Clinical trials: Cancer in Children/Adolescents
Soft Tissue Sarcoma of the Lower Extremity, Bone Tumor of the Lower Extremity
Prehabilitation in Childhood Soft Tissue or Bone Sarcomas
This study aims to investigate the feasibility of a prehabilitative training intervention. The intervention includes specific strength and balance exercises during neoadjuvant chemotherapy with children and adolescents diagnosed…
- Conditions
- Soft Tissue Sarcoma of the Lower Extremity, Bone Tumor of the Lower Extremity, Childhood and Adolescent Cancer
- Trial name
- Prehab4Kids (NCT06743958)
- Testing
- Exercise intervention
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- Technical University of Munich
Smokeless Tobacco Cessation
Improvement in Knowledge and Perception About Hazards of Smokeless Tobacco
Oral cancer is a serious and growing problem in many parts of the globe. Oral cancer is the eighth most common cancer worldwide.The annual estimated incidence is around 275,000 for oral and 130,300 for pharyngeal cancers…
- Trial name
- NCT03418506
- Testing
- SMOKELESS TOBACCO AWARENESS PROGRAM
- Where
- Pakistan
- Volunteers
- 1,327 people
- Sponsor
- Aga Khan University
Childhood Cancer
Strength Training and ADLs in Childhood Leukemia and Lymphoma Patients
Reduced activity levels and reduced muscular strength could severely impair the activities of daily living (ADLs) in pediatric leukemia and Non-Hodgkin lymphoma patients.
- Trial name
- NCT03934060
- Testing
- Exercise
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Technical University of Munich
Pediatric Cancer, Pediatric Cancer Patients
Real World Pediatric Oncology Rehabilitation in Italy ( ReWori )
This observational study aims to describe changes in the functional abilities of children, adolescents and young adults with cancer who are undergoing physiotherapy or neuropsychomotor rehabilitation.
- Conditions
- Pediatric Cancer, Pediatric Cancer Patients, Pediatric Oncology, Rehabilitation
- Trial name
- REWORI (NCT07368582)
- Testing
- Rehabilitation intervention
- Where
- 13 sites in Italy
- Volunteers
- 249 people
- Sponsor
- Associazione Italiana Ematologia Oncologia Pediatrica
Leukemia
A Phase II Study of Dasatinib in Children and Adolescents With Newly Diagnosed Chronic Phase Chronic Myelogenous Leukemia (CML) or With Ph+ Leukemias Resistant or Intolerant to Imatinib
The purpose of this study is to determine whether dasatinib is safe and effective in children and adolescents with newly diagnosed chronic myeloid leukemia (CML), or in children with Ph+ acute lymphoblastic leukemia (ALL)…
- Trial name
- NCT00777036
- Testing
- Dasatinib
- Where
- 174 sites in United States, Argentina and 16 more
- Volunteers
- 133 people
- Sponsor
- Bristol-Myers Squibb
Brain and Central Nervous System Tumors, Leukemia
Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment
RATIONALE: Drugs used in chemotherapy, such as talotrexin, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Brain and Central Nervous System Tumors, Leukemia, Lymphoma, Unspecified Childhood Solid Tumor, Protocol Specific
- Trial name
- NCT00458744
- Testing
- talotrexin, chemotherapy
- Sponsor
- Children's Oncology Group
Malignant Melanoma
Phase 2 Study of Ipilimumab in Children and Adolescents (12 to < 18 Years) With Previously Treated or Untreated, Unresectable Stage III or Stage lV Malignant Melanoma
The purpose of the study is to comply with the Pediatric Investigation Plan requirements of Ipilimumab
- Trial name
- NCT01696045
- Testing
- Ipilimumab
- Where
- 32 sites in United States, Belgium and 6 more
- Volunteers
- 14 people
- Sponsor
- Bristol-Myers Squibb
Bone Sarcoma, Childhood Cancer
Culturally Adapted Mobile Treatment of Chronic Pain in Adolescent Survivors of Pediatric Cancer
This is a prospective study that will conduct a series of focus groups with non-Hispanic Black and Hispanic childhood cancer survivors to obtain their input on culturally adapting a mobile CBT program for chronic pain and tDCS…
- Trial name
- NCT05746429
- Testing
- Cognitive Behavior Therapy, Transcranial Direct Current Stimulation, Questionnaire Administration
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- St. Jude Children's Research Hospital
Neuropathy, Cancer
Glutamine for the Prophylaxis of Vincristine-induced Neuropathy in Children and Adolescents With Cancer.
The goal of this clinical trial is to assess the efficacy of glutamine in preventing the occurrence of vincristine induced neuropathy and to compare the reduction in rate of any dose reductions and premature chemotherapy…
- Trial name
- NCT07287592
- Testing
- Glutamine (Pharmacological doses)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Rare Diseases
Rare Tumours in Children and Adolescents (STEP)
The aim of the STEP registry is to collect and evaluate experience and data on the diagnosis and treatment of rare childhood tumors in order to use the knowledge gained to improve the treatment prospects for our patients.
- Trial name
- STEP 2 0 (NCT05773651)
- Testing
- Data collection
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Tuebingen
Recurrent Acute Myeloid Leukemia, Refractory Acute Myeloid Leukemia
Flotetuzumab for the Treatment of Pediatric Recurrent or Refractory Acute Myeloid Leukemia
This phase I trial studies the side effects, best dose of flotetuzumab and how well it works in treating patients with acute myeloid leukemia (AML) that has come back (recurrent) or has not responded to treatment (refractory).
- Trial name
- NCT04158739
- Testing
- Cytarabine, Flotetuzumab
- Where
- 19 sites in United States
- Volunteers
- 16 people
- Sponsor
- Children's Oncology Group
Early Melanoma, Advanced Melanoma
Impact of Anti PD-1 Therapy in Children, Adolescents and Young Adults (CAYA) Melanoma Patients
This is a retrospective observational cohort study, the primary objective is investigate the activity and efficacy of anti PD-1 antibodies in children, adolescents and young adult melanoma patients, with radically resected or…
- Trial name
- MELCAYA (NCT06281912)
- Where
- 13 sites in France, Germany and 5 more
- Volunteers
- 70 people
- Sponsor
- Azienda Ospedaliera di Perugia
Leukemia, Lymphoma
Beta-Glucan and Rituximab in Treating Young Patients With Relapsed or Progressive Lymphoma or Leukemia, or Lymphoproliferative Disorder Related to Donor Stem Cell Transplantation
RATIONALE: Monoclonal antibodies such as rituximab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Conditions
- Leukemia, Lymphoma, Lymphoproliferative Disorder
- Trial name
- NCT00087009
- Testing
- beta-glucan, rituximab
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastrointestinal Cancer, Colorectal Cancer
GastroIntestinal Cancer in Children and Adolescents
The goal of this observational population-based cohort study is to investigate the clinical characteristics and outcomes of children and adolescents with primary gastrointestinal malignancies registered in the publicly available…
- Conditions
- Gastrointestinal Cancer, Colorectal Cancer, Gastric Cancer, Hepatoblastoma
- Trial name
- GICCA (NCT05693519)
- Where
- 2 sites in Netherlands
- Volunteers
- 2,500 people
- Sponsor
- Paul G. Kemps, MD
Survivorship, Fatigue
Mobile Health Fitness Program for Adolescent and Young Adult Childhood Cancer Survivors
This clinical trial studies a mobile health fitness program for adolescent and young adult childhood cancer survivors. Adolescent and young adult childhood cancer survivors are at risk to have negative late effects from treatment…
- Trial name
- TLCFIT (NCT02688192)
- Testing
- Exercise Intervention, Internet-Based Intervention, Monitoring Device
- Where
- 2 sites in United States
- Volunteers
- 49 people
- Sponsor
- Rutgers, The State University of New Jersey
Very Rare Tumors, Very Rare Cancers
NCI Childhood Cancer Data Initiative (CCDI) Led Pediatric, Adolescent, and Young Adult Rare Cancer Registry for Very Rare Solid Tumors
Background: All childhood cancers are rare, but some are called very rare. Very rare cancers are diagnosed in 2 or fewer out of 1 million people each year.
- Conditions
- Very Rare Tumors, Very Rare Cancers, Other Solid Tumors, Solid Tumor
- Trial name
- NCT07489378
- Testing
- Natural history study of individuals with very rare tumors
- Where
- United States
- Volunteers
- 4,000 people
- Sponsor
- National Cancer Institute (NCI)
Anaplastic Astrocytoma, Diffuse Brainstem Glioma
Testing Cerebrospinal Fluid for Cell-free Tumor DNA in Children, Adolescents, and Young Adults With Brain Tumors
Recent advances in technology have allowed for the detection of cell-free DNA (cfDNA). cfDNA is tumor DNA that can be found in the fluid that surrounds the brain and spinal cord (called cerebrospinal fluid or CSF) and in the…
- Conditions
- Anaplastic Astrocytoma, Diffuse Brainstem Glioma, Glioblastoma Multiforme, High-grade Astrocytoma NOS
- Trial name
- NCT05934630
- Where
- 10 sites in United States, Canada
- Volunteers
- 57 people
- Sponsor
- Pediatric Brain Tumor Consortium
Adolescent Behavior, Pediatric Cancer
Feasibility Usability & Acceptability Study: Symptom Reporting by Children Adolescents & Young Adults w/Cancer
The purpose of this project is to pilot test an electronically delivered symptom assessment tool Pediatric Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (Ped-PRO-CTCAE), completed by…
- Conditions
- Adolescent Behavior, Pediatric Cancer, Oncology
- Trial name
- NCT06824441
- Testing
- Age- and Role-Specific Questionnaire Administration
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- Stanford University
Solid Tumors
Tabectedin to Treat Children and Adolescents With Cancer
Background: Trabectedin is an experimental drug that kills some cancer cells in the laboratory and in mice by interfering with genetic material (DNA) in cancer cells.
- Trial name
- NCT01453283
- Testing
- Trabectedin (ecteinascidin-743, ET-743, YONDELIS [R])
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Leukemia, Lymphocytic, Acute
NOPHO ALL-2008 Pilot Study on Consolidation Therapy for Children and Adolescents With Acute Lymphoblastic Leukemia
The present pharmacokinetic (PK)-pharmacodynamic (PD) study will explore the toxicity and antileukemic response during the initial 3 months of individualised therapy of children and young adults with acute lymphoblastic leukemia…
- Trial name
- NCT00548431
- Testing
- 6-mercaptopurine
- Where
- 3 sites in Denmark, Sweden
- Volunteers
- 38 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet