Clinical trials: Cancer Pediatric
Pediatric ALL
Dexamethasone & Ketamine as Adjuvants to Bupivacaine for Incisional Infiltration in Pediatric Abdominal Operations
The aim of this study is to compare the effects of both ketamine and dexamethasone on the duration and magnitude of analgesia when combined with bupivacaine for incisional infiltration in pediatric abdominal operations.
- Trial name
- NCT05190952
- Testing
- Bupivacaine, Ketamine, Dexamethasone
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ain Shams University
Cancer, Pediatric Solid Tumor
A Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100)
PARC is an international phase I/II trial evaluating the safety and activity of pegylated recombinant human arginase (BCT-100) in children and young people with relapsed/refractory leukaemia, neuroblastoma, sarcoma and high grade…
- Conditions
- Cancer, Pediatric Solid Tumor, Pediatric AML, Pediatric ALL
- Trial name
- PARC (NCT03455140)
- Testing
- PEG- BCT-100
- Where
- 14 sites in Australia, Netherlands and 1 more
- Volunteers
- 49 people
- Sponsor
- University of Birmingham
Childhood Cancer
Epigenetic and Metabolomic Changes in Childhood Cancer Survivors
The purpose of this research study is to try and identify markers in childhood cancer survivors to help predict if they will develop late effects from their cancer treatment.
- Trial name
- NCT03866707
- Testing
- One-time blood draw, Evaluation of CpG methylation, Metabolomic analysis
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Leukemia
Allogeneic Transplantation for Pediatric Leukemias With Unrelated Donors
The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant from unrelated donor peripheral blood stem…
- Trial name
- NCT00679536
- Testing
- Busulfan, Fludarabine, Thymoglobulin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Brain Tumor, Pediatric
Utility of PET-MRI in Surveillance of Paediatric Brain Tumours
This is a pilot project to explore the utility of PET-MRI in the post-treatment surveillance of high-grade gliomas or medulloblastomas in children in our institution.
- Trial name
- PET-MRI (NCT05553899)
- Testing
- PET-MRI
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Frailty, Childhood Cancer
An Open-Label Intervention Trial to Reduce Senescence and Improve Frailty in Adult Survivors of Childhood Cancer
This is a first-in survivor pilot study with the goal of establishing preliminary evidence of efficacy, safety, and tolerability of two senolytic regimens to reduce markers of cellular senescence (primary outcome: p16^INK4a) and…
- Trial name
- NCT04733534
- Testing
- Dasatinib plus Quercetin, Fisetin
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- St. Jude Children's Research Hospital
Cancer Survivor, Pediatric Cancer
Vascular Endothelial Inflammation and Dysfunction in Pediatric Long-term Cancer Survivors
Survivors of childhood cancer have an increased risk of death from cardiovascular disease due to both the therapies they received while undergoing treatment and diet and lifestyle factors.
- Trial name
- NCT02032121
- Testing
- Blood specimen, Echocardiography
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Miami
Hodgkin Lymphoma
Therapy for Pediatric Hodgkin Lymphoma
With the success of current chemotherapy for Hodgkin's disease, the goal of this protocol is to maintain the currently successful cure rate and reduce treatment related side effects and long term toxicity.
- Trial name
- NCT00145600
- Testing
- 12 Week Stanford V Chemotherapy, 4 cycles of VAMP chemotherapy, 2 alternating cycles of VAMP/COP chemotherapy
- Where
- 5 sites in United States
- Volunteers
- 296 people
- Sponsor
- St. Jude Children's Research Hospital
Pheochromocytoma, Paraganglioma
Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma
This is a compassionate use protocol to allow palliative therapy for patients with malignant pheochromocytoma and paragangliomas.
- Trial name
- NCT01377532
- Testing
- 131 I-Metaiodobenzylguanidine (131 I-MIBG)
- Where
- United States
- Sponsor
- University of California, San Francisco
Adverse Drug Reactions
Influence of CYP2C19 Genotype on Safety and Efficacy of Voriconazole in Pediatric Patients With Hematologic Malignancy
Voriconazole is a drug used to treat invasive fungal infections. The amount of voriconazole in a person's blood helps to determine how effectively it treats an infection, and how safe it is.
- Trial name
- NCT04743544
- Testing
- Voriconazole
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Dokuz Eylul University
Febrile Neutropenia
Risk Factors & Outcomes for Clinically Documented Infections in Pediatric Cancer Patients With Fever & Neutropenia
The aim of the study is to identify clinical and laboratory parameters, present at the time of initial evaluation that could help predict which children with cancer, fever, and neutropenia will be at risk for developing…
- Trial name
- NCT02536599
- Where
- Egypt
- Volunteers
- 360 people
- Sponsor
- Assiut University
Acute Lymphoblastic Leukemia ALL, Childhood Cancer Survivors
Online Physical Activity and Health Counseling for Survivors of Childhood Acute Lymphoblastic Leukemia
Advances in the medical treatment of childhood acute lymphoblastic leukemia (ALL) have resulted in 5-year survival rates above 90%- however, the success is not without consequences.
