Clinical trials: Cancer Progression
HIV Infections, Hepatitis C
Pegylated Interferon Alfa-2a Maintenance Therapy and Liver Disease Progression in People Infected With Both HIV and Hepatitis C Virus (HCV)
Infection with both HIV and hepatitis C virus (HCV) may result in serious and sometimes fatal liver disease. The purpose of this study was to test the effectiveness of long-term pegylated interferon alfa-2a (PEG-IFN) and…
- Conditions
- HIV Infections, Hepatitis C, Liver Disease
- Trial name
- NCT00078403
- Testing
- Peginterferon alfa-2a, Ribavirin
- Where
- 37 sites in United States, Puerto Rico
- Volunteers
- 333 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Kidney Disease
Queen's University Investigation of Calcification in Chronic Kidney Disease
Kidney disease is a fundamental part of medicine because of its prominence in Western society. Common conditions such as diabetes, hypertension and kidney infections can all progress to End-Stage Renal Disease (ESRD) also known…
- Trial name
- QUICK (NCT00687661)
- Testing
- Bisphosphonate
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Queen's University
Androgen Receptor Abnormal, Endometrial Disorder
The Effect of Androgen Receptor Polymorphism on Endometrial Cancer
Endometrial tissue is a hormonal-dependent tissue in both pre- and postmenopausal period. The endometrial cells are expressing receptors for all sex hormones, mainly for estrogen, progesterone and androgens.
- Trial name
- AREC (NCT05157373)
- Testing
- Endometrial sampling and Peripheral blood collection, FSFI Scale
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Small Cell Lung Cancer
A Randomized Study to Evaluate the Effect of Two Different Doses of Enoxaparin Sodium in Combination With Standard Chemotherapy in Patients With Stage Small Cell Lung Cancer (SCLC)
The purpose of this research study is to see if adding enoxaparin sodium to standard treatment with the chemotherapy drugs cisplatin and etoposide will help treat extensive stage SCLC.
- Trial name
- NCT00916669
- Testing
- Etoposide, Cisplatin, enoxaparin sodium
- Where
- 4 sites in United States
- Sponsor
- Massachusetts General Hospital
Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies
Mayo AVC Registry and Biobank
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT03049254
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Liver Cancer, Cirrhosis
Omega-3 Fatty Acid-Based Parenteral Nutrition Improves Postoperative Recovery for Cirrhotic Patients With Liver Cancer
The safety and efficacy of ω-3 fatty acid in patients with liver cancer followed hepatectomy is not known. This study provided evidences that ω-3 fatty acid-based parenteral nutrition improved postoperative recovery for cirrhotic…
- Trial name
- NCT02321202
- Testing
- Omega-3 Fatty Acid-Based Parenteral Nutrition, Structolipid
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Huazhong University of Science and Technology
Prostate Cancer, Prostatic Neoplasm
Dietary Fibre Supplementation to Delay Disease Progression in Early Prostate Cancer
This qualitative research study, based on semi-structured interviews and a focus group, aims to explore the attitudes of prostate cancer patients on active surveillance (AS) towards dietary fibre supplementation, given the…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Dietary Fibre Modification, Active Surveillance
- Trial name
- DEFINITE (NCT07790003)
- Testing
- Qualitative semi-structured interviews, Focus group
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Aberdeen
Tricuspid (Valve) Insufficiency (Rheumatic)
PROphylactic triCuspID Annuloplasty in Patients With Dilated Tricuspid Annulus
Patients elected to undergo mitral valve surgery (either repair or replacement) with less equal than moderate (≤+2) tricuspid regurgitation and dilated tricuspid annulus (>21mm/m2) at preoperative echocardiography will be…
- Trial name
- PROCIDA (NCT03129737)
- Testing
- Mitral valve surgery, Tricuspid valve annuloplasty
- Where
- 8 sites in Italy
- Volunteers
- 200 people
- Sponsor
- Ettore Sansavini Health Science Foundation
Small Cell Lung Cancer
Study Comparing Rovalpituzumab Tesirine Versus Topotecan in Subjects With Advanced or Metastatic Small Cell Lung Cancer With High Levels of Delta-like Protein 3 (DLL3) and Who Have First Disease Progression During or Following Front-line Platinum-based Chemotherapy (TAHOE)
The purpose of this randomized, open-label, 2-arm, phase 3 study is to assess the efficacy, safety and tolerability of rovalpituzumab tesirine versus topotecan in participants with advanced or metastatic SCLC with high levels of…
- Trial name
- TAHOE (NCT03061812)
- Testing
- Rovalpituzumab tesirine, Topotecan, Dexamethasone
- Where
- 195 sites in United States, Australia and 31 more
- Volunteers
- 444 people
- Sponsor
- AbbVie
Chronic Obstructive Pulmonary Disease
Imaging Progression of Chronic Obstructive Pulmonary Disease Using MRI and CT (MR-COPDII)
In this follow-up trial, MRI and CT images of the lung will be acquired prospectively in a subcohort of 370 patients, three years after they successfully participated in the first COSYCONET subtrial with CT and MRI ("MR-COPD I"…
- Trial name
- MR-COPDII (NCT03591562)
- Where
- 10 sites in Germany
- Volunteers
- 252 people
- Sponsor
- University Hospital Heidelberg
Kidney Transplant; Complications, Coronavirus Infection
Blood Biomarkers as Predictors of COVID-19 Disease Progression in Recently Infected Kidney Transplant Patients
SARS-CoV-2 induces over-production of inflammatory cytokines, and especially interleukin-6 (IL-6). The apparently strong association between blood levels of inflammaory cytokines and SARS-CoV-2 disease severity has led clinicians…
- Trial name
- PredictCovidT (NCT04369456)
- Testing
- blood sample
- Where
- 7 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Bradyarrhythmia, Atrioventricular Block
PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial
PROTECT-SYNC study is a multicenter, randomized, controlled trial. A total of 7 medical centers across Republic of Korea will enroll 450 patients during 2 years of enrollment period, and followed for 2 years of follow-up period.
