Clinical trials: Cancer Neck
Esophageal Cancer
Inter-observer Variation in Gross Tumor Delineation of Esophageal Cancer on MR, CT and PET CT
The aim of the study is to investigate inter-observer variation in gross tumor volume (GTV) delineation of oesophageal cancer on different imaging modalities - CT, PET CT and MR.Twenty-three consecutive patients with esophageal…
- Trial name
- NCT05611658
- Testing
- MR, PET CT
- Where
- Slovenia
- Volunteers
- 23 people
- Sponsor
- Institute of Oncology Ljubljana
Xerostomia, Head and Neck Cancers
Efficacy of Traditional Persian Medicine Preparation Versus Artificial Saliva for Radiation Induced Xerostomia
Head and neck cancers(HNC) is one of the most common cancers worldwide. Xerostomia is one of the most common side effect of radiation therapy among patients with HNC.
- Trial name
- NCT02854358
- Testing
- mixed powder of A. digitata and M. sylvestris, Hypozalix spray (artificial saliva)
- Volunteers
- 60 people
- Sponsor
- Shiraz University of Medical Sciences
Head & Neck Cancer
Radiotherapy In a Sitting Position for Enhanced Reproducibility
Qualitative, longitudinal and single-center study To explore the reproductibility and the acceptability of the sitting position for head and neck cancer patients through their experience of sitting and supine positions in the…
- Trial name
- RISE R (NCT07887048)
- Testing
- Simulation of radiotherapy session in sitting position
- Volunteers
- 16 people
- Sponsor
- Centre Leon Berard
Thyroid Cancer, Colon Cancer
QUILT-3.040: ETBX-011 (Ad5 [E1-, E2b-]-CEA(6D)) Vaccine in Combination With ALT-803 (Super-agonist IL-15) in Subjects Having CEA-Expressing Cancer
This is a phase 1b/2 study to evaluate the safety, tolerability, and efficacy of ETBX-011 vaccine used in combination with ALT-803 in subjects with locally advanced or metastatic CEA-expressing cancers whose tumor has recurred…
- Conditions
- Thyroid Cancer, Colon Cancer, Ovarian Cancer, Breast Cancer
- Trial name
- NCT03127098
- Testing
- ETBX-011, ALT-803
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- NantCell, Inc.
Cervical Dysplasia
A Comparison of Immediate Treatment of CIN1 With Cryotherapy and 12 Month Cytology Follow up in HIV Seropositive Women
Based on the high incidence of cervical cancer and high grade dysplasia and increased progression and incomplete treatment of CIN2 and 3 in South Africa, we propose to study the effect of cryotherapy among HIV-positive women…
- Trial name
- NCT02250716
- Testing
- cryotherapy
- Where
- South Africa
- Volunteers
- 480 people
- Sponsor
- University of Witwatersrand, South Africa
Algorithm for Cervix Carcinoma Screening
Algorithm for Cervix Carcinoma Screening in CZ Using the Detection of HPV DNA and CINtec Plus
Cervix carcinoma has been a serious, long-term issue in the Czech Republic. The cause of nearly all cervix carcinomas is human papilomavirus (HPV).
- Trial name
- LIBUSE (NCT05578833)
- Testing
- HPV DNA test with selective HPV 16/18 genotyping (cobas® 4800 HPV Test, Roche), p16 and Ki-67 biomarker detection in the form of dual cytological staining (CINtec Plus, Roche), standard conventional cytology PAP test
- Where
- Czechia
- Volunteers
- 2,426 people
- Sponsor
- AeskuLab Pathology Prague
Non Small Cell Lung Cancer, Colorectal Cancer
FT536 Monotherapy and in Combination With Monoclonal Antibodies in Advanced Solid Tumors
This is a Phase 1 dose-finding study of FT536 given in combination with a monoclonal antibody following lymphodepletion in participants with advanced solid tumors.
- Conditions
- Non Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Ovarian Cancer
- Trial name
- NCT05395052
- Testing
- FT536, Cyclophosphamide, Fludarabine
- Where
- 5 sites in United States
- Volunteers
- 5 people
- Sponsor
- Fate Therapeutics
Cervical Intraepithelial Neoplasia, Cervical Cancer
Lot Consistency Clinical Trial of of Recombinant HPV Bivalent Vaccine in 9 to14 Years Old Healthy Female
This study is to evaluate lot-lot consistency of Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) .
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Cancer, Vaginal Intraepithelial Neoplasia, Vulvar Intraepithelial Neoplasia
- Trial name
- NCT05426148
- Testing
- Recombinant Human Papillomavirus Bivalent (Types 16, 18) Vaccine (Escherichia coli) / Cecolin®
- Where
- China
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Xiamen Innovax Biotech Co., Ltd
Esophageal Cancer, Gastric Cancer
Docetaxel and Irinotecan in Treating Patients With Advanced Cancer of the Esophagus or Stomach
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of combining docetaxel and irinotecan in treating patients…
- Trial name
- NCT00004235
- Testing
- docetaxel, irinotecan hydrochloride
- Where
- 19 sites in United States, Canada
- Volunteers
- 47 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Head and Neck (HNSCC)
HYperfractionated Radiation Therapy Versus Concurrent Chemoradiation for Head and Neck Cancer (HYTC)
This is an international multi-centre, non-inferiority phase III randomized controlled trial comparing concurrent chemoradiation with high dose cisplatin (Arm A) vs.
