Clinical trials: Cancer Esophagus
Esophagus Cancer, Chemoradiation
Definitive (Chemo)Radiotherapy for Patients With Esophageal Cancer - 3JECROG R-01
The aim of this observational study is to retrospectively collect survival data for 3000 primary esophageal cancer patients from multicenter between January 2000 to present.
- Conditions
- Esophagus Cancer, Chemoradiation, Chemotherapy Effect, Radiotherapy Side Effect
- Trial name
- NCT03298204
- Where
- China
- Volunteers
- 2,762 people
- Sponsor
- Chinese Academy of Medical Sciences
Esophageal Cancer, Oesophageal Cancer
Morbidity and Mortality After Esophageal and Esophagogastric Junction Cancer Surgery
Esophageal and esophagogastric junction cancer is still one of the main health care issue and esophagectomy with lymph node dissection is the only chance to be cure.
- Conditions
- Esophageal Cancer, Oesophageal Cancer, Siewert Type I Adenocarcinoma of Esophagogastric Junction, Siewert Type III Adenocarcinoma of Esophagogastric Junction
- Trial name
- ESOSTAT (NCT06277921)
- Testing
- Elective Surgery for gastric cancer
- Where
- 18 sites in Belarus, Russia
- Volunteers
- 230 people
- Sponsor
- P. Herzen Moscow Oncology Research Institute
Head and Neck Cancer, Esophageal Cancer
Plasma Circulating Deoxyribonucelic Acid (DNA) as a Response Marker
This study investigates whether the amount of circulating plasma DNA can be used as a response marker for anti-cancer treatment in treating gross tumors.
- Trial name
- NCT00318604
- Sponsor
- Far Eastern Memorial Hospital
Esophageal Cancer
Multimodal Al for Precision Diagnosis of Esophageal Cancer
This study intends to construct two multimodal deep learning models: one for the diagnosis of esophageal cancer and the prediction of invasive depth to assess suitability for endoscopic resection; the other model, based on this…
- Trial name
- NCT07629921
- Testing
- NAT, ESD, surgery
- Where
- China
- Volunteers
- 264 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Cancer, Surgery
Conventional Oral Intake vs Delayed Oral Intake With Jejunostomy Feeding After Esophagectomy (JNS Study)
Comparison of nutritional and early surgical outcome between early and delayed oral feeding after esophagectomy for esophageal cancer
- Conditions
- Esophageal Cancer, Surgery, Jejunostomy; Complications, Nutrition Related Cancer
- Trial name
- JNS (NCT05318404)
- Testing
- Jejunostomy feeding
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Seoul National University Hospital
Esophageal Cancer, Chemoradiotherapy
Consolidation of Toripalimab and Capecitabine After Chemoradiotherapy in ESCC
Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced unresectable esophageal cancer, but its efficacy remains unsatisfactory.
- Trial name
- EC-CRT-008 (NCT07177794)
- Testing
- toripalimab, capecitabine
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Sun Yat-sen University
Tumor
Radiation Therapy and Cardiac Enzymes
The goal of this clinical research study is to learn if the radiation that you are receiving will result in an increase in certain proteins produced by the heart called cardiac biomarkers.
- Trial name
- NCT00777751
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Tumor of Esophagus, Stomach and Duodenum
The Effect of Chemotherapy and Surgery for Cancer on Exercise Capacity
Neoadjuvant chemotherapy (NAC) prior to surgery for upper gastrointestinal (oesophageal and gastric) cancer is associated with improved survival.
- Trial name
- NCT01325883
- Where
- United Kingdom
- Volunteers
- 253 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Esophageal Cancer, Radiation Therapy
Toripalimab Plus Radiotherapy for Elderly Esophageal Cancer Patients Treated With Non-chemotherapy Strategy
The goal of this clinical trial is to explore the therapeutic efficacy of immune checkpoint inhibitors combined with radical radiotherapy in elderly patients with esophageal cancer.
- Conditions
- Esophageal Cancer, Radiation Therapy, Immunotherapy, Chemotherapy
- Trial name
- NCT05817201
- Testing
- Toripalimab, Tegafur, IMRT
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Taizhou Hospital
Immunotherapy;Envafolimab; Esophageal Cancer
Envafolimab Combined With Abraxane and Cisplatinas as Neoadjuvant Treatment for Resectable Esophageal Cancer
Big breakthroughs have been made in the combination therapy of immune checkpoint inhibitors when it comes to the neoadjuvant therapy of esophageal cancer.
- Trial name
- NCT05828381
- Testing
- Envafolimab, Abraxane, Cisplatin
- Volunteers
- 33 people
- Sponsor
- Fujian Medical University Union Hospital
Esophageal Cancer
The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer
To determine whether sorafenib is able to change pre-cancerous cells in a way that we believe is important in the progression of cancer.
- Trial name
- Barrett's (NCT00619242)
- Testing
- sorafenib
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Chicago
Esophageal Neoplasms, Head and Neck Neoplasms
Evaluate the Efficacy of Adding Intraluminal Brachytherapy After CCRT for Local-regional Thoracic Esophageal Cancer.
The purpose of this study is to observe the safety and effectiveness of the add-on of intraluminal brachytherapy with BRAXX esophageal brachytherapy applicator after definitive CCRT in patients with thoracic esophageal cancer.
- Conditions
- Esophageal Neoplasms, Head and Neck Neoplasms, Gastrointestinal Neoplasms, Digestive System Diseases
- Trial name
- NCT06365866
- Testing
- "BRAXX" Esophageal Brachytherapy Applicator., Add-on of intraluminal brachytherapy
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Esophageal Cancer
Camrelizumab Combined With CRT for Treatment of Patients With Local Recurrence of Esophageal Cancer
China is a country with a large incidence of esophageal cancer. The prevalence and mortality rate of esophageal cancer in China ranks fifth in the world.
- Trial name
- NCT04390945
- Testing
- Camrelizumab
- Where
- China
- Volunteers
- 62 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Cervical Cancer, Gastric Cancer
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of INCAGN02390 in participants with select advanced malignancies.
- Conditions
- Cervical Cancer, Gastric Cancer, Stomach Cancer, Gastroesophageal Junction Cancer
- Trial name
- NCT03652077
- Testing
- INCAGN02390
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Incyte Corporation
Astrocytoma, Brain Cancer
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QBS10072S
This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers…
- Conditions
- Astrocytoma, Brain Cancer, Brain Metastases, Bladder Cancer
- Trial name
- NCT04430842
- Testing
- QBS10072S
- Where
- 2 sites in Australia
- Volunteers
- 15 people
- Sponsor
- Quadriga Biosciences, Inc.
Esophageal Carcinoma, Limited-Stage Small Cell Esophageal Carcinoma
The Impact of Surgical Treatment on Survival in Localized Small Cell Esophageal Cancer
Limited-stage small cell esophageal carcinoma (LS-SCEC) is a rare and highly aggressive malignancy with poor prognosis and no established standard treatment strategy.
- Trial name
- NCT07596654
- Where
- China
- Volunteers
- 4 people
- Sponsor
- yi shen
Superficial Esophageal Cancers
Status of Superficial Esophageal Cancers Treated by Endoscopy "OESOFARE"
In 2013, esophageal cancer was the 9th cause of cancer in the world and the 6th in terms of cancer mortality. The prognosis of this cancer varies according to geographical areas, but in Europe and the USA, the 5-year survival…
- Trial name
- OESOFARE (NCT03674801)
- Where
- France
- Volunteers
- 151 people
- Sponsor
- Nantes University Hospital
Barrett's Esophagus With High Grade Dsyplasia, Early Esophageal Cancer
Probe-based Volumetric Laser Endomicroscopy (pVLE) of Endoscopic Mucosal Resection (EMR) Tissue in Patients With Barrett's Dysplasia
This study is to assess the diagnostic accuracy and precision of the Probe-based Volumetric Laser Endomicroscopy (pVLE) imaging system in detecting dysplasia in BE in both in vivo and ex vivo imaging of Endoscopic Mucosal…
- Trial name
- VLE EMR (NCT02366039)
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Mayo Clinic
Stage IV Esophagus Squamous Cell Carcinoma
Phase II Clinical Study of Camrelizumab Combined With Chemotherapy or Anlotinib in Advanced Esophageal Squamous Cell Cancer
To observe and evaluate the efficacy and safety of camrelizumab combined with chemotherapy or anlotinib in patients with advanced esophageal squamous cell carcinoma previously Treated With First-line Immunotherapy
- Trial name
- NCT05322499
- Testing
- Camrelizumab, Irinotecan, Paclitaxel
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Zhejiang Cancer Hospital
Gastroesophageal-junction Cancer, Esophageal Cancer
Registry for Esophageal and Gastroesophageal Junction Cancer
The purpose of this registry study is to create a database-a collection of information-for better understanding standard treatments for esophageal and Gastroesophageal Junction Cancer/GEJ cancer.
- Trial name
- NCT06558786
- Testing
- EORTC QLQ-C30 questionnaire, QLQ-OGS25 questionnaire
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
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