Clinical trials: Cancer Pediatric
Regional Osteoporosis as a Result of Chemotherapy
Bone Mineral Density in Adult Survivors of Solid Pediatric Cancers
Specific subgroups of children who survive treatment for childhood malignancies have been shown to develop relative osteopenia following chemotherapy and are felt to be at risk for developing osteoporosis later in life due to…
- Trial name
- NCT00634816
- Testing
- DXA Scan
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- State University of New York - Upstate Medical University
Effects of Chemotherapy
Assessing Fertility Potential in Female Cancer Survivors
Hypothesis: Girls and women exposed to chemotherapy and/or radiation therapy experience endocrine changes more similar to women in their late reproductive years than to same-age peers.
- Trial name
- NCT01143844
- Where
- 2 sites in United States
- Volunteers
- 391 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Soft Tissue Sarcoma, Lymphoma
Liposomal Vincristine for Pediatric and Adolescent Patients With Relapsed Malignancies
The goal of this clinical research study is to learn if treatment with the drug liposomal vincristine can shrink or slow the growth of the patient's cancer. The safety of this drug will also be studied.
- Conditions
- Soft Tissue Sarcoma, Lymphoma, Leukemia, Wilms' Tumor
- Trial name
- NCT00038207
- Testing
- Liposomal Vincristine
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- M.D. Anderson Cancer Center
Stress, Cancer
Maternal Problem-Solving in Childhood Cancer
The purpose of this study is to help mothers of children with cancer to cope more effectively by increasing their problem-solving skills.
- Trial name
- NCT00234793
- Testing
- Problem-Solving Skills Training
- Where
- 4 sites in United States
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Pediatric ALL
Pharmacokinetics of Drugs Administered to Children
This is a prospective study of children <21 years of age with the goal of characterizing the PK of drugs administered per standard of care as prescribed by the treating caregiver.
- Trial name
- NCT03481881
- Testing
- Standard of care drug
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Anthracycline Induced Cardiotoxicity
Late Anthracycline Induced Cardiotoxicity- Childhood Cancer Survivors
Anthracyclines treat up to 60% of childhood malignancies with remarkable improvements survival rates. Unfortunately anthracyclines are associated with an increased cardiomyopathy risk.
- Trial name
- NCT04852965
- Where
- United Kingdom
- Volunteers
- 103 people
- Sponsor
- Queen's University, Belfast
Solid Tumor, Childhood, Lymphoma
Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitors BMS-986158 and BMS-986378 in Pediatric Cancer
Arm 1 of this research study is studying an investigational drug called BMS-986158 as a possible treatment for pediatric solid tumors or lymphoma.
- Conditions
- Solid Tumor, Childhood, Lymphoma, Brain Tumor, Pediatric
- Trial name
- NCT03936465
- Testing
- BMS-986158, BMS-986378
- Where
- 6 sites in United States, Canada
- Volunteers
- 41 people
- Sponsor
- Dana-Farber Cancer Institute
Bone Diseases
Free Nonvascularized Fibula Autograft for Tumor-like Lesions in Femoral Neck Using in Pediatric Patients
This study was to evaluate the safety and efficacy of free nonvascularized fibula autograft in the treatment of the femoral neck tumor-like lesions before epiphyseal closure in pediatric patients, by presenting the…
- Trial name
- NCT03129230
- Testing
- free nonvascularized fibula autograft
- Where
- 2 sites in China
- Volunteers
- 16 people
- Sponsor
- Yulin Orthopedics Hospital of Chinese and Western Medicine
Pediatric Acute Myeloid Leukemia
Home or Away From Home - Descriptive Interviews (Aim 2)
The primary objectives of this study are to identify what outcomes related to the management of neutropenia are most important to children with AML and their caregivers.
- Trial name
- NCT02794207
- Where
- 11 sites in United States
- Volunteers
- 86 people
- Sponsor
- Children's Hospital of Philadelphia
Acute Lymphoblastic Leukemia
A Roll-over Study to Provide Continued Treatment With Lyophilized Pegaspargase (S95014) in Pediatric Patients With Acute Lymphoblastic Leukemia (ALL)
The purpose of this study is to provide treatment with lyophilized S95014 in pediatric patients with ALL who completed the CL2-95014-002 study during the induction phase and who are clinically benefitting from S95014 without…
- Trial name
- ALL (NCT04956666)
- Testing
- Lyophilized S95014
- Where
- 6 sites in Russia
- Volunteers
- 75 people
- Sponsor
- Institut de Recherches Internationales Servier
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study
This clinical trial tests the impact of a culturally-tailored home-based physical activity program on physical fitness in Hispanic or Latino/Latina adolescent and young adult (AYA) childhood cancer survivors.
