Clinical trials: Cancer of Brain
Osteosarcoma, Ewing's Sarcoma
Informed Consent in Pediatric Cancer Trials
Background: Informed consent is the process by which prospective participants in clinical trials learn about clinical research in order to decide whether they want to enroll in the study.
- Conditions
- Osteosarcoma, Ewing's Sarcoma, Neuroblastoma, Brain Tumors
- Trial name
- NCT00923650
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- National Cancer Institute (NCI)
Brain Tumors With Ill-defined Margins
Intra-operative Use of Indigo Carmine Dye for the Delineation of Ill Defined Tumor Borders Using Stereotactic Injection
The purpose of this study is to investigate whether stereotactic indigo carmine injection can safely increase the extent of tumor resection.
- Trial name
- NCT01767415
- Testing
- Indigo carmine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Weill Medical College of Cornell University
Primary Brain Neoplasms
The Effect of Education Brain Tumors
This study was designed to evaluate the impact of education programs for patients with primary brain tumors and their caregivers on quality of life and the burden of care experienced by caregivers.
- Trial name
- Education&BT (NCT07617168)
- Testing
- structured training based on the Life Model in Nursing
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Istanbul University - Cerrahpasa
Lymphoma
PET-based Evaluation of Chemotherapy-induced Brain Damage in Lymphoma
Positron emission tomography (PET) with 18-fluoro-deoxy-glucose (PET-FDG) is emerging as a promising approach for detecting brain lesions in dementia, among which Alzheimer's disease has been the most widely studied.
- Trial name
- LYMCOTEP (NCT02601547)
- Testing
- PET-FDG brain imaging and NPT
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse
Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors
Intraoperative Neurophysiological Monitoring in Brain Tumor Surgery: Prospective Cohort Studies
BACKGROUND Brain tumor surgery requires balancing two competing priorities: maximizing the extent of tumor resection to improve survival while preserving neurological function.
- Conditions
- Intraoperative Neurophysiological Monitoring, Malignant Brain Tumors, Motor Evoked Potential Monitoring, Cortico-cortical Evoked Potential Monitoring
- Trial name
- NCT07789938
- Testing
- Intraoperative neurophysiological monitoring, no Intraoperative neurophysiological monitoring
- Where
- Denmark
- Volunteers
- 166 people
- Sponsor
- Odense University Hospital
Non Small Cell Lung Cancer, Brain Metastases
Cadonilimab Combined With Stereotactic Radiotherapy as Second-line Treatment for Brain Metastases
The goal of this clinical trial is to evaluate the efficacy and safety of Cadonilimab combined with stereotactic radiation therapy in the second-line treatment of brain metastases from non-small cell lung cancer (NSCLC).
- Conditions
- Non Small Cell Lung Cancer, Brain Metastases, Stereotactic Radiation, Immunotherapy
- Trial name
- NCT06702826
- Testing
- Cadonilimab combined with SRS
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Rongrong Zhou
Brain and Central Nervous System Tumors
Cellular Adoptive Immunotherapy in Treating Patients With Glioblastoma Multiforme
RATIONALE: Biological therapies, such as cellular adoptive immunotherapy, may stimulate the immune system in different ways and stop tumor cells from growing.
- Trial name
- NCT00331526
- Testing
- aldesleukin, therapeutic autologous lymphocytes, adjuvant therapy
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
High-grade Glioma of the Brain
PET Imaging of High-grade Glioma Using 18F-fluoromethylcholine: a Tool for the Early Detection of Tumour Recurrence After Combined Radiochemotherapy?
The aim of the study is to define preferential sites of tumour recurrence by observing tracer uptake in the tumour in sequential PET images with 18F-fluoromethylcholine (and perfusion MR, see also below).
- Trial name
- NCT00628940
- Testing
- PET images with 18F-fluoromethylcholine
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- University Ghent
Advanced Solid Tumor Cancer, Metastatic Solid Tumor
A First-in-Human Study of ZE94-0605 in Patients With Advanced Solid Tumors
ZE94-0605 is an oral, selective cyclin-dependent kinase 2 (CDK2) inhibitor. This multicenter, open-label, first-in-human Phase 1 study will evaluate ZE94-0605 in adults with advanced, unresectable or metastatic solid tumors.
- Trial name
- NCT07524140
- Testing
- ZE94-0605
- Where
- 3 sites in Australia, Uzbekistan
- Volunteers
- 60 people
- Sponsor
- Eilean Therapeutics
Brain and Central Nervous System Tumors, Neuroblastoma
Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal Tumors
RATIONALE: Radiation therapy uses x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00003846
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 13 sites in United States
- Volunteers
- 25 people
- Sponsor
- Children's Oncology Group
Breast Cancer, Esophageal Cancer
Brodalumab in the Treatment of Immune-Related Adverse Events
The purpose of this study is to test the safety and effectiveness of using brodalumab in patients who develop side effects from cancer immune therapy.
- Conditions
- Breast Cancer, Esophageal Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT06673329
- Testing
- Brodalumab, CT scan
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Brian Henick, MD
Glioma, Glioblastoma Multiforme
Study of DC Vaccination Against Glioblastoma
This is a Phase II study in a single center to determine the efficacy of autologous dendritic cells (DCs) loaded with autogeneic glioma stem-like cells (A2B5+) administered as a vaccination in adults with glioblastoma multiforme…
- Conditions
- Glioma, Glioblastoma Multiforme, Neoplasms
- Trial name
- NCT01567202
- Testing
- Surgery, Chemotherapy, Radiotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Recurrent Glioblastoma Multiforme
Safety & Radiation Distribution Study of Cotara® in Patients With Recurrent Glioblastoma Multiforme
RATIONALE: Cotara® is an experimental new treatment that links a radioactive isotope (iodine 131) to a targeted monoclonal antibody.
- Trial name
- NCT00509301
- Testing
- 131-I-chTNT-1/B MAB
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Peregrine Pharmaceuticals
Brain Tumor
MEP and Neuromuscular Blocker
It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the…
- Trial name
- NCT04768400
- Testing
- Arm I (MEP)
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Gangnam Severance Hospital
Glioblastoma Multiforme of Brain, Brain Cancer
Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme
This study aims to treat patients who have been diagnosed with brain cancer glioblastoma multiforme (GBM) including diffuse intrinsic pontine glioma (DIPG) and diffuse midline glioma (DMG).
- Trial name
- NCT03170141
- Testing
- Antigen-specific IgT cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Brain Tumors
Tandem High Dose Chemotherapy and Autologous Stem Cell Rescue for High Risk Pediatric Brain Tumors
The investigators plan to improve event free survival rate and reduce treatment related toxicities of pediatric patients with high risk/recurrent CNS tumors by administrating tandem high dose chemotherapy and autologous stem cell…
- Trial name
- NCT01342237
- Testing
- HDCT 1(TTC), HDCT2(MEC)
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Seoul National University Hospital
Childhood Cancer, Childhood Solid Tumor
Precision Medicine for Every Child With Cancer
To improve outcomes for childhood cancer patients through the implementation of precision medicine.
- Conditions
- Childhood Cancer, Childhood Solid Tumor, Childhood Brain Tumor, Childhood Leukemia
- Trial name
- ZERO2 (NCT05504772)
- Testing
- Whole Genome Sequencing, RNA seq, DNA Methylation
- Where
- 11 sites in Australia, New Zealand
- Volunteers
- 3,500 people
- Sponsor
- Australian & New Zealand Children's Haematology/Oncology Group
Pediatric Cancers
Carotid Artery Disease in Childhood Cancer Survivors
The goal of this clinical research study is to find out if long-term survivors of childhood head or neck cancer, who received radiation therapy as part of the overall treatment plan, are at increased risk of thickening or…
- Trial name
- NCT00591539
- Testing
- Carotid Ultrasound
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Non Small Cell Lung Cancer
Immune Treatment of Brain Metastasis of Lung Cancer Combined With Large-segmentation Precision Radiotherapy
This is a prospective multicenter clinical study. This study aims to construct an auxiliary decision-making system for lung cancer immunotherapy combined with radiotherapy by fusing three modes of imagomics, clinicopathological…
- Trial name
- NCT05584267
- Testing
- radiotherapy, Chemotherapy + immunotherapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hunan Province Tumor Hospital
Brain Cancer, Brain Tumor
HOBSCOTCH-CA (HOme-Based Self-management and COgnitive Training CHanges Lives in Brain CAncer)
The purpose of this study is to assess the ability of the home-based intervention, HOBSCOTCH-CA, to improve the quality of life and cognitive function in Service Members, Veterans and civilians who are survivors of brain cancer…
- Conditions
- Brain Cancer, Brain Tumor, Brain Neoplasms, Primary Brain Tumor
- Trial name
- HOBSCOTCH-CA (NCT06930846)
- Testing
- HOBSCOTCH-CA
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
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