Clinical trials: Cancer Pediatric
Acute Myeloid Leukemia, Acute Lymphoblastic T-cell Leukemia
Feasibility and Safety of Donor-derived NK-cell Infusions for Leukemia Relapse Prophylaxis After Hematopoietic Stem Cell Transplantation
This pilot clinical trial aims to evaluate the feasibility, adverse reactions and maximum tolerated dose of mbIL21 ex vivo-expanded donor-derived NK-cell infusions before and after haploidentical or matched-related hematopoietic…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoblastic T-cell Leukemia, Mixed Phenotype Acute Leukemia
- Trial name
- NCT07256210
- Testing
- Donor-derived Natural Killer Cell
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Neutropenia, Sarcoma
Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor
Phase II trial to study the effectiveness of combination chemotherapy in treating patients with newly diagnosed metastatic Ewing's sarcoma or primitive neuroectodermal tumor.
- Trial name
- NCT00002643
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 49 sites in United States, Australia and 3 more
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Childhood Neoplasm
Biokinetics Study for F-18 FDG in Pediatric Molecular Imaging
The radiation exposure resulting from medical imaging is a topic of some concern. Nuclear medicine provides potentially life-saving information regarding physiological processes, and is of particular value in children where the…
- Trial name
- NCT03107325
- Testing
- Modification in acquisition protocol, F-18 Fluorodeoxyglucose
- Where
- United States
- Sponsor
- Boston Children's Hospital
Lymphoma
Combination Chemotherapy in Treating Pediatric Patients With Stage III or IV Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and using drugs in different ways may kill more tumor cells.
- Trial name
- NCT00002691
- Testing
- filgrastim, asparaginase, cyclophosphamide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Childhood Cancer, Cancer
CANnabinoids in Pediatric ONCology
CANnabinoids in Pediatric ONCology is a randomized, double blind, adaptive clinical trial looking at the tolerability of cannabinoids in children with cancer across 3 Canadian children's hospitals.
- Trial name
- CAN-PONC (NCT05754840)
- Testing
- MPL-001, MPL-005, MPL-009
- Where
- 3 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Chronic Pain, Survivorship
WebMAP for Childhood Cancer Survivors
Background: There are over 500,000 survivors of childhood cancer in North America alone. One in four survivors experiences chronic pain after treatment has completed.
- Conditions
- Chronic Pain, Survivorship, Childhood Cancer
- Trial name
- NCT05241717
- Testing
- Web-based Management of Adolescent Pain (WebMAP)
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- University of Calgary
Left Ventricular Dysfunction, Heart Failure
Cardiovascular Assessment of Pediatric Cancer Survivors
The goal of this observational study is to evaluate cardiac and vascular health status of pediatric cancer survivors.
- Trial name
- CASPER (NCT05939089)
- Testing
- ECG, Echocardiography, cTnI, NT-ProBNP
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma
Bortezomib, Ifosfamide, and Vinorelbine Tartrate in Treating Young Patients With Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Therapy
This phase II trial studies the side effects and efficacy of bortezomib with ifosfamide and vinorelbine in children and young adults with Hodgkin's lymphoma that was recurrent or did not respond to previous therapy.
- Conditions
- Adult Lymphocyte Depletion Hodgkin Lymphoma, Adult Lymphocyte Predominant Hodgkin Lymphoma, Adult Mixed Cellularity Hodgkin Lymphoma, Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma
- Trial name
- NCT00381940
- Testing
- ifosfamide, bortezomib, vinorelbine tartrate
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Pain, Postoperative, Agitation States as Acute Reaction to Exceptional Stress
Gabapentin as Preanesthetic Medication to Fast Procedures in Pediatric´s Oncology
This study is a clinical trial, prospective, randomized and double-blinded. Placebo, Gabapentin syrup at 15 mg/kg, and Gabapentin syrup at 30 mg/kg were administered to reduce agitation before and after in children submitted…
- Conditions
- Pain, Postoperative, Agitation States as Acute Reaction to Exceptional Stress, Anesthesia, Vomiting
- Trial name
- NCT03681574
- Testing
- GABA 15mg/kg Group, GABA 30mg/kg Group
- Where
- Brazil
- Volunteers
- 135 people
- Sponsor
- Hospital Infantil Albert Sabin
Refractory Solid Tumors in Children
Clinical Trial of Rapamycin and Irinotecan in Pediatric Patients With Refractory Solid Tumors
Therapeutic solutions to treat solid tumors that are resistant to conventional treatments are now limited. Laboratory data in animals (on pediatric tumors such as brain tumors, sarcomas and neuroblastomas) have shown that the…
- Trial name
- RAPIRI (NCT01282697)
- Testing
- Combined administration of irinotecan and rapamycin
- Where
- 9 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Lymphoblastic Leukemia, Pediatric, ALL, Infants
Combined Immuno-chemotherapy for Patients With B-linear Acute Lymphoblastic Leukemia Diagnosed From 0 to 365 Days of Life (ALL-Baby-2021)
The innovation of this protocol is the risk-adapted choice of therapy and the use of a combination of chemotherapy with immunotherapy and hematopoietic stem cell transplantation for patients with risk factors.
