Clinical trials: Cancer of Brain
Glioma, Dapagliflozin (Forxiga)
Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients
The aim of the study is to compare between the role of dapagliflozin versus dexamethasone in pre-operative management of non-diabetic glioma patients on levetiracetam as anti-seizure drug.
- Conditions
- Glioma, Dapagliflozin (Forxiga), Dexamethasone
- Trial name
- NCT06750458
- Testing
- DexamethasoneGroup III (n=25) (Dexamethasone group)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Brain Metastases, Adult
Intrafractional Head Movement During Radiosurgery
This study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head movements.
- Trial name
- NCT03896555
- Testing
- ExacTrac position verification
- Where
- Austria
- Volunteers
- 5 people
- Sponsor
- Medical University Innsbruck
Pituitary Neoplasms
Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection
Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation.
- Trial name
- NCT05088252
- Testing
- Desflurane, Propofol
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Beijing Tiantan Hospital
Ependymoma, Brainstem Glioma
A Pilot Study Evaluating 18F-L-Thymidine (FLT) PET Imaging in Children With Gliomas
Background: Children with brain tumors often have magnetic resonance imaging (MRI) scans to see if the tumor has responded to therapy or to see if the tumor has grown.
- Conditions
- Ependymoma, Brainstem Glioma, Astrocytoma, Glioblastoma Multiforme
- Trial name
- NCT01117155
- Sponsor
- National Cancer Institute (NCI)
Childhood Brain Tumors
Antineoplaston Therapy in Treating Children With Brain Tumors
RATIONALE: Current therapies for childhood brain tumors provide limited benefit to the patient. The anti-cancer properties of Antineoplaston therapy suggest that it may prove beneficial in the treatment of childhood brain tumors.
- Trial name
- NCT00003458
- Testing
- Antineoplaston therapy (Atengenal + Astugenal)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Burzynski Research Institute
Brain Metastases, Posterior Fossa Lesion
A Study to Assess the Efficacy of Cerebellar IMRT Combined With Cerebral SRS in Patients With Brain Metastases
A single-arm pilot study, to assess the efficacy of cerebellar IMRT combined with cerebral SRS in patients with brain metastases that are predominantly in the posterior fossa - a novel treatment approach
- Conditions
- Brain Metastases, Posterior Fossa Lesion, Cerebral Lesion
- Trial name
- NCT05477316
- Testing
- Radiation treatment
- Where
- Israel
- Volunteers
- 37 people
- Sponsor
- Hadassah Medical Organization
Cerebral Cavernous Malformations
Effect of Oral Propranolol on mRNA Expresssion in Symptomatic Cavernous Malformation
This is a single center, randomized, trial that will enroll twenty (n=20) patients with a diagnosis of symptomatic cavernous malformations who are planned candidates for surgical resection by one of the investigators, and who…
- Trial name
- NCT03474614
- Testing
- Propranolol, DNA and RNA Analysis
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Glioblastoma Multiforme, Anaplastic Astrocytoma
AZD8055 for Adults With Recurrent Gliomas
Background: AZD8055 is an experimental cancer treatment drug that works by inhibiting a protein called mTOR, which is known to promote tumor cell and blood vessel growth and to control tumor s energy and nutrient levels.
- Conditions
- Glioblastoma Multiforme, Anaplastic Astrocytoma, Anaplastic Oligodendroglioma, Malignant Glioma
- Trial name
- NCT01316809
- Testing
- AZD8055
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Hematological Neoplasms, Non-Hodgkin's Lymphoma
Bioequivalence & Food Effect Study in Patients With Solid Tumor or Hematologic Malignancies
This is a Phase 1, open-label, multicenter, randomized, 2-stage crossover study consisting of 2 phases: Stage I - Pharmacokinetics (Bioequivalence), with an Extension Stage II - Pharmacokinetics (Food Effect) with an Extension…
- Conditions
- Hematological Neoplasms, Non-Hodgkin's Lymphoma, Hodgkin's Lymphoma, Lymphoma
- Trial name
- NCT02223052
- Testing
- CC-486, Vidaza
- Where
- 10 sites in United States
- Volunteers
- 89 people
- Sponsor
- Celgene
Quality of Life, Stroke, Acute
Cerebrovascular Disease: Quality of Life (CODE: QoL)
The goal of this observational study is to learn about quality of life, stress and caregiver burden in patients with stroke and their caregivers.
- Conditions
- Quality of Life, Stroke, Acute, Sexual Behavior, Stress
- Trial name
- CODE:QoL (NCT06443268)
- Testing
- questionnaire, hair samples, blood samples, clinical exam
- Where
- Switzerland
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Brain Tumour, Glioma
Use of Non-invasive Optical Analysis in Neurosurgery
The present study aims to investigate the potential application of multispectral analysis, hyperspectral imaging, and fluorescence during neuro-oncological procedures, specifically during brain tumour debulking / resection.
- Conditions
- Brain Tumour, Glioma, Meningioma, Brain Metastases
- Trial name
- NCT04712214
- Testing
- Intra-operative multispectral / hyperspectral analysis
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Hemangioma
Topical Timolol Gel for the Treatment of Infantile Hemangiomas
We plan to conduct a study, to see how safe and effective timolol maleate 0.5% gel-forming solution is for infantile hemangiomas (IH) and the response of hemangiomas to timolol maleate 0.5% .
- Trial name
- NCT02145884
- Testing
- timolol maleate 0.5% gel
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Rady Children's Hospital, San Diego
Brain Cancer
A Pilot Study to Determine Nutrition Status in Glioblastoma Multiforme Patients
The study is designed to evaluate how the composition of a participant's body, diagnosed with a brain tumor (glioblastoma multiforme) as determined by bioelectrical impedance analysis can predict the progression and outcomes of…
- Trial name
- BEAM (NCT01770626)
- Testing
- Nutrition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Brain and Central Nervous System Tumors
Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma
RATIONALE: Radiolabeled monoclonal antibodies can locate tumor cells and deliver tumor-killing substances to them without harming normal cells. This may be an effective treatment for some types of brain tumors.
- Trial name
- NCT00004017
- Testing
- conventional surgery, iodine I 131 monoclonal antibody TNT-1/B
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Peregrine Pharmaceuticals
Brain Tumor
Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors
This clinical trial studies optical imaging in assessing activity during surgery in patients with brain tumors. New procedures, such as optical spectroscopy, may help doctors maximally remove brain tumors and minimize damage to…
- Trial name
- NCT01627535
- Testing
- Interoperative Optical Imaging and Spectroscopy
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- City of Hope Medical Center
Brain Neoplasms, Child
Effectiveness of Musical Training in Children Surviving Brain Tumours
This study aims to examine the effects of musical training on improving the neurocognitive function and psychological well-being of children surviving brain tumours.
- Trial name
- NCT02754908
- Testing
- musical training, tutoring classes
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Pituitary Tumor, Surgery
Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery
Pituitary tumours have an estimated prevalence of 20% in the general population and the number of clinically relevant pituitary adenomas is increasing with time.
- Conditions
- Pituitary Tumor, Surgery, Olfactory Nerve Injuries
- Trial name
- NCT03773705
- Testing
- Electrocautery versus scalpel
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Metastatic BRCA Hereditary Breast Carcinoma, Metastatic Breast Carcinoma
Cisplatin With or Without Veliparib in Treating Patients With Recurrent or Metastatic Triple-Negative and/or BRCA Mutation-Associated Breast Cancer With or Without Brain Metastases
This randomized phase II trial studies how well cisplatin works with or without veliparib in treating patients with triple-negative breast cancer and/or BRCA mutation-associated breast cancer that has come back (recurrent) or has…
- Conditions
- Metastatic BRCA Hereditary Breast Carcinoma, Metastatic Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain, Metastatic Triple-Negative Breast Carcinoma
- Trial name
- NCT02595905
- Testing
- Cisplatin, Laboratory Biomarker Analysis, Veliparib
- Where
- 810 sites in United States, Puerto Rico
- Volunteers
- 344 people
- Sponsor
- National Cancer Institute (NCI)
Glioma, Brain Neoplasms
Susceptibility-Weighted Imaging in Preoperative Grading of Cerebral Gliomas
Gliomas are the most common primary brain tumors in adults. Determining whether a glioma is low-grade or high-grade before surgery is essential for surgical planning, choosing treatment pathways, and determining prognosis.
- Conditions
- Glioma, Brain Neoplasms, Cerebral Glioma
- Trial name
- NCT07813741
- Volunteers
- 90 people
- Sponsor
- Assiut University
Brain and Central Nervous System Tumors, Breast Cancer
Study of Cerebrospinal Fluid Samples in Diagnosing Carcinomatous Meningitis in Patients With Cancer or Meningeal Syndrome
RATIONALE: Studying samples of cerebrospinal fluid from patients with cancer or meningeal syndrome may help doctors identify biomarkers related to cancer.
- Conditions
- Brain and Central Nervous System Tumors, Breast Cancer, Metastatic Cancer
- Trial name
- NCT00938756
- Testing
- diagnostic laboratory biomarker analysis, immunoenzyme technique, magnetic resonance imaging
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Oscar Lambret
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