- Trial name
- NCT07801235
- Testing
- 70 gy 35 fractions/7weeks+high dose of cisplatin, 81.6 Gy /68 fractions BID FOR 7 WEEKS
- Where
- Jordan
- Volunteers
- 604 people
- Sponsor
- King Hussein Cancer Center
Breast Cancer, Cervical Cancer
Early Detection of Breast Cancer and Cervical Cancer in Women in India
RATIONALE: Health education programs and screening methods, such as clinical breast examination and examination of the cervix, may help reduce the number of women who develop breast cancer and cervical cancer.
- Trial name
- NCT00632047
- Testing
- active surveillance, educational intervention, examination
- Where
- India
- Volunteers
- 151,538 people
- Sponsor
- Tata Memorial Hospital
Cervical Carcinoma, Human Papillomavirus Infection
Multilevel HPV Self-Testing Intervention for the Increase of Cervical Cancer Screening Among Women in Appalachia
This trial studies how well a multilevel human papillomavirus (HPV) self-testing intervention works in increasing cervical cancer screening among women in Appalachia.
- Trial name
- NCT04411849
- Testing
- Best Practice, HPV Self-Collection, Informational Intervention
- Where
- 4 sites in United States
- Volunteers
- 802 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Head and Neck Squamous Cell Carcinoma
A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)
The study is a prospective, longitudinal, non-interventional, multicenter study of participants with HNSCC who will have tissue and blood based molecular biomarker profiling during their standard of care treatment.
- Trial name
- NCT06163534
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 500 people
- Sponsor
- Tempus AI
Cancer of Head and Neck
Prognostic Value of 18FDG PET/CT Textural Indices in HNSCC
Head and neck (HN) cancer is the sixth most common malignancy worldwide, with around 800,000 new cases and 320,000 deaths in 2015.
- Trial name
- ImpactTextureO (NCT03378193)
- Where
- France
- Volunteers
- 284 people
- Sponsor
- University Hospital, Brest
Recurrent Thyroid Cancer, Stage IVA Follicular Thyroid Cancer
Decitabine in Treating Patients With Metastatic Papillary Thyroid Cancer or Follicular Thyroid Cancer Unresponsive to Iodine I 131
This phase II trial is studying how well decitabine works in treating patients with metastatic papillary thyroid cancer or follicular thyroid cancer that has stopped responding to radioactive iodine.
- Conditions
- Recurrent Thyroid Cancer, Stage IVA Follicular Thyroid Cancer, Stage IVA Papillary Thyroid Cancer, Stage IVB Follicular Thyroid Cancer
- Trial name
- NCT00085293
- Testing
- Decitabine, Iodine I 131, Recombinant thyrotropin alfa
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Malignant Neoplasm of Cervix, Endometrium and Ovary
A Modified Approach for Morbid Obese With Gynecologic Cancer
Comparing standard midline approach with the modified approach in management of morbid obese patients with gynecologic cancers.
- Trial name
- NCT03096652
- Testing
- Approach for cancer resection
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Neoplasm Neck
Phage II Trial of Stathmin as Predictive Biomarker for TPF Induction Chemotherapy in OSCC
To investigate the predictive value of stathmin expression as a predictive biomarker in OSCC patients, who treated with TPF (docetaxel, cisplatin and 5-fluorouracil ) induction chemotherapy followed by radical surgery and…
- Trial name
- NCT03326947
- Testing
- docetaxel, cisplatin and 5-fluorouracil
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Nasopharyngeal Carcinoma
GAPP Induction and Concurrent Chemoradiotherapy Followed by Toripalimab Maintenance for Nasopharyngeal Carcinoma.
In order to explore the efficacy and safety of targeted therapy and immunotherapy combined with GP chemotherapy in the treatment of high risk advanced nasopharyngeal carcinoma, the investigators design a single-arm, Phase II…
- Trial name
- NCT06851247
- Testing
- Toripalimab, Anlotinib, Gemcitabine
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Sun Yat-sen University
Bladder Cancer, Cervical Cancer
Vinorelbine and Paclitaxel Plus Radiation Therapy in Treating Patients With Advanced Cancer Arising in the Pelvis
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy with may kill more tumor cells.
- Conditions
- Bladder Cancer, Cervical Cancer, Endometrial Cancer, Vaginal Cancer
- Trial name
- NCT00002949
- Testing
- paclitaxel, vinorelbine tartrate, radiation therapy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Chicago
Neoplasms
Topical Curcumin for Precancer Cervical Lesions
The purpose of this study is to see if curcumin can reverse a cervical precancerous state by looking at people who have the condition and intervening with a study drug or placebo (an inactive drug), prior to planned therapeutic…
- Trial name
- NCT02944578
- Testing
- Curcumin
- Where
- 2 sites in United States
- Volunteers
- 7 people
- Sponsor
- Lisa Flowers
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