Clinical trials: Cancer of Brain
Glioblastoma, Glioma
Blood-Brain Barrier Disruption (BBBD) for Liquid Biopsy in Subjects With GlioBlastoma Brain Tumors
The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type 2.0/2.1 for liquid biopsy in subjects with suspected Glioblastoma brain tumors
- Conditions
- Glioblastoma, Glioma, Liquid Biopsy
- Trial name
- NCT05383872
- Testing
- Focused Ultrasound (Exablate Model 4000)
- Where
- 17 sites in United States, Canada
- Volunteers
- 71 people
- Sponsor
- InSightec
Malignant Neoplasm, Metastatic Malignant Neoplasm in the Brain
DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis
This trial studies how well dual energy computed tomography (DECT) works in imaging patients with solid organ cancer that has spread to the brain.
- Trial name
- NCT03685539
- Testing
- Dual-Energy Computed Tomography
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- M.D. Anderson Cancer Center
Glioblastoma Multiforme, Primary Brain Tumor
Temozolomide Plus Bevacizumab in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status
The optimal treatment of glioblastoma multiforme (GBM) in patients aged ≥70 years with a Karnofsky performance status (KPS) <70 is unestablished.
- Trial name
- ATAG (NCT02898012)
- Testing
- Temozolomide, Bevacizumab
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Child With Cancer, Muscular Atrophy, Spinal
A BHI to Increase Hope Level and Stress Level of Parents With a CMC
Being a parent of a child with medical complexity (CMC) poses an enormous stress because these CMC have a multisystem disease, a severe neurologic condition or cancer which may result in premature death.
- Conditions
- Child With Cancer, Muscular Atrophy, Spinal, Child With Cerebral Palsy, Endocrine System Diseases
- Trial name
- NCT05269693
- Testing
- Brief Hope Intervention
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
Tumor, Brain
Multi-parametric MRI/Fluorine-18 Fluciclovine PET-CT in Glioblastoma
Glioblastoma is the most common adult brain tumour with approximately 2000 new cases each year in the UK. Optimal treatment consists of surgery followed by radiotherapy and chemotherapy but despite this survival is poor with only…
- Trial name
- NCT03409549
- Testing
- Fluciclovine PET/CT
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Brain Neoplasms, Lung Neoplasms
18F-fluorodeoxyglucose (18F-FDG) Positron Emission Tomography in Oncology
Positron emission tomography (PET) is a nuclear medicine procedure based on the measurement of positron emission from radiolabelled tracer molecules.
- Conditions
- Brain Neoplasms, Lung Neoplasms, Lymphoma, Melanoma
- Trial name
- NCT00207298
- Testing
- Positron Emission Tomography
- Where
- Canada
- Volunteers
- 39,242 people
- Sponsor
- British Columbia Cancer Agency
Glioma
Phase 2 Study of Vinblastine in Children With Recurrent or Refractory Low Grade Glioma
This study is examining whether Vinblastine is an effective drug to shrink low grade glioma brain tumors in children, and what the side effects are.
- Trial name
- NCT00213278
- Testing
- vinblastine sulphate injection
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- The Hospital for Sick Children
Brain Metastasis, Radiation Therapy
18F-FLUC PET/MR in Patients With Brain Mets
The goal of this clinical trial is to use new imaging methods to help in finding out whether the imaging shows that there is a tumor in people with a brain metastasis.
- Conditions
- Brain Metastasis, Radiation Therapy, Immunotherapy, Active
- Trial name
- NCT06159335
- Testing
- F-Fluciclovine radiotracer
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Brain Cancer
Fatigue, Sleep and Cytokines in Primary Brain Tumor (PBT) Patients
This goal of this research study is to learn more about fatigue, sleep quality, and other symptoms in patients with primary brain tumors who are being treated with radiation therapy. Objectives: PRIMARY OBJECTIVE: 1.
- Trial name
- NCT00876499
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Brain and Central Nervous System Tumors
Lymphokine-Activated Killer Cells or Gliadel Wafer in Treating Patients With Newly Diagnosed Glioblastoma Multiforme That Can Be Removed by Surgery
RATIONALE: Biological therapies, such as lymphokine-activated killer cells, may stimulate the immune system in different ways and stop tumor cells from growing.
- Trial name
- NCT00814593
- Testing
- lymphokine-activated killer cells, polifeprosan 20 with carmustine implant
- Where
- United States
- Sponsor
- Lisata Therapeutics, Inc.
Metastatic Colon Cancer
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients
The aim of this study is to prospectively determine the incidence of brain metastases in metastatic colorectal cancer patients using systematic annual screening by MRI.
- Trial name
- NCT03694938
- Testing
- Magnetic resonance imaging
- Where
- 4 sites in France
- Volunteers
- 143 people
- Sponsor
- Poitiers University Hospital
Metastatic Intracranial Malignant Neoplasm, Recurrent Intracranial Neoplasm
18F-fluciclovine PET/MRI Imaging for the Detection of Tumor Recurrence After Radiation Injury to the Brain
This phase I trial studies the ability and amount of fluciclovine positron emission tomography (PET) imaging needed to recognize tumors that have come back (recurrence) after brain injury from radiation therapy (radionecrosis) in…
- Trial name
- NCT04462419
- Testing
- Dynamic Contrast-Enhanced Magnetic Resonance Imaging with Positron Emission Tomography, Fluciclovine F18
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Mayo Clinic
Brain Tumor Adult
Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
This study evaluates the use of specialized magnetic resonance imaging (MRI) techniques including magnetic resonance (MR) perfusion and 2-hydroxyglutarate (2HG) spectroscopy in the surgical treatment of gliomas.
- Trial name
- NCT03542409
- Testing
- MR Perfusion Scan, 2HG Spectroscopy Scan, Standard of Care Intraoperative MRI
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Utah
Von Hippel-Lindau Syndrome, Renal Cell Carcinoma
Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow
The goal of this clinical research study is to learn if sunitinib malate (SU011248) can help to control VHL. The safety of this drug will also be studied.
- Conditions
- Von Hippel-Lindau Syndrome, Renal Cell Carcinoma, Hemangioblastoma
- Trial name
- NCT00330564
- Testing
- SU011248
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Pediatric Recurrent/Refractory BRAFV600E-mutant Gliomas
Vemurafenib in Children With Recurrent/Refractory BRAF Gene V600E (BRAFV600E)-Mutant Gliomas
This is a multicenter, safety and pharmacokinetic trial to determine the MTD and/or select a recommended phase 2 dose (RP2D) of vemurafenib in children with recurrent or refractory gliomas containing the BRAFV600E or BRAF Ins T…
- Trial name
- NCT01748149
- Testing
- Vemurafenib
- Where
- 21 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Metastatic Breast Cancer, Brain Metastases
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Patients with metastatic breast cancer with at least 2 brain metastases will receive pembrolizumab every 3 weeks. Patients will undergo stereotactic radiosurgery (SRS) to one of the brain lesions.
- Trial name
- NCT03449238
- Testing
- Pembrolizumab
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Weill Medical College of Cornell University
Cancer, Breast Cancer
Mind Over Matter for Black and African American Women: A Single Arm Trial Examining Feasibility and Acceptability of a Supportive Intervention
The goal of this study is to learn if the Mind Over Matter (MOM) Intervention, a 5-week group program, can help Black and African American women deal with the fears, worries and sadness that often accompany cancer diagnosis and…
- Conditions
- Cancer, Breast Cancer, Brain Cancer, Central Nervous System Cancer
- Trial name
- MOM (NCT06168825)
- Testing
- Mind Over Matter (MOM)
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Inova Health Care Services
Tumor, Brain
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation
Elucidating the structure-function relationship of the brain is one of the main open questions in neuroscience. The capabilities of diffusion MRI-based (dMRI) techniques to quantify the connectivity strength between brain areas…
- Trial name
- NCT03503110
- Testing
- electrocorticography with electrostimulation, dRMI
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Brain Cancer, Pituitary Adenoma
A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors
The purpose of this study is to test if PET scans using 89Zr-DFO-cRGDY-PEG-Cy5-C' dot particles, can be used to take pictures of brain tumors.
- Trial name
- NCT03465618
- Testing
- 89Zr-DFO-cRGDY-PEG-Cy5-C' dots PET Imaging, Blood and Urine samples
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Lymphoma, Malignant
Efficacy of Patient Management for Lymphoma Diagnosed at Nimes University Hospital From 1999 to 2018. DVR-Lym-Nim
Observation of a cohort of 400 patients with different types of lymphomas.
- Trial name
- DVR-Lym-Nim (NCT04947618)
- Where
- France
- Volunteers
- 136 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes