Clinical trials: Cancer in Children/Adolescents
Cancer
A Web-Based Physical Activity Intervention in Adolescent Survivors of Childhood Cancer
Five year survival following a diagnosis of childhood cancer has reached 83%, making long term health outcomes among survivors an important concern.
- Trial name
- NCT01778127
- Testing
- Activity Monitor, Interactive Website, Educational Materials
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- St. Jude Children's Research Hospital
Solid Tumors
Study of EZN-2208 Pediatric Patients With Solid Tumors
The goal of this clinical research study is to find the highest tolerable dose of EZN-2208 that can be given to pediatric patients with Relapsed or Refractory Solid Tumors.
- Trial name
- NCT01295697
- Testing
- EZN-2208
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Enzon Pharmaceuticals, Inc.
Paediatric Oncology, Malnutrition in Children
Development of a Digital Personalised Nutrition Tool for Adolescents Undergoing Cancer Treatment
This study aims to develop and test MybYte, a smartphone tool designed to support personalised nutrition for teenagers aged 12-18 undergoing cancer treatment.
- Trial name
- MybYte (NCT07865117)
- Testing
- The MybYte tool, a digital personalised nutrition tool for adolescents undergoing cancer treatment
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- KU Leuven
Ovarian Cyst Benign
Save the Ovaries - Surgical Management of Simple Ovarian Cysts in Children and Adolescents
The purpose of this study is to evaluate which operative technique should be used for managing simple ovarian cysts in girls and adolescents.
- Trial name
- NCT06852313
- Testing
- Laparoscopic ovarian cyst surgery
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- University Children's Hospital, Zurich
Solid Tumor, Lymphoma
Durvalumab in Pediatric and Adolescent Patients
This clinical trial is the first clinical trial to study Durvalumab, a checkpoint inhibitor which stimulates the patient's own immune system to act against cancer cells in children and adolescents.
- Conditions
- Solid Tumor, Lymphoma, Central Nervous System Tumors
- Trial name
- NCT02793466
- Testing
- Durvalumab; MEDI4736
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Leo Mascarenhas
Relapsed Pediatric Solid Tumor, Refractory Pediatric Solid Tumor
Combination Chemotherapy With Pazopanib in Children and Adolescents With Relapsed/Refractory Solid Tumors
The purpose of this study is to evaluate the safety and efficacy of combination chemotherapy with Pazopanib in pediatric patients with relapsed/refractory solid tumor
- Trial name
- NCT03628131
- Testing
- Pazopanib, Ifosfamide, Carboplatin
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Samsung Medical Center
Hodgkin Lymphoma
Feasibility of High Intensity Interval Training in Survivors of Childhood, Adolescent, and Young Adult Hodgkin Lymphoma
This pilot study evaluates the feasibility of a 12-week high intensity interval training (HIIT) program in survivors of childhood, adolescent, and young adult Hodgkin lymphoma within 24 months of completing treatment.
- Trial name
- NCT07222345
- Testing
- High Intensity Interval Training (HIIT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Jude Children's Research Hospital
Neurofibromatosis 1, Neurofibroma, Plexiform
Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials
Background: Neurofibromatosis type 1 (NF1) is a genetic disorder. It has a broad variety of effects on the body. Up to half of people with NF1 get plexiform neurofibromas (PNs). These are benign tumors.
- Trial name
- NCT03531814
- Testing
- Medication Event Monitoring System (MEMS^TM), Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Thoracic Surgery, Scoliosis; Adolescence
Chronic Pain After Scoliosis and Thoracic Surgery in Children
The aim of this epidemiologic prospective study is to determine the prevalence of CPSP defined as pain occurring 4 months after scoliosis and thoracic surgery and rated > 3 on a 10 point visual analogue scale or FLACC scale, in…
- Conditions
- Thoracic Surgery, Scoliosis; Adolescence, Pediatric ALL, Chronic Pain
- Trial name
- PEDIACHROII (NCT02995525)
- Where
- France
- Volunteers
- 68 people
- Sponsor
- University Hospital, Bordeaux
Ependymoma, Ewing Sarcoma
A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in Children, Adolescents and Young Adults With Recurrent or Treatment-resistant Cancer
The purpose of this study is to first, in Part A, assess the safety, tolerability and drug levels of Bempegaldesleukin (BEMPEG) in combination with nivolumab and then, in Part B, to estimate the preliminary efficacy in children…
- Conditions
- Ependymoma, Ewing Sarcoma, High-grade Glioma, Leukemia and Lymphoma
- Trial name
- PIVOT IO 020 (NCT04730349)
- Testing
- Nivolumab, NKTR-214
- Where
- 18 sites in United States, Australia and 4 more
- Volunteers
- 15 people
- Sponsor
- Bristol-Myers Squibb
Acute Lymphoblastic Leukemia, Pediatric
Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Children and Adolescents
Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children. The cancer comes from a cell in the blood called a lymphocyte.
- Trial name
- NCT03020030
- Testing
- Pegaspargase, Erwinia asparaginase, Cyclophosphamide
- Where
- 9 sites in United States, Canada
- Volunteers
- 560 people
- Sponsor
- Dana-Farber Cancer Institute
Osteonecrosis
Functional Outcomes Following Hip Core Decompression in Younger Participants With Osteonecrosis
Although uncommon in the general pediatric population, osteonecrosis (ON) is prevalent in children and adolescents with cancer, particularly among those that have had chronic exposure to glucocorticoids and among those having…
- Trial name
- NCT02458937
- Testing
- Functional Mobility Assessment, GAITRite® System, Range of Motion
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- St. Jude Children's Research Hospital
Lymphoblastic Leukemia, Acute, Childhood;
Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia
With this protocol the ALL-SZT BFM international study group wants to evaluate whether hematopoietic stem cell transplantation (HSCT) from matched family or unrelated matched donors (MD) is equivalent to the HSCT from matched…
- Trial name
- NCT01423747
- Testing
- VP16, TBI, VP16, ATG
- Where
- 24 sites in Austria, Germany
- Volunteers
- 400 people
- Sponsor
- St. Anna Kinderkrebsforschung
Refractory or Relapsed RMS and Soft Tissue Sarcomas
Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Rhabdomyosarcoma and Other Soft Tissue Sarcomas
The purpose of this study is to determine the Everolimus aim response in children and adolescents with refractory or relapsed Rhabdomyosarcoma and other soft tissue sarcomas
- Trial name
- NCT01216839
- Testing
- Everolimus
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Sidnei Epelman
Childhood Glioblastoma
Autologous Dendritic Cells, Metronomic Cyclophosphamide and Checkpoint Blockade in Children With Relapsed HGG
This phase I/II trials evaluates the feasibility, safety and efficacy of an individualized cancer vaccine, based on autologous, tumor-lysate loaded dendritic cells in children and adolescents with relapsed high-grade gliomas.
- Trial name
- NCT03879512
- Testing
- depletion of regulatory T cells, reoperation, cancer vaccine
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Wuerzburg University Hospital
Neoplasms
An Exploratory Study of the Use of Five Wishes as a Tool for Advanced Care Planning in Young Adults With Metastatic, Recurrent, or Progressive Cancer or HIV Infection
Background: Few resources exist for helping adolescents and young adults with cancer or HIV disease understand their changing physical, emotional and social needs when treatment is no longer effective.
- Trial name
- NCT01445145
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute (NCI)
B-cell Acute Lymphoblastic Leukemia
A Study of CNCT19 Treatment in Children and Adolescent r/r ALL Patients(Pediatric)
This is a multi-center, phase Ib/II trial to evaluate the safety and efficacy of CNCT19 treatment in Children and Adolescent (pediatric) patients with relapsed or refractory B-cell acute lymphoblastic leukemia (r/r B-cell ALL).
- Trial name
- NCT05667506
- Testing
- single dose of CNCT19
- Where
- 9 sites in China
- Volunteers
- 47 people
- Sponsor
- Juventas Cell Therapy Ltd.
Pediatric Cancer
Longitudinal Identity Study of Childhood Cancer Survivors
The study investigators plan to conduct a longitudinal questionnaire study in adolescents and emerging adults (14-25 years of age at the start of the study) who survived childhood cancer to chart their identity development and…
- Trial name
- LInC (NCT03424343)
- Testing
- Questionnaire bundle, Obtaining information from survivors' medical file
- Where
- Belgium
- Volunteers
- 126 people
- Sponsor
- KU Leuven
Health Literacy, Health Related Quality of Life
Feasibility of a Life Coping Program: A Study Protocol
The goal of this observational study is to evaluate the feasibility of the intervention Life Coping Program in children and adolescents 8-16 years of age.
- Conditions
- Health Literacy, Health Related Quality of Life, Physical Activity, Pediatric ALL
- Trial name
- LifeCOPE (NCT06709248)
- Testing
- Life Coping Program
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Haukeland University Hospital
Cachexia; Cancer, Muscle Wasting
Muscle Wasting in Children and Adolescents With Cancer
The series of the 3-year study aims to explore parents' experience of caring for a child's weight change among parents of children and adolescents with cancer, examine the associations and trends among muscle wasting and…
- Conditions
- Cachexia; Cancer, Muscle Wasting, Child Development, Adolescent Development
- Trial name
- NCT04353063
- Testing
- Multidisciplinary care with a personalized care
- Where
- Taiwan
- Volunteers
- 440 people
- Sponsor
- National Taiwan University Hospital