Clinical trials: Cancer Colon
Colorectal Cancer, Colorectal Cancer Metastatic
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
Colorectal cancer (CRC) has the third highest cancer incidence in the world. There is mounting evidence that the intestinal microbiota plays an important role in colorectal carcinogenesis.
- Conditions
- Colorectal Cancer, Colorectal Cancer Metastatic, Intestinal Parasite, Protozoan Infections
- Trial name
- NCT03173001
- Testing
- Parasitological examination
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Research Institute of Epidemiology, Microbiology and Infectious Diseases, Uzbekistan
Colorectal Surgery, Benign or Malignant Rectal or Colon Tumors
Laparoscopic Colorectal Surgery Using Low-pressure Combined With Warm and Humidified Carbon Dioxide Insufflation
To improve post-operative recovery, medical device was developed combining low-pressure pneumoperitoneum and heated and humidified Carbon Dioxide (95˚F \& 95% RH) during laparoscopic surgery to reduce the harmful effects of…
- Trial name
- PAROS3 (NCT05934981)
- Testing
- Laparoscopic surgery under low pressure and warm and humidified CO2 Insufflation, Laparoscopic surgery under low pressure and conventional Insufflation
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Bordeaux Colorectal Institute Academy
Colorectal Adenoma, Colorectal Cancer (CRC)
Evaluation of Gixam's Performance in a FIT Negative Population
In the United States, colorectal cancer ranks second to lung cancer as a cause of cancer death and is the third most commonly occurring cancer in both men and women.
- Conditions
- Colorectal Adenoma, Colorectal Cancer (CRC), Colorectal Cancer (CRC) Screening
- Trial name
- NCT06612281
- Testing
- colorectal cancer (CRC) screening, colorectal cancer screening, Colonoscopy after bowel cleansing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Jubaan Ltd.
Colorectal Cancer
VXM01 Phase I Study in Patients With Metastatic Colorectal Cancer With Liver Metastasis
Phase I study in patients with metastatic colorectal cancer with liver metastasis under second or third line therapy to examine safety, efficacy, and immune biomarkers after treatment with VXM01
- Trial name
- NCT02718430
- Testing
- VXM01
- Where
- Germany
- Volunteers
- 6 people
- Sponsor
- Vaximm GmbH
Oesophageal Squamous Cell Carcinoma, Gastric Cancer
A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)
The study is a phase 2 non-randomized, open-label, multi-cohort, multi-center study assessing the clinical benefit of SAR444245 (THOR-707) combined with other anticancer therapies for the treatment of participants aged 18 years…
- Conditions
- Oesophageal Squamous Cell Carcinoma, Gastric Cancer, Hepatocellular Carcinoma, Colorectal Cancer
- Trial name
- NCT05104567
- Testing
- THOR-707, Pembrolizumab, Cetuximab
- Where
- 29 sites in United States, Belgium and 7 more
- Volunteers
- 138 people
- Sponsor
- Sanofi
Colorectal Cancer
Cetuximab and Simvastatin in Treating Patients With Advanced or Metastatic Colorectal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- NCT01190462
- Testing
- cetuximab, simvastatin, laboratory biomarker analysis
- Where
- 2 sites in Netherlands
- Volunteers
- 51 people
- Sponsor
- Leiden University Medical Center
Colorectal Adenocarcinoma, Colorectal Surgery
Trends and Outcomes in Laparoscopic Versus Open Surgery for Rectal Cancer
Retrospective cohort study used to analyze trends in minimally invasive versus open surgery in colorectal surgery, over time, in outcome in the laparoscopic, robotic and open surgery groups in patients receiving colorectal…
- Trial name
- NSQIPc (NCT03683446)
- Testing
- Laparoscopic rectal surgery, Open rectal surgery
- Volunteers
- 31,795 people
- Sponsor
- Catherine H. Davis, MD
Metastatic Colon Adenocarcinoma, Metastatic Rectal Adenocarcinoma
Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation
This phase II trial tests whether adding nivolumab to the usual treatment (encorafenib and cetuximab) works better than the usual treatment alone to shrink tumors in patients with colorectal cancer that has spread to other places…
- Conditions
- Metastatic Colon Adenocarcinoma, Metastatic Rectal Adenocarcinoma, Stage III Colon Cancer AJCC v8, Stage III Rectal Cancer AJCC v8
- Trial name
- NCT05308446
- Testing
- Cetuximab, Encorafenib, Nivolumab
- Where
- 286 sites in United States, Puerto Rico
- Volunteers
- 86 people
- Sponsor
- National Cancer Institute (NCI)
Locally Advanced Rectal Cancer, Electrochemotherapy
Endoscopic Assisted Electrochemotherapy in Addition to Neoadjuvant Treatment of Locally Advanced Rectal Cancer
The purpose of this study is to evaluate the efficacy and safety of neoadjuvant electrochemotherapy on locally advanced rectal cancer (UICC II-III) in an intended curative clinical setting, using an endoscopic electroporation…
- Conditions
- Locally Advanced Rectal Cancer, Electrochemotherapy, Neoadjuvant Therapy, Down Staging
- Trial name
- nECT (NCT03040180)
- Testing
- Electrochemotherapy with bleomycin, EndoVE
- Where
- 2 sites in Denmark
- Volunteers
- 40 people
- Sponsor
- Zealand University Hospital
Colorectal Cancer
Tislelizumab in People With Colorectal Cancer
The researchers are doing this study to find out whether tislelizumab is an effective treatment for people with colorectal cancer who are living in Nigeria. The researchers will also look at the safety of the study drug.
