Clinical trials: Cancer Esophagus
Esophageal Cancer, Amino Acid Transport Disorder
Research on the Role of SLC1A5 in the Development of Esophageal Cancer
To explore the significance of Solute Carrier Family 1 Member 5 (SLC1A5) in the occurrence of esophageal cancer, by comparing the expression of SLC1A5 between esophageal cancer tissues and adjacent tissues.
- Trial name
- NCT02633436
- Testing
- SLC1A5 expression
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Esophageal Cancer
Laparoscopic Ischemic Conditioning Prior to Esophagectomy
This is a two center phase II prospective single-arm safety and feasibility trial for 20 patients with resectable esophageal carcinoma with an increased risk for anastomotic leakage, as based upon UCS and NASCET calcification…
- Trial name
- ISCON (NCT03896399)
- Testing
- Laparoscopic ischemic conditioning followed by esophagectomy
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 22 people
- Sponsor
- UMC Utrecht
Oesophageal Carcinoma
A Study of APR-246 in Oesophageal Cancer
The purpose of this study is to determine whether APR-246, 5-FU and cisplatin are safe and effective in the treatment of platinum resistant oesophageal cancer.
- Trial name
- APROC (NCT02999893)
- Testing
- APR-246
- Where
- 5 sites in Australia
- Volunteers
- 5 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Esophageal Squamous Cell Carcinoma
Substudy 06E: Umbrella Study of Combination Therapies in Esophageal Cancer (MK-3475-06E/KEYMAKER-U06)
Researchers are looking for new ways to treat esophageal squamous cell carcinoma (ESCC). ESCC is a type of cancer that starts in certain cells that line the esophagus.
- Trial name
- NCT06780111
- Testing
- Pembrolizumab, I-DXd, Leucovorin
- Where
- 52 sites in United States, Brazil and 14 more
- Volunteers
- 298 people
- Sponsor
- Merck Sharp & Dohme LLC
Lung Neoplasms, Esophagitis
Study of Epigallocatechin-3-gallate (EGCG) for Esophagus Protection in Patients With Lung Cancer Receiving Radial Radiotherapy
The investigators conducted this phase II study of EGCG therapy protection of the esophagus from damage induced by radiotherapy.
- Conditions
- Lung Neoplasms, Esophagitis, Prevention & Control, Epigallocatechin Gallate
- Trial name
- NCT02577393
- Testing
- EGCG, mLDG
- Volunteers
- 83 people
- Sponsor
- Shandong Cancer Hospital and Institute
Esophageal Adenocarcinoma
RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).
BACKGROUND: For patients with esophageal cancer, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent.
- Trial name
- ROBOT-2 (NCT04306458)
- Testing
- Minimally invasive esophagectomy, daVinci Xi system
- Where
- Germany
- Volunteers
- 218 people
- Sponsor
- University Medical Center Mainz
Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck
A Study of Sigvotatug Vedotin in Advanced Solid Tumors
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors.
- Conditions
- Carcinoma, Non-Small Cell Lung, Squamous Cell Carcinoma of Head and Neck, HER2 Negative Breast Neoplasms, Esophageal Squamous Cell Carcinoma
- Trial name
- NCT04389632
- Testing
- sigvotatug vedotin, pembrolizumab, cisplatin
- Where
- 158 sites in United States, France and 5 more
- Volunteers
- 1,006 people
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
Esophageal Cancer, Gastric Cancer
S0101 Gemcitabine and Irinotecan in Treating Patients With Metastatic or Recurrent Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00012363
- Testing
- gemcitabine hydrochloride, irinotecan hydrochloride
- Where
- 96 sites in United States
- Volunteers
- 61 people
- Sponsor
- SWOG Cancer Research Network
Esophageal Cancer
Outside the Cage (OTC) Robotic Esophagectomy
The goal of this clinical trial is to evaluate the feasibility and safety of a novel non-intercostal robotic approach for minimally invasive esophagectomy (OTC MIE) in the treatment of esophageal cancer.
- Trial name
- NCT06735638
- Testing
- OTC MIE Esophagectomy
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Esophagus Cancer, Esophagogastric Junction Cancer
Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer
Definitive chemoradiotherapy is the standard of care in unresectable esophageal or esophagogastric cancer. A multidisciplinary approach, including chemotherapy and radiotherapy, is important for these patients.
- Conditions
- Esophagus Cancer, Esophagogastric Junction Cancer, Chemoradiation, Targeted Therapy
- Trial name
- NCT04821778
- Testing
- Radiotherapy, Platinum based chemotherapy, Paclitaxel based chemotherapy
- Where
- 5 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Esophagus Cancer, Esophageal Cancer
Radiation Dose Intensification With Accelerated Hypofractionated Intensity Modulated Radiation Therapy and Concurrent Carboplatin and Paclitaxel for Inoperable Esophageal Cancer
Rates of local disease control in patients with locally advanced esophageal cancer who are not candidates for surgical resection are suboptimal.
- Conditions
- Esophagus Cancer, Esophageal Cancer, Cancer of the Esophagus
- Trial name
- NCT04046575
- Testing
- Intensity Modulated Radiation Therapy, Carboplatin, MD Anderson Symptom Inventory (MDASI)-Plus module
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Washington University School of Medicine
Barrett Esophagus
OCT Pilot in Esophagus
This is a pilot study to test a newly developed optical coherence tomography (OCT) device to determine 1) whether adequate tissue contact can be attained to acquire high quality images, and 2) to identify if these images can…
- Trial name
- NCT03434834
- Testing
- optical coherence tomography
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Duke University
Pancreatic Cancer, Esophageal Cancer
HOPE - A Study to Evaluate the Effect of a Prehabilitation Program on GI Cancer Patients Planning to Undergo Surgery
A one-group prospective cohort study design with measures collected pre- and post-intervention. The primary goal of this study is to evaluate the effect of a multimodal prehabilitation preoperative program on changes in frailty…
- Conditions
- Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- HOPE (NCT03642093)
- Testing
- Nutritional Intervention, Physical Activity Intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Siobhan Trotter
Barrett Syndrome, Barrett's Syndrome
Detection Of Neoplastic Tissue in Barrett's Esophagus With In vivO Probe-based Confocal Endomicroscopy
This study will collect data from patients routinely undergoing a endoscopic surveillance and Cellvizio endomicroscopy procedure due to confirmed Barrett's esophagus.
- Conditions
- Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus
- Trial name
- DONTBIOPCE (NCT00795184)
- Testing
- Imaging procedures (NBI), HDWLE, pCLE
- Where
- 5 sites in United States, France and 1 more
- Volunteers
- 122 people
- Sponsor
- Mauna Kea Technologies
Esophageal Squamous Cell Carcinoma
A Perioperative Sintilimab and Chemotherapy in Esophageal Squamous Cell Carcinoma
This study is aimed to evaluate the efficacy and safety of sintilimab combined with chemotherapy versus chemotherapy in perioperative treatment of locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT06152978
- Testing
- Sintilimab, Chemotherapy
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fudan University
Barrett Esophagus
Healing of the Esophageal Mucosa After RFA of Barrett's Esophagus
Radiofrequency ablation (RFA) is a mainstay of treatment for patients who have Barrett's esophagus (BE) with dysplasia. For unclear reasons, Barrett's esophagus recurs after successful RFA treatment in approximately 1/3 of…
- Trial name
- NCT02688114
- Testing
- Baseline surveillance endoscopy, Radiofrequency ablation, Follow up endoscopy 1
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Dallas VA Medical Center
Barrett's Esophagus
Detection of Barrett s Esophagus in Patients Without GERD Symptoms
The purpose of this study is to develop a method to detect Barrett's esophagus (BE) in individuals with a new office-based diagnostic test.
- Trial name
- NCT04880044
- Testing
- EsoCheck/EsoGuard (EC/EG), Esophago-gastro-duodenoscopy (EGD)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer, Reflux, Gastroesophageal
Evaluating Acid Reflux After Oesophageal Stenting Using Anti-reflux Stents
Incurable oesophageal cancer remains a global problem and in South Africa the vast majority of patients with oesophageal cancer have advanced disease at first presentation and are not curable.
- Trial name
- NCT05303298
- Testing
- Anti-reflux oesophageal stent, Conventional oesophageal stent
- Where
- South Africa
- Volunteers
- 72 people
- Sponsor
- University of Cape Town
Squamous Cell Carcinoma of Esophagus
Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell Carcinoma of Esophagus
Albumin-bound paclitaxel regimen in advanced NSCLC has a better tumor response rate and safety than solvent-based paclitaxel. However, the safety and efficacy is uncertain in neoadjuvant therapy in esophageal cancer.
- Trial name
- NCT02033538
- Testing
- nanoparticle albumin-bound paclitaxel
- Where
- China
- Sponsor
- Zhejiang University
Esophageal Squamous Cell Carcinoma, Chemoradiotherapy
To Compare the Effect of Different Nutritional Pathways on Improving Nutritional Status of Esophageal Cancer Patients Undergoing Chemoradiotherapy
This study prospectively recruited esophageal squamous-cell carcinoma patients who received nasogastric tube (NG), gastrostomy feeding and oral intake to compare the changes in nutritional status and quality of life during…
- Conditions
- Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Enteral Nutrition
- Trial name
- NCT04199832
- Testing
- Dietary guidance
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
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