Clinical trials: Cancer Neck
Human Papillomavirus
Alinity m HR HPV Specimen Collection Study From Women Undergoing Routine Cervical Cancer Screening
A prospective multicenter interventional study will be conducted to enroll women undergoing routine cervical cancer screening to collect cervical liquid-based cytology (LBC) specimen(s).
- Trial name
- NCT04746872
- Testing
- Alinity m HR HPV
- Where
- 63 sites in United States
- Volunteers
- 14,935 people
- Sponsor
- Abbott Molecular
Head and Neck Neoplasm, Gastrostomy
Endoscopic Direct-PEG Placement in Patients Unable to Undergo Pull-PEG Procedure
Placement of a feeding tube through a gastrostomy can be performed endoscopically or radiologically. While percutaneous endoscopic gastrostomy (PEG) tube placement is most frequently performed using a "pull" technique, this…
- Conditions
- Head and Neck Neoplasm, Gastrostomy, Esophageal Stenosis and Obstruction
- Trial name
- PEG (NCT04151030)
- Testing
- PEG placement
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Kansas City Veteran Affairs Medical Center
Cervical Cancer, Cervical Intraepithelial Neoplasias
Diagnostic Imaging Aid for Management of Cervical Lesions
A handheld digital colposcope which utilizes flurorescent light is being tested for the rapid detection and management of cervical lesions.
- Conditions
- Cervical Cancer, Cervical Intraepithelial Neoplasias, Digital Colposcopy, Precancerous Cervical Lesions
- Trial name
- FFC (NCT02406365)
- Testing
- Diagnostic imaging aid for one-visit management of cervical lesions
- Where
- United States
- Volunteers
- 618 people
- Sponsor
- Brookdale University Hospital Medical Center
Esophageal Cancer, Esophageal Neoplasms
Rehabilitation and Recovery for Persons With Esophageal or Gastric Cancer
This study aims to develop and evaluate a model for systematic and evidence-based cancer rehabilitation for people with esophageal and gastric cancer to provide conditions for a better quality of life and fewer cancer-related…
- Conditions
- Esophageal Cancer, Esophageal Neoplasms, Gastric Cancer, Stomach Neoplasm
- Trial name
- NCT05698992
- Testing
- evidence-based individualized rehabilitation
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Region Skane
Cancer, Neoplasms
A Study to Evaluate the Safety and Pharmacokinetics of OC-001 in Patients With Locally Advanced or Metastatic Cancers
This study will investigate OC-001 as monotherapy, and in combination with, Avelumab, in various cancer types
- Conditions
- Cancer, Neoplasms, Metastatic Cancer, Triple Negative Breast Cancer
- Trial name
- NCT04260802
- Testing
- OC-001, Drug: OC-001 in Combination with Avelumab
- Where
- 5 sites in Canada
- Volunteers
- 73 people
- Sponsor
- Ocellaris Pharma, Inc.
Esophageal Cancer, Gastric (Stomach) Cancer
Timing of Comprehensive Local Treatment After First-Line Systemic Therapy in Oligometastatic Esophageal or Gastric Adenocarcinoma
Purpose of the Study: This clinical study investigates whether a shorter or longer duration of systemic therapy before local treatment (surgery or radiation) results in better disease control in patients with esophageal or…
- Conditions
- Esophageal Cancer, Gastric (Stomach) Cancer, Gastric Adenocarcinoma, Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
- Trial name
- OMEC-5 (NCT07000253)
- Testing
- Chemotherapy, Targeted Systemic Therapy, Immunotherapy
- Where
- 5 sites in Netherlands, Norway and 1 more
- Volunteers
- 290 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Head and Neck Cancer
PD-L1 ImagiNg to prediCt Durvalumab Treatment Response in HNSCC
Non-invasive imaging of tumor PD-L1 expression with 89Zr-labeled durvalumab PET/CT predicts response to durvalumab.
- Trial name
- PINCH (NCT03829007)
- Testing
- PD-L1 imaging, Durvalumab
- Where
- 4 sites in Netherlands
- Volunteers
- 33 people
- Sponsor
- Radboud University Medical Center
Metastatic Solid Tumor, Advanced Solid Tumor
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
The main purpose of this study is to evaluate the safety and preliminary efficacy of CHS-114 in combination with toripalimab and/or other standard of care (SOC) compound(s) in participants with advanced or metastatic solid tumors.
- Trial name
- NCT06657144
- Testing
- CHS-114, Toripalimab, 5 Fluorouracil
- Where
- 30 sites in United States, Taiwan
- Volunteers
- 154 people
- Sponsor
- Coherus Oncology, Inc.
Cervical Cancer
System to Evaluate the Risk of Lymph Node Metastasis Preoperatively in Cervical Cancer
The lymph node status is difficult to be assessed preoperatively, this study aimed to develop a scoring system for predicting the risk of LNM in cervical cancer patients before operation.
