Clinical trials: Cancer Pediatric
Epilepsy, Dravet Syndrome
A Phase 2, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of TAK-935 (OV935) as an Adjunctive Therapy in Pediatric Participants With Developmental and/or Epileptic Encephalopathies
The purpose of this study is to investigate the effect on the frequency of all seizures (convulsive and drop) in participants treated with TAK-935 compared to placebo.
- Conditions
- Epilepsy, Dravet Syndrome, Lennox-Gastaut Syndrome
- Trial name
- ELEKTRA (NCT03650452)
- Testing
- TAK-935
- Where
- 44 sites in United States, Australia and 6 more
- Volunteers
- 141 people
- Sponsor
- Takeda
Acute Lymphoblastic Leukemia, Pediatric
MRD Detection by NGS in Pediatric B-ALL
This retrospective analysis aims to investigate pediatric patients with B-cell acute lymphoblastic leukemia who were detected for minimal residual disease (MRD) using next-generation sequencing (NGS).
- Trial name
- NCT05973032
- Testing
- MRD
- Where
- China
- Volunteers
- 430 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Acute Lymphoblastic Leukemia
Whole Genome Sequencing (ChromoSeq®) for Acute Lymphoblastic Leukemia (ALL) Patients
This is a prospective data collection study evaluating the feasibility of using the ChromoSeq® assay for upfront classification in a real-time clinical setting of pediatric and young patients suspected of having ALL.
- Trial name
- NCT07313592
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission
CAR-20/19-T Cells in Patients With Relapsed/Refractory B Cell ALL
This phase 1 study will evaluate the safety and efficacy of a CAR-T cell therapy directed against two B cell antigens (CD19 CD20) and produced under good manufacturing practice (GMP) conditions using the closed system CliniMACS…
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Acute Lymphoblastic Leukemia With Failed Remission, Acute Lymphoblastic Leukemia Recurrent, Acute Lymphoblastic Leukemia Not Having Achieved Remission
- Trial name
- CAR-20/19-T (NCT04049383)
- Testing
- CAR-20/19-T cells (5 x 10^5 CAR-20/19-T cells/kg), CAR-20/19-T cells (1 x10^6 CAR-20/19-T cells/kg), CAR-20/19-T cells (2.5 x10^6 CAR-20/19-T cells/kg)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Medical College of Wisconsin
COVID-19, Pediatric ALL
Symptom Patterns and Life With Longer Term COVID-19 in Children and Young People (SPLaT-19 Cohort & Qualitative Study)
Introduction: While there is a substantial body of knowledge about acute Covid-19 in children and young people (CYP), less is known about long-COVID, where symptoms continue beyond four weeks, particularly since the most recent…
- Trial name
- SPLaT-19 (NCT05422937)
- Where
- United Kingdom
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- Keele University
Pediatric Solid Tumors
Perifosine With Temsirolimus for Recurrent Pediatric Solid Tumors
The purpose of this study is to test the safety and effectiveness of 2 drugs, perifosine in combination with temsirolimus in children with solid tumors.
- Trial name
- NCT01049841
- Testing
- perifosine + temsirolimus
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Craniopharyngioma, Growth Hormone Deficiency (GHD)
Hypothalamic-Stratified Nursing Pathway for Pediatric Craniopharyngioma
The goal of this multicenter retrospective cohort study is to determine whether MRI-graded hypothalamic injury severity predicts growth-hormone deficiency (GHD) and neuropsychological morbidity in 500 children and adolescents (≤…
- Trial name
- NCT07342686
- Where
- China
- Volunteers
- 500 people
- Sponsor
- West China Hospital
Flatfoot, Pediatric ALL
Effectiveness of Subtalar Arthroereisis With Endorthesis for Pediatric Flexible Flat Foot
Pediatric flexible flatfoot is sometimes asymptomatic but it can also cause physical impairment, pain, and difficulty walking. We evaluate the radiographic effectiveness of intervention of subtalar arthroereisis with endorthesis…
- Trial name
- NCT03372642
- Testing
- Subtalar endorthesis
- Volunteers
- 60 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Childhood Acute Lymphoblastic Leukemia, Childhood Lymphoblastic Lymphoma
Exploring the Effect of Calaspargase Pegol on the Coagulation System in Pediatric Acute Lymphoblastic Leukemia (ALL) Patients: Pilot Study
This study evaluates the impact of calaspargase pegol (Cal-PEG) on the coagulation system in pediatric patients with acute lymphoblastic leukemia/lymphoma (ALL).
- Trial name
- NCT07071051
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Mayo Clinic
Childhood Cancer
FAMily Oriented Support (FAMOS): Psychosocial Intervention for Childhood Cancer Survivors and Their Families
To investigate whether a home-based psychosocial family intervention that takes place shortly after ending the primary medical treatment can help families adjust to their cancer-related psychological issues.