- Trial name
- NCT06410209
- Testing
- Discussion, Goal Setting, Interview
- Where
- 77 sites in United States, Puerto Rico
- Volunteers
- 190 people
- Sponsor
- Children's Oncology Group
Cancer, Chemoradiation
GnRHA Therapy and Ovarian Preservation in Pediatric Cancer Patient
This is a prospective case control study. Participants will be enrolled as case subjects or control subjects, depending upon the gonadotoxicity of their chemoradiation therapy.
- Trial name
- NCT02677311
- Testing
- Blood draw, Pelvic Ultrasound
- Volunteers
- 2 people
- Sponsor
- University of Kentucky
Pediatric Cancer, Cancer-related Fatigue
Wearable Technology-Supported Exercise Program for Fatigue and Quality of Life in Pediatric Cancer Patients (WE-EX PedsCa)
Children and adolescents receiving cancer treatment often experience fatigue, reduced physical activity, and decreased quality of life.
- Conditions
- Pediatric Cancer, Cancer-related Fatigue, Quality of Life, Exercise
- Trial name
- WE-EX PedsCa (NCT07337681)
- Testing
- standart care, Wearable Technology-Supported Exercise Program
- Volunteers
- 50 people
- Sponsor
- Istanbul University
Hodgkin Lymphoma
Phase II Study Of Nivolumab Plus AVD In Pediatric, Adolescent, And Young Adult Patients With CHL
The goal of this clinical research study is to learn if nivolumab plus AVD (doxorubicin, vinblastine, and dacarbazine) can help to control newly diagnosed early-stage non-bulky cHL in pediatric, adolescent, and young adult…
- Trial name
- NCT07551583
- Testing
- Nivolumab, Doxorubicin Hydrochloride, Vinblastine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Congenital Heart Disease, Pediatric ALL
HIIT in Youth With Congenital Heart Disease (MedBIKE)
Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood.
- Trial name
- NCT04575883
- Testing
- MedBIKE HIIT
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- University of Alberta
Glioblastoma (GBM), DIPG
Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma
The standard therapy of glioblastoma (GBM) consists of gross total resection followed by focal irradiation to the tumor bed with concomitant and adjuvant temozolomide (TMZ).
- Conditions
- Glioblastoma (GBM), DIPG, Brainstem Glioma, Pediatric, Diffuse Spinal Glioma
- Trial name
- NCT02758366
- Testing
- Doxorubicin
- Where
- Italy
- Volunteers
- 21 people
- Sponsor
- Meyer Children's Hospital IRCCS
Cancer, Leukemia
Lactation Outcomes Among Survivors of Pediatric Cancer
While the majority of women in the general population can breastfeed successfully, the investigators have limited knowledge about the correlates and sequelae of lactation success among women treated for pediatric malignancies.
- Trial name
- NCT02399956
- Testing
- Survey
- Where
- United States
- Volunteers
- 471 people
- Sponsor
- St. Jude Children's Research Hospital
Tethered Spinal Cord, Including Thickened Filum, Lipomas, Myelomeningocele and Meningocele
Inflammatory Response in Children Suffering From Tethered Cord
Embryologic phenomenons that lead to dysraphisms are known, but pathophysiology remains questioned. It is supposed not to be a simple mechanistic dysfunction, and other biological phenomenons are implied in spinal cord damaging.
- Trial name
- TETHERIC (NCT07611058)
- Testing
- CSF sampling during surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Lille
Papilloma, Recurrent Respiratory Papillomatosis
A Trial Study of SGN-00101 in Treating Pediatric Patients With Recurrent Respiratory Papillomatosis
Recurrent Respiratory Papillomatosis (RRP) causes wart-like lesions along the throat area and can obstruct the airway or become malignant. The cause has been related to specific types of Human Papillomavirus (HPV).
- Trial name
- NCT00038714
- Testing
- SGN-00101
- Where
- 8 sites in United States
- Volunteers
- 27 people
- Sponsor
- Nventa Biopharmaceuticals Corporation
Pediatric Cancer, Critically Ill
ONCOTIPNET: Multicenter Study on Risk Factors and Outcome in Cancer Pediatric Patients Admitted in Italian PICUs
The study will describe characteristics of pediatric cancer patients admitted to Italian PICUs and will analyze risk factors of PICU admission, neurological outcome, and mortality.
- Trial name
- ONCOTIPNET (NCT04581655)
- Where
- 17 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Azienda Ospedaliera di Padova
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