Clinical trials: Cancer Patient
Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia
BMS-214662 in Treating Patients With Acute Leukemia, Myelodysplastic Syndrome, or Chronic Myeloid Leukemia
Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Phase I trial to study the effectiveness of BMS-214662 in treating patients who have acute leukemia, myelodysplastic…
- Conditions
- Adult Acute Promyelocytic Leukemia (M3), Blastic Phase Chronic Myelogenous Leukemia, Childhood Myelodysplastic Syndromes, Previously Treated Myelodysplastic Syndromes
- Trial name
- NCT00006213
- Testing
- BMS-214662, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Metastatic Melanoma, Nausea
Nausea and Vomiting In Patients Receiving Consecutive Days of Cisplatin
The purpose of this study is to observe the incidence of nausea with systemic chemotherapy that includes consecutive days (more than one day)of cisplatin medication.
- Trial name
- NCT00716560
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Chronic Myeloid Leukemia
2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients
The main goal of the study is the assessment of duration of major molecular response (MMR) or better at 12 and 36 months after stopping tyrosine kinase inhibitors (TKI) therapy a second or third time in patients with at least…
- Trial name
- NAUT (NCT02917720)
- Testing
- TKI discontinuation, nilotinib
- Where
- 15 sites in Germany, Netherlands
- Volunteers
- 75 people
- Sponsor
- European LeukemiaNet
Breast Cancer
Assessment of Tartrate-Resistant Acid Phosphatase (TRAP) as a Bone Resorption Marker in Stage IV Breast Cancer Patients With Bone Metastasis
The purpose of this research study is to evaluate the usefulness of the TRAP protein as (1) an early indicator of bone destruction and (2) a tool for assessing the effect of Zometa® in treating symptoms of bone metastases due to…
- Trial name
- NCT00264082
- Testing
- Zometa(drug)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Locally Advanced Malignant Neoplasm, Inflammatory Breast Carcinoma
Olaparib and Radiotherapy in Inoperable Breast Cancer
The majority of breast cancer patients receive radiotherapy as part of their treatment. Radiotherapy improves both locoregional control and overall survival.
- Conditions
- Locally Advanced Malignant Neoplasm, Inflammatory Breast Carcinoma, Triple-Negative Invasive Breast Carcinoma
- Trial name
- NCT02227082
- Testing
- radiotherapy, olaparib
- Where
- Netherlands
- Volunteers
- 7 people
- Sponsor
- The Netherlands Cancer Institute
Depression, Psychological Distress
German Evaluation of the Effectiveness of the Psychological Intervention Managing Cancer and Living Meaningfully (CALM)
Purpose of this randomized controlled trial is to test the efficacy of the individual psychotherapeutic intervention Managing Cancer and Living Meaningfully (CALM) in a German sample of patients with advanced cancer.
- Trial name
- NCT02051660
- Testing
- Manualized CALM intervention, Non-manualized supportive intervention.
- Where
- 2 sites in Germany
- Volunteers
- 206 people
- Sponsor
- University of Leipzig
Prostate Cancer, Adenocarcinoma of the Prostate
Prospective Prostate Cancer and Patient-reported Outcomes Registry
This study aims to evaluate the use of a digital solution, integrated into the electronic health record, for prospective and structured reporting of clinical and patient-reported outcomes for patients diagnosed with localized or…
- Conditions
- Prostate Cancer, Adenocarcinoma of the Prostate, Locally Advanced Prostate Carcinoma, Locally Advanced Prostate Adenocarcinoma
- Trial name
- Prosquare (NCT04694924)
- Testing
- standard of care
- Where
- 4 sites in Belgium
- Volunteers
- 5,000 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Squamous Cell Carcinoma of the Oropharynx, HPV
Reduced-intensity Therapy for Oropharyngeal Cancer in Non-smoking HPV-16 Positive Patients
Taking into account the excellent prognosis of patients with HPV-positive oropharyngeal cancer with < 10 pack-year smoking, the investigators hypothesize that reducing the intensity of therapy for these patients will reduce…
- Trial name
- NCT01663259
- Testing
- Cetuximab, Radiotherapy
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Michigan Rogel Cancer Center
Breast Cancer
Analysis of Surgery in Patients Presenting With Stage IV Breast Cancer
The purpose of this study is to study patients presenting with stage IV breast cancer. Stage IV means that the breast cancer has spread to another part of the body outside the breast.
- Trial name
- NCT00941759
- Where
- 20 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pediatric Cancer Patients
Tissue Doppler Assessment of Right Ventricle Function in Pediatrics Underwent Chemotherapy
Tissue Doppler assessment of right ventricular function in newly diagnosed pediatric cancer patients underwent chemotherapy in South Egypt Cancer Institute.
