Clinical trials: Cancer Gi
Cancer Abdomen, Elderly (People Aged 65 or More)
Functional Decline and Quality of Life After Gastrointestinal Cancer Surgery in Older Adults
This prospective cohort study will evaluate functional decline, health-related quality of life, and long-term oncological outcomes in adults aged 65 years and older undergoing curative-intent resective surgery for…
- Conditions
- Cancer Abdomen, Elderly (People Aged 65 or More), Quality of Life, Sarcopenia in Elderly
- Trial name
- NCT07412379
- Where
- Colombia
- Volunteers
- 590 people
- Sponsor
- Hospital Universitario Mayor Méderi
Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Tumors (GIST) Registry
The goal of this observational research study is to establish a registry of information regarding how different physicians treat and manage patients with gastrointestinal stromal tumors (GISTs). Objectives: 1.
- Trial name
- NCT00507273
- Testing
- GIST Registry
- Where
- United States
- Volunteers
- 1,800 people
- Sponsor
- M.D. Anderson Cancer Center
Digestive Cancer
A Trial Assessing Several Schedules of Oral S-1 in Combination With a Fixed Dose of Oxaliplatin and Irinotecan
This study is to determine the Maximal Tolerated Dose (MTD), the Dose Limitant Toxicities (DLTs) and the safety profile of S-1 combined with fixed doses of Irinotecan (SIRI schedule) and fixed doses of Irinotecan and Oxaliplatin…
- Trial name
- SIRINOX (NCT02387138)
- Testing
- S-1, Irinotecan, Oxaliplatin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Decision Making, Quality of Health Care
Evaluation of the Decision-making During Multidisciplinary Meetings for Digestive Cancers
Nowadays, the recommended approach for decision-making for oncology patients is based on multidisciplinary meetings (MDT). However, the quality of decision-making during MDT depends on other factors such as the quality of…
- Conditions
- Decision Making, Quality of Health Care, Neoplasms/Therapy, Patient Care Team
- Trial name
- NCT04000802
- Testing
- response to questionnary
- Where
- Morocco
- Volunteers
- 200 people
- Sponsor
- Moroccan Society of Surgery
Advanced Biliary Tract Cancer
NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary Cancer
This is a study to evaluate the clinical activity of the combination of fluorouracil, leucovorin, and nanoliposomal irinotecan as second-line treatment in patients with advanced biliary tract cancers following gemcitabine and…
- Trial name
- NCT04005339
- Testing
- Nanoliposomal Irinotecan, Leucovorin, Fluorouracil
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Georgetown University
Colorectal Cancer, Pancreatic Cancer
Feasibility of the LUM Imaging System for Detection of Gastrointestinal Cancers
The overall goal of this feasibility study is to assess the initial safety and efficacy of LUM015 in ex vivo far-red imaging of colorectal, pancreatic, and esophageal cancers (adenocarcinoma) using the LUM Imaging System.
- Conditions
- Colorectal Cancer, Pancreatic Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT02584244
- Testing
- LUM015, LUM 2.6 Imaging Device
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Lumicell, Inc.
Malignant Neoplasm of Breast, CNS Malignancy
Phase I Study of MLN8237 and Pazopanib in Patients With Solid Tumors
This phase I trial using the EffTox design will evaluate activity and safety of alisertib, an Aurora A kinase inhibitor, when given in combination with the selective VEGFR inhibitor pazopanib in patients with advanced, previously…
- Conditions
- Malignant Neoplasm of Breast, CNS Malignancy, Malignant Neoplasm of Gastrointestinal Tract, Genitourinary Neoplasms Malignancy and Gender Unspecified
- Trial name
- NCT01639911
- Testing
- Alisertib, Pazopanib
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Illinois at Chicago
Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms
A Real-World Study of Fecal Transplants for Cancer Therapy Side Effects
The goal of this clinical trial is to learn if fecal microbiota transplantation can treat in Gastrointestinal cancer patients with chemotherapy / targeted gastrointestinal symptoms.
- Conditions
- Fecal Microbiota Transplantation (FMT), Gastrointestinal Neoplasms, Antineoplastic Agents, Drug-related Side Effects and Adverse Reactions
- Trial name
- NCT07319364
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pancreatic Cancer, Gastrointestinal Neoplasms
Permission to Collect Blood Over Time for Research
To determine whether biomarkers assessed in blood samples can be used to detect individuals at risk for developing blood clots or worsening of their underlying disease.
- Conditions
- Pancreatic Cancer, Gastrointestinal Neoplasms, Colon Rectal Cancer Adenocarcinoma, Esophageal Cancer
- Trial name
- NCT00767234
- Testing
- Observation
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Stanford University
Gastrointestinal Cancer
Use of DRS Probe and Tracking for In-vivo Application
A spectroscopic probe is a sensor designed to illuminate and gather light directly from the tissue while touching it. The probe contains optical fibres, some which illuminate the surface of the tissue with harmless visible…
- Trial name
- NCT05830292
- Testing
- Diffuse reflectance spectroscopy (DRS) probe
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Childhood Soft Tissue Sarcoma, Childhood Liver Cancer
Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I trial to study the effectiveness of liposomal doxorubicin in treating children who have…
- Conditions
- Childhood Soft Tissue Sarcoma, Childhood Liver Cancer, Bone Cancer, Brain Tumor
- Trial name
- NCT00019630
- Testing
- doxorubicin HCl liposome
- Where
- 2 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Gastrointestinal Cancer
'Penny', a SMS Text-based Chatbot Intervention for Medication Adherence and Side Effect Management Among Patients With GI Cancers
There has been a dramatic paradigm shift over the last 25 years within cancer care due to the onset of many new targeted therapies and a transition from inpatient to outpatient care.
- Trial name
- NCT05113264
- Testing
- 'Penny' via Memora Platform
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Advanced Heart Failure, Advanced Non-Colorectal Gastrointestinal Cancer
Tier Palliative Care For Patients With Advanced Heart Failure or Cancer
TIER-PC is an adaptive model of delivering palliative care that provides the right level of care to the right patients at the right time.
- Conditions
- Advanced Heart Failure, Advanced Non-Colorectal Gastrointestinal Cancer, Advanced Lung Cancer, Advanced Triple Negative Breast Cancer
- Trial name
- TIER-PC (NCT07391956)
- Testing
- Tier-Palliative Care, Community Health Worker
- Where
- 5 sites in United States
- Volunteers
- 400 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Malignant Neoplasms of Independent (Primary) Multiple Sites
The Effect of Yogurt in Cancer Patient With Moderate Gastrointestinal (GI) Symptoms
The goal of this clinical research study is to learn if probiotics found in yogurt can help to decrease gastrointestinal (GI) symptoms in cancer patients.
- Trial name
- NCT03177681
- Testing
- Tongue Assessment, Stool Sample, Questionnaires
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Gastric Cancer, Oesophageal Cancer
Anorexia iN Cancer Patients: ANCHOR
The rationale for this study is to prospectively investigate the outcomes of patients undergoing standard dietetic interventions alongside treatment for their advanced gastrointestinal cancers, and to further characterise the…
- Trial name
- ANCHOR (NCT04791254)
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- The Christie NHS Foundation Trust
Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7
Ropidoxuridine in Treating Patients With Advanced Gastrointestinal Cancer Undergoing Radiation Therapy
This phase I trial studies the side effects and best dose of ropidoxuridine in treating patients with gastrointestinal cancer that has spread to other places in the body and usually cannot be cured or controlled with treatment…
- Conditions
- Advanced Bile Duct Carcinoma, Stage II Esophageal Cancer AJCC v7, Stage II Pancreatic Cancer AJCC v6 and v7, Stage IIA Esophageal Cancer AJCC v7
- Trial name
- NCT02381561
- Testing
- Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis, Pharmacological Study
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Pancreas Cancer, Biliary Tract Cancer
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
The primary objective of this study is to evaluate the ability to recruit and retain participants, and to successfully conduct a psilocybin-based protocol, for a study of the treatment of distress related to stage IV or…
- Conditions
- Pancreas Cancer, Biliary Tract Cancer, Psychological Distress, Gastrointestinal Cancer
- Trial name
- NCT05220046
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Nebraska
Malignant Melanoma
GI Complications in Cancer Immunotherapy Patients
The purpose of this study is to establish a prospective observational cohort of cancer immunotherapy patients with GI side effects in order to identify biomarkers that predict GI complications due to treatment.
- Trial name
- NCT02784366
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Colorectal Neoplasms
Study With AG-013736 Combined With Chemotherapy And Bevacizumab In Patients With Metastatic Colorectal Cancer
To determine the safety and efficacy of AG-013736 in combination with other standard of care medication in patients with first line metastatic colorectal cancer.
- Trial name
- NCT00460603
- Testing
- bevacizumab, AG-013726, AG-013736 (axitinib)
- Where
- 106 sites in United States
- Volunteers
- 187 people
- Sponsor
- Pfizer
Solid Tumors
Study of INCB123667 in Subjects With Advanced Solid Tumors
This is an open-label, dose-escalation and dose-expansion study to determine the safety, tolerability, PK, pharmacodynamics, and preliminary efficacy of INCB123667 when administered as monotherapy and in combination with…
- Trial name
- NCT05238922
- Testing
- INCB0123667, Palbociclib, Bevacizumab
- Where
- 41 sites in United States, France and 6 more
- Volunteers
- 291 people
- Sponsor
- Incyte Corporation