- Conditions
- Bradyarrhythmia, Atrioventricular Block, Left Bundle Branch Area Pacing
- Trial name
- NCT05585411
- Testing
- Left bundle branch area pacing, Right ventricular pacing
- Where
- 8 sites in South Korea
- Volunteers
- 450 people
- Sponsor
- Yonsei University
Brain Metastases
A Pilot Study to Assess the Clinical Utility of 18F-Fluciclovine (Axumin) PET-CT for Detecting True-versus Pseudo-Progression of Brain Metastases on Immunotherapy
To learn if 18F-Fluciclovine (Axumin) PET-CT scans can be used to better detect brain metastatic lesions in patients who are receiving immunotherapy.
- Trial name
- NCT06015295
- Testing
- 18F-Fluciclovine (Axumin), Pet Scan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
COVID19, Coronavirus Infection
Northeast COVID-19 and Pregnancy Study Group
A prospective and retrospective cohort study. The objective will to determine the frequency of COVID-19 in pregnant and postpartum women hospitalized with flu syndrome, to evaluate clinical and laboratory predictors of COVID-19…
- Conditions
- COVID19, Coronavirus Infection, Pregnancy Disease, Severe Acute Respiratory Syndrome
- Trial name
- NCOVIP (NCT04462367)
- Where
- Brazil
- Volunteers
- 180 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
HIV Infections
A Study of HIV-Disease Development in Aging
The purpose of this study is to better understand the relationship between age and HIV disease progression. This study will explore the possible relationship between age and HIV disease progression.
- Trial name
- NCT00006144
- Testing
- Lopinavir/Ritonavir, Emtricitabine, Stavudine
- Where
- 45 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Sleep, HIV Infections
Sleep, HIV Disease Progression, and Function in HIV Infected Children and Adolescents
This study is a first step in approaching the gap existing between understanding sleep abnormalities, alterations in sleep-regulating cytokines and HIV-1 disease regulating cytokines, and abnormal higher cortical function.
- Trial name
- NCT00253695
- Testing
- Wrist Actigraphy
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
FSHD - Facioscapulohumeral Muscular Dystrophy
1 Year MRI Followup in Facioscapulohumeral Muscular Dystrophy
An investigation of disease progression in adult danish patients with facioscapulohumeral muscular dystrophy. The disease progression is followed for a year with two test-days, including functional muscle tests and a MRI scan of…
- Trial name
- FSHD (NCT02159612)
- Testing
- MRI
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Grete Andersen, MD
Renal Insufficiency, Chronic
Effects of Low Protein Diet in Preventing the Progression of Chronic Kidney Disease(CKD)---a Prospective Study
The purpose of this study is to determine whether low protein diet and very low protein diet supplemented keto-/amino acid is effective in preventing the progression of chronic kidney disease (CKD , stage 2 to 5).
- Trial name
- NCT02886975
- Testing
- low protein diet plus α-keto acid
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Non-Hodgkin's Lymphoma
A Study Comparing Maintenance Subcutaneous Rituximab With Observation Only in Participants With Relapsed or Refractory Indolent Non-Hodgkin's Lymphoma Who Had Responded to Rituximab-based Immunochemotherapy Induction and 2-year Maintenance With Subcutaneous Rituximab
This multicenter, randomized, open-label, parallel-group study will evaluate the efficacy and safety of subcutaneously administered rituximab in comparison with observation only as maintenance therapy in participants with…
- Trial name
- MabCute (NCT01461928)
- Testing
- Chemotherapy (Induction Period), Rituximab
- Where
- 180 sites in Albania, Argentina and 22 more
- Volunteers
- 692 people
- Sponsor
- Hoffmann-La Roche
Neuroendocrine Tumors
PFS and OS of Patients With Advanced Neuroendocrine Cancer (NEN) After Systemic Treatment
This is a retrospective study. The analysis includes patients with advanced neuroendocrine cancer (NEN) treated with systemic therapy, because of inoperable primary tumor or/and metastasis, clinical, imaging, biochemical disease…
- Trial name
- NCT04331912
- Where
- 2 sites in Poland
- Volunteers
- 100 people
- Sponsor
- University of Warmia and Mazury
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.