Clinical trials: Cancer Pediatric
Pediatric Cancer, Adolescent and Young Adult Cancer
Improving Communication Between AYA Oncology Patients and Clinicians: A Patient-Centered Intervention
The overarching goal is to develop and demonstrate proof-of-concept of ReSPECT (Reproductive and Sexual Health Patient Education and Communication Tool), a multi-modal communication intervention to improve adolescent and young…
- Trial name
- NCT06982066
- Testing
- ReSPECT
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Connecticut Children's Medical Center
Recurrent Solid Tumor, Refractory Solid Tumor
ODSH + ICE Chemotherapy in Pediatric Solid Tumors
This study will be with pediatric patients who have refractory/recurrent solid tumors. They will receive standard chemotherapy (ICE) and we are investigating if the addition of a new drug, ODSH, will help to increase the time of…
- Conditions
- Recurrent Solid Tumor, Refractory Solid Tumor, Sarcoma, Wilms' Tumor
- Trial name
- NCT02164097
- Testing
- ODSH
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- New York Medical College
Neurofibromatosis 1
A Decentralized Clinical Trial to Promote Evidence-Based Care for Underserved Patients With Neurofibromatosis 1
The goal of this fully decentralized, randomized controlled trial is to compare the efficacy of two educational interventions for individuals with Neurofibromatosis 1 (NF1).
- Trial name
- NCT06262113
- Testing
- Letters about NF1 Care (Content Type 1), Letters about NF1 Care (Content Type 2)
- Where
- United States
- Volunteers
- 294 people
- Sponsor
- Massachusetts General Hospital
Leukemia (Both ALL and AML), Brain Tumors
Efficacy of a Smart Holistic Health Care Platform Intervention on Cancer Children and Parents' Bio-Psycho-Social and Spiritual Health
This multicenter randomized controlled trial aims to develop and evaluate two Smart Holistic Health Care Platforms (SHHCPs) for families of children with cancer in Taiwan: the Parent Smart Holistic Health Care Platform (P-SHHCP)…
- Trial name
- NCT07805096
- Testing
- Parent Smart Holistic Health Care Platform (P-SHHCP), Child Smart Holistic Health Care Platform (C-SHHCP)
- Where
- Taiwan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Defense Medical University, Taiwan
Participants Undergoing Anthracycline Chemotherapy
Remote Ischemic Conditioning in Oncology
This is a feasibility study at a single site, Cincinnati Children's Hospital Medical Center. Patients undergoing anthracycline chemotherapy for Hodgkin disease and soft-tissue and bone sarcoma who meet eligibility requirements…
- Trial name
- RICO (NCT04805346)
- Testing
- autoRIC®
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Relapse B Acute Lymphoblastic Leukemia, Refactory Childhood Acute Lymphoblastic Leukemia
Clinical Trial of CMD63 Chimeric Antigen Receptor T-cell (CAR T-cell) in Children With Acute Lymphoblastic Leukemia (ALL)
A Phase 1 clinical trial to evaluate the safety and early efficacy of Chimeric Antigen Receptor T-cell (CAR T-cell) with IL-7Rα signaling targeting CD19 in children with relapsed and refractory B-cell Acute Lymphoblastic Leukemia…
- Trial name
- CMD63 (NCT07078929)
- Testing
- CD19-IL7Ra CAR-T cells
- Where
- 3 sites in Thailand
- Volunteers
- 16 people
- Sponsor
- Chulalongkorn University
Diffuse Intrinsic Pontine Glioma
A Phase II Study of Pegylated Interferon Alfa 2b (PEG-Intron(Trademark)) in Children With Diffuse Pontine Gliomas
Diffuse pontine gliomas are tumors on the pons portion of the brainstem. Their peak incidence is in children between 5 and 10 years old. Their location makes surgical resection impossible.
- Trial name
- NCT00036569
- Testing
- adjuvant therapy, pegylated interferon alfa
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- National Cancer Institute (NCI)
Solid Tumors
Karenitecin in Pediatric Patients With Refractory or Recurrent Solid Tumors N10010)
This is a Phase 1, open-label, single-center, dose-escalating study in pediatric patients with refractory or recurrent solid tumors.
- Trial name
- KTN10010 (NCT00586560)
- Testing
- Kareniticin and cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Baylor College of Medicine
Acute Lymphoblastic Leukemia, Pediatric, Obesity, Pediatric
Low GI Diet in Children and Adolescents With ALL
The study aims to determine the feasibility of a 6-month low glycemic dietary intervention in children and adolescents undergoing treatment for acute lymphoblastic leukemia.
