Clinical trials: Cancer Pancreas
Disease Free Survival, Overall Survival
Efficacy of Chemopreventive Agents on Disease-free and Overall Survival in Patients With Pancreatic Ductal Adenocarcinoma: The CAOS Study
The evidence on the value of aspirin, statins, metformin, beta-blocking ACE inhibitors agents as chemopreventive agents in patients with pancreatic ductal adenocarcinoma is limited.
- Conditions
- Disease Free Survival, Overall Survival, Pancreatic Cancer
- Trial name
- CAOS (NCT04245644)
- Testing
- use of targeted drugs such as aspirin, B-Blockers, Metformin, ACE-inhibitors, Statins
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Massimo Falconi
Pancreas Cancer
Establishment of Radiomics Database by Clinical Application of Multiparametric MRI Based on Incoherent Undersampling
This study aims to establish radiomics database for pancreas cancer from multiparametric MRI including DCE-MRI obtained by using incoherent undersampling and radial acquisition for clinical staging as well as quantitative…
- Trial name
- NCT02944006
- Testing
- multi-parametric MRI
- Where
- South Korea
- Volunteers
- 29 people
- Sponsor
- Seoul National University Hospital
Pancreatic Cancer
Abdominal Exploration Without Incisions
This study is being conducted to determine whether an endoscope, (a small, flexible tube with a camera mounted on the end) passed down through the throat, through the stomach, and into the abdomen can safely and accurately…
- Trial name
- NCT00427752
- Testing
- Transgastric endoscopic peritoneoscopy.
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Jeffrey Hazey
Advanced Gastroenteropancreatic Neuroendocrine Tumor
Gallium (68Ga) Edotreotide PET/CT for Imaging Patients With Gastrointestinal Pancreatic Neuroendocrine Tumors
This is a single-arm imaging study using DOTATOC peptide, labelled with the Gallium (68Ga) tracer.
- Trial name
- NCT06091748
- Testing
- 68Ga-DOTATOC
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Pancreatic Cancer, Liver Metastases
The Significance and Indications of Surgery for Synchronous Liver Metastatic Pancreatic Cancer
To explore the clinical characteristics of pancreatic cancer patients with liver metastases who can benefit from surgery, and to develop evaluation criteria for surgical indications, so as to provide basis for comprehensive…
- Conditions
- Pancreatic Cancer, Liver Metastases, Surgery, Adjuvant Therapy
- Trial name
- PCLM:CSSG (NCT06873178)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- China-Japan Friendship Hospital
Pancreatic Cancer
Focused Ultrasound for the Treatment of Pancreatic Cancer - an International Registry
This pancreatic cancer registry aims to collect information on people around the world who select focused ultrasound (FUS) as part of their treatment for pancreatic cancer to learn about the performance of the focused ultrasound…
- Trial name
- ARRAY (NCT03724435)
- Where
- 4 sites in Bulgaria, South Korea and 2 more
- Volunteers
- 21 people
- Sponsor
- Focused Ultrasound Foundation
Pancreatic Neuroendocrine Tumor (pNET), Extra-Pancreatic Neuroendocrine Tumor (epNET)
Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
The primary purpose of this study is to assess the effectiveness of zanzalintinib compared to everolimus in participants with previously treated, unresectable, locally advanced or metastatic neuroendocrine tumors.
- Trial name
- STELLAR-311 (NCT06943755)
- Testing
- Zanzalintinib, Everolimus
- Where
- 133 sites in United States, Australia and 15 more
- Volunteers
- 440 people
- Sponsor
- Exelixis
Pancreatic Cancer
First in Human Phase1/2a Clinical Trial of Anti-PAUF Monoclonal Antibody PBP1510 in Patients With Pancreatic Cancer
The first in human clinical study is planned as an open-label, dose-escalation, and dose-expansion, multicentre, two-part, Phase 1/2a study of PBP1510 administered to patients with advanced/metastatic pancreatic cancer.
- Trial name
- NCT05141149
- Testing
- PBP1510 (400mg/16mL), Gemcitabine (1000 mg/m^2)
- Where
- 4 sites in United States, Australia and 2 more
- Volunteers
- 80 people
- Sponsor
- Prestige Biopharma Limited
Pancreatic Cancer
Integrated Positron Emission Tomography - Computed Tomography (PET-CT) in Patients With Pancreatic Cancer
In suspecting pancreatic cancer, dynamic phase pancreatic CT is the most effective tool in diagnosis and staging. In addition, magnetic resolution image, endoscopic ultrasonography, endoscopic retrograde pancreatography…
- Trial name
- NCT00885248
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Asan Medical Center
Pancreatic Cancer, Pancreatic Fistula
Anastomotic Techniques in Pancreaticoduodenectomy
There are two principal ways of draining the remnant of the pancreas back into the intestine after removal of the head of the pancreas for cancer. This can be performed either to the jejunum or to the stomach.
- Trial name
- PG/PJ (NCT00855985)
- Testing
- type of anastomosis after pancreaticoduodenectomy
- Where
- India
- Volunteers
- 312 people
- Sponsor
- Lakeshore Hospital
Biomarkers Study in Pancreatic Cancer
Biomarkers Study in Pancreatic Cancer
Study Design: Patients are eligible if (1) enrolled to TCOG 3207(2) received surgery or biopsy for pancreatic cancer; (3) willing to sign informed consent.
- Trial name
- NCT01666184
- Volunteers
- 270 people
- Sponsor
- National Health Research Institutes, Taiwan
Metastatic Pancreatic Carcinoma
HRS-4642 With Nimotuzumab and Chemotherapy for First-line Treatment of Advanced Pancreatic Cancer Patients
This study is a single-arm phase II clinical study to include 32 patients with advanced pancreatic cancer with KRAS G12D mutation to evaluate the effectiveness of HRS-4642 combined with nitutuzumab and AG for first-line treatment…
- Trial name
- NCT06770452
- Testing
- HRS-4642, Nimotuzumab, gemcitabine + nab-paclitaxel
- Where
- 2 sites in China
- Volunteers
- 133 people
- Sponsor
- Zhejiang University
Pancreatic Cancer
Biological Effect of Warfarin on Pancreatic Cancer
This study aims to asses the effect of warfarin on markers of AXL pathway in patients with pancreatic adenocarcinoma.
- Trial name
- NCT03536208
- Testing
- Warfarin
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Pancreas Cancer
Development of a Prediction Platform for Neoadjuvant Treatment and Prognosis in Pancreatic Cancer Using Organoid
The investigators create organoid from the pancreatic cancer tissue obtained via EUS-FNA and EUS-FNB within the pancreatic cancer diagnostic process.
- Trial name
- NCT04777604
- Testing
- Organoid
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Samsung Medical Center
Pancreatic Ductal Adenocarcinoma, Minimally Invasive Surgery
Clinical Study Between Robotic and Open Surgery in Patients With Pancreatic Cancer
The purpose of this study is to determine whether robotic surgery has limitations in terms of patient age, tumor size, location, and vascular relationship when compared to open surgery for pancreatic cancer.
- Trial name
- NCT04211948
- Testing
- robotic surgery, open surgery
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Ruijin Hospital
Pancreatic Cancer
High-activity Natural Killer Immunotherapy for Small Metastases of Pancreatic Cancer
The aim of this study is the safety and efficacy of high-activity natural killer immunotherapy to small metastases of pancreatic cancer.
- Trial name
- NCT03008304
- Testing
- High-activity natural killer
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Cancer
Irinotecan and Capecitabine in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003867
- Testing
- capecitabine, irinotecan hydrochloride
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Montefiore Medical Center
Breast Cancer, Colorectal Cancer
Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or Pancreatic Cancer
RATIONALE: Counting the number of circulating cancer cells in samples of blood from patients with metastatic cancer may help doctors find out how much the cancer has spread.
- Conditions
- Breast Cancer, Colorectal Cancer, Ovarian Cancer, Pancreatic Cancer
- Trial name
- NCT00898781
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Non Small Cell Lung Cancer, Colorectal Cancer
A Study of Personalized Neoantigen Cancer Vaccines
The purpose of this study is 1) to evaluate the feasibility of manufacturing a patient-specific neoantigen cancer vaccine, which involves predicting the patient's neoantigens and generating a vaccine that encodes the predicted…
- Conditions
- Non Small Cell Lung Cancer, Colorectal Cancer, Gastroesophageal Adenocarcinoma, Urothelial Carcinoma
- Trial name
- NCT03794128
- Testing
- Blood collection for research (next-generation sequencing [NGS]), Blood collection for research (HLA typing)
- Where
- 5 sites in United States
- Volunteers
- 93 people
- Sponsor
- Gritstone bio, Inc.
Metastatic Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer
MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma
The investigators hypothesize that MK2 inhibition may improve efficacy of mFOLFIRINOX chemotherapy for patients with pancreatic ductal adenocarcinoma (PDAC).
- Conditions
- Metastatic Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer, Cancer of the Pancreas
- Trial name
- NCT06648434
- Testing
- Zunsemetinib, mFOLFIRINOX
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Washington University School of Medicine