- Trial name
- NCT06032481
- Testing
- surgery
- Volunteers
- 426 people
- Sponsor
- Fujian Maternity and Child Health Hospital
Thyroid Cancer, Non-Cancer Thyroid Disease
Scientific Protocol for the Study of Thyroid Cancer and Other Thyroid Disease in Ukraine Following the Chernobyl Accident
The nuclear power plant accident at Chornobyl released large quantities of Iodine-131 and other radioisotopes of iodine in the atmosphere, contaminating thousands of square kilometers and exposing millions of people.
- Conditions
- Thyroid Cancer, Non-Cancer Thyroid Disease, Non Thyroid Cancer
- Trial name
- NCT00341094
- Where
- Ukraine
- Volunteers
- 23,143 people
- Sponsor
- National Cancer Institute (NCI)
Parathyroid Neoplasms
Using X-Ray Dye to Locate Hidden Parathyroid Tumors
Occasionally tumors of the parathyroid gland cannot be detected by standard x-ray diagnostic procedures (CT scans, MRIs, and ultrasounds). In order for the tumor to be removed surgically it must first be localized.
- Trial name
- NCT00001394
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cervical Cancer
Retrospective Study of the Relationship Between Human Papillomavirus Genotype and Cervical Epithelial Lesions
Human papillomavirus (HPV) infection plays a key role in the carcinogenesis of cervical cancer and pre-invasive lesions. There are hundred types of HPV, including high risk and low risk types, and it is proved the close…
- Trial name
- NCT00872937
- Where
- Taiwan
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Smoking, Head and Neck Neoplasms
Efficacy of Smoking Cessation Intervention for Head and Neck Cancer Patients
The purpose of this study is to determine whether a brief smoking ENT-resident-based intervention increased smoking cessation in patients with Head and Neck cancer attending a Lebanese university hospital, as compared with usual…
- Trial name
- NCT03786172
- Testing
- Smoking cessation Intervention, Usual care
- Where
- 2 sites in Lebanon
- Volunteers
- 100 people
- Sponsor
- Saint-Joseph University
Esophageal Cancer
Pemetrexed, Cisplatin, and Radiation Therapy in Treating Patients With Esophageal or Gastroesophageal Junction Cancer
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- NCT00701857
- Testing
- cisplatin, Pemetrexed, radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Arizona
Parathyroid Carcinoma, Hypercalcemia
An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism
This is an intra-individual titration study of KRN1493 to evaluate the safety and efficacy of KRN1493 for the treatment of hypercalcemia in patients with parathyroid carcinoma or intractable primary hyperparathyroidism (PHPT).
- Conditions
- Parathyroid Carcinoma, Hypercalcemia, Primary Hyperparathyroidism
- Trial name
- NCT01460030
- Testing
- Cinacalcet HCl
- Where
- Japan
- Sponsor
- Kyowa Kirin Co., Ltd.
Cervical Cancer, Cancer of the Cervix
Ultrasound and Photoacoustic Imaging for Cervical Cancer
The investigators have developed co-registered transvaginal photoacoustic and ultrasound (US) imaging techniques that allow them to visualize ovarian tumor structure and functional changes simultaneously, which may potentially…
- Trial name
- NCT03318107
- Testing
- Transvaginal probe using photoacoustic and ultrasound imaging
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Cancer
Study of Pemetrexed and Bevacizumab in Patients With Head and Neck Cancer
The purpose of this study is to determine if the combination of two new drugs pemetrexed (Alimta) and bevacizumab (Avastin) can increase the effectiveness of treatment for head and neck cancer.
- Trial name
- NCT00222729
- Testing
- Pemetrexed, Bevacizumab
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Pittsburgh
Oral Cancer
Epstein-Barr Detection in Oral Cancer
The aim of this study is to analyze oral squamous cell carcinoma and healthy oral mucosa for the possible presence of Epstein-Barr virus (EBV).
- Trial name
- NCT01039272
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Cervical Cancer
Tirapazamine, Cisplatin, and Radiation Therapy in Treating Patients With Stage IB, Stage II, Stage III, or Stage IVA Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as tirapazamine and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00098995
- Testing
- cisplatin, tirapazamine, brachytherapy
- Where
- 2 sites in Australia, Canada
- Volunteers
- 22 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Oral Cancer , Oral Squamous Cell Carcinoma, Oral Cavity Cancer
Immunohistochemical Expression of EGFR in the Patients Having Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) is one of the top 10 most common malignancies worldwide. Oral squamous cell carcinoma forms a major health problem in many countries.
- Trial name
- EGFR (NCT06606301)
- Testing
- BioSB EGFR antibody
- Where
- Pakistan
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Combined Military Hospital, Pakistan
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