystic kidney disease (ADPKD) who are overweight or obese.
- Trial name
- NCT03342742
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Colorado, Denver
Obesity
Impact of Whey and Soy Protein Ingestion in Conjunction With Energy Restriction in Overweight/Obese Individuals
It is known that dieting (restricted energy intake) without resistance training leads to a reduced metabolic rate, and the loss of both fat and muscle mass.
- Trial name
- NCT01530646
- Testing
- Weight loss, Soy, Whey
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- McMaster University
Energy Metabolism
Dynamic Effects of Different Dietary Interventions on Visceral Fat and Biochemical Markers
This randomized clinical trial aims to evaluate the dynamic effects of various dietary interventions on visceral fat and biochemical markers among healthy adults.
- Trial name
- NCT06754306
- Testing
- Balanced diet (100% energy), 16+8 time-restricted eating group (100% energy), 16+8 time-restricted eating group (75% energy)
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Medical Oncology, Integrative Oncology
A Pilot, Feasibility Study of Intermittent Caloric Restriction Plus Plant-based Diet in Cancer Patients Receiving Chemotherapy
Caloric restriction may alter the response to chemotherapy induced stress response and enhance its antitumor effect. This study intends to use an intermitted caloric restriction protocol with alternate days before the…
- Conditions
- Medical Oncology, Integrative Oncology, Medical Nutrition Therapy
- Trial name
- NCT05359848
- Testing
- Diet
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Obesity
Effects of Very Low-calorie Diet Versus Bariatric Surgery on Body Composition and Gut Microbiota Pattern
Obesity is a chronic disease characterized by the excessive accumulation of fat in body and it continues to be a major public health problem worldwide.
- Trial name
- NCT05459675
- Testing
- Very low-calorie diet, Bariatric surgery
- Where
- Thailand
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Weight Loss, Vitamin D or Placebo
The Effect of Vitamin D Supplementation During Caloric Restriction on Intestinal Calcium Absorption
The purpose of this study is to learn how the amount of vitamin D supplementation influences intestinal fractional calcium absorption (a measure of the amount of calcium absorbed).
- Trial name
- NCT00472654
- Testing
- Weight Loss, Vitamin D 2500 IU, Weight Maintenance
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Morbid Obesity, Steatosis
Very Low Calorie Liquid Diet for Pre op Patients
Despite the relative consensus on the benefits of pre-surgical weight loss, i.e., the reduction of comorbidities associated with surgical act, such as decreased visceral fat, liver volume, hemorrhage perioperative and surgical…
- Trial name
- NCT01748682
- Testing
- A very low calorie diet of two different consistencies
- Where
- Brazil
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Silvia Leite Faria
Type 2 Diabetes Mellitus in Obese, Type 2 Diabetes
LCMD for Type 2 Diabetes Remission: Evaluation of Effectiveness and Exploration of Individual Differences
Type 2 diabetes (T2DM) has become a major public health problem. Achieving remission (HbA1c<6.5% without glucose-lowering medications) has recently become a new treatment goal.
- Trial name
- LCMD (NCT06442150)
- Testing
- Low-Calorie Medicine Diet, Low-Calorie Diet
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Dietary Modification
Erythrocytes and Skeletal-muscle Fatty Acids Are Positively Correlated After Caloric Restriction and Exercise
The aim is compare and correlate skeletal muscle and erythrocytes fatty acids (FAs) profiles in adult healthy human after caloric restriction and acute exercise in order to validate erythrocyte FAs profile as marker of changes in…
- Trial name
- NCT02533479
- Testing
- Caloric restriction
- Where
- Spain
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Centre d'Alt Rendiment
Low-Calorie Diet, Diet, High-Protein
The Effect of Diet Counseling for Low Calorie-High Protein on the Body Composition, Inflammation Marker, and Oxidative Stress Marker in Obese People With Weight Cycling
The world prevalence of obesity in adult population in 2014 was nearly 13% while in Indonesia, it has reached 32.9% in the same year. Obesity is an established risk factors for cardiovascular diseases.
- Conditions
- Low-Calorie Diet, Diet, High-Protein, Obesity; Pituitary, Weight Cycling
- Trial name
- NCT03374150
- Testing
- diet counseling
- Where
- 2 sites in Indonesia
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia