Clinical trials: Cancer Progression
Alzheimer's Disease
Delaying the Progression of Driving Impairment in Individuals With Mild Alzheimer's Disease
The purpose of the study is to determine whether memantine delays the progression of driving impairment in patients with mild Alzheimer's Disease (AD).
- Trial name
- NCT00476008
- Testing
- Memantine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida Atlantic University
Metastatic Castration-resistant Prostate Cancer
XL092 in Patients With Metastatic Castration-Resistant Prostate Cancer
The purpose of this study is to determine how well the study drug XL092 is helping to treat a participant's cancer after 16 weeks of treatment.
- Trial name
- PRO-XL (NCT06568562)
- Testing
- XL092
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Utah
Biomarkers
DIGIPREDICT-Physio-DE
The study aims to investigate short-term physiological and biochemical inflammatory and cardiocirculatory biomarker kinetics in heart failure patients, using the DIGIPREDICT Physiopatch device - an investigational device that…
- Trial name
- NCT05886569
- Testing
- DIGIPREDICT Physiopatech
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Metastatic Breast Cancer
Pembrolizumab + Paclitaxel in HR+/HER2- Non-luminal (by PAM50) Advanced Breast Cancer After CDK4/6 Inhibitor Progression
This is an open-label, single arm, multicenter phase II study evaluating treatment with pembrolizumab in combination with paclitaxel in patients with locally advanced or metastatic non-luminal hormone receptor-positive (HR+)…
- Trial name
- TATEN (NCT04251169)
- Testing
- Pembrolizumab, Paclitaxel
- Where
- 7 sites in Spain
- Volunteers
- 20 people
- Sponsor
- SOLTI Breast Cancer Research Group
Glomerulonephritis, Immunoglobulin A (IgA)
Beginning of Effective and Safe Treatment in Immunoglobulin A-1 Nephropathy-1
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. IgAN is progressive, particularly when patients have a significant proteinuria (proteinuria >1g/g creatinine), impaired kidney function, or…
- Trial name
- BEST-IgAN-1 (NCT03357653)
- Testing
- Losartan group
- Volunteers
- 174 people
- Sponsor
- Ewha Womans University
Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer
Rociletinib Genomic Landscape in Non-small Cell Lung Cancer (NSCLC)
Though patients whose tumors harbor EGFR T790M mutation appear to benefit from rociletinib, there is a need to understand the molecular mechanisms that lead to primary and acquired resistance to rociletinib.
- Conditions
- Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer
- Trial name
- NCT02705339
- Testing
- Rociletinib, Biopsy, Blood draw
- Sponsor
- Washington University School of Medicine
Facioscapulohumeral Muscular Dystrophy Type 2
An 18-month Prospective Natural History Study to Gain Insight Into FSHD2 Pathophysiology and Disease Progression
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common inherited myopathies in adults. It is associated with genetic and epigenetic deregulation of the D4Z4 locus on the sub-telomeric region of chromosome 4q35…
- Trial name
- INSIGHT FSHD2 (NCT06079567)
- Testing
- Validation of new COMs for FSHD2 patients
- Where
- 9 sites in Belgium, France and 3 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Cancer
Demographics, Clinical Outcomes, and Physician Attitudes in Patients Who Have Received The MiCK Assay (CorrectChemo)
Recently an automated test for measuring cancer cell death in the presence of chemotherapy has been developed. This test has been called the MiCK assay during the ten year development phase and is now called Correct Chemo.
- Trial name
- NCT02137811
- Testing
- MICK Assay
- Where
- 2 sites in United States, Canada
- Sponsor
- Pierian Biosciences
Akut Kidney Injury
The Role of Furosemide Stress Test in the Intensive Care Clinic
AKI causes high mortality and morbidity, especially in critically ill patients, and prolongs the patient's stay in the intensive care unit.
- Trial name
- NCT06765031
- Testing
- Furosemide
- Where
- Turkey (Türkiye)
- Volunteers
- 121 people
- Sponsor
- Gulhane Training and Research Hospital
Diabetic Kidney Disease, Potassium Imbalance
Impact of Long-term Serum Magnesium and Potassium Levels Optimization and Multifactorial Adherence Intervention on the Progression of Diabetic Kidney Disease.
Insufficient clinical evidence correlates the progression of diabetic kidney disease with electrolyte homeostasis in patients diagnosed with type 2 diabetes mellitus (T2DM), especially in the United Arab Emirates (UAE) population…
- Conditions
- Diabetic Kidney Disease, Potassium Imbalance, Magnesium Deficiency
- Trial name
- NCT04942119
- Testing
- Multifactorial intervention
- Where
- United Arab Emirates
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Labor, Obstetric, Epidural Analgesia, Obstetric
Integrated Intrapartum Supportive Care and Pushing Strategies in Women Receiving Low-Dose Epidural Analgesia
This prospective, three-arm, non-randomized quasi-experimental study aims to evaluate integrated intrapartum supportive care combined with different pushing strategies among women at 37-42 weeks of gestation who receive low-dose…
- Conditions
- Labor, Obstetric, Epidural Analgesia, Obstetric, Labor Duration
- Trial name
- NCT07663500
- Testing
- Integrated Care with Immediate Pushing, Integrated Care with Spontaneous Pushing Group, Standard Routine Care
- Where
- Taiwan
- Volunteers
- 159 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Heart Failure With Preserved Ejection Fraction
Heart Failure and Preserved Ejection Fraction: Observation of Its Progression and Prognosis (HOPP-BERN)
Analysis of longitudinal data, cardiovascular magnetic resonance (CMR) imaging and health related data, of patients with heart failure and preserved ejection fraction (HFpEF) over a timeframe of 5 years per patient.
- Trial name
- HOPP-BERN (NCT04395846)
- Where
- Switzerland
- Volunteers
- 350 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetic Retinopathy
Evaluation of Progression of Diabetic Retinopathy With Rapid Correction of Hyperglycemia
The investigators are doing this research for two reasons. The first is to see how the retina (back of your eye) changes when your blood sugar is treated with medication for the first time.
- Trial name
- NCT02326259
- Testing
- Initiation of treatment of diabetes
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Castration-resistant Prostate Cancer
GZ17-6.02 in Advanced CRPC After Progression on Anti-Androgen Therapy
The purpose of this clinical trial is to determine if GZ17-6.02 delays progression of castration-resistant prostate cancer.
- Trial name
- NCT06636123
- Testing
- Investigational Agent Administration
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Hepatitis C, Chronic
Evaluation of Irbesartan on Hepatic Fibrosis in Chronic Hepatitis C
The purpose of this study is to examine the efficacy of irbesartan on the progression of liver fibrosis in adult patients with chronic hepatitis C. The expected total enrollment is 200 patients.
- Trial name
- Fibrosar (NCT00265642)
- Testing
- Irbesartan
- Where
- France
- Volunteers
- 166 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Clinically Isolated Syndrome, Relapsing-Remitting Multiple Sclerosis
Mitochondrial Dysfunction and Disease Progression
While the last several years have seen great strides in the treatment of relapsing forms of MS, progressive MS, responsible for the majority of MS-related disability, lags far behind.
- Conditions
- Clinically Isolated Syndrome, Relapsing-Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
- Trial name
- NCT02549703
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Disease, Coronary Artery Disease Progression
Clinical Features, Current Treatment and Clinical Outcomes in Patients With INR-CAD: a Cohort Study
This is a cohort study to investigate the clinical features, current treatment and clinical outcomes in patients with inflammation-associated non-rapidly-progressive coronary artery disease (INR-CAD).
- Conditions
- Coronary Artery Disease, Coronary Artery Disease Progression, Coronary Artery Stenosis, Coronary Artery Restenosis
- Trial name
- NCT06845410
- Testing
- Healthy life style, Secondary prevention for atherosclerotic coronary artery disease, Immunosuppressive Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking Union Medical College Hospital
Myopia
Dual-focus Soft Contact Lenses for Controlling Rapid Progressive Myopia in Young Adults
This study aims to evaluate the effectiveness and acceptability of dual-focus soft contact lenses in controlling rapid myopia progression in adults through a randomized controlled trial.
- Trial name
- NCT06528860
- Testing
- MiSight® 1 day soft contact lenses, Proclear® 1 day soft contact lenses
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Heart Failure
Heart Failure Evaluation Study
Heart failure (HF) is a highly prevalent conditions that impose a significant burden to the patients, the hospital and the healthcare system. In Hong Kong, HF was one of the commonest causes of hospitalization and death.
- Trial name
- NCT05583513
- Testing
- MLHFQ (Minnesota Living with Heart Failure Questionnaire), KCCQ (the Kansas City Cardiomyopathy Questionnaire)
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Non-small Lung Cancer
Real-world Study of Taletrectinib in Advanced ROS1+ NSCLC Following Entrectinib Progression
This is a multicenter, non-interventional, observational real-world study to evaluate the efficacy and safety of Taletrectinib in ROS1-positive non-small cell lung cancer (NSCLC) following Entrectinib progression.
- Trial name
- NCT07199010
- Testing
- Taletrectinib
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Innovent Biologics (Suzhou) Co. Ltd.
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