Clinical trials: Cancer Screening, open to volunteers
Gastric Cancer (Diagnosis)
Screening and Validation of Serum Protein Biomarkers for Early Diagnosis of Gastric Cancer
This study focuses on the discovery of protein biomarkers for the early diagnosis of gastric cancer and the development of corresponding detection methods.
- Trial name
- NCT07096752
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Lung Neoplasms
TELEhealth Shared Decision-making COaching for Lung Cancer Screening in Primary Care (TELESCOPE) for Hispanics
Aim 1: Culturally adapt the TELESCOPE intervention for Hispanics. Using iterative qualitative feedback from a study-specific Community Advisory Board, focus groups, and interviews with community members, the investigators will…
- Trial name
- TELESCOPE-H (NCT07165691)
- Testing
- TELESCOPE, Remote Decision Coaching with Navigation Intervention
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pancreatic Cancer, Diabetes
Artificial Intelligence-based Early Screening of Pancreatic Cancer and High Risk Tracing (ESPRIT-AI)
Pancreatic cancer is one of the most fatal malignancies with a 5-year survival rate of only ~6%[1]. The reasons for this high mortality rate can be attributed to several factors, of which perhaps the most important is delayed…
- Conditions
- Pancreatic Cancer, Diabetes, Familial Pancreatic Cancer, Pancreatic Cystic Neoplasm
- Trial name
- ESPRIT-AI (NCT04743479)
- Testing
- high-resolution MRI/CT examinations
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Changhai Hospital
Breast Cancer, Lung Cancer (Diagnosis)
Building on Trust: Navigating Preventive Lung, Breast, and Prostate Cancer Screenings at Community Resource Spots
To evaluate a community-based outreach initiative for screening, diagnosis, and treatment of breast, lung, and prostate cancers in underserved adults using the Reach, Effectiveness, Adoption, Implementation, Maintenance (RE-AIM)…
- Conditions
- Breast Cancer, Lung Cancer (Diagnosis), Prostate Cancer
- Trial name
- NCT07231159
- Testing
- referral for definitive diagnosis based on their cancer screening results, Engagement
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- AdventHealth
Health Behaviors, Risk Factors
Targeted Health Dialogues in Primary Care
The County Council of Region Skåne, Sweden, has recently initiated Targeted Health Dialogues in primary care. The prevention program includes health dialogues provided by specially trained personnel, collection of clinical and…
- Conditions
- Health Behaviors, Risk Factors, Cardiovascular Diseases, Cancer
- Trial name
- NCT04912739
- Testing
- Targeted health dialogues
- Where
- Sweden
- Volunteers
- 18,000 people
- Sponsor
- Region Skane
Ovarian Cancer
Transvaginal Ultrasonography as a Screening Method for Ovarian Cancer
This is a large, prospective, single-arm cohort study of transvaginal ultrasonographic screening for ovarian cancer in intermediate to high-risk women from Kentucky.
- Trial name
- NCT04473833
- Testing
- Serial Transvaginal Ultrasonography
- Where
- United States
- Volunteers
- 65,000 people, healthy volunteers welcome
- Sponsor
- John R van Nagell
Metastatic Pancreatic Cancer, Advanced Pancreatic Cancer
Profiling Program of Advanced/Metastatic Pancreatic Cancer Patients
The proposal is to implement a molecular screening program for advanced/metastatic pancreatic cancer patients before the initiation of 1st line treatment in order to allow a better selection of patients for rationale personalized…
- Trial name
- NCT05380414
- Testing
- Tumor samples (archival FFPE and optional de novo biopsy) and blood samples
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Centre Leon Berard
Cervical Cancer, HPV
Automated Cervical Cancer Screening Using a Smartphone-based Artificial Intelligence Classifier
Cervical cancer remains a major public health challenge in low- and middle-income countries (LMICs) due to financial and logistical issues.
- Trial name
- NCT04859530
- Testing
- AVC test
- Where
- Cameroon
- Volunteers
- 5,886 people, healthy volunteers welcome
- Sponsor
- Prof. Patrick Petignat
Familial Pancreatic Cancer, Familial Pancreatic Carcinoma
A Liquid Biopsy for Pancreatic Cancer Early-detection and Disease Monitoring
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy characterized by an asymptomatic early phase, late diagnosis, and poor survival, particularly in individuals who develop disease outside the context of…
- Conditions
- Familial Pancreatic Cancer, Familial Pancreatic Carcinoma, Hereditary Pancreatic Cancer, Hereditary Pancreatitis
- Trial name
- PANXEON (NCT07700992)
- Testing
- PANXEON
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Università Vita-Salute San Raffaele
Cancer
Hair Isotope Analysis for Early Cancer Detection
Cancer is a major health challenge, and early detection is crucial for improving patient outcomes. Research has shown that cancer can alter the way the body processes nutrients.
- Trial name
- HI-CARE (NCT07006909)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Reading
Lung Cancer, Lung Cancer Screening
Prediction Augmented Screening Initiative
Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans.
- Trial name
- PASI (NCT06538636)
- Testing
- PCP-Facing Tools, LCS team population management tools
- Where
- 4 sites in United States
- Volunteers
- 23,520 people
- Sponsor
- VA Office of Research and Development
Glioblastoma
Personalized Targeted Glioblastoma Therapies by ex Vivo Drug Screening
Patient derived cell line (PDC) -based drug screening will be applied to formulate a personalized treatment approach.
- Trial name
- ATTRACT (NCT06512311)
- Testing
- CBMed Drug Screening Plattform
- Where
- Austria
- Volunteers
- 240 people
- Sponsor
- Medical University of Vienna
Solid Tumor Cancer
Oncogeriatric Screening and Evaluation Program
This study aims to develop, train, and validate a machine learning-based prediction model (PROTEGER) to provide treatment decision recommendations for older adults diagnosed with solid tumor cancers.
- Trial name
- PROTEGER (NCT07805642)
- Where
- 2 sites in Brazil
- Volunteers
- 412 people
- Sponsor
- Latin American Cooperative Oncology Group
Ovarian Cancer
Liquid Biopsy-based Early Detection of Ovarian Cancer: a Proof-of-concept Study ( PROFOUND-OC )
This study is a multi-center, observational study aiming at developing a machine learning-based early detection model using prospectively collected liquid biopsy samples from newly diagnosed ovarian cancer.
- Trial name
- NCT06249308
- Testing
- Blood collection
- Where
- 3 sites in China
- Volunteers
- 168 people
- Sponsor
- Fudan University
Cervical Cancer Screening
Community Implementation of Urine HPV Test and Reflex DNA Methylation Test in Cervical Cancer Screening
Aims: The project aims to explore the acceptability and feasibility of a self-sampling, urine-based HPV test (INDICAID HPV Urine Test) in a community setting, and the effectiveness of DNA methylation test for triaging high-risk…
- Trial name
- NCT07468578
- Where
- Hong Kong
- Volunteers
- 8,620 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Patient With Radiotherapy (Linac MRI), Mobile Cancerous Lesion
Impact of Non-magnetic Screen Respiratory Self-guidance During MRI-guided Radiotherapy Sessions for Mobile Lesions
The patients eligible for the study are those treated by radiotherapy on Linac MRI for a mobile cancerous lesion (pancreas, liver, kidneys, adrenals, lung, adenopathy above or below the diaphragm ...).
- Trial name
- RespEcran (NCT05783908)
- Testing
- With non-magnetic screen
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Georges Francois Leclerc
Lung Cancer Screening
Pilot Testing a Web-based Prototype of a Lung Cancer Screening Digital Health Tool
The purpose of this study is to evaluate the acceptability, usability, and preliminary efficacy of a web-based prototype of a digital health tool for lung cancer screening (LCS).
- Trial name
- NCT07716527
- Testing
- Digital health tool prototype, Control Arm - standard of care
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Rutgers, The State University of New Jersey
Advanced Malignant Tumours
A Platform Study of In Vivo CAR-T for Treating Advanced Malignant Tumors Based on Target Screening
This is a single-arm, open-label, single-center, dose-escalation Phase I platform study designed to evaluate the safety, tolerability, preliminary efficacy, pharmacokinetics, and pharmacodynamics of an in vivo CAR-T therapy (V001…
- Trial name
- NCT07395479
- Testing
- V001-BCMA, V001-GPRC5D, V001-DLL3
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Cancer, Early Detection of Cancer
CancerenD24 Screening as an Aid to the Clinician for the Diagnosis of Cancer
The purpose of the researchers is to test whether the CancerenD24 index, an algorithm based on the quantitative value of CD24, CD11b, clinical and laboratory characteristics, developed in the laboratory can help in the early…
- Trial name
- CancerenD24 (NCT06656728)
- Testing
- Blood-based liquid biopsy
- Where
- Israel
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Prostate Cancer, Prostate Cancer Screening Decision
Clinical Utility of ClarityDX Prostate
ClarityDX Prostate builds upon the utility of total and free PSA as well as simple clinical features in a decision support model to determine a patient's risk of having clinically significant prostate cancer.
- Conditions
- Prostate Cancer, Prostate Cancer Screening Decision, Prostate Cancer Screening
- Trial name
- NCT06678828
- Testing
- ClarityDX Prostate, ClarityDX Prostate, blinded
- Where
- 5 sites in Canada
- Volunteers
- 1,450 people
- Sponsor
- Nanostics