Clinical trials: Cancer Progression
Radiation Injury, Radiation Necrosis
Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2*
Using a multi-echo gradient echo sequence to calculate R2* and quantitative susceptibility maps and well as susceptibility-weighted imaging post processing the investigators hypothesize that the investigators would be able to…
- Trial name
- NCT02212964
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Centre for Functional and Metabolic Mapping
Alzheimer Disease
Effect of Indomethacin on the Progression of Alzheimer's Disease
The purpose of this study is determine whether indomethacin is able to retard disease progression in patients with mild to moderate Alzheimer's disease.
- Trial name
- NCT00432081
- Testing
- indomethacin
- Where
- 2 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Radboud University Medical Center
Myopic Progression
Monthly Replacement Orthokeratology for Myopia Control in Young Children
The two-year prospective study aims at investigating frequently replacement effect on myopia control in young children, and the use of weekly protein removal system in monthly replacement modality orthokeratology lenses on…
- Trial name
- MR2 (NCT04293328)
- Testing
- orthokeratology, Menicon Progent A+B
- Where
- Hong Kong
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Parkinson Disease
LRRK2 Activity and Markers of Parkinson's Disease in G2385R Carriers
The goals of this study are 1. To compare the functional effects of the LRRK2 G2385R variant among carriers with and without Parkinson's disease (PD) and non-carriers with and without PD 2.
- Trial name
- NCT04349865
- Where
- China
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- Xuanwu Hospital, Beijing
Demineralization, Tooth, Demineralization, Fissure
Compariing a Bioactive Resin Material Used As A Fissure Sealant To A Conventional Resin
The aim of this study is to investigate the retention, marginal integrity and potential to prevent lesion progression of a bioactive resin material compared to a conventional resin-based flowable composite during management of…
- Conditions
- Demineralization, Tooth, Demineralization, Fissure, Non-Cavitated Caries
- Trial name
- NCT04052802
- Testing
- Fissure sealing
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polycystic Kidney, Autosomal Dominant
Effect of Statin Therapy on Disease Progression in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
The purpose of this study is to determine whether the medication pravastatin will ameliorate renal and cardiovascular disease over a 3-year period in children and young adults with autosomal dominant polycystic kidney disease…
- Trial name
- NCT00456365
- Testing
- pravastatin
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Colorado, Denver
Glaucoma
The Study of Ocular Hemodynamics With Glaucoma Progression
To determine the relationships between ocular hemodynamics and glaucomatous optic neuropathy progression.
- Trial name
- IGPS (NCT01145911)
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Indiana University
Alzheimer Disease, Dementia
Cognitive Impairment Cohort Study of the Elderly Population in SheMountain
This study is a prospective observational study, which involves a cohort of 2000 all-sex and all-ethnic people aged 60 years and above with permanent residence in Tianma area, SheMountain Town, Songjiang District (suburban area)…
- Conditions
- Alzheimer Disease, Dementia, Neurodegenerative Diseases, Cognitive Impairment
- Trial name
- SheMountain (NCT05667935)
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Osteoarthritis, Knee
Telerehabilitation Gait Modification
Excessive knee joint loads during walking can contribute to knee osteoarthritis progression. Changing the rotation of the foot (in-toeing or out-toeing) while walking can lower knee joint loads and improve pain and function.
- Trial name
- TELEMOD (NCT04683913)
- Testing
- Foot rotation modification, Waiting Period - Delayed Group
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Prostate Cancer
R-Flurbiprofen in Treating Patients With Localized Prostate Cancer at Risk of Recurrence
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. R-flurbiprofen may be effective in delaying the recurrence of localized prostate cancer.
- Trial name
- NCT00045123
- Testing
- tarenflurbil, adjuvant therapy
- Where
- 58 sites in United States
- Sponsor
- Myrexis Inc.
Chronic Obstructive Pulmonary Disease
Imaging Progression of Chronic Obstructive Pulmonary Disease Using MRI and CT (MR-COPDII)
In this follow-up trial, MRI and CT images of the lung will be acquired prospectively in a subcohort of 370 patients, three years after they successfully participated in the first COSYCONET subtrial with CT and MRI ("MR-COPD I"…
- Trial name
- MR-COPDII (NCT03591562)
- Where
- 10 sites in Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Heidelberg
Endometrial Cancer
Biomarkers for Diagnosis and Prognosis of Endometrial Carcinoma
Endometrial cancer (EC) is the most frequent gynecological malignancy but there is currently lack of both non-invasive diagnostic tools and novel markers to stratify patients based on their risk of future recurrence.