- Trial name
- NCT02200731
- Testing
- FAMOS: psychosocial family intervention
- Where
- Denmark
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Pernille Bidstrup
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study
This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Acute Myeloid Leukemia Post Cytotoxic Therapy, Juvenile Myelomonocytic Leukemia
- Trial name
- NCT04726241
- Testing
- Biospecimen Collection
- Where
- 184 sites in United States, Australia and 3 more
- Volunteers
- 960 people
- Sponsor
- PedAL BCU, LLC
Pain, Fear
Effect of VR on Pain, Fear and Anxiety During Accessing a Port With Huber Needle in Pediatric Cancer Patients
Virtual Reality (VR) can be used during needle-related procedures in children with cancer. The aim of this study was to investigate the effect of VR during access the venous port with Huber needle-related pain, fear and anxiety…
- Conditions
- Pain, Fear, Anxiety State
- Trial name
- NCT04093154
- Testing
- wearing the virtual headset
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Dokuz Eylul University
Magnetic Resonance Imaging, Brain Neoplasms, Childhood
Fast Brain MRI in Children With Suspected Brain Tumor
This study aims to assess the diagnostic performance of a new fast MRI sequence named Neuromix compared to routine clinical MRI for brain tumor in pediatric patients
- Conditions
- Magnetic Resonance Imaging, Brain Neoplasms, Childhood, Brain Neoplasms, Brain Tumor
- Trial name
- Fast MRI (NCT05776602)
- Testing
- Fast MRI (Neuromix)
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska University Hospital
Survivorship
Staying Healthy With Follow-up Care: A Mobile Chatbot Feasibility Study for AYA Cancer Survivors
The purpose of this project is to identify effective strategies to assist survivors of childhood and young adult cancers (diagnosed between birth and age 39) who have not returned for follow-up cancer care for 3 or more years, to…
- Trial name
- NCT05863702
- Testing
- Penny
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
CREATE: Art for Children With Cancer
This clinical trial is being done to develop and test how well creative arts interventions (drawing, painting, making sculptures) compared to watching videos can affect symptoms and impact the quality of life in children with…
- Trial name
- NCT06342453
- Testing
- Art Therapy, Discussion, Media Intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- OHSU Knight Cancer Institute
Metastatic and/or High Risk Solid Tumor of Children
Use of Specific Genetic Alteration s of Tumoral Cells Identified by the Next Generation Sequencing Techniques (NGS) to Follow Peripheral Samples of Children With Metastatic and/or High Risk Solid Tumor - NGSKids
The search for genetic alterations in primary tumor by NGS techniques followed by the detection of these alterations in circulating tumor DNA and/or CTC/DTC present in peripheral samples (blood, cerebrospinal fluid, bone marrow…
- Trial name
- NGSKids (NCT02546453)
- Testing
- Tumoral specific genetic alterations
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Institut Curie
Solid Tumor
Evaluation of [18F]FLT PET/CT as an Early Predictor of Outcome in Pediatric Solid Tumors
The experimental [18F]FLT-PET/CT will be completed before initiation of chemotherapy at either diagnosis or initiation of salvage chemotherapy at relapse and prior to the third cycle (or month) of chemotherapy.
- Trial name
- NCT03905538
- Testing
- [18F]FLT-PET/CT
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Brain Tumor
Laser Interstitial Thermal Therapy (LITT) for the Treatment of Pediatric Central Nervous System Tumors
Laser Interstitial Thermal Therapy (LITT) is a minimally invasive surgical technique that allows for biopsy and thermal ablation of brain tumors.
- Trial name
- NCT02451215
- Testing
- Laser Interstitial Thermotherapy (LITT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Neuroblastoma
Haploidentical Natural Killer (NK) Cells in Patients With Relapsed or Refractory Neuroblastoma
Primary: Evaluate safety, feasibility, persistence, and anti-tumor effect of infused haploidentical donor-derived natural killer (NK) cells and low-dose interleukin-2 (IL-2).
- Trial name
- NCT00698009
- Testing
- Fludarabine, Cyclophosphamide, Natural Killer Cell Infusion
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Myelitis, Transverse, Flaccid Paraplegia, Complete, Acute
Collaborative Assessment of Pediatric Transverse Myelitis: Understand, Reveal, Educate or CAPTURE Study
Patients and families are invited to participate in an online registry and data repository specifically for patients with transverse myelitis (TM) or acute flaccid myelitis (AFM).
- Conditions
- Myelitis, Transverse, Flaccid Paraplegia, Complete, Acute, Flaccid Paraplegia, Incomplete, Acute
- Trial name
- TMCAPTURE (NCT02144935)
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of Texas Southwestern Medical Center
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