Clinical trials: Cancer of Brain
Glioblastoma
A Study to Evaluate Bevacizumab Alone or in Combination With Irinotecan for Treatment of Glioblastoma Multiforme (BRAIN)
This is a Phase II, open-label, multicenter, randomized, non comparative study consisting of two concurrent single-arms. Approximately 160 subjects will be randomized in a 1:1 ratio to Arm 1 (bevacizumab alone) or Arm 2…
- Trial name
- BRAIN (NCT00345163)
- Testing
- bevacizumab, irinotecan
- Volunteers
- 167 people
- Sponsor
- Genentech, Inc.
Non Small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer
Dose-escalation by Hypofractionated Stereotactic Radiotherapy for Brain Metastases in Non Small Cell Lung Cancer
The objective of this trial is to assess the safety and feasibility of delivering SBRT to patients with limited BMs (less than 10 lesions of lung cancer) by establishing the maximally tolerated dose (MTD) of SABR in 5 fractions.
- Conditions
- Non Small Cell Lung Cancer, Stage IV Non-small Cell Lung Cancer, Brain Metastases
- Trial name
- NCT05588206
- Testing
- Hypofractionated Stereotactic Radiotherap
- Where
- China
- Volunteers
- 21 people
- Sponsor
- First People's Hospital of Hangzhou
Brain Tumor
Memantine +/- Raloxifene for Cognitive Preservation After Radiation Therapy to the Brain
The study investigators are testing to see if patients receiving radiation treatment for brain cancer along with raloxifene plus memantidine take longer to develop memory issues.
- Trial name
- MemoryRT (NCT07470606)
- Testing
- Memantine, Raloxifene
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Glioblastoma, Malignant Glioma
Dexamethasone and Azeliragon for Management of Post-Resection Cerebral Edema in Patients with Glioblastoma
This phase I trial tests the safety, side effects, and best dose of dexamethasone when given with azeliragon in managing cerebral edema after surgery (post-resection) in patients with glioblastoma.
- Trial name
- NCT05773664
- Testing
- Azeliragon, Biospecimen Collection, Computed Tomography
- Sponsor
- City of Hope Medical Center
Glioblastoma, Gliosarcoma
Phase I Portion of Phase I/II Sorafenib With Radiation and Temozolomide in Newly Diagnosed Glioblastoma or Gliosarcoma
The goal of this clinical research study is to find the highest tolerable dose of sorafenib that can be given in combination with temozolomide. The safety of this combination will also be studied.
- Trial name
- NCT00734526
- Testing
- Temozolomide, Radiation, Sorafenib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Metastases, Adult
Fractionated Stereotactic Radiotherapy for Limited Small Volume Brain Metastases
This is a single-center, open lable, single-arm phase II clinical study to evaluate the efficacy and safety of fractionated stereotactic radiotherapy (FSRT) in patients with 1-4 brain metastases with ≤2cm in diameter.
- Trial name
- NCT07405047
- Testing
- fractionated stereotactic radiotherapy
- Where
- China
- Volunteers
- 33 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Glioma, Epilepsy
Connectivity Alterations After Levetiracetam Application
This study aimed to analyze the connectivity alterations in brain networks of LGG patients with epilepsy who take levetiracetam at short-term preoperatively.
- Trial name
- NCT04425798
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Neurosurgical Institute
Glioblastoma
Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade Gliomas
This study was conducted to evaluate the efficacy and safety of depatuxizumab mafodotin (ABT-414) alone or with temozolomide versus temozolomide or lomustine alone in adult participants with recurrent glioblastoma.
- Trial name
- INTELLANCE-2 (NCT02343406)
- Testing
- Depatuxizumab mafodotin, Temozolomide, Lomustine
- Where
- 102 sites in United States, Australia and 19 more
- Volunteers
- 266 people
- Sponsor
- AbbVie
Brain Metastases
NTS-WBRT in Brain Metastases
This research is being done to assess the quality of life and symptom burden in participants who receive (normal tissue sparing whole brain radiation therapy (NTS-WBRT).
- Trial name
- NCT05013892
- Testing
- NTS-WBRT (normal tissue sparing whole brain radiation therapy), Memantine
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Massachusetts General Hospital
Intracranial Venous Blood, Brain Cancers
A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers
To learn if drawing blood directly from veins inside the brain is safe and can effectively provide the same kind of detailed information about high-grade glioma as traditional surgical biopsy.
- Conditions
- Intracranial Venous Blood, Brain Cancers, Liquid Biopsy, Evaluate the Safety
- Trial name
- NCT07467109
- Testing
- blood sampling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer
MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors
Brain metastases are the most common intracranial malignancy occurring in 20-40% of all cancers, and the presence of CNS metastases is associated with a poor prognosis.
