Clinical trials: Cancer Progression
Breast Cancer
An Observational Study of Patients With HER2-Positive Metastatic or Locally Advanced Breast Cancer Treated With Herceptin (Trastuzumab) in 1st Line and Without Progression For 3 Years
This observational study will characterize retrospectively patients with HER2-positive metastatic or locally advanced breast cancer who had received treatment with Herceptin (trastuzumab) in 1st line and who were without…
- Trial name
- NCT01480674
- Testing
- Trastuzumab
- Where
- 78 sites in France
- Volunteers
- 160 people
- Sponsor
- Hoffmann-La Roche
Lewy Body Disease
Longitudinal Imaging Biomarkers of Disease Progression in DLB
The Researchers are trying to determine the paths of change in imaging biomarkers of Dementia with Lewy bodies (DLB) and their associations with rate of cognitive and functional decline.
- Trial name
- NCT03582488
- Testing
- 18F-Flortaucipir
- Where
- 2 sites in United States
- Volunteers
- 135 people
- Sponsor
- Kejal Kantarci
Sjogren's Syndrome
Interstitial Lung Diseases in Primary Sjogren's Syndrome
Patients with pSS seen in the Division of Rheumatology, the second affiliated hospital of Zhejiang University, School of Medicine (SAHZU) during January 2016 to July 2018, were retrospectively reviewed.
- Trial name
- NCT04978883
- Testing
- No intervention
- Volunteers
- 170 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bile Duct Neoplasms Malignant
Clinicopathologic Characteristics, Progression, and Prognostic Analysis of IPNB
The main aim of this observational study is to understand the clinicopathological and prognostic information of IPNB, a rare tumor.
- Trial name
- NCT06887023
- Where
- China
- Volunteers
- 118 people
- Sponsor
- The First Hospital of Jilin University
IGA Nephropathy
"Steroids and Azathioprine Versus Steroids Alone in IgAN"
In a previous trial the investigators found that the effect of steroids in IgA nephropathy diminish over time. The difference in renal survival is striking up till the third year, but then remains constant.
- Trial name
- NCT00755859
- Testing
- steroids plus azathioprine, steroids
- Where
- 28 sites in Italy, Switzerland
- Volunteers
- 206 people
- Sponsor
- A. Manzoni Hospital
Ankylosing Spondylitis
Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression
It will be a pilot, 2 year, prospective, randomized, double-blind, placebo-controlled (for pamidronate) study. All patients with AS will receive treatment with TNF inhibitor, while randomization will be performed for pamidronate…
- Trial name
- NCT02313727
- Testing
- Pamidronate
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Bnai Zion Medical Center
Myopia Progression
Evaluation of the Effectiveness of a New Generation of Myopia Control Lens on the Progression of Myopia in Children Aged 6 to 14 Years
The goal of this clinical investigation is to learn how much a new generation of myopia control lens (MCL1 - Myopia Control Lens 1) is helpful in reducing myopia progression in children from 6 to 14 yo.
- Trial name
- VERCORS (NCT07462897)
- Testing
- MCL1, MCL2
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Essilor International
Tuberous Sclerosis Complex, Epilepsy
Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC Infants
This phase I/II clinical trial is an open-label clinical trial design to verify safety and dosing for TAVT-18 (sirolimus) powder for oral solution in TSC infants (N=5).
- Trial name
- STOP2 (NCT04595513)
- Testing
- TAVT-18 (sirolimus)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Metastatic Non-Small Cell Lung Cancer, NSCLC Stage IV
Stereotactic Body Radiotherapy for Oligo-Progression Metastatic Non-Small Cell Lung Cancer
The goal of this clinical trial is to learn if Stereotactic Body Radiotherapy (SBRT) can treat the oligo-progressive metastatic non-small cell lung cancer (NSCLC) after first-line chemotherapy.
- Conditions
- Metastatic Non-Small Cell Lung Cancer, NSCLC Stage IV, OligoProgressive Metastatic Disease
- Trial name
- OPPRESS (NCT06523673)
- Testing
- Stereotactic Body Radiotherapy, second-line systemic therapy
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Valve Disease, Mitral Valve (MV) Regurgitation
Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease
The objective of this study is to evaluate and predict the progression of moderate cardiac valve stenosis and regurgitation using clinical, biological, echocardiographic, computed tomography (CT), and magnetic resonance imaging…
- Conditions
- Heart Valve Disease, Mitral Valve (MV) Regurgitation, Mitral Valve Disease, Mitral Valve Stenosis
- Trial name
- VALVE-COMPASS (NCT07267117)
- Where
- 15 sites in China
- Volunteers
- 10,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Prostate Cancer, Prostatic Neoplasm
Dietary Fibre Supplementation to Delay Disease Progression in Early Prostate Cancer
This qualitative research study, based on semi-structured interviews and a focus group, aims to explore the attitudes of prostate cancer patients on active surveillance (AS) towards dietary fibre supplementation, given the…
- Conditions
- Prostate Cancer, Prostatic Neoplasm, Dietary Fibre Modification, Active Surveillance
- Trial name
- DEFINITE (NCT07790003)
- Testing
- Qualitative semi-structured interviews, Focus group
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Aberdeen
Coronary Artery Disease Progression, Radial Wall Strain
Natural History of Coronary Atherosclerosis
The present study sought to explore the predictive value of radial wall strain (RWS, derived solely from angiograms) for coronary artery lesion progression compared with lesion vulnerability assessed by optical coherence…
- Conditions
- Coronary Artery Disease Progression, Radial Wall Strain, Atherosclerotic Lesion, Optical Coherence Tomography
- Trial name
- NASCENT (NCT06040073)
- Where
- China
- Volunteers
- 125 people
- Sponsor
- China National Center for Cardiovascular Diseases
Diagnosis, Gastric Cancer
PWP1's Expression in Gastric Cancer.
Background：Gastric cancer is a globally important disease and the fifth most diagnosed malignant cancer in the world. Because it is usually diagnosed at an advanced stage, gastric cancer has a high mortality rate, making it the…
- Trial name
- NCT06392750
- Testing
- Collection of tumor tissue specimens
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Northern Jiangsu People's Hospital
Obesity and Type 2 Diabetes
Role of KATP Channel Loss in Type 2 Diabetes
Insulin is a hormone that is made by β-cells in the pancreas and when released into the bloodstream helps control blood sugar levels.
- Trial name
- BC (NCT06830096)
- Testing
- 10 mg glipizide ingestion
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Carcinoma Prostate
Multiparametric Assessment of Bone Response in mCRPC Patients Treated With Cabozantinib
Multiparametric assesment of bone response in mCRPC patients treated with Cabozantinib upon progression to chemotherapy and next generation hormonal agents: a phase II study
- Trial name
- MERIDIAN (NCT05265988)
- Testing
- Cabozantinib
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Alfredo Berruti
Coronary Artery Disease, Diabetes Mellitus, Type 2
CArdioMetabolism and Atherosclerotic PlaqUe progreSsion
Systematic metabolic diseases are closely related to prevalence and progression of atherosclerosis. This prospective cohort consecutively enrolls patients with coronary artery disease compliacted with metabolic abnormalities such…
- Conditions
- Coronary Artery Disease, Diabetes Mellitus, Type 2, Dyslipidemias, Obesity
- Trial name
- CAMPUS (NCT05117424)
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Ruijin Hospital
COVID-19, SARS-CoV-2
FREEDOM COVID-19 Anticoagulation Strategy
Coronavirus Disease (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has led to unprecedented morbidity and mortality in the modern era.
- Trial name
- FREEDOM COVID (NCT04512079)
- Testing
- Enoxaparin, Apixaban
- Where
- 21 sites in United States, Brazil and 3 more
- Volunteers
- 3,460 people
- Sponsor
- Valentin Fuster
Multiple Myeloma, Multiple Myeloma in Relapse
Sequential CAR-T Cells Targeting BCMA/GPRC5D in Patients With Relapsed/ Refractory Multiple Myeloma
This is an open, single-arm, clinical study to evaluate the efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) targeting BCMA or GPRC5D or both sequentially in the treatment of Relapsed/ Refractory…
- Conditions
- Multiple Myeloma, Multiple Myeloma in Relapse, Multiple Myeloma Progression, Multiple Myeloma, Refractory
- Trial name
- BAH2573 (NCT07032129)
- Testing
- BCMA/GPRC5D CAR-T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Essen Biotech
Non-muscle Invasive Bladder Cancer, Cystoscopy
Biomarkers of Recurrence and Progression in Non-muscle Invasive Bladder Cancer
Bladder cancer (BC) is one of the most common type of cancer globally. Due to its high incidence rate, high risk of recurrence and progression, and frequent cystoscopy surveillance, BC contributes to major healthcare costs across…
- Conditions
- Non-muscle Invasive Bladder Cancer, Cystoscopy, Recurrence, Progression
- Trial name
- NCT06235853
- Testing
- Blood serum: sUPAR, PAI-1, IL-8., Urine: IL-8, APOE, VEGF.
- Where
- Poland
- Volunteers
- 240 people
- Sponsor
- Wroclaw Medical University
Glioblastoma
Improving Treatment of Glioblastoma: Distinguishing Progression From Pseudoprogression
Glioblastoma is the most aggressive kind of brain cancer and leads on average to 20 years of life lost, more than any other cancer.
- Trial name
- NCT04359745
- Where
- 15 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
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