Clinical trials: Cancer Pelvis
Locally Advanced Cervical Carcinoma
HYpofractionated Pelvic Radiotherapy for Advanced Cervical Cancers INeligible for ChemoTherapy
BACKGROUND: For patients with locally advanced cervical cancer (LACC) ineligible for concurrent chemotherapy, radiotherapy (RT) alone achieves complete response rate (CRR) <70% and long-term locoregional control (LRC) <62%.
- Trial name
- HYACINCT (NCT05210270)
- Testing
- Hypofractionation
- Volunteers
- 55 people
- Sponsor
- University of Santo Tomas Hospital, Philippines
Liver Metastasis, Pelvic Cancer
Photodynamic Therapy System for Patients With Refractory/Unresponsive Solid Tumors
This multi-center photodynamic therapy study plans to treat patients with large tumors in any superficial location, sarcoma, tumors of oral/oro-pharyngeal cavity, tumors with extensive pelvic involvement, or liver metastasis.
- Conditions
- Liver Metastasis, Pelvic Cancer, Head and Neck Cancer, Sarcoma
- Trial name
- NCT00028405
- Testing
- LS 11(Taporfin Sodium), Lumaflex Light Delivery Catheter
- Where
- 6 sites in United States
- Volunteers
- 48 people
- Sponsor
- Light Sciences LLC
Prostate Cancer, Urinary Incontinence
Pre-Operative Nurse-Led Education With Direct Physiotherapy Referral to Reduce Post-Prostatectomy Incontinence
Urinary incontinence is a common complication following radical prostatectomy and can significantly impact quality of life. Pelvic floor physiotherapy is recommended to reduce post-operative incontinence; however, referral…
- Conditions
- Prostate Cancer, Urinary Incontinence, Postoperative Complications, Radical Prostatectomy
- Trial name
- PRO-ACT (NCT07426861)
- Testing
- Standard Pre-Operative Education and Physiotherapy Recommendation, Pre-Operative Nurse-Led Education with Direct Physiotherapy Referral
- Where
- Ireland
- Volunteers
- 80 people
- Sponsor
- Royal College of Surgeons, Ireland
Cervical Cancer
Inactivated KAWAI Bacteria for Diarrhea Prevention During Pelvic Radiotherapy in Postoperative Cervical Cancer
This is a multicenter, randomized, double-blind, placebo-controlled study. The purpose of this study is to evaluate whether an oral probiotic supplement (KAWAI inactivated bacteria) can reduce the side effects (especially…
- Trial name
- NCT07900477
- Testing
- KAWAI powder
- Volunteers
- 100 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Carcinoma of the Endometrium, Hysterectomy
Lymphedema After Primary Surgery for Endometrial Cancer
The purposes of this study are to determine the prevalence, size and impact on quality of life of lymphedema of the lower extremities after primary radical surgery with hysterectomy +/- pelvic - and paraaortic lymphadenectomy in…
- Conditions
- Carcinoma of the Endometrium, Hysterectomy, Lymphadenectomy
- Trial name
- LASEC (NCT02115477)
- Testing
- Lymphadenectomy
- Where
- 16 sites in Sweden
- Volunteers
- 262 people
- Sponsor
- Preben Kjolhede, MD, professor
Localized Renal Pelvis and Ureter Urothelial Carcinoma, Locally Advanced Bladder Urothelial Carcinoma
Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer
This phase III trial studies how well pembrolizumab works in treating patients with bladder cancer that has spread into the deep muscle of the bladder wall (muscle-invasive) or urothelial cancer that has spread from where it…
- Conditions
- Localized Renal Pelvis and Ureter Urothelial Carcinoma, Locally Advanced Bladder Urothelial Carcinoma, Locally Advanced Renal Pelvis and Ureter Urothelial Carcinoma, Locally Advanced Ureter Urothelial Carcinoma
- Trial name
- AMBASSADOR (NCT03244384)
- Testing
- Biospecimen Collection, Clinical Observation, Computed Tomography
- Where
- 914 sites in United States, Guam
- Volunteers
- 739 people
- Sponsor
- National Cancer Institute (NCI)
Pelvis Neoplasms
Pelvis Adaptive Radiotherapy (ART)
Pelvis Adaptive radiotherapy (ART) is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for cancer patients having radiotherapy in the pelvic region.
- Trial name
- Pelvis ART (NCT06650033)
- Testing
- Adaptive radiotherapy +/- margin reduction, Image guided radiotherapy
- Where
- Australia
- Volunteers
- 280 people
- Sponsor
- Royal North Shore Hospital
Urothelial Cancer (Urinary Bladder, Ureters, or Renal Pelvis Cancer)
Study of Regorafenib for Urothelial Cancer Following Chemotherapy (UAB 1477)
This study will test how well Regorafenib controls disease progression in urothelial cancer (cancer occurring in the urinary bladder, ureters, or renal pelvis) following previous therapy with chemotherapy.
- Trial name
- NCT02459119
- Testing
- Regorafenib
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Alabama at Birmingham
Endometrial Cancer
Systematic Pelvic Lymphadenectomy Versus no Lymphadenectomy in Clinical Stage I-II Endometrial Cancer
The purpose of this trial is to determine whether the addition of systematic pelvic lymphadenectomy to hysterectomy with bilateral adnexectomy improves disease-free survival (DFS) and overall survival (OS) in patients with…
- Trial name
- NCT00482300
- Testing
- Systematic pelvic lymphadenectomy
- Sponsor
- University of Roma La Sapienza
Rectal Carcinoma
PR in Endoscopic LAR for Rectal Cancer
The anastomotic leakage remains the major early complication after laparoscopic anterior resection(LAR) for medium \& low rectal cancer.
- Trial name
- NCT04078828
- Testing
- Pelvic floor Reconstruction
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southwest Hospital, China
Ureteral Neoplasms
Lymphadenectomy in Urothelial Carcinoma
Two out of three tumours in the upper urinary tract are located in the renal pelvis. Muscle-invasive urothelial carcinoma is probably more common among tumours in the upper urinary tract compared to tumours in the urinary…
- Trial name
- NCT02607709
- Testing
- Lymphadenectomy in conjugation with nephroureterectomy, Nephroureterectomy without lymphadenectomy
- Where
- Denmark
- Volunteers
- 366 people
- Sponsor
- Zealand University Hospital
Prostate Cancer
Prostate Radiation Therapy or Short-Term Androgen Deprivation Therapy and Pelvic Lymph Node Radiation Therapy With or Without Prostate Radiation Therapy in Treating Patients With a Rising Prostate Specific Antigen (PSA) After Surgery for Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Androgens can cause the growth of prostate cancer cells.
- Trial name
- NCT00567580
- Testing
- PBRT, PLNRT, AA
- Where
- 460 sites in United States, Canada and 2 more
- Volunteers
- 1,792 people
- Sponsor
- Radiation Therapy Oncology Group
Cervical Cancer Treated with Pelvic Radiotherapy, Cervical Cancers
Establishment and Validation of Prediction Model of Simultaneous Chemoradiotherapy for Cervical Cancer Organoids
This is a single-arm, single-center, open-label, Phase II study aimed at assessing the efficacy of organoids in predicting the response to radiotherapy and chemotherapy in cervical cancer
- Trial name
- ECCO (NCT06786780)
- Testing
- Drug: Cisplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chongqing University Cancer Hospital
Endometrial Cancer, Cervical Cancer
Evaluation of Indocyanine Green-guided Systematic Pelvic Lymphadenectomy in Endometrial and Cervical Cancer
The lymph nodes involvement is one of the most important prognostic factors in endometrial (EC) and cervical cancer (CC). Indeed, the lymph node involvement in cancer patients modifies the International Federation of Gynecology…
- Trial name
- NCT04246580
- Testing
- Indocyanine green-guided systematic pelvic lymphadenectomy
- Volunteers
- 230 people
- Sponsor
- Università degli Studi dell'Insubria
Uterine Neoplasms, Cervix Neoplasms
Combidex USPIO - Ultra-small Superparamagnetic Iron Oxide
The purpose of this study is to test whether or not a new contrast agent called Combidex, a contrast agent formulated from ultra-small superparamagnetic iron oxide (USPIO) improves the ability of Magnetic Resonance Imaging (MRI)…
- Conditions
- Uterine Neoplasms, Cervix Neoplasms, Bladder Neoplasms, Prostatic Neoplasms
- Trial name
- NCT00188695
- Testing
- MRI contrast agent Combidex (ferumoxtran-10)
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University Health Network, Toronto
Osteosarcoma
Osteosarcoma in Patients Older Than 40 Years. Prognostic Factors and Survival
The purpose of this work is to carry out an exhaustive analysis of the characteristics of osteosarcoma in patients with an age equal to or greater than 40 years, in the Hospital de la Santa Creu and Sant Pau in Barcelona, during…
- Trial name
- NCT03911245
- Testing
- Retrospective study. Analyze of data in medical records
- Where
- Spain
- Volunteers
- 195 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Gynecologic Cancer
Identification and Prevention of Pelvic Floor Dysfunction in Gynecologic Cancer Survivors
The two goals of this study are to establish a standardized method of assessing the pelvic floor for patients undergoing pelvic radiation and to determine the feasibility of inverse-RT planning using MRI to identify dosimetric…
- Trial name
- NCT05769062
- Testing
- Single digit pelvic exam
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Washington University School of Medicine
Colon Cancer, Inflammatory Bowel Diseases
Functional Restoration After Abdominal and Pelvic Laparoscopic Surgery: Effect of Perioperative Intravenous Lidocaine
This is a blinded randomized controlled trial in patients undergoing laparoscopic colon surgery. The aim of this study is to assess whether perioperative intravenous lidocaine has an impact on the early post operative physical…
- Conditions
- Colon Cancer, Inflammatory Bowel Diseases, Diverticulitis
- Trial name
- NCT00982618
- Testing
- Lidocaine, Epidural Block, PCA Morphine
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Metastatic Solid Tumor, Recurrent Solid Tumor
A Study of LY4101174 in Participants With Recurrent, Advanced or Metastatic Solid Tumors
The purpose of this study is to find out whether the study drug, LY4101174, is safe, tolerable and effective in participants with select advanced or metastatic solid tumors.
- Conditions
- Metastatic Solid Tumor, Recurrent Solid Tumor, Advanced Solid Tumor, Urinary Bladder Neoplasm
- Trial name
- EXCEED (NCT06238479)
- Testing
- LY4101174
- Where
- 28 sites in United States, Australia and 5 more
- Volunteers
- 490 people
- Sponsor
- Eli Lilly and Company
Prostate Cancer
Hemopatch to Prevent Lymphatic Leak After Robotic Prostatectomy and Pelvic Lymph Node Dissection
Robotic prostatectomy (RARP) is a surgery for treatment localized prostate cancer. Bilateral pelvic lymph node dissection (BPLND) will also be performed if there is an estimated risk of occult nodal metastases exceeding 5%.
- Trial name
- NCT04185922
- Testing
- Hemopatch
- Where
- Hong Kong
- Volunteers
- 32 people
- Sponsor
- Chinese University of Hong Kong