Clinical trials: Cancer of Esophagus
Gastric Cancer Adenocarcinoma Metastatic, Gastric Adenocarcinoma and Gastroesophageal Junction Adenocarcinoma
Phase II RAINSPOT: Zolbetuximab-Paclitaxel-Ramucirumab for CLDN18.2 Positive Gastro-esophageal Cancer
This study examines whether adding the drug Zolbetuximab to an existing treatment (Paclitaxel and Ramucirumab) can improve patients' survival.
- Trial name
- RAINSPOT (NCT06962137)
- Testing
- zolbetuximab, Retrospective cohort, no intervention
- Where
- 6 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sarcoma, Melanoma
A Study of PRT1419 in Patients With Advanced Solid Tumors
This is a Phase 1 dose-escalation study of PRT1419, a myeloid cell leukemia 1 (MCL1) inhibitor, in patients with advanced solid tumors.
- Conditions
- Sarcoma, Melanoma, Lung Cancer, Breast Cancer
- Trial name
- NCT04837677
- Testing
- PRT1419
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Prelude Therapeutics Incorporated
Epiphora Due to Insufficient Drainage, Left Side, Epiphora Due to Insufficient Drainage, Right Side
Minimally Invasive Intrathoracic Esophagogastric Side to Side Anastomosis vs. End to Side Anastomosis
On the basis of minimally invasive Ivor Lewis operation for the treatment of lower thoracic esophageal cancer or esophageal gastric junction cancer, the purpose of this study is to compare the probability of anastomotic leakage…
- Trial name
- NCT05812495
- Testing
- Esophagogastric Side to Side Anastomosis, Esophagogastric End to Side Anastomosis
- Where
- China
- Volunteers
- 402 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Esophageal Cancer
Efficacy and Safety of Penpulimab Combined With Anlotinib and Chemotherapy
This study is a two arm, randomized, prospective, multicenter study on the perioperative treatment of locally advanced resectable esophageal cancer with penpulimab combined with anlotinib hydrochloride and chemotherapy.
- Trial name
- EASOPCWAAC (NCT06586242)
- Testing
- Penpulimab;Anlotinib;albumin paclitaxel;oxaliplatin;lobaplatin
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Xijing Hospital
Esophageal Squamous Cell Carcinoma, Chemoradiation
Comparing Paclitaxel/Cisplatin and Cisplatin/5-fluorouracil in Neo-CRT for ESCC
This clinical trial has two stages: phase II and phase III. Eligible patients will be randomized 1:1 to the two arms: paclitaxel plus cisplatin and cisplatin plus 5-fluorouracil.
- Trial name
- NCT03623737
- Testing
- neoadjuvant chemoradiation
- Where
- Taiwan
- Volunteers
- 248 people
- Sponsor
- National Taiwan University Hospital
Esophageal Squamous Cell Carcinoma (ESCC)
A Study to Investigate Tislelizumab (BGB-A317) Versus Placebo in Combination With Concurrent Chemoradiotherapy in Participants With Localized Esophageal Squamous Cell Carcinoma
This is a phase 3, randomized, double-blind, placebo-controlled study to compare the efficacy and safety of tislelizumab (BGB-A317) versus placebo in combination with chemoradiotherapy in participants with localized esophageal…
- Trial name
- NCT03957590
- Testing
- Tislelizumab, Paclitaxel, Cisplatin
- Where
- 33 sites in China
- Volunteers
- 370 people
- Sponsor
- BeiGene
Esophagus Cancer
The Efficacy and Safety of Caffeic Acid for Esophageal Cancer
Caffeic acid can target inhibit GASC1 (gene amplified in squamous cell carcinoma 1, also known as KDM4C and JMJD2C) expression and GASC1 is confirmed to be a new oncogene in several cancers including esophageal cancer.
- Trial name
- CAEC (NCT03070262)
- Testing
- CA
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital of Henan University of Science and Technology
Stomach Neoplasm, Intestinal Neoplasm
Multicentric Study an Endoscopic Treatment of Digestive Neoplasia by Submucosal Dissection Evaluation of a New Water Jet System
safety evaluation of endoscopic sub-mucosal dissection with nestis enki2 system. This system is a new water jet system which allows to perform Endoscopic submucosal dissection with a bifunctional catheter (injection and cutting).