- Trial name
- NCT06529523
- Testing
- Tislelizumab
- Where
- 3 sites in United States, Nigeria
- Volunteers
- 40 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Colorectal Adenoma
A Study on a Blood-based Dual-target Test for CRC Detection
To evaluate the effectiveness and accuracy of the ctDNA dual-target test kit in a large case-control cohort for the detection of colorectal cancer and advanced adenomas.
- Trial name
- NCT05508503
- Testing
- Test of methylated NTMT1 and MAP3K14-AS1, FIT
- Where
- China
- Volunteers
- 1,378 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Metastatic Colorectal Cancer (CRC)
Impact of Fusobacterium Nucleatum on Response to Anti-EGFR Therapy in Metastatic Colorectal Cancer
This retrospective observational cohort study investigates the association between the intratumoral burden of the bacterium Fusobacterium nucleatum (Fn) and the efficacy of anti-EGFR targeted therapies (cetuximab or panitumumab)…
- Trial name
- NCT07619859
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Barretos Cancer Hospital
Colorectal Cancer
Study SBX-01-101: A Stool Collection Study in Colorectal Cancer (CRC) Patients Treated With Irinotecan-Based Regimens
The primary objective of the study is to determine whether there is a correlation between the intestinal side effects of chemotherapy treatment and the expression/activity profiles of glucuronidase enzymes in the stool microbiome…
- Trial name
- NCT05821582
- Testing
- Stool Collection and Survey Completion
- Where
- United States
- Sponsor
- Sanguine Biosciences
Neuroendocrine Tumors, Carcinoid Tumors
Study of Pasireotide Long Acting Release (LAR) in Patients With Metastatic Neuroendocrine Tumors (NETs)
The goal of this clinical research study is to learn if the study drug, Pasireotide LAR can shrink or slow the growth of Metastatic Neuroendocrine Carcinomas. The safety of this drug will also be studied.
- Trial name
- NCT01253161
- Testing
- Pasireotide Long Acting Release (LAR)
- Where
- 2 sites in United States
- Volunteers
- 29 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Pancreas Cancer, Pancreatitis
Pancreas Registry and High Risk Registry
The purpose of this study is to establish a registry of patients with pancreatic diseases. Patients included in the registry may include those with: pancreatic cancer, precancerous lesions of the pancreas, inflammatory lesions of…
- Conditions
- Pancreas Cancer, Pancreatitis, Chronic Pancreatitis, Pancreatic Cyst
- Trial name
- NCT02775461
- Where
- 2 sites in United States
- Volunteers
- 1,368 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Aberrant Crypt Foci
The Effects of Curcuminoids on Aberrant Crypt Foci in the Human Colon
The purpose of this study is to determine the effectiveness of curcumin in reducing the number of aberrant crypt foci (ACF) in the colon.
- Trial name
- NCT00176618
- Testing
- sulindac, curcumin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Colorectal Cancer, Carcinoma
Evaluating ABX-EGF in Patients With Metastatic ColorectalCarcinoma
The purpose of this study is to determine if ABX-EGF is safe and efficacious in patients with metastatic colorectal cancer.
- Trial name
- NCT00111774
- Testing
- ABX-EGF
- Volunteers
- 150 people
- Sponsor
- Amgen
BRAF V600 Colorectal Cancer
A Study of Select Drug Combinations in Adult Patients With Advanced/Metastatic BRAF V600 Colorectal Cancer
A phase Ib, open-label platform study of select drug combinations chosen in order to characterize safety and tolerability of each treatment arm tested and to identify recommended doses and regimens for future studies.
- Trial name
- NCT04294160
- Testing
- Dabrafenib, LTT462, Trametinib
- Where
- 18 sites in United States, Australia and 8 more
- Volunteers
- 122 people
- Sponsor
- Novartis Pharmaceuticals
Metastatic Colorectal Cancer
Study Comparing Different Dose Approaches of Induction Treatment of Regorafenib in MCRC
The purpose of this study is to assess the safety and tolerability of different dose-escalation approaches of regorafenib in mCRC patients.
- Trial name
- RE-ARRANGE (NCT02835924)
- Testing
- Regorafenib
- Where
- Spain
- Volunteers
- 299 people
- Sponsor
- Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Acute Abdomen, Ileus
Rectus Sheath Catheters Following Midline Laparotomy
Rectus sheath catheters (RSC) are used for postoperative analgesia following midline laparotomies. Local anesthetics are applied to the posterior rectus sheath via the RSC.
- Conditions
- Acute Abdomen, Ileus, Colorectal Carcinoma
- Trial name
- NCT07099924
- Testing
- Ropivacaine 0.2%, Saline 0.9%
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Asklepios Kliniken Hamburg GmbH
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