- Trial name
- NCT05029531
- Testing
- the risk-adapted choice of therapy and the use of a combination of chemotherapy with immunotherapy and hematopoietic stem cell transplantation for patients with risk factors.
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Mature B-Cell Neoplasm, Non Hodgkin Lymphoma
Study of SGR-1505 in Mature B-Cell Neoplasms
The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.
- Conditions
- Mature B-Cell Neoplasm, Non Hodgkin Lymphoma, DLBCL, Waldenstrom Macroglobulinemia
- Trial name
- NCT05544019
- Testing
- SGR-1505
- Where
- 36 sites in United States, France and 6 more
- Volunteers
- 98 people
- Sponsor
- Schrödinger, Inc.
Pain, Acute, Burns
Distraction As Multimodal Pain Management
A randomized controlled trial will be performed at the Ngwelezana Hospital, Empangeni, South Africa. Paediatric patients between the age of 5-12 years with minor and superficial partial thickness burn injuries who require…
- Conditions
- Pain, Acute, Burns, Pediatric ALL
- Trial name
- DISTRACT (NCT06591195)
- Testing
- Distraction by use of kaleidoscope
- Volunteers
- 126 people
- Sponsor
- Radboud University Medical Center
Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy, Multiple Myeloma
Long-term Follow-up of Patients Treated With Genetically Modified Autologous T Cells
Long-term follow-up of patients exposed to an AUTO CAR T cell therapy for up to 15 years following their first AUTO CAR T cell therapy infusion.
- Conditions
- Patients Followed for up to 15 Years Following Their First Dose of AUTO CAR T Cell Therapy, Multiple Myeloma, DLBCL, ALL, Adult and Pediatric
- Trial name
- NCT03628612
- Testing
- AUTO CAR T cell therapy
- Where
- 9 sites in United States, Spain and 1 more
- Volunteers
- 500 people
- Sponsor
- Autolus Limited
Hematologic Malignancy
Study of a Reduced-toxicity Myeloablative Conditioning Regimen Using Fludarabine and Full Doses of Intravenous Busulfan in Pediatric Patients Not Eligible for Standard Myeloablative Conditioning Regimens
The purpose of this study is to assess transplant-related mortality (TRM) at one year after allogeneic hematopoietic stem cell transplantation (allo-HSCT) prepared by a "reduced toxicity myeloablative" conditioning regimen in…
- Trial name
- FB4-PEDIA (NCT01572181)
- Testing
- Fludarabine IV- Busulfan IV (Busilvex®) - Anti-thymocyte globulines (Thymoglobuline®)
- Where
- 15 sites in France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
Survivor of Childhood Cancer, Insomnia
Transcutaneous Auricular Vagus Nerve Stimulation for Insomnia in Survivors of Childhood Acute Lymphoblastic Leukemia
This pilot study will assess the usefulness and potential effectiveness of using transcutaneous auricular vagus nerve stimulation (tVNS) for treating insomnia in adult survivors of childhood acute lymphoblastic leukemia (ALL).
- Conditions
- Survivor of Childhood Cancer, Insomnia, Acute Lymphoblastic Leukemia (ALL)
- Trial name
- NCT07191119
- Testing
- Soterix tVNS device, Sleep Quality, Neurocognitive and mental health outcomes
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- St. Jude Children's Research Hospital
Brain Stem Neoplasms, Primary, Neoplasms, Brain Stem
Thalomid and Carboplatin for the Treatment of Pediatric Brain Stem Glioma
Treatment on this study combines two drugs: Thalomid™ (thalidomide) and carboplatin. Thalidomide has been available for many years and has been used to treat many different illnesses.
- Trial name
- NCT00179881
- Testing
- Carboplatin, Thalomid, External Beam Radiation Therapy
- Where
- 6 sites in United States
- Volunteers
- 47 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Sarcoma
Effect of A Multimodal Exercise Intervention on Chemotherapy Uptake in Newly Diagnosed Pediatric and AYA Sarcoma Patients
The purpose of this study is to determine the effects of a multimodal exercise intervention on chemotherapy uptake in newly diagnosed pediatric, adolescent and young adult (AYA) Sarcoma patients.
- Trial name
- ACTIVE-SARC (NCT07359911)
- Testing
- Exercise Intervention, Usual Care Control, Exit Interview
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Lymphoma, Sarcoma
A Phase I Study of Vorinostat and Bortezomib in Children With Refractory of Recurrent Solid Tumors, Including CNS Tumors and Lymphomas
Background: Vorinostat and bortezomib are anti-tumor drugs that have been approved by the Food and Drug Administration to treat different kinds of myeloma and lymphoma in adults.
- Conditions
- Lymphoma, Sarcoma, WilmsTumor, Neuroblastoma
- Trial name
- NCT01132911
- Testing
- Vorinostat (SAHA), Velcade (PS-341, Bortezomib)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Cancer Institute (NCI)
Long-term Effects Secondary to Cancer Therapy in Children, Pulmonary Complications
Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation
RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment.
- Trial name
- NCT00009711
- Testing
- management of therapy complications
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Fred Hutchinson Cancer Center
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