Clinical trials: Cancer Progression
Aortic Valve Stenosis
The Effect of Lipitor on Aortic Stenosis
The purpose of this study is to find out if an approved medicine that is used to lower cholesterol called Lipitor can slow or stop progressive narrowing of the aortic heart valve in patients with a condition called aortic…
- Trial name
- NCT00590135
- Testing
- atorvastatin (Lipitor)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease, Atherosclerosis
Coronary Artery Disease Progression in Patients With Prediabetes
Prediabetes is a disorder of glucose metabolism that reflects the natural history of progression from normoglycaemia to type 2 diabetes mellitus.
- Conditions
- Coronary Artery Disease, Atherosclerosis, Prediabetic State
- Trial name
- NCT02744976
- Testing
- Metformin, Lifestyle recommendations
- Where
- Latvia
- Volunteers
- 70 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Oncologic Disorders
Disease Course in Oncological Patients During Inpatient Rehabilitation and After Three Months Follow-up
Constant improvements in the areas of diagnostics and treatment lead to an increase of patients surviving an oncological diagnosis ("cancer survivors") thus increasing the cost factor on both society and health care systems.
- Trial name
- NCT04842214
- Testing
- Oncological Rehabilitation
- Where
- Switzerland
- Volunteers
- 250 people
- Sponsor
- Klinik Valens
Myopia
Efficacy and Safety of the New Defocus Spectacle Lens in Preventing Progression of Myopia
The clinical effects of new technical spectacles with refractive correction function are mixed. A randomised trial is designed to compare the effects of new defocusing spectacle lenses and traditional aspheric spectacle lenses on…
- Trial name
- NCT05740904
- Testing
- New defocus spectacle lenses, Convenional aspheric single-vision spectacle lenses
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
IBMPFD
Natural History Study of Patients With VCP-related Disease
A natural history study to understand the expected progression of disease in patients with confirmed mutations in the VCP gene over 1 year.
- Trial name
- NCT04823143
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Nationwide Children's Hospital
Alzheimer's Disease
DHA (Docosahexaenoic Acid), an Omega 3 Fatty Acid, in Slowing the Progression of Alzheimer's Disease
The purpose of this study is to determine whether chronic DHA (Docosahexaenoic Acid) supplementation slows the progression of cognitive and functional decline in mild to moderate Alzheimer's disease (AD).
- Trial name
- DHA (NCT00440050)
- Testing
- DHA (Docosahexaenoic Acid)
- Where
- 51 sites in United States
- Volunteers
- 402 people
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Atherosclerosis
Efficacy and Safety of Simvastatin-ezetimibe Combination Therapy Among Patients With SLE
This is a randomized single-blind trial. This study aimed to determine if intensive lipid-lowering therapy (simvastatin-ezetimibe combination therapy) could reduce the progression of atherosclerosis effectively and safely among…
- Trial name
- NCT02548936
- Testing
- Ezetimibe+Simvastatin Drug Combination
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Liver Cirrhosis, Portal Hypertension
Extension Study of Carvedilol RCT Study
Patients who have completed 2-years treatment in RCT Study of carvedilol will receive another 2-years extension therapy, aiming to investigate the long-term efficacy of carvedilol for the prevention of esophageal varices in…
- Trial name
- NCT05021406
- Testing
- Carvedilol 12.5 MG
- Where
- 14 sites in China
- Volunteers
- 240 people
- Sponsor
- Beijing Friendship Hospital
Lung Cancer
Development of a Model to Predict Progression-Free Survival After Erlotinib in Patients With Non-Small Cell Lung Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897533
- Testing
- gene mapping, polymorphism analysis, diagnostic laboratory biomarker analysis
- Volunteers
- 137 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Coronary Artery Disease, Coronary Artery Stenosis
Disease Characteristics of IR-CAD: a Case-control Study
The present case-control study is designed to investigate the disease characteristics of IR-CAD by comparing the demographics, clinical features, lab results, imaging findings, and prior treatment between 20 patients with IR-CAD…
- Conditions
- Coronary Artery Disease, Coronary Artery Stenosis, Coronary Artery Restenosis, Coronary Artery Disease Progression
- Trial name
- NCT06007248
- Testing
- Protocol-defined Examinations
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Alzheimer's Disease
Effects of LY450139, on the Progression of Alzheimer's Disease as Compared With Placebo
Alzheimer's disease (AD) is a fatal degenerative disease of the brain for which there is no cure. AD causes brain cells to die. AD is thought to be caused by an excess of beta amyloid (β-amyloid), a sticky protein in the brain…
- Trial name
- IDENTITY-2 (NCT00762411)
- Testing
- LY450139
- Where
- 91 sites in United States, Brazil and 16 more
- Volunteers
- 1,111 people
- Sponsor
- Eli Lilly and Company
Cardiogenic Shock
Study of Multistep Pharmacological and Invasive Management for Cardiogenic Shock
The purpose of this study is to evaluate efficacy and safety of i.v. adrenaline infusion as an early and fast haemodynamic stabilizer, associated with a tight tissue perfusion monitoring, in the context of a stepwise progression…
- Trial name
- NCT02591771
- Testing
- adrenaline
- Where
- 2 sites in Italy
- Volunteers
- 24 people
- Sponsor
- Niguarda Hospital
Prehypertension, Hypertension
Equity in Prevention and Progression of Hypertension by Addressing Barriers to Nutrition and Physical activitY
The goal of this study is to test an intervention to prevent high blood pressure among rural, Black adults living in Alabama. Black adults in this region have one of the highest rates of high blood pressure in the US.