- Trial name
- NCT04831359
- Testing
- Doppler ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Advanced Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm
Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Patients With Advanced Cancer
This phase III trial compares olanzapine to placebo in decreasing nausea and vomiting in patients with cancer that has spread to other places in the body (advanced).
- Trial name
- NCT05403580
- Testing
- Olanzapine, Questionnaire Administration
- Sponsor
- Mayo Clinic
Colorectal Cancer
Study of TAS-102 Plus Radiation Therapy for the Treatment of the Liver in Patients With Hepatic Metastases From Colorectal Cancer
This research study is studying a drug in combination with radiation therapy as a possible treatment for hepatic metastases from colorectal cancer.
- Trial name
- NCT03223779
- Testing
- TAS-102, Photon SBRT
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Lung Cancer
VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003847
- Testing
- biricodar dicitrate, doxorubicin hydrochloride, vincristine sulfate
- Where
- 9 sites in United States
- Volunteers
- 36 people
- Sponsor
- Vertex Pharmaceuticals Incorporated
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute
Bone Marrow Transplant From Partially Matched Donors and Nonmyeloablative Conditioning for Blood Cancers (BMT CTN 0603)
Bone marrow transplants are one treatment option for people with leukemia or lymphoma. Family members or unrelated donors with a similar type of bone marrow usually donate their bone marrow to the transplant patients.
- Conditions
- Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Myeloid, Acute, Burkitt Lymphoma, Lymphoma, B-Cell
- Trial name
- NCT00849147
- Testing
- Haploidentical Bone Marrow Transplantation, GVHD prophylaxis
- Where
- 17 sites in United States
- Volunteers
- 55 people
- Sponsor
- Medical College of Wisconsin
Cutaneous Melanoma, Stage IV, BRAF V600 Mutation
Advanced Melanoma in Russian Experience
Retrospective chart review Study of patients with BRAF V600 positive advanced (unresectable or metastatic) melanoma, who were treated with targeted therapy in routine clinical practice in Russian Federation
- Trial name
- ADMIRE (NCT03663647)
- Where
- 11 sites in Russia
- Volunteers
- 382 people
- Sponsor
- MelanomaPRO, Russia
Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma, Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor
CREATE: Cross-tumoral Phase 2 With Crizotinib
The study will primarily assess the antitumor activity of crizotinib in a variety of tumors with alterations in ALK and/or MET pathways.
- Conditions
- Locally Advanced and/or Metastatic Anaplastic Large Cell Lymphoma, Locally Advanced and/or Metastatic Inflammatory Myofibroblastic Tumor, Locally Advanced and/or Metastatic Papillary Renal Cell Carcinoma Type 1, Locally Advanced and/or Metastatic Alveolar Soft Part Sarcoma
- Trial name
- CREATE (NCT01524926)
- Testing
- Crizotinib (PF-02341066)
- Where
- 25 sites in Belgium, France and 8 more
- Volunteers
- 582 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
High Risk Hematologic Malignancy, Cord Blood Transplant
UM171 Expanded Cord Blood In Patients With High-Risk Acute Leukemia/Myelodysplasia
Allogeneic hematopoietic stem cell transplantation is a life-saving procedure in patients with blood cancers. Cord blood (CB) represents an alternative source of stem cells, which is associated with a lower risk of relapse…
- Trial name
- NCT03913026
- Testing
- Transplant with an expanded ECT-001 cord blood
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
To Predict Early Post-hepatectomy Mortality for HCC
Calculator Predicts Early Mortality Post Hepatocellular Carcinoma Resection
Using the multicenter data, we developed and validated an individualized online calculator to predict early mortality after liver resection for hepatocellular carcinoma.
- Trial name
- NCT06621485
- Where
- China
- Volunteers
- 4,966 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Myeloma Multiple
A Study of the Efficacy and Safety of BCD-248 in Combination With Daratumumab in Patients With Relapsed or Refractory Multiple Myeloma (AMMADINA)
The aim of the study is to assess the efficacy and safety of the BCD-248 in combination with daratumumab versus the combination of daratumumab, pomalidomide, and dexamethasone in the treatment of relapsed or refractory multiple…
- Trial name
- AMMADINA (NCT07742215)
- Testing
- BCD-248 + daratumumab, Daratumumab + pomalidomide + dexamethasone
- Where
- 16 sites in Belarus, Russia
- Volunteers
- 390 people
- Sponsor
- Biocad
Uveal Melanoma
Neoadjuvant Immunotherapy for Patients With High-risk Eye Melanoma
The goal of this clinical trial is to investigate the safety and feasibility of neoadjuvant immunotherapy for patients with high-risk uveal melanoma.
- Trial name
- NCT07501117
- Testing
- Nivolumab & Ipilimumab
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- Inge Marie Svane
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