- Conditions
- Stomach Neoplasm, Intestinal Neoplasm, Rectal Neoplasm
- Trial name
- NCT01910974
- Testing
- endoscopic sub-mucosal dissection
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hôpital Edouard Herriot
Esophageal Neoplasms
Influence of Esophageal Washout on Local Carcinoma Recurrence After Curative Resection
The LOCARE-Trial is an investigator initiated, randomized-controlled trial with two parallel arms (n=60 each) and investigates the influence of esophageal washout on long-term outcomes in patients undergoing elective esophageal…
- Trial name
- LOCARE (NCT02676791)
- Testing
- Povidone-Iodine
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technische Universität Dresden
Oesophageal Cancer
Understanding the Variation of Modern Endoscopic Ultrasound Use in Patients With Oesophageal Cancer (VALUE)
This is an observational trial that will look at patients undergoing endoscopic ultrasound (EUS) in patients with oesophageal cancer and to determine the proportion of cases in which EUS changes disease management in these…
- Trial name
- VALUE (NCT06440174)
- Testing
- endoscopic ultrasound
- Where
- 14 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Esophageal Cancer (EC)
A Phase II Study of Anlotinib + PD-1 Inhibitor vs. PD-1 Inhibitor Maintenance After First-Line Chemoimmunotherapy in Advanced ESCC (Esophageal Squamous Cell Carcinoma)
Chemotherapy combined with PD-1 inhibitor immunotherapy is the standard treatment for advanced esophageal squamous cell carcinoma (ESCC), yet patient prognosis remains unsatisfactory, with a median PFS of only about 6 months and…
- Trial name
- NCT07863141
- Testing
- anlotinib + PD-1 inhibitor, PD-1 inhibitor
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Sun Yat-sen University
Esophageal Cancer, Gastric Cancer
Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus
The main purpose of this study is to see whether the combination of selinexor (KPT-330) and irinotecan can help people with esophageal or stomach cancer.
- Trial name
- NCT02283359
- Testing
- Selinexor, Irinotecan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cancer, Squamous Cell Carcinoma
Esophagectomy for Patients With Esophageal Cancer and Cervical Lymph Node Metastases
There is no world-wide consensus on the oncological benefit versus increased morbidity associated with three field lymphadenectomy in patients with esophageal cancer and cervical lymph node metastases.
- Conditions
- Cancer, Squamous Cell Carcinoma, Adenocarcinoma, Malignancy
- Trial name
- Node (NCT02426879)
- Testing
- esophagectomy with three-field lymphnode dissection
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Solid Tumors
Investigator Initiated Phase 1 Study of TBI-1301
Following pre-treatment with cyclophosphamide and/or fludarabine, NY-ESO-1-specific TCR gene transduced T lymphocytes are transferred to the patients with NY-ESO-1-expressing solid tumors.
- Trial name
- NCT02366546
- Testing
- TBI-1301, Cyclophosphamide, Fludarabine
- Where
- Japan
- Volunteers
- 9 people
- Sponsor
- Mie University
Esophageal Cancer
Cisplatin, Capecitabine, and Radiation Therapy With or Without Cetuximab in Treating Patients With Esophageal Cancer
RATIONALE: Drugs used in chemotherapy, such as cisplatin and capecitabine, work in different ways to kill tumor cells or stop them from growing. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- NCT00509561
- Testing
- cetuximab, capecitabine, cisplatin
- Where
- 55 sites in United Kingdom
- Volunteers
- 259 people
- Sponsor
- Wales Cancer Trials Unit
Barrett's Esophagus
Confocal Laser Endomicroscopy vs Conventional Histology for the Identification of Intestinal Metaplasia
Real-time Diagnosis of Barrett's Esophagus: Comparing Confocal Laser Endomicroscopy with Conventional Histology for the Identification of Specialized Intestinal Metaplasia
- Trial name
- NCT02632682
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Minnesota Institute for Minimally Invasive Surgery
Barrett Esophagus
Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus
This pilot clinical trial studies non-endoscopic brushing of the esophagus using a non-endoscopic inflatable balloon for the esophagus in screening for Barrett esophagus, a condition where the lining of the esophagus has changed…
- Trial name
- NCT02451124
- Testing
- non-endoscopic inflatable balloon for the esophagus, Questionnaire Administration, Laboratory Biomarker Analysis
- Where
- 2 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Esophageal Cancer
The Diagnostic Value of Nitrogen Element (N) in Esophagus Cancer
The purpose of this study is to determine the diagnostic value of various nitrogen components in oral gas for esophagus cancer (ESCA) .
- Trial name
- NCT05494359
- Testing
- The nitrogen isotope
- Where
- 3 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Barrett Esophagus, Gastroesophageal Reflux
Multi-Site Detection of Barrett's Esophagus in Patients Without Chronic GERD Symptoms
The goal of this clinical trial is to develop a method to detect Barrett's esophagus in individuals with a new office based diagnostic test.
- Conditions
- Barrett Esophagus, Gastroesophageal Reflux, Esophageal Adenocarcinoma
- Trial name
- NCT06687603
- Testing
- EsoCheck, EsoGuard
- Where
- 5 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Case Comprehensive Cancer Center
Gastro-Intestinal Cancer
sFOLFOXIRI in Advanced Gastroesophageal Cancer, (SAGE)
The primary objective is to determine the clinical efficacy of treatment regimen in terms of objective response rate (ORR). The secondary objectives is to determine the clinical efficacy of the study treatment in terms of…
- Trial name
- NCT05332002
- Testing
- Four week alternating FOLFOX and FOLFIRI (sFOLFOXIRI)
- Where
- 6 sites in United States
- Volunteers
- 38 people
- Sponsor
- Rutgers, The State University of New Jersey