- Conditions
- Prehypertension, Hypertension, Blood Pressure
- Trial name
- EPIPHANY (NCT05367544)
- Testing
- Health Education, Individual-Level Peer Support, Community-Level Peer Support
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Glioblastoma, Radionecrosis of Brain
FET-PET-Guided Management of Pseudoprogression in Glioblastoma
The goal of this diagnostic randomised clinical trial is to determine, in glioblastoma patients with diagnostic uncertainty between pseudoprogression and tumor progression on follow-up MRI after chemoradiation, the added value of…
- Trial name
- FET-POPPING (NCT06480721)
- Testing
- Clinical management based on the index MRI and an additional [¹⁸F] FET PET scan
- Where
- 8 sites in Netherlands
- Volunteers
- 144 people
- Sponsor
- Veerle Ruijters
Colorectal Neoplasms
Intra-arterial Hepatic Bevacizumab and Systemic Chemotherapy
The purpose of the study is to assessed the efficiency of treatment based on the objective response rate (RECIST 1.1)
- Trial name
- BEVIAC (NCT01677884)
- Testing
- Bevacizumab, Capecitabine, Irinotecan
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Thyroid Dysfunction, Atherosclerosis
The TRUST Study - CardioVascular Imaging IMT
Coronary heart disease (CHD) are the leading causes of mortality and morbidity, particularly with the current context of an aging population.
- Conditions
- Thyroid Dysfunction, Atherosclerosis, Heart Failure
- Trial name
- NCT02832934
- Testing
- Levothyroxine
- Where
- 3 sites in Switzerland
- Volunteers
- 184 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronavirus, Severe Acute Respiratory Syndrome
Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial
ACT is a randomized clinical trial to assess therapies to reduce the clinical progression of COVID-19.
- Trial name
- ACTCOVID19 (NCT04324463)
- Testing
- Colchicine, Interferon-Beta, Aspirin
- Where
- 66 sites in Brazil, Canada and 10 more
- Volunteers
- 6,667 people
- Sponsor
- Population Health Research Institute
Atherosclerosis
Aliskiren Effect on Aortic Plaque Progression
This study is being done to assess the effectiveness of short term (~9 months) Aliskiren/Placebo therapy to slow down the progression of atherosclerotic disease in thoracic and abdominal aorta.
- Trial name
- ALPINE (NCT01417104)
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Ohio State University
Myopia, Myopia Progression
The Effectiveness and Safety of Two Low-concentration Atropine Sulfate Eye Drops (0.01%/0.02%) for Delaying the Pediatric Myopia Progression
The clinical trial aims to test the effectiveness and safety of two low-dose atropine sulfate eye drops for delaying myopia progression in children and adolescents.
- Trial name
- NCT06708156
- Testing
- Atropine sulfate eye drops 0.01%, Atropine sulfate eye drops 0.02%
- Where
- 25 sites in China
- Volunteers
- 606 people
- Sponsor
- Oupushifang Pharmaceutical Technology Co., Ltd.
Multiple Sclerosis, Magnetic Resonance Spectroscopy
MRI Biomarkers Predictive of Disability Progression in Patients With Multiple Sclerosis
The transition from relapsing-remitting multiple sclerosis to secondarily progressive multiple sclerosis (SPMS) is difficult to identify.
- Trial name
- NCT05491031
- Testing
- magnetic resonance spectroscopy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Poitiers University Hospital
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