- Conditions
- Acute Lymphoblastic Leukemia ALL, Childhood Cancer Survivors, Exercise, Rehabilitation Exercise
- Trial name
- OPAC-ALL (NCT07042932)
- Testing
- Exercise
- Volunteers
- 82 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ewing's Sarcoma, Rhabdomyosarcoma
A Pilot Study of Tumor-Specific Peptide Vaccination and IL-2 With or Without Autologous T Cell Transplantation in Recurrent Pediatric Sarcomas
Arm A: Peripheral blood apheresis by harvesting chemotherapy-naive T cells and populations enriched for professional APCs. T cells and APCs are separated from the apheresis product using countercurrent centrifugal elutriation and…
- Trial name
- NCT00001564
- Testing
- EF-1 Peptide, EF-2 Peptide, PXFK Peptide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
NTRK Fusion-positive Solid Tumors
Repotrectinib Post-Marketing Surveillance in Pediatric Patients With NTRK Fusion-Positive Tumors in Japan
This study will collect safety information during routine medical care for children and adolescents in Japan who have been diagnosed with NTRK fusion-positive advanced or recurrent solid tumors who start treatment with…
- Trial name
- NCT07755826
- Testing
- Repotrectinib
- Where
- 2 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Bristol-Myers Squibb
Osteosarcoma
A Phase I Feasibility And Safety Study of Fluorescein-Specific (FITC-E2) CAR T Cells In Combination With Parenterally Administered Folate-Fluorescein (UB-TT170) For Osteogenic Sarcoma
The purpose of this study is to see if a new treatment could help patients who have osteosarcoma that does not go away with treatment (is refractory) or comes back after treatment (is recurrent).This study is testing a…
- Trial name
- NCT05312411
- Testing
- SCRI-E2CAR_EGFRtv1, UB_TT170
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Seattle Children's Hospital
Indications for Laparoscopic Thoracic and Abdominal Surgery in Children, Congenital or Acquired Surgical Conditions Requiring Minimally Invasive Surgery in Children
Clinical Trial on Safety and Efficacy of Thoracoabdominal Endoscopic Surgical System for Pediatric Surgery
This is a prospective, multi-center, single-arm, target-value clinical trial conducted to evaluate the safety and effectiveness of the Thoracic and Abdominal Endoscopic Surgery System (model WJ-SR01-200) in pediatric surgical…
- Conditions
- Indications for Laparoscopic Thoracic and Abdominal Surgery in Children, Congenital or Acquired Surgical Conditions Requiring Minimally Invasive Surgery in Children, Pyeloplasty, Ureteral Reimplantation
- Trial name
- NCT07530133
- Testing
- Thoracic and Abdominal Endoscopic Surgery System
- Where
- 3 sites in China
- Volunteers
- 64 people
- Sponsor
- Hangzhou Kangji Weijing Medical Robotics Co., Ltd.
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
HEM-SURVIVE: Structuralized Follow-up for Childhood Hematological Malignancy Survivors
This study aims to construct a structuralized follow-up model for survivors of childhood hematological malignancies in China. Using a multicenter prospective cohort design, it will identify the burden and risk factors of late…
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Lymphoma, Leukemia
- Trial name
- NCT07483749
- Where
- 3 sites in China
- Volunteers
- 400 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Acute Lymphoblastic Leukemia, Pediatric
Long Non-coding RNAs and Their Role on Epigenome as Diagnostic Markers in Childhood Acute Lymphoblastic Leukemia of T Cells.
Long non-coding RNAs (lncRNAs) are a class of biomarkers of crescent interest in the hematologic and oncologic field. They do not encode proteins and can alter gene expression by acting on different steps of regulation, including…
- Trial name
- NCT06334835
- Testing
- lncRNA signature analyses
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS SYNLAB SDN
Glioma, Neuroectodermal Tumors, Primitive
Anti-Angiogenic Therapy Post Transplant (ASCR) for Pediatric Solid Tumors
The purpose of this research study is to determine whether taking either of two low dose drugs that would prevent new blood vessels from growing after stem cell transplant is feasible, and what the side effects of taking each of…
- Conditions
- Glioma, Neuroectodermal Tumors, Primitive, Wilms Tumor, Rhabdomyosarcoma
- Trial name
- ASCR (NCT01661400)
- Testing
- Metronomic Cyclophosphamide, Thalidomide
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Washington University School of Medicine
Leukemia, Pediatric Acute Lymphoblastic Leukemia
Weight Gain in Pediatric Leukemia Survivors
This is a trial assessing the efficacy of two weight maintenance programs for children with acute lymphoblastic leukemia (ALL) and the patients' caregivers.
- Conditions
- Leukemia, Pediatric Acute Lymphoblastic Leukemia, Pediatric Acute Lymphoblastic Leukemia in Remission, Pediatric Obesity
- Trial name
- NCT07374315
- Testing
- Modified Guided Self-Help Family Intervention, NIH Educational Resources, FitBit Ace
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
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