- Trial name
- BioEndoCar (NCT03553589)
- Testing
- Blood sampling
- Where
- 5 sites in Netherlands, Poland and 1 more
- Volunteers
- 400 people
- Sponsor
- Andrea Romano
Coronary Arterial Disease (CAD), Erectile Dysfunction
Erectile Dysfunction Progression After Percutaneous Coronary Angiography: Is Residual SYNTAX Score a Predictive Marker
Participant Information Sheet Dear Participant, Investigators would like to invite participants to participate in a research study and explain what it involves.
- Trial name
- NCT07010913
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kırıkkale University
Labor Pain
The Effect of Metrics Based Performance Based Progression in Provision of Labor Epidural Analgesia
Procedural skills are an important determinant of clinical outcomes for certain patient groups. Training for procedural skills in the medical profession is still largely based on an apprenticeship model.
- Trial name
- NCT02185079
- Testing
- Training to proficiency, Conventional training
- Where
- Ireland
- Volunteers
- 16 people
- Sponsor
- Cork University Hospital
Rectal Neoplasms
Predicting RadIotherapy ReSponse of Rectal Cancer With MRI and PET
The purpose of this study is to investigate if PET/CT and MRI scans performed early in treatment and six weeks after treatment can predict the response of rectal cancer following chemotherapy and radiotherapy.
- Trial name
- PRISM (NCT02233374)
- Testing
- Early MRI and PET/CT - 2 weeks after commencing chemo/RT, Late MRI and PET/CT 6 weeks post chemo/RT
- Where
- Australia
- Volunteers
- 27 people
- Sponsor
- Royal North Shore Hospital
HIV Infections
A Randomized Trial of the Efficacy and Safety of a Strategy of Starting With Nelfinavir Versus Ritonavir Added to Background Antiretroviral (AR) Nucleoside Therapy in HIV-Infected Individuals With CD4+ Cell Counts Less Than or Equal to 200/mm3
To compare nelfinavir (NFV) with ritonavir (RTV) for delaying disease progression or death in HIV-infected patients with CD4+ cell counts less than 100 cells/mm3 [AS PER AMENDMENT 3/11/98: less than or equal to 200 cells/mm3].
- Trial name
- NCT00000859
- Testing
- Indinavir sulfate, Ritonavir, Nelfinavir mesylate
- Where
- 44 sites in United States, Canada
- Volunteers
- 1,300 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Actinic Keratosis
Long-term Effects of Imiquimod and Diclofenac in Actinic Keratoses (LEIDA 2)
This clinical trial serves the purpose to compare the long-term effects of a treatment of actinic keratosis - your skin disorder - using Aldara® 5% cream (Imiquimod) or Solaraze® 3% gel (Diclofenac) on the face or the scalp.
- Trial name
- LEIDA 2 (NCT01453179)
- Testing
- Imiquimod, Diclofenac
- Where
- 17 sites in Austria, Germany
- Volunteers
- 221 people
- Sponsor
- MEDA Pharma GmbH & Co. KG
Breast Neoplasms
Comparative Analysis of the Efficacies in Neoadjuvant Chemotherapy of Breast Cancer
The purpose of this study is to compare the short-term and long-term efficacies and the safeties of pirarubicin plus docetaxel(AT group) and pirarubicin plus cyclophosphamide followed by docetaxel(AC-T group) in neoadjuvant…
- Trial name
- NCT02613026
- Testing
- Pirarubicin, Docetaxel, Cyclophosphamide
- Where
- 5 sites in China
- Volunteers
- 104 people
- Sponsor
- 307 Hospital of PLA
Parkinson Disease (PD), Gut Microbiota
Developing Precision Microbiota-Based Cocktail Modification Therapy to Delay the Progression of Parkinson's Disease (PD) - Use Preclinical Human Trials to Confirm the Impact of the Optimal "Probiotic Y7, Tryptophan and Branched-chain Amino Acid" Cocktail Formula on Early Stage PD Patients
Preclinical human trials will be utilized to validate the research direction, followed by clinical trials to assess the impact of a cocktail formula product containing the optimal probiotic Y7 combined metabolites on motor…
- Conditions
- Parkinson Disease (PD), Gut Microbiota, Probiotic
- Trial name
- NCT07619560
- Testing
- Y7
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei Medical University
Non-Alcoholic Fatty Liver Disease
MRI and Stable Isotope Tracer Studies for Detecting the Progression of Non-Alcoholic Steatohepatitis (NASH)
One-third of the world's population suffers from Non-Alcoholic Fatty Liver Disease (NAFLD), that is a disease with an accumulation of fat in the liver.
- Trial name
- MRI-Detect (NCT04227782)
- Testing
- Magnetic Resonance Imaging, Stable Isotope Study
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
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