Clinical trials: Cancer Uterus Cervix
Cervix Cancer, Cervix Neoplasm
Artesunate Pessaries (Vaginal Inserts) for Cervical Precancer in Kenya
To investigate the use of self-administered artesunate vaginal pessaries as treatment for cervical precancer in low and middle-income countries (LMIC).
- Conditions
- Cervix Cancer, Cervix Neoplasm, Precancerous Conditions, Cervical Precancer
- Trial name
- NCT06165614
- Testing
- Artesunate pessary, Colposcopy
- Where
- Kenya
- Volunteers
- 17 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervix Cancer
Hyaluronic Acid-based Gel Spacers in Gynecologic Malignancies
This pilot feasibility study evaluates the use of a hyaluronic acid-based spacing gel (Barrigel) in participants with cervical cancer undergoing chemoradiotherapy (chemoRT), including brachytherapy, as part of standard care.
- Trial name
- NCT07292818
- Testing
- Barrigel gel spacer
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma
Fludeoxyglucose (FDG) F 18 PET Scan, CT Scan, and Ferumoxtran-10 MRI Scan Before Chemotherapy and Radiation Therapy in Finding Lymph Node Metastasis in Patients With Locally Advanced Cervical Cancer or High-Risk Endometrial Cancer
This phase I/II trial is studying how well fludeoxyglucose F 18 PET scan, CT scan, and ferumoxtran-10 MRI scan finds lymph node metastasis before undergoing chemotherapy and radiation therapy in patients with locally advanced…
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Cell Carcinoma, Cervical Small Cell Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT00416455
- Testing
- fludeoxyglucose F 18, positron emission tomography, computed tomography
- Where
- 33 sites in United States, Canada and 2 more
- Volunteers
- 384 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Lung Cancer
The Effectiveness of the Screening Inventory of Psychosocial Problems (SIPP) in Cancer Patients
The purpose of this study is to evaluate the effectiveness and feasibility of the Screening Inventory of Psychosocial Problems (SIPP) in consultation settings with respect to early recognition and treatment of psychosocial…
- Conditions
- Breast Cancer, Lung Cancer, Prostate Cancer, Bladder Cancer
- Trial name
- NCT00859768
- Testing
- Questionnaire administration
- Where
- Netherlands
- Volunteers
- 568 people
- Sponsor
- Netherlands Open University
Cervical Cancer, Ovarian Cancer
Thermal Spread Into the Interstitial Portion of the Fallopian Tubes Using the Ligasure Device at Time of Hysterectomy
Some patients, specifically those with a diagnosed genetic mutation, will have their ovaries and fallopian tubes removed without removal of the uterus in an attempt to prevent ovarian and fallopian tube cancer from developing.
- Conditions
- Cervical Cancer, Ovarian Cancer, Uterine Cancer
- Trial name
- NCT00746018
- Testing
- LigaSure vessel sealing system
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervical Intraepithelial Neoplasia Grade 2/3, High-risk HPV (Any Strain)
Intravaginal Artesunate for the Treatment of HPV+ High Grade Cervical Intraepithelial Neoplasia (CIN2/3)
This phase I research protocol is designed to assess immunogenicity and clinical endpoints in patients with human papillomavirus (HPV) 16 cervical intraepithelial neoplasia (CIN)2/3.
- Trial name
- NCT02354534
- Testing
- Artesunate Suppositories
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Cervical Cancer, Cervix Cancer
Minimally Invasive Simple Hysterectomy in Low Risk Cervical Cancer
The rationale of the present study is to assess the safety of the minimally invasive surgery approach in patients meeting the SHAPE trial inclusion criteria.The SHAPE trial was designed to answer the clinical question of whether…
- Trial name
- LASH (NCT06416748)
- Testing
- Minimally invasive simple hysterectomy
- Where
- Italy
- Volunteers
- 974 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cervical Cancer, Endometrial Cancer
Pelvic Fractures and Radiation Therapy for Cervical Cancer
The goal of this study is to estimate how often pelvic fractures occur in women treated with radiation therapy for either newly diagnosed or recurrent cervical, endometrial, or vaginal cancer.
- Conditions
- Cervical Cancer, Endometrial Cancer, Vaginal Cancer
- Trial name
- NCT00800644
- Testing
- CT or MRI + Blood Test
- Where
- United States
- Volunteers
- 239 people
- Sponsor
- M.D. Anderson Cancer Center
Cervix Cancer
Optimized Magnetic Resonance Brachytherapy (MR BT) in Cervix Cancer
Patients with cervix cancer usually require external radiation given to the whole pelvis then an internal radiation boost, also called brachytherapy, to treat any remaining tumour.
- Trial name
- NCT00938106
- Testing
- optimised magnetic resonance image-guided intra-uterine brachytherapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Cervix Carcinoma, Cervical Squamous Cell Carcinoma
Hybrid PET/MR in the Therapy of Cervical Cancer
This is a two arm, single center feasibility study of 20 patients with non-metastatic cervical cancer managed with surgery and/or chemoradiation therapy at UNC Hospitals.
- Conditions
- Cervix Carcinoma, Cervical Squamous Cell Carcinoma, Cervical Adenosquamous Carcinoma
- Trial name
- NCT01759355
- Testing
- FDG PET/MR
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cervical Intraepithelial Neoplasia, Cervix Uteri Cancer
Incidence of Cervical Cancer in HPV-positive Women With Low-grade Cytological Abnormalities
The goal of this observational study is to assess the five-year incidence of histologically confirmed cervical cancer among women who test positive for human papillomavirus (HPV) with low-grade cytological abnormalities, to…
- Conditions
- Cervical Intraepithelial Neoplasia, Cervix Uteri Cancer, Human Papilloma Virus, Cervix Carcinoma
- Trial name
- NCT07259616
- Volunteers
- 46,079 people
- Sponsor
- Gynaecologisch Oncologisch Centrum Zuid
Cervical Cancer
Human Papillomavirus Infection and Virus Genotyping in Uterine Cervix Cancer in Venezuela
1. Hypothesis: If high risk genotypes of human papillomavirus (HPV) is the cause of cervical cancer worldwide, the genotypes associated with cervical cancer in Venezuela would be the same types found in other countries. 2.
- Trial name
- HPI (NCT00937547)
- Where
- 2 sites in Venezuela
- Volunteers
- 329 people
- Sponsor
- Instituto Oncologico Luis Razetti
Fallopian Tube Patency Tests, Fibroid/Myoma (Uterus/Cervix)
Assessment of Tubal Occlusion During Minimally Invasive Myomectomy
This study uses a procedure called chromopertubation to look at how fibroids and fibroid surgery affect the fallopian tubes. Specifically, this study will test if the fallopian tubes are occluded or patent (open) before and after…
- Conditions
- Fallopian Tube Patency Tests, Fibroid/Myoma (Uterus/Cervix), Myomectomy, Fallopian Tube Disease
- Trial name
- ATOM (NCT06988774)
- Testing
- chromopertubation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medstar Health Research Institute
Cervical Dysplasia, Uterine, Vaginal Dysplasia
Clinical, Translational and Biomarker-Based Female Genital HPV Induced Dysplasia and Cancer Screening Study Using Cf-HPV-DNA Blood Tests
Uterine cervical dysplasia and other female genital dysplasia continue to be significant health problems despite Cervical Screening Programs and HPV vaccinations being available.
- Conditions
- Cervical Dysplasia, Uterine, Vaginal Dysplasia, Vulvar Dysplasia
- Trial name
- TTMV HPV DNA (NCT05536843)
- Volunteers
- 500 people
- Sponsor
- University of Mississippi Medical Center
Cervical Intraepithelial Neoplasia, Cervical Neoplasms
Gene Therapy Follow up Protocol for Subjects Previously Enrolled in NCI Center for Immuno-Oncology Studies
Background: Gene therapy is closely followed by the U.S. Food and Drug Administration (FDA). The FDA requires researchers to conduct long-term follow-up of people who have had the treatment.
- Conditions
- Cervical Intraepithelial Neoplasia, Cervical Neoplasms, Oropharyngeal Neoplasms, Squamous Intraepithelial Lesions of the Cervix
- Trial name
- NCT04266093
- Testing
- GeneTherapy
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma
Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer
This phase II clinical trial is studying the how well veliparib, topotecan hydrochloride, and filgrastim or pegfilgrastim work in treating patients with persistent or recurrent cervical cancer.
- Conditions
- Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Cervical Small Cell Carcinoma, Cervical Squamous Cell Carcinoma
- Trial name
- NCT01266447
- Testing
- Filgrastim, Laboratory Biomarker Analysis, Pegfilgrastim
- Where
- 78 sites in United States
- Volunteers
- 27 people
- Sponsor
- National Cancer Institute (NCI)
Cervical Intraepithelial Neoplasia, Cervix Neoplasms
Cold Knife Conization With and Without Lateral Hemostatic Sutures
The treatment of high grade Cervical Intraepithelial Neoplasia (CIN) 2, 3 is defined according to the colposcopic evaluation of the patient.
- Trial name
- NCT02184975
- Testing
- Cold Knife Conization with stitches, Cold knife Conization without stitches
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Barretos Cancer Hospital
Cancer of Cervix
Comparative Study of Gemcitabine,Cisplatin and Radiation Versus Cisplatin and Radiation in Cancer of the Cervix
The purpose of this study is to compare the effectiveness of two methods of treating cancer of the cervix. Half the patients will receive gemcitabine plus cisplatin while undergoing radiation therapy, followed by adjuvant…
- Trial name
- NCT00191100
- Testing
- Gemcitabine, Cisplatin, Brachytherapy
- Where
- 7 sites in Argentina, Bosnia and Herzegovina and 5 more
- Volunteers
- 515 people
- Sponsor
- Eli Lilly and Company
Cervical Cancer
Predictive Assays In Cervix Cancer
The experiments outlined in this proposal will compare a number of currently available techniques for assessing hypoxia and interstitial fluid pressures in patients with cervix cancer.
- Trial name
- NCT01181375
- Testing
- Tumour Biopsies and Blood Sampling
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University Health Network, Toronto
Cervical Cancer
GSK1120212+GSK2141795 for Cervical Cancer
This research study is evaluating the combination of two drugs called GSK1120212 (trametinib) and GSK2141795 as a possible treatment for recurrent or persistent cervical cancer.
- Trial name
- NCT01958112
- Testing
- GSK1120212 (trametinib), GSK2141795
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Dana-Farber Cancer Institute