Clinical trials: Cancer Uterus Cervix
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN)
Dual-Modality Immunotherapy for HPV Clearance (DUAL-HPV)
Persistent high-risk human papillomavirus infection is an important precursor of cervical cancer and related cervical lesions. This single-center, randomized, assessor-blinded, parallel-group controlled trial evaluates whether…
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia (CIN), Low-Grade Squamous Intraepithelial Lesions
- Trial name
- DUAL-HPV (NCT07735039)
- Testing
- Oral Immunomodulator, Vaginal Ovule, Standard Supportive Care
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Cervical Cancer
Study of Adjuvant Topotecan and Cisplatin With Concurrent Radiation Therapy for Advanced Cervical Cancer
A Phase I Study of Adjuvant Topotecan and Cisplatin with Concurrent Radiation Therapy for Advanced Cervical Cancer.
- Trial name
- NCT00320983
- Testing
- Topotecan, Cisplatin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of New Mexico
Cervix Carcinoma
A Diagnostic Nomogram for Predicting Vaginal Invasion in Cervical Cancer
This study aims to develop a diagnostic nomogram based on clinical factors with the prediction values of vaginal invasion in cervical cancer to optimize the treatment plan and surgical procedures.
- Trial name
- NCT06039982
- Testing
- no intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fujian Cancer Hospital
Cervical Cancer
Paclitaxel, Topotecan, and Cisplatin in Treating Patients With Advanced, Persistent, or Recurrent Cervical Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, topotecan, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00276796
- Testing
- cisplatin, paclitaxel, topotecan hydrochloride
- Volunteers
- 66 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer
Laparoscopic Approach to Cervical Cancer
The goal of this clinical research study is to compare the long-term outcomes of different surgical methods for the treatment of cervical cancer.
- Trial name
- LACC (NCT00614211)
- Testing
- Total Abdominal Radical Hysterectomy, Total Laparoscopic or Robotic Radical Hysterectomy
- Where
- 33 sites in United States, Argentina and 11 more
- Volunteers
- 636 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Atypical Squamous Cell of Undetermined Significance, ASC-US
Comparison Of Cytology And Molecular Screening For Detecting Cervical Reactive Cellular Changes In General Population
This study compares the efficacy of cytology (Pap smear) with the molecular screening in their ability to detect reactive cellular changes in the cervix among an open population
- Conditions
- Atypical Squamous Cell of Undetermined Significance, ASC-US, Atypical Glandular Cells of Uncertain Significance, AGUS
- Trial name
- NCT07211204
- Testing
- Physical examination, Liquid-based cytology, Molecular screening
- Where
- Mexico
- Volunteers
- healthy volunteers welcome
- Sponsor
- Timser SAPI de CV
Prostate Cancer, Salivary Gland Cancer
A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With Advanced Cancer
The purpose of this study is to determine the tolerability profile of OPB-111001 and to determine the most suitable dose of OPB-111001 in patients with advanced cancer
- Conditions
- Prostate Cancer, Salivary Gland Cancer, Endometrial Cancer, Squamous Cell Carcinoma of the Cervix
- Trial name
- NCT02042885
- Testing
- OPB-111001
- Where
- 2 sites in United Kingdom
- Volunteers
- 79 people
- Sponsor
- Otsuka Novel Products GmbH
Uterine Cervix Cancer
Hypofractionated Radiochemotherapy
The goal of this clinical trial is to investigate the use of hypofractionated radiation (delivery of fewer but larger doses of radiation) with concurrent chemotherapy for women with metastatic of bulky uterine cervix cancer.
- Trial name
- NCT06331468
- Testing
- Cisplatin, intensity modulated radiation therapy (IMRT), high-dose-rate (HDR) brachytherapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Denise Fabian
Cervical Intraepithelial Neoplasia, Uterine Cervical Dysplasia
A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL)
A-007 is an investigational therapy which may be effective in the treatment of pre-cancerous cervical dysplasia (abnormal cell growth).
- Trial name
- TG-003 (NCT00596258)
- Testing
- A-007
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Tigris Pharmaceuticals
Cervix Cancer
Development of Clinically High Efficient Platforms for Individualised Treatment of Cervix Cancer
Retrospective study utilizing patient data to develop and validate Machine Learning application. Available imaging data sets of patients who have completed treatment will be used to develop Normal tissue complication probability…
- Trial name
- NCT05102240
- Where
- India
- Volunteers
- 1,800 people
- Sponsor
- Tata Memorial Hospital
Carcinoma in Situ of Uterine Cervix
Follow-up of Abnormal and Inadequate Smear-test Results
Denmark has a higher incidence of cervical cancer than other Nordic countries, although all Danish women (aged 23-65) are screened regularly to identify possible cervical dysplasia or asymptomatic invasive cancer.
- Trial name
- NCT02002468
- Testing
- Test result sent by letter, Test result conveyed by general practitioners
- Where
- Denmark
- Volunteers
- 125,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cervical Cancer, Cervical Abnormalities
Cervix Image Sharing Protocol (CISP)
The Clinical Epidemiology Unit in the Clinical Genetics Branch of the Division of Cancer Epidemiology, NCI has a strong interest in fostering cervical cancer prevention solutions for all kinds of settings, including lowresource…
- Trial name
- NCT03179306
- Where
- United States
- Volunteers
- 27,084 people
- Sponsor
- National Cancer Institute (NCI)
Papillomavirus Infections
Efficacy of 851B Gel for Treating High-Risk Cervical Human Papillomavirus Infection in Women.
The purpose of this study was to evaluate efficacy of 851B gel over a range of concentrations and dosing regimens on high-risk cervical human papillomavirus infection in women.
- Trial name
- NCT00117884
- Testing
- 851B
- Where
- 23 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Takeda
Algorithm for Cervix Carcinoma Screening
Algorithm for Cervix Carcinoma Screening in CZ Using the Detection of HPV DNA and CINtec Plus
Cervix carcinoma has been a serious, long-term issue in the Czech Republic. The cause of nearly all cervix carcinomas is human papilomavirus (HPV).
- Trial name
- LIBUSE (NCT05578833)
- Testing
- HPV DNA test with selective HPV 16/18 genotyping (cobas® 4800 HPV Test, Roche), p16 and Ki-67 biomarker detection in the form of dual cytological staining (CINtec Plus, Roche), standard conventional cytology PAP test
- Where
- Czechia
- Volunteers
- 2,426 people
- Sponsor
- AeskuLab Pathology Prague
Cervix Cancer
CAmpto-CISplatine Plus Radiotherapy in Advanced Cervix Cancer : Search of Tolerated Maximum Dose of Campto
Search of maximum tolerated irinotecan dose in association with cisplatin and pelvic radiotherapy in patients with an advanced cervix cancer.
- Trial name
- NCT00251888
- Testing
- campto (irinotecan), cisplatin (cisplatyl)
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- ARCAGY/ GINECO GROUP
Cervix Neoplasm
Comparison of Tomotherapy Versus Intensity-modulated Step-and-shoot and Conventional Radiation Treatment Plans for Patients With Locally-advanced Squamous Cell Carcinoma of the Cervix
Standard treatment for non-operable cervix cancer is radiation and chemotherapy. This treatment combination can result in significant radiation side-effects involving the bladder, small bowel and rectum.
- Trial name
- NCT00124488
- Testing
- Tomotherapy Treatment Planning
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Alberta Health services
Cervical Cancer, Vaginal Cancer
Paclitaxel in Treating Patients With Advanced, Refractory, or Recurrent Cervical or Vaginal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of paclitaxel in treating patients with advanced…
- Trial name
- NCT00002562
- Testing
- paclitaxel
- Where
- 50 sites in United States
- Volunteers
- 25 people
- Sponsor
- Gynecologic Oncology Group
Cervical Cancer, Cervix
Assessment of EGFR Genomic Alterations as Prognostic Markers in Cervical Cancer
The Tissue Repository will search for cases, pull slides, Paraffin-embedded tissue (PET) blocks.
- Trial name
- NCT00298064
- Testing
- Tissue Repository
- Where
- United States
- Sponsor
- University of New Mexico
Cervical Intraepithelial Neoplasia Grade 2/3, High-risk HPV (Any Strain)
Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
This phase I research protocol is designed to assess immunogenicity and clinical endpoints in patients with human papillomavirus (HPV) 16 cervical intraepithelial neoplasia (CIN)2/3.
- Trial name
- NCT02354534
- Testing
- Artesunate Suppositories
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Metastatic Tumor, Advanced Solid Tumor
A Clinical Study of CD70-targeted CAR-T in the Treatment of CD70-positive Advanced/Metastatic Solid Tumors
This is a phase I clinical study to evaluate the safety and tolerability of CAR-T in patients with CD70-positive advanced/metastatic solid tumors, and to obtain the maximum tolerated dose of CAR-T and phase II Recommended dose.
- Conditions
- Metastatic Tumor, Advanced Solid Tumor, Renal Cell Carcinoma, Ovarian Cancer
- Trial name
- NCT05518253
- Testing
- CD70 CAR-T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Weijia Fang, MD