- Trial name
- NCT03157323
- Testing
- Low Glycemic Index Diet
- Where
- 5 sites in United States
- Volunteers
- 88 people
- Sponsor
- Columbia University
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Virtual Buddy Movement Therapy for Psychomotor and Social Development in Pediatric Oncology Patients in Remission
Acute lymphoblastic leukemia is the most common type of cancer in children diagnosed between the ages of two and five. After cancer treatment, children suffer from fatigue and exhaustion, and thus a decrease in daily physical…
- Trial name
- NCT07522905
- Testing
- Virtual BUDDY-Movement Therapy
- Where
- Slovakia
- Volunteers
- 24 people
- Sponsor
- Comenius University
Leukemia, Solid Tumors
Haploidentical Transplant With NK Cell Infusion for Pediatric Acute Leukemia and Solid Tumors
This study will assess the feasibility of utilizing a reduced intensity conditioning regimen, in the setting of haploidentical transplantation, for patients with recurrent acute lymphoblastic leukemia (ALL), AML and high risk or…
- Trial name
- NCT00582816
- Testing
- Clinimacs Cell Separation System, conditioning chemotherapy, DLI
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Inguinal Hernia, Indirect, Children, Only
Inflammatory Stress Response in Pediatric Inguinal Hernia Repair
Today there are various surgical techniques for inguinal hernia. In this study, investigators want to compare the ''PIRS'' operating technique laparoscopy and modified "Marcy" operating technique with open inguinal access.
- Conditions
- Inguinal Hernia, Indirect, Children, Only, Inflammatory Response, Surgery
- Trial name
- NCT03203343
- Testing
- Operation - PIRS, Operation - MARCY
- Where
- Croatia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital of Split
Compare Two Nutrition Screening Tools
Pilot Test for a Newly Developed Nutrition Screening Method: Pediatric Subjective Global Assessment
Researchers are studying ways to predict if cancer patients are at risk for poor nutrition during their chemotherapy treatment. They hope to identify children with nutrition problems early in treatment.
- Trial name
- NCT00665691
- Testing
- Nutritional Screening Tools
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- St. Jude Children's Research Hospital
Neuroblastoma, Ganglioneuroblastoma
Induction Chemoimmunotherapy for Patients With High-risk Neuroblastoma
The modern strategy of therapy of high-risk neuroblastoma, stage 4, consists of three phases - induction, consolidation and post- consolidation.
- Trial name
- NCT06071897
- Testing
- monoclonal antibodies GD2
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Pediatric Solid Tumor, Germ Cell Tumor
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults
This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of…
- Conditions
- Pediatric Solid Tumor, Germ Cell Tumor, Retinoblastoma, Hepatoblastoma
- Trial name
- NCT04483778
- Testing
- second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Seattle Children's Hospital
Leukemia, Lymphoma
CD19-specific CAR T Cells With a Fully Human Binding Domain for CD19+ Leukemia or Lymphoma
Patients with relapsed or refractory leukemia or lymphoma are often refractory to further chemotherapy. In this study, the investigators will attempt to use T cells obtained directly from the patient, which can be genetically…
- Trial name
- NCT03684889
- Testing
- SCRI-huCAR19v1, SCRI-huCAR19v2
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Seattle Children's Hospital
Glioblastoma, Diffuse Intrinsic Pontine Glioma
A Study of DSP-7888 in Pediatric Patients With Relapsed or Refractory High Grade Gliomas
This is a phase 1/2, uncontrolled, open-label, multicenter study in patients with recurrent and relapsed diffuse intrinsic pontine glioma, glioblastoma, or grade III or IV glioma.
- Trial name
- NCT02750891
- Testing
- DSP-7888
- Where
- 6 sites in Japan
- Volunteers
- 18 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Pain, Pediatric Oncology
Does the Level of Pain in Pediatric Oncology Patients Affect the Level of Psychological Resilience in Parents?
Resilience is defined as generating coping strategies for the problems and situations that individuals face throughout their lives and developing these strategies in each new situation.
- Conditions
- Pain, Pediatric Oncology, Psychological Resilience
- Trial name
- NCT06445816
- Testing
- chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Gelisim University
Central Nervous System Tumor
Longitudinal Study of Biomarkers
Biomarkers are small molecules that can be detected in the body fluids of patients; they often correlate with the presence of a cancer. MicroRNAs and proteins are small molecules which have recently been discovered in cells.
- Trial name
- NCT01595126
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Acute Lymphoblastic Leukemia, Pediatric
Physical Exercise and Dairy Probiotics in Childhood Cancer Survivors
The goal of this clinical trial is to to compare the structure of the intestinal microbiome between children shortly after treatment for acute lymphoblastic leukemia (1-3 years after cancer treatment) and healthy controls.
- Trial name
- Exerbioall (NCT05939791)
- Testing
- Lacticaseibacillus paracasei subsp. Paracasei CNCMI-1518, Physical exercise
- Where
- Slovakia
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Comenius University
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