- Conditions
- Non-Small Cell Lung Cancer, Nonsmall Cell Lung Cancer, Breast Cancer, Cancer of Breast
- Trial name
- NCT02669914
- Testing
- MEDI4736
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Cranial Diseases (e.g., Brain Tumors, Stroke, Neurodegenerative Disorders)
Construction of AI Model for Precision Imaging Diagnosis of Cranial Diseases
The goal of this observational study is to develop and validate a high-precision AI diagnostic model for cranial diseases by integrating clinical knowledge systems (pathophysiological classification, age stratification, and…
- Trial name
- NCT07446842
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Glioblastoma Multiforme, Anaplastic Astrocytoma
Study of a Retroviral Replicating Vector Combined With a Prodrug to Treat Patients Undergoing Surgery for a Recurrent Malignant Brain Tumor
This is a multicenter study evaluating the safety and tolerability of increasing doses of Toca 511, a retroviral replicating vector, injected into the resection cavity of patients with Grade III or Grade IV Gliomas who have…
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Anaplastic Oligoastrocytoma
- Trial name
- NCT01470794
- Testing
- Toca 511 vector, Toca FC
- Where
- 8 sites in United States
- Volunteers
- 58 people
- Sponsor
- Tocagen Inc.
Pediatric Tumor of CNS, Pediatric Tumor of Brain
A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors
This is an open label, Phase 1b safety, dose-finding, brain tumor delivery, and pharmacokinetics study of intranasal NEO100 in patients with pediatric-type diffuse high grade gliomas.
- Conditions
- Pediatric Tumor of CNS, Pediatric Tumor of Brain, Diffuse Midline Glioma, H3 K27M-Mutant, Pediatric Tumor of Brain Stem
- Trial name
- NCT06357377
- Testing
- NEO100
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Neonc Technologies, Inc.
Cognitive Impairment, Cognitive Decline
Normative Values for the German Version of the Montreal Cognitive Assessment (MoCA)
This observational cohort study in healthy volunteers establishes normative data for the German version of the Montreal Cognitive Assessment (MoCA) and investigates the possible impacts of demographics on the MoCA total score.
- Conditions
- Cognitive Impairment, Cognitive Decline, Cognition Disorders, Cognitive Symptom
- Trial name
- MoCA-Norm (NCT03246269)
- Testing
- MoCA
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Andreas Monsch
Cerebral Vein Thrombosis, Deep Vein Thrombosis
Apixaban in Preventing Secondary Cancer Related Venous Thrombosis in Cancer Patients Who Have Completed Anticoagulation Therapy
This randomized phase III trial studies the best dose of apixaban and how well it works in preventing secondary cancer related venous thrombosis in cancer patients who have completed anticoagulation therapy.
- Conditions
- Cerebral Vein Thrombosis, Deep Vein Thrombosis, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT03080883
- Testing
- Apixaban
- Where
- 32 sites in United States
- Volunteers
- 370 people
- Sponsor
- Academic and Community Cancer Research United
Congestive Heart Failure, Diabetes
Evaluation of Programs of Coordinated Care and Disease Management
This is a Congressionally mandated study. In the original study, 16 demonstration programs provided care coordination services to beneficiaries with chronic illness in Medicare's fee-for-service program.
- Conditions
- Congestive Heart Failure, Diabetes, Coronary Artery Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- Coca (NCT00627029)
- Testing
- Care Coordination
- Where
- 15 sites in United States
- Volunteers
- 18,277 people
- Sponsor
- Mathematica Policy Research, Inc.
Brain Tumor, Glioma
Spinal Motor Evoked Potentials in Brain Surgery
During neurosurgical resection of brain tumors within brain areas for motor control, it is important to monitor motor function. For this muscle motor evoked potentials are used.
- Trial name
- NCT02402075
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Glioblastoma, CNS Disease
Dasatinib Plus Radiation Therapy/Temozolomide in Newly-Diagnosed Glioblastoma
Phase I: Primary Objectives: -To define the maximum tolerated dose (MTD) of dasatinib (Sprycel) with radiotherapy (RT) and 6 weeks of concomitant temozolomide (TMZ) administered at 75 mg/m^2/day in patients with newly-diagnosed…
- Conditions
- Glioblastoma, CNS Disease, Brain Diseases
- Trial name
- NCT00895960
- Testing
- Dasatinib, RT (Radiotherapy), TMZ (Temozolomide)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Metastases, Radionecrosis
Contribution of the CEST Sequence in the Characterization of Radionecrosis of Brain Metastases of Pulmonary Origin
The aim of the study is to determine whether the use of the CEST sequence would have diagnostic performance equivalent to the reference method of T2* infusion with contrast injection in the diagnosis of radionecrosis of lung…
- Conditions
- Brain Metastases, Radionecrosis, Pulmonary Cancer
- Trial name
- ACROP (NCT05977803)
- Testing
- MRI with CEST sequence, IVIM and ASL sequence
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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