Clinical trials: Cancer Progression
B-Cell Prolymphocytic Leukemia, Hypodiploidy
Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia
This phase II trial studies autologous peripheral blood stem cell transplant followed by donor bone marrow transplant in treating patients with high-risk Hodgkin lymphoma, non-Hodgkin lymphoma, multiple myeloma, or chronic…
- Conditions
- B-Cell Prolymphocytic Leukemia, Hypodiploidy, Loss of Chromosome 17p, Plasma Cell Leukemia
- Trial name
- NCT01008462
- Testing
- Allogeneic Bone Marrow Transplantation, Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer
Low Dose Metronomic Poly-chemotherapy for Metastatic CRC
This study investigates the activity of a new regimen of treatment for patients with metastatic colorectal carcinoma. This includes a combination of well-known chemotherapy agents and anti-inflammatory agents, when administered…
- Trial name
- LDMchemoCRC (NCT02280694)
- Testing
- Capecitabine, Cyclophosphamide, Methotrexate
- Where
- Israel
- Volunteers
- 45 people
- Sponsor
- HaEmek Medical Center, Israel
Ewing Sarcoma, Sarcoma
Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma
Background: Mithramycin is a drug that was first tested as a cancer therapy in the 1960s. It acted against some forms of cancer, but was never accepted as a treatment.
- Trial name
- NCT01610570
- Testing
- Mithramycin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Colorectal Liver Metastasis (CRLM)
Ablation With Systemic Therapy vs Liver Resection With Systemic Therapy for Colorectal Liver Metastasis
For patients with colorectal liver metastases (CRLM) ≤5 cm, Clinical guidelines recommend surgery, but a growing number of studies have shown that thermal ablation is as effective as surgery.
- Trial name
- ASRS-CRLM (NCT07559851)
- Testing
- ablation combined with systemic therapy, liver resection combined with systemic therapy
- Where
- China
- Volunteers
- 151 people
- Sponsor
- The First Hospital of Jilin University
Hypertension
SAPPHIRe III in Taiwan-Progression Evaluation and Cardiovascular Outcomes of Hypertensive Families
The purpose of this study is to determine the progression evaluation, cardiovascular outcomes, and genetic determinations of hypertension in Chinese
- Trial name
- NCT00631956
- Where
- Taiwan
- Volunteers
- 1,038 people
- Sponsor
- National Health Research Institutes, Taiwan
Sars-CoV2, COVID-19
Home Pulse Oximeter Use in Patients With COVID-19
The purpose of this study is to investigate the use of home pulse oximetry monitoring in patients with COVID-19 to trend disease progression and identify need for hospitalization.
- Conditions
- Sars-CoV2, COVID-19, COVID
- Trial name
- NCT04373161
- Testing
- Home Pulse Oximetry Monitoring
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Swedish Hospital
Alzheimer's Disease
Study of MK0677 for the Treatment of Alzheimer's Disease (0677-030)(COMPLETED)
An investigational drug (MK0677) will be studied to determine whether it helps the memory and cognition of patients with Alzheimer's Disease.
- Trial name
- NCT00074529
- Testing
- MK0677
- Volunteers
- 512 people
- Sponsor
- Merck Sharp & Dohme LLC
Stage I Prostate Adenocarcinoma AJCC v7, Stage II Prostate Adenocarcinoma AJCC v7
PROSTVAC (PSA-TRICOM) in Preventing Disease Progression in Patients With Localized Prostate Cancer Undergoing Active Surveillance
This randomized phase II trial studies how well PROSTVAC (prostate-specific antigen [PSA]-TRICOM) works in preventing disease progression in patients with prostate cancer undergoing active surveillance.
- Trial name
- NCT02326805
- Testing
- Laboratory Biomarker Analysis, Rilimogene Galvacirepvec
- Where
- 7 sites in United States
- Volunteers
- 154 people
- Sponsor
- National Cancer Institute (NCI)
COVID19
Using Biovitals® Sentinel to Monitor Disease Progression in Subjects Quarantined for Suspected COVID-19
The novel coronavirus (COVID-19) emerged in December 2019, and in mere months has spread to more than 104 countries, resulting in an outbreak of viral pneumonia worldwide.
- Trial name
- NCT04343794
- Testing
- BIOVITALS
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- The University of Hong Kong
Chronic Kidney Disease
Kremezin Study Against Renal Disease Progression in Korea
1. To evaluate the effectiveness of AST-120 (spherical carbon adsorbent) added to standard-of-care therapy in moderate to severe Chronic Kidney Disease (CKD III-IV), on time to first occurrence of any event of the triple…
- Trial name
- K-STAR (NCT00860431)
- Testing
- AST-120
- Where
- South Korea
- Volunteers
- 578 people
- Sponsor
- Seoul National University Hospital
Colorectal Cancer
A Study of Avastin (Bevacizumab) in Combination Chemotherapy in Patients With Metastatic Cancer of the Colon or Rectum
A study of Avastin (bevacizumab) in combination chemotherapy in patients with metastatic cancer of the colon or rectum. The anticipated time on study treatment is until disease progression.
- Trial name
- NCT01131078
- Testing
- Bevacizumab [Avastin], Capecitabine, Irinotecan
- Where
- 44 sites in Italy
- Volunteers
- 306 people
- Sponsor
- Hoffmann-La Roche
Atrial Fibrillation
Reappraisal of Atrial Fibrillation: RACE-V - Work Package 5
In the proposed study the investigators aim to clarify the relative contribution of these different mechanisms to the progression of atrial fibrillation (AF).
- Trial name
- RACE V- WP 5 (NCT03124576)
- Testing
- Implantable loop recorder
- Where
- Netherlands
- Volunteers
- 380 people
- Sponsor
- Academisch Ziekenhuis Maastricht
Parkinson Disease, Neurological Disorders
Amyloid Beta and Cognition in Parkinson Disease
The investigators propose to study persons with Parkinson Disease (PD) with detailed clinical, cognitive and imaging at the time of study entry and repeat these assessments 2 years later.
- Trial name
- NCT01754168
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Colorectal Cancer
Irinotecan Hydrochloride and Cetuximab With or Without Ramucirumab in Treating Patients With Advanced Colorectal Cancer With Progressive Disease After Treatment With Bevacizumab-Containing Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01079780
- Testing
- cetuximab, ramucirumab, irinotecan hydrochloride
- Where
- 255 sites in United States
- Volunteers
- 136 people
- Sponsor
- Eastern Cooperative Oncology Group
Pancreatic Cancer, Metastatic, PDAC - Pancreatic Ductal Adenocarcinoma
A Clinical Trial to Evaluate EDV Nanocell Therapy With Gemcitabine and Nab-paclitaxel in Pancreatic Cancer
The purpose of this study is to evaluate the safety and tolerability and overall survival (OS) of E-EDV-D682/GC in combination with gemcitabine and nab-paclitaxel versus gemcitabine and nab-paclitaxel alone in participants with…
- Trial name
- Carolyn-USA (NCT07049055)
- Testing
- E-EDV-D682, EDV-GC, Gemcitabine
- Where
- 4 sites in United States
- Volunteers
- 144 people
- Sponsor
- Engeneic Pty Limited
Erectile Dysfunction, Depression
Depression, Illness Perception, and Erectile Dysfunction Outcomes
The goal of this observational study is to evaluate the impact of illness perception and depressive symptoms on treatment outcomes in adult male patients diagnosed with erectile dysfunction (ED).
- Conditions
- Erectile Dysfunction, Depression, Perception and Beliefs
- Trial name
- NCT06996925
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Haseki Training and Research Hospital
Prostatic Neoplasms, Low Grade Prostate Cancer
Molecular Mechanisms of Dutasteride and Dietary Interventions to Prevent Prostate Cancer and Reduce Its Progression
The purpose of this study is to determine whether marine omega-3 fatty acids and 5-alpha-reductase inhibitor are effective in the progression of prostate cancer for low-risk prostate cancer patients.
- Trial name
- NCT01653925
- Testing
- Dietary intervention first, Drug (Dutasteride) intervention first
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- CHU de Quebec-Universite Laval
Chronic Kidney Disease
Effects of Low Protein Diet Supplemented Keto-/Amino Acid in Preventing the Progression of Chronic Kidney Disease (CKD)- ELPD Study
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 3b and 4).
- Trial name
- ELPD-CKD (NCT01418508)
- Testing
- low protein diet plus α-keto acid, very low protein diet plus α-keto acid
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Breast Cancer
Markers for Breast Cancer
This study will analyze blood samples to identify substances that are associated with the development of breast cancer. It will determine if: Women who are diagnosed with a benign breast condition that is related to a…
- Trial name
- NCT00339248
- Where
- United States
- Volunteers
- 2,632 people
- Sponsor
- National Cancer Institute (NCI)
Parkinson Disease
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease
Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to…
- Trial name
- ICEBERG (NCT02305147)
- Testing
- Clinical, biological and imaging followup
- Where
- France
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.