Clinical trials: Cancer Progression
Lymphedema, Breast Cancer
Lymphedema Progression Screening Using MRI
This study will apply novel, noninvasive structural and functional magnetic resonance imaging (MRI) methods to patients with mild and moderate breast cancer-related lymphedema (BCRL) for the first time to test fundamental…
- Trial name
- INFORM (NCT02611557)
- Testing
- Manual lymphatic drainage therapy
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Esophageal Cancer (EC)
A Phase II Study of Anlotinib + PD-1 Inhibitor vs. PD-1 Inhibitor Maintenance After First-Line Chemoimmunotherapy in Advanced ESCC (Esophageal Squamous Cell Carcinoma)
Chemotherapy combined with PD-1 inhibitor immunotherapy is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC), yet patient prognosis remains unsatisfactory, with a median PFS of only about 6 months and…
- Trial name
- NCT07863141
- Testing
- anlotinib + PD-1 inhibitor, PD-1 inhibitor
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-sen University
Parkinson's Disease
Genotypic Influences on Network Progression in Parkinson's Disease
In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations.
- Trial name
- NCT04228172
- Testing
- DNA/GeneticTesting, FDG PET scan, MRI scan
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Northwell Health
Sepsis
Effect of Citrulline on the Clinical and Biochemical Evolution of Patients With Sepsis.
Triple blind placebo-controlled study to determine if administering citrulline in patients with sepsis and severe sepsis slows progression to multiple organ failure and death, measuring biomarkers of endothelial dysfunction.
- Trial name
- CITRUSEP (NCT02370030)
- Testing
- Citrulline malate
- Where
- 2 sites in Mexico
- Volunteers
- 160 people
- Sponsor
- Instituto Mexicano del Seguro Social
Patients With COVID-19 Pneumonia Will Allow to Detect an Absolute Reduction in the Rate of Respiratory-failure
Defibrotide in COVID-19 Pneumonia
Phase II, prospective, interventional, single-arm, multicentric, open label trial, with a parallel retrospective collection of data on not treated patients from IRCCS, San Raffaele Scientific Institute included in the…
- Trial name
- DEFI-VID19 (NCT04335201)
- Testing
- Defibrotide Injection
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS San Raffaele
Myopia
The Effect of Blue-light Filtering Spectacle Lenses on Myopia Progression in Schoolchildren
The purpose of this study is to investigate if the blue-light filtering spectacle lenses promote myopia progression in schoolchildren.
- Trial name
- NCT03538002
- Testing
- Blue-light filtering spectacle lenses
- Where
- Hong Kong
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Multiple Myeloma, Refractory, Multiple Myeloma in Relapse
A Phase I Study to Assess the Tolerability of 225Ac-DOTATATE in Patients With Refractory and Relapsing Multiple Myeloma Expressing Somatostatin Receptors
This study aims to determine the safety and the recommended phase II dose of RYZ101 (actinium-225 labelled DOTA-octreotate (225Ac-DOTATATE)) in participants with refractory and relapsing multiple myeloma (MM) that have received…
- Conditions
- Multiple Myeloma, Refractory, Multiple Myeloma in Relapse, Multiple Myeloma Progression
- Trial name
- AcTRESS (NCT06411301)
- Testing
- 225Ac-DOTATATE
- Where
- Belgium
- Sponsor
- Jules Bordet Institute
Alcoholic Hepatitis
Randomized, Controlled Trial of S-adenosylmethionine in Alcoholic Liver Disease
Background: Alcoholic liver disease is one of the most important causes of chronic liver disease in this country. There is currently no treatment for chronic alcoholic liver disease other than abstinence.
- Trial name
- RCT SAMe (NCT00851981)
- Testing
- SAMe
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Loma Linda University
HIV Infections, Papillomavirus Infections
Viral Load Determination and Biomarkers of High Risk Human Papillomavirus (HPV) - Types in HIV-positive Men
Human papillomavirus (HPV)-infection belongs to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men (MSM) are strongly associated with a higher prevalence of genital HPV-infection, a…
- Conditions
- HIV Infections, Papillomavirus Infections, Anal Intraepithelial Neoplasia
- Trial name
- NCT00365729
- Testing
- Smear and biopsy testing for HPV-types and viral load
- Where
- 2 sites in Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Deutsche Luft und Raumfahrt
Non-Small Cell Lung Cancer
Using E-Nose Technology to Track Treatment Response in People With Non-Small Cell Lung Cancer
The researchers are doing this study to test the ability of a new technology called breathprinting, or electronic nose (E-Nose), to measure changes in certain chemicals in the breath before and after standard neoadjuvant therapy…
- Trial name
- NCT07218601
- Testing
- Breath sample collection, Research blood collection
- Where
- 7 sites in United States
- Volunteers
- 60 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Glioblastoma Multiforme
Application of FET-PET in Fusion With MRI in the Treatment of Glioblastoma Multiforme [TYR-GLIO]
Glioblastoma multiforme (GBM WHO IV) is the most common and aggressive primary brain tumor in adults, carrying a poor prognosis with a median survival of 12-16 months.
- Trial name
- TYR-GLIO (NCT06466031)
- Testing
- MRI & PET fusion, MRI+T1C
- Where
- Poland
- Volunteers
- 189 people
- Sponsor
- Copernicus Memorial Hospital
Infertility, Infertility (IVF Patients)
Language Matters: Exploring the Impact of Language Concordance on Fertility Treatment Progression
Currently, patients presenting to the Fertility and Reproductive Medicine Center meet with an English-speaking provider and communicate through an interpreter, as none of the physicians speak Spanish.
- Conditions
- Infertility, Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Ovulation Ind
- Trial name
- ImpaLa (NCT06636838)
- Testing
- Spanish-Speaking Provider
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Washington University School of Medicine
Retinitis Pigmentosa
Exercise and RP (AVAMC and Emory)
The purpose of this study is to look in humans at the relationship between moderate or little exercise and their potential effects on the retina in patients with Retinitis Pigmentosa (RP).
- Trial name
- NCT03381235
- Testing
- Spin exercise
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Emory University
Epidural Analgesia, Obstetric
Impact of Low-Dose Epidural Analgesia on Labour Progression in Low-Risk Women
Aim of the study was to analyse data on cervical dilation and fetal descent patterns in low-risk women, who did or did not receive intermittent low-dose epidural analgesia (EA), and who had either a vaginal or a caesarean…
- Trial name
- NCT06987591
- Where
- Italy
- Volunteers
- 5,995 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Advanced Hepatocellular Carcinoma
Oral Fecal Microbiota Transplantation in Advanced Hepatocellular Carcinoma After Progression on ICI-TKI Therapy
This prospective, single-center, single-arm phase 2 study evaluates the efficacy and safety of adding oral fecal microbiota transplantation (FMT) capsules to continued immune checkpoint inhibitor (ICI) plus tyrosine kinase…
- Trial name
- NCT06563947
- Testing
- Oral fecal microbiota transplantation capsules
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xu Yong, MD
Colorectal Cancer, Liver Metastases
Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chemotherapy for Patients With Colorectal Cancer Metastatic to the Liver
Background: Many people with colorectal cancer get liver metastases. Standard treatment for this is a combination of chemotherapy drugs. Directing the chemotherapy to the liver may be effective.
- Conditions
- Colorectal Cancer, Liver Metastases, Colorectal Adenocarcinoma, Colorectal Cancer With Hepatic Metastases
- Trial name
- NCT03366155
- Testing
- Codman 3000 constant flow pump catheter, Panitumumab, FUDR-Dex
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Heart Failure With Preserved Ejection Fraction, Arterial Hypertension
Ambulatory Blood Pressure in HFPEF Outcomes Global Registry
Heart failure and preserved ejection fraction (HFPEF) is a disease with increasing prevalence world wide. Due to its etiological and prognostic relationship with hypertension, it is highly interesting to know the characteristics…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Arterial Hypertension, Frailty Syndrome, Comorbidities and Coexisting Conditions
- Trial name
- HFPEFGlobal (NCT04065620)
- Testing
- ambulatory blood pressure measurement
- Where
- Spain
- Volunteers
- 5,000 people
- Sponsor
- Hospital Clinic of Barcelona
Meningioma
Cabozantinib for Patients With Recurrent or Progressive Meningioma
A Phase II Study of Cabozantinib for Patients with Recurrent or Progressive Meningioma
- Trial name
- NCT05425004
- Testing
- Cabozantinib
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Baptist Health South Florida
Metastatic Castration Resistant Prostate Cancer
A Study to Assess the Benefit of Treatment Beyond Progression With Enzalutamide in Men Who Are Starting Treatment With Docetaxel After Worsening of Their Prostate Cancer When Taking Enzalutamide Alone
The purpose of the study was to understand if there was benefit in continued treatment with a medicine called enzalutamide, when starting treatment with docetaxel and prednisolone (a standard chemotherapy for prostate cancer)…
- Trial name
- PRESIDE (NCT02288247)
- Testing
- Enzalutamide, Docetaxel, Prednisolone
- Where
- 89 sites in Austria, Belgium and 14 more
- Volunteers
- 688 people
- Sponsor
- Astellas Pharma Europe Ltd.
Non-small Cell Lung Cancer
Pembrolizumab Plus Chemotherapy in NSCLC With Targetable Genetic Alterations After Progression on Targeted Agents
Investigators hypothesize that addition of pembrolizumab will enhance the efficacy of carboplatin and pemetrexed in patients with EGFR-mutation-positive NSCLC, or patients with other genetic alterations, and who have disease…
- Trial name
- NCT03242915
- Testing
- Pembrolizumab, Carboplatin, Pemetrexed
- Where
- 7 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Michigan